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Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint

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World Journal of Pediatrics 2020年第1期16卷 60-67页

作者： Mengxia Li Alexander Sauer Annette Holl-Wieden thomas pabst Henning Neubauer Department of Radiation Oncology University Hospital Würzburg97080 WürzburgGermany Department of Diagnostic and Interventional Radiology University Hospital Würzburg97080 WürzburgGermany Department of Pediatrics University Hospital Würzburg97080 WürzburgGermany Department of Diagnostic and Interventional Radiology University Hospital Ulm89081 UlmGermany SRH Clinic of Radiology Albert-Schweitzer-Str.298527 SuhlGermany

Background Diffusion-weighted imaging(DWI)of synovitis has been suggested as a possible non-invasive alternative to contrast-enhanced t1w imaging(ce-t1w).We aimed to study DWI for diagnosing synovitis in the knee joint of pediatric patients,to quantify inter-observer agreement on DWI and ce-t1w and to calculate quantitative measures of synovial diffusivity and *** Forty consecutive patients with known or suspected arthritis of the knee(25 girls,median age 12 years)underwent routine 1.5t MRI with ce-t1w and transverse DWI with b values 50 and 800 s/*** apparent diffusion coefficient(ADC)values and signal intensity of inflamed synovium,joint effusion and muscle were measured with regions of interest ***-contrast t1 w images(diagnostic standard)and diffusion-weighted images at b=800 s/mm2 with ADC map were separately rated by three independent and blinded readers with different levels of expertise for the presence and degree of synovitis along with the level of diagnostic *** thirty-one(78%)patients showed at least some synovial contrast enhancement,17(43%)children were diagnosed with synovitis on *** by the 1st reader on ce-t1w and on DWI for synovitis showed very good agreement(kappa=0.90).Inter-observer agreement on DWI ranged from moderate to substantial with kappa values between 0.68 and 0.79(all Pt and diagnostic confidence were generally lower in patients with mild and without synovial enhancement,compared to patients with *** yielded higher signal of inflamed synovium *** tissue,but lower signal *** effusion,compared to ce-t1 w(all Pted imaging is a promising,though reader-dependent alternative to contrast-enhanced imaging in patients with arthritis of the knee,based on our preliminary *** holds potential for increasing patient safety and comfort.

关键词： Diffusion-weighted imaging Knee joint Magnetic resonance imaging Pediatric Synovitis

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CAIPIRINHA-accelerated t1w 3D-FLASH for small-bowel MR imaging in pediatric patients with Crohn's disease:assessment of image quality and diagnostic performance

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World Journal of Pediatrics 2016年第4期12卷 455-462页

作者： Mengxia Li Anke Dick Nicole Hassold thomas pabst thorsten Bley Herbert Köstler Henning Neubauer Department of Radiation Oncology University Hospital Wuerzburg97080 WuerzburgGermany Department of Pediatrics University Hospital Wuerzburg97080 WuerzburgGermany Department of Diagnostic and Interventional Radiology University Hospital Wuerzburg97080 WuerzburgGermany

Background:the“Controlled Aliasing In Parallel Imaging Results In Higher Acceleration”(CAPIRINHA)technique greatly accelerates t1w 3D fast low angle shot(FLASH)scans while maintaining high image *** studied image quality and conspicuity of inflammatory lesions on CAIPIRINHA-accelerated imaging for pediatric small-bowel magnetic resonance imaging(MRI).Methods:Forty-four consecutive patients(mean 14±3 years,18 girls)underwent small-bowel MRI(MR enterography,MRE)at 1.5 t including diffusion-weighted imaging(DWI),contrast-enhanced CAIPIRINHA 3D-FLASH and standard 2D-FLASH ***’s disease(CD)was confirmed in 26 patients,18 patients served as *** blinded readings were performed for grading of image quality and conspicuity of CD lesions on CAIPIRINHA FLASH and standard FLASH images in comparison to a reference standard comprising imaging and endoscopic ***:CAIPIRINHA FLASH yielded significantly higher image quality with good inter-observer agreement(κ=0.68)and showed better visual delineation in 40%of the assessed bowel lesions,as compared to standard *** was full agreement for identification of CD patients between CAIPIRINHA and standard *** FLASH detected two small-bowel lesions that were not seen on standard *** revealed additional inflammatory lesions inconspicuous on contrast-enhanced *** showed an overall diagnostic accuracy of 93%.Conclusion:We present first evidence that CAIPIRINHA greatly accelerates t1w imaging in paediatric MRE without trade-off in image quality or lesion conspicuity and is thus preferable to standard FLASH imaging.

关键词： CAIPIRINHA Crohn's disease FLASH pediatrics small-bowel MRI

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奔腾4VS新雷鸟

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电脑新时代 2001年第2期 98-100页

作者：陈潇恺 pabst,t

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头颈部肿瘤的磁共振成像

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放射学实践 1993年第4期 150-156页

作者： C.Wagner-Manslau C.Laubenbacher E.vandeFlierdt U.Gebhardt R.Dorn H.W.pabst B.Clasen M.Herzog 王虹 Nuklearmedizinische Klinik der tU Munchen Ismaninger Str. 22 同济医科大学附属同济医院

磁共振成像（KSt）越来越多地用于肿瘤分级和拟订治疗计划。除可作多个层面扫描外,其组织对比度高,因而特别适用于判断肿瘤的扩展、浸润和转移。技术参数头颈部肿瘤的诊断与选用适宜的检查序列有关,首先应行t1或t2加权序列检查。静脉注... 详细信息

磁共振成像（KSt）越来越多地用于肿瘤分级和拟订治疗计划。除可作多个层面扫描外,其组织对比度高,因而特别适用于判断肿瘤的扩展、浸润和转移。技术参数头颈部肿瘤的诊断与选用适宜的检查序列有关,首先应行t1或t2加权序列检查。静脉注射造影剂（Gd-DtPA.0.1mmol/kg）后,在t1加权序列图像及返转回波（IE）序列图

关键词：序列图像周围信号增强淋巴结淋巴组织肿瘤大小磁共振成像信号特征造影增强弛豫时间负信号加权图头颈部肿瘤头颈肿瘤

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黏附及脱颗粒促进适配蛋白基因缺失联合共刺激通道阻断对移植小肠的保护作用

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中华移植杂志（电子版） 2009年第4期3卷 278-278页

作者：田炯 Jose-Ignacio Rodrguez-Barbosa Oliver pabst Dorothee Roemermann Reinhold Foerster Jan Backmann Matthias W.Hoffmann 不详

黏附及脱颗粒促进适配蛋白(adhesion and degranulation promoting adapter protein,ADAP)在t淋巴细胞的激活中具有非常重要的作用.2007年,笔者发表在(transplantation)杂志上的研究结果提示,ADAP基因缺失能明显延长小鼠移植心脏的存活... 详细信息

黏附及脱颗粒促进适配蛋白(adhesion and degranulation promoting adapter protein,ADAP)在t淋巴细胞的激活中具有非常重要的作用.2007年,笔者发表在(transplantation)杂志上的研究结果提示,ADAP基因缺失能明显延长小鼠移植心脏的存活时间.而难治性排斥反应是影响移植物存活的主要因素之一.与其他器官相比,小肠移植后的排斥反应程度更为剧烈,且较难抑制.抗CD40单克隆抗体在移植物免疫耐受方面发挥着重要的作用,但在小肠移植中单独应用抗CD40单克隆抗体不能延长移植小肠的存活时间.因此,我们试图探索ADAP基因缺失联合抗CD40单克隆抗体阻断共刺激通道在抑制小鼠小肠移植后排斥反应中的协同作用.

关键词：黏附及脱颗粒促进适配蛋白共同刺激通道阻断小肠移植排斥反应

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