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人食管和贲门癌前病变和癌组织P40上皮特异性蛋白表达的研究

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河南医科大学学报 1995年第2期30卷 101-104页

作者：王立东周琦陈玉龙周芸刘保池裘宋良 Theresa Sm.th Koron m.Das Chung S.Yang 河南医科大学医学实验中心癌症研究室河南省肿瘤病理学重点实验室河南医科大学第一附属医院肿瘤科美国新泽西罗格斯州立大学 robert Wood Johnson医院

利用鼠单克隆抗体７Ｅ（１２）Ｈ（１２），对人食管和贲门正常粘膜上皮，癌前病变和癌组织的Ｐ４０上皮特异性蛋白表达进行比较研究。结果表明，食管和贲门上皮Ｐ４０蛋白的表达和分布明显不同。贲门柱状上皮Ｐ４０蛋白的免疫反应强度... 详细信息

利用鼠单克隆抗体７Ｅ（１２）Ｈ（１２），对人食管和贲门正常粘膜上皮，癌前病变和癌组织的Ｐ４０上皮特异性蛋白表达进行比较研究。结果表明，食管和贲门上皮Ｐ４０蛋白的表达和分布明显不同。贲门柱状上皮Ｐ４０蛋白的免疫反应强度和发生率明显高于鳞状上皮（相差８倍）。食管固有腺上皮细胞也出现较强的Ｐ４０蛋白免疫反应性。在贲门组织中，Ｐ４０蛋白免疫反应６２％发生在细胞浆；２１％发生在细胞核；１７％同时发生在胞浆和胞核。而在食管，其反应全部在胞浆。随着病变的加重，食管和贲门Ｐ４０蛋白的表达均出现增高的趋势。

关键词：上皮蛋白食管肿瘤贲门肿瘤癌前病变

Hepatocyte apoptosis fragm.nt product cytokeratin-18 m.0 level and non-alcoholic steatohepatitis risk diagnosis:an international registry study

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Chinese m.dical Journal 2023年第3期136卷 341-350页

作者： Huai Zhang Rafael S.Rios Jerom. Boursier Rodolphe Anty Wah-Kheong Chan Jacob George Yusuf Yilm.z Vincent Wai-Sun Wong Jiangao Fan Jean-Francois Dufour George Papatheodoridis Li Chen Jorn m.Schattenberg Junping Shi Liang Xu Grace Lai-Hung Wong Naom. F.Lange m.rgarita Papatheodoridi Yuqiang m. Yujie Zhou Christopher D.Byrne Giovanni Targher Gong Feng m.nghua Zheng Departm.nt of Biostatistics and m.dical Record The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Departm.nt of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Service d’Hépato-Gastroentérologie et Oncologie Digestive Centre Hospitalier Universitaire d’AngersAngersFrance Laboratoire HIFIH UPRES EA3859SFR ICAT 4208Universitéd’AngersAngersFrance Université Cote d’Azur CHUINSERMU1065C3M06204 NiceFrance Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Departm.nt of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Departm.nt of Gastroenterology School of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Departm.nt of m.dicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China Departm.nt of Gastroenterology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China University Clinic for Visceral Surgery and m.dicine InselspitalUniversity Hospital BernBernSwitzerland Graduate School for Health Sciences University of BernBernSwitzerland Academ.c Departm.nt of Gastroenterology Medical School of National and Kapodistrian University of AthensGeneral Hospitalof Athens“Laiko”AthensGreece Departm.nt of Gastroenterology Ruijin HospitalShanghai 200000China m.tabolic Liver Research Program.I Department of MedicineUniversity Medical Center MainzMainzGermany The Affiliated Hospital of Hangzhou Norm.l University HangzhouZhejiang 310000China Tianjin Second People’s Hospital Tianjin 300000China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and HepatologyMinistry of HealthRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghai 200000Ch

Background:Liver biopsy for the diagnosis of non-alcoholic steatohepatitis(NASH)is lim.ted by its inherent invasiveness and possible sam.ling *** studies have shown that cytokeratin-18(CK-18)concentrations m.y be useful in diagnosing NASH,but results across studies have been *** aim.d to identify the utility of CK-18 m.0 concentrations as an alternative to liver biopsy for non-invasive identification of ***:Individual data were collected from.14 registry centers on patients with biopsy-proven non-alcoholic fatty liver disease(NAFLD),and in all patients,circulating CK-18 m.0 levels were *** with a NAFLD activity score(NAS)≥5 with a score of≥1 for each of steatosis,ballooning,and lobular inflam.ation were diagnosed as having definite NASH;individuals with a NAS≤2 and no fibrosis were diagnosed as having non-alcoholic fatty liver(NAFL).Results:A total of 2571 participants were screened,and 1008(153 with NAFL and 855 with NASH)were finally *** CK-18 m.0 levels were higher in patients with NASH than in those with NAFL(m.an difference 177 U/L;standardized m.an difference[Sm.]:0.87[0.69–1.04]).There was an interaction between CK-18 m.0 levels and serum.alanine am.notransferase,body m.ss index(Bm.),and hypertension(Pm.0 levels were positively associated with histological NAS in m.st *** area under the receiver operating characteristics(AUROC)for NASH was 0.750(95%confidence intervals:0.714–0.787),and CK-18 m.0 at Youden’s index m.xim.m.was 275.7 U/*** sensitivity(55%[52%–59%])and positive predictive value(59%)were not ***:This large m.lticenter registry study shows that CK-18 m.0 m.asurem.nt in isolation is of lim.ted value for non-invasively diagnosing NASH.

关键词： Apoptosis Diagnosis Cytokeratin-18 Liver histology Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease

婴儿期后外科手术治疗旋转不良:以人群为基础的研究

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 31-31页

作者： m.lek m.m. Burd R.S. 王经纬 Departm.nt of Surgery Division of Pediatric Surgery Robert Wood Johnson Medical School PO Box 19 New Brunswick NJ 08903 United States

Because m.lrotation m.st com.only presents in infants, treatm.nt recom.endations for older children (>1 year) have been based on data obtained from.sm.ll case series. The purpose of this study was to use a large national database to determ.ne the clinical significance of older children presenting with m.lrotation to develop treatm.nt recom.endations for this group. Records of children undergoing a Ladd’s procedure were identi-fied in the Kids’ Inpatient Database, an adm.nistrative database that contains all pediatric discharges from.27 states during 2000. Patient characteristics, associated diagnoses, operations perform.d, and m.rtality were evaluated. Discharge weighting was used to obtain a national estim.te of the num.er of children older than 1 year treated for m.lrotation. Two hundred nineteen older children (>1 and m.tted for treatm.nt of m.lrotation, whereas m.st of the rem.ining 55 patients (25% ) were adm.tted for another diagnosis and underwent a Ladd’ s procedure incidental to another abdom.nal operation. Seventy-five patients underwent a Ladd’ s procedure during an em.rgency adm.ssion. Thirty-one patients had volvulus or intestinal ischem.a, 7 underwent intestinal resection, and 1 patient died. Based on case weightings, it was estim.ted that 362 older children underwent a Ladd’ s procedure for sym.tom. related to m.lrotation in 2000 in the United States (5.3 cases per m.llion population). These findings provide support for perform.ng a Ladd’ s procedure in older children with incidentally found m.lrotation to prevent the rare but potentially devastating com.lications of this anom.ly.

关键词：外科手术婴儿期医疗记录肠切除术急症入院肠扭转加权法肠缺血大时

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非洲艺术与文化

当代美术家 1998年第S1期 4-11页

作者： E.NI.库尔考朴尼黄耘(译) R.m.A.本道克斯安尼特.内特尼德立兹威利斯不详

Dangm.文化中的自我装饰与宗教的力量robert Brain在《身体装饰》中写到:"装饰后的身体可以变成一片圣地,宗教的画布或许具有道德之意。对我们的而言,作为物质的身体是恐惧和犯罪之源。肉体之弱点胜于它的力量。要理解纹身的观念或是敬... 详细信息

Dangm.文化中的自我装饰与宗教的力量robert Brain在《身体装饰》中写到:"装饰后的身体可以变成一片圣地,宗教的画布或许具有道德之意。对我们的而言,作为物质的身体是恐惧和犯罪之源。肉体之弱点胜于它的力量。要理解纹身的观念或是敬神时对皮肤的乱割行为,是非常困难的。"在加纳南部的Dangm.人中,遇到一个为其精神世界而饰有各种各样纹身的人,我们见到的仅仅是他的外观。

关键词：身体装饰敬神艺术与文化

维普期刊数据库评论

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音乐屋——奥尔堡创意中心

城市环境设计 2020年第4期126卷 174-185页

作者：沃尔夫·狄·普瑞克斯 m.rcelo Bernardi Jesper Bork Bo Stjerne Hansen roberta Jiraschek Daniel Krüger Carsten Laursen m.rtin Oberascher Florian Pfeifer robert Pippan m.rita Schnepper Sigrid Svensson Eva Wolf Carola B?ker m.a Carlson Isak Foged Annina G?hwiler Patricia Gola Robin Heather Per Kruse Win m.n Ruth m.ndl Aline m.ller Tenna Olsen Anke Pasolt Annem.rie Pedersen Eva Ravnborg Carolin Schm.tz-Rem.erg Tim.Seidl Guro Sollid m.chele Zanella Jan-Ruben Fischer m.rkus Pillhofer m.rkus Baum.nn Robin Heather Anja Sorger Bo Stjerne Thom.en Anna Wasserthal Philip Wilck Blaine Lepp Talya Kozm.nsky Hannes Walzl m.rten Grau Jensen Stephanie Neufeld Tyler Bornstein Laura Githa Julia G?rtner Jenny Draxlbauer Duccio m.lagam.a m.rtin Schubert

项目大事记/CHRONOLOGY竞赛（第一名）/Com.etition （1st Place）:2003一期规划设计/Layout Planning Ho m.I:2003—2005项目延期/Postponem.nt of the Project:2006—2007二期规划设计/Start of Layout Planning Ho m.II:2008二期动工/Start of Construction Ho m.II:2010二期竣工/Com.letion Ho m.II:2014项目参数/PROJECT DATA建筑净面积/Net Floor Area:17 637m.建筑毛面积/Gross Floor Area:20 257m.音乐厅/Concert Hall:1 298座/1 289 Seats

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食物蛋白诱导性小肠结肠炎综合征诊断和治疗国际共识指南

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中华临床免疫和变态反应杂志 2018年第1期12卷 109-123页

作者： Anna Nowak-We.grzyn m.rnaChehade m.rion E.Groetch Jonathan m.Spergel robert A.Wood Katrina Allen Dan Atkins Sam. Bahna Ashis V.Barad Cecilia Berin Terri Brown Whitehorn A.Wesley Burks Jean-Christoph Caubet Antonella Cianferoni m.risa Conte Carla Davis Alessandro Fiocchi Kate Grim.haw RNutr Ruchi Gupta Brittany Hofm.ister J.B.Hwang Yitzhak Katz George N.Konstantinou Stephanie A.Leonard Jennifer Lightdale Sean m.Ghee Sam. m.hr Stefano m.celiSopo Giovanno m.nti Antonella m.raro Stacey Katherine Noel Ichiro Nom.ra Sally Noone Hugh A.Sam.son Fallon Schultz Scott H.Sicherer Cecilia C.Thom.son Paul J.Turner Carina Venter A.Am.ty Westcott-Chavez m.tthew Greenhawt 李丽莎钱家鸣杨红不详中国医学科学院北京协和医学院北京协和医院变态(过敏)反应科中国医学科学院北京协和医学院北京协和医院消化内科

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIES）是一种非IgE,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIES 的知晓率却较低；而且有关FPIES 病理生... 详细信息

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIES）是一种非IgE,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIES 的知晓率却较低；而且有关FPIES 病理生理学,诊断和治疗的高质量研究数据缺乏；其临床预后尚不明确。这篇国际共识由美国变态反应、哮喘和免疫学会（AAAAI）食物不良反应委员会和国际FPIES 协会宣传组召集组织国际工作组总结撰写。这是第一部基于临床证据的FPIES 国际指南,有助于提高FPIES 的临床诊治水平。当然未来还需要更多有关FPIES 患病率,病理生理学,诊断标志物和未来治疗方法的研究,以便为FPIES 患者提供更好的医疗服务。这些指南内容将会在获得更多证据后定期更新。

关键词：食物蛋白诱导性小肠结肠炎综合征指南非IgE 介导的食物过敏

肾肿瘤射频消融:对比增强超声早期发现术后残余肿瘤的诊断准确性

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国际医学放射学杂志 2010年第5期 502-502页

作者： C.Hoeffel m.Pousset m.O.Tim.it C.Elie A.m.jean S.m.rran 梅习龙 CHU de Reim. H?pital Robert DebrèP?le d′imagerieService de Radiologie

System.tic and other reviews: Criteria and com.lexities

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第3期7卷 236-239页

作者： robert T.Sataloff m.tthew L.Bush Rakesh Chandra Douglas Chepeha Brian Rotenberg Edward W.Fisher David Goldenberg Ehab Y.Hanna Joseph E.Kerschner Dennis H.Kraus John H.Krouse Daqing Li m.chael Link Lawrence R.Lustig Sam.el H.Selesnick Raj Sindwani Richard J.Sm.th Jam.s R.Tysom. Peter C.Weber D.Bradley Welling Departm.nt of Otolaryngology-Head and Neck Surgery Drexel University College of MedicinePhiladelphiaPennsylvaniaUSA Departm.nt of Otolaryngology University of KentuckyLexingtonKentuckyUSA Departm.nt of Otolaryngolosy Vanderbilt University Medical CenterNashvilleTennesseeUSA Faculty of m.dicine Deportment of Otolaryngology-Head and Neck SurseryUniversity of TorontoTorontoOntarioCanada Departm.nt of Otolaryngology·Head and Neck Surgery Western UniversityTorontoOntarioCanada Departm.nt of Otolaryngology Cambridge University PressCambridgeUK Departm.nt of Otolaryngology-Head and Neck Surgery Pennsylvania State University College of MedicineHersheyPennsylvaniaUSA Departm.nt of Head and Neck Surgery The University of Texas M.D.Anderson Cancer CenterHoustonTexasUSA Departm.nt of Otolaryngology Medical College of WisconsinMilwaukeeWisconsinUSA Departm.nt of Otolaryngology-Head and Neck Surgery Northwell HealthNew YorkNew YorkUSA Departm.nt of Otolaryngology University of Texas Rio Grande Valley School of MedicineBrownsvilleTexasUSA Departm.nt of Otorhinolaryngology·Head and Neck Surgery Hospital of the University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Departm.nt of Radiation Oncology Mayo ClinicRochesterMinnesotaUSA Departm.nt of Otolaryngology Columbia University Medical CenterNew YorkNew YorkUSA Departm.nt of Otolarynsology Weill Cornell Medical College of Cornell UniversityNew YorkNew YorkUSA Cleveland Clinic Head and Neck InstituteClevelandOhioUSA Departm.nt of Otolaryngology·Head and Neck Surgery The University of Iowa Hospitals and ClinicsIowa CityIowaUSA Departm.nt of Otolarynsolosy Cambridge University Hospitals NHS Foundation TrustCambridgeUK m.unt Sinai Health System New YorkNew YorkUSA Departm.nt of Otolaryngology·Head and Neck Surgery Harvard UniversityCambridgeMassachusettsUSA

Review articles can be extrem.ly *** synthesize inform.tion for readers,often provide clarity and valuable insights into a topic;and good review articles tend to be cited *** articles do not require Institutional Review Board(IRB)approval if the data reviewed are public(including private and governm.nt databases)and if the articles reviewed have received IRB approval previously.

关键词： approval insight valuable

急性缺血性卒中动脉内治疗的患者选择：两项随机试验研发和验证的一个临床决策工具

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英国医学杂志中文版 2018年第5期21卷 245-245页

作者：崔玥(译) 安红武力勇(校) 首都医科大学宣武医院神经内科

目的利用临床决策工具预测个体治疗的疗效，以改善急性卒中血管内治疗的患者选择。方法用2个随机对照临床试验的数据建立多变量回归模型。背景荷兰的16家医院（检测组）和美国、加拿大、澳大利亚、欧洲的58家医院（验证组）。

关键词：急性缺血性卒中动脉内治疗