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Therapeutic Effect of Dimethyl Dimethoxy Biphenyl Dicarboxylate on Collagen-Induced Arthritis in Rats

Chinese Journal of Integrative medicine 2015年第11期21卷 846-854页

作者： roba m talaat Amira S Abo-EI-Atta Sabah m Farou Karima I EI-Dosoky molecular Biology Department Genetic Engineering and Biotechnology Research InstituteMenofia UniversitySadat Branch Pathology Department Faculty of MedicineTanta University

Objective： To study the effect of oral administration of dimethyl dimethoxy biphenyl dicarboxylate （DDB） on adjusting angiogeneic/inflammatory mediators and ameliorating the pathology of bones in rats with collagen-induced arthritis （CIA）. methods： Wistar rat model of CIA was set up using bovine collagen type H. Fifty rats were divided into five groups randomly： normal, CIA model, DDB treatment, methotrexate （mTX） treatment, and combined DDB＋mTX treatment. Ankle joints of rats were imaged with digital X-ray machine to show the destruction of joints. Fore and hind paw and knee joints were removed above the ankle joint then processed for haematoxylin and eosin staining. Plasma levels of vascular endothelial growth factor （VEGF）, platelet derived growth factor, interleukin-8 （IL-8）, IL-4, tumor necrosis factor α （TNF-α）, and cyclooxygenase-2 （COX-2） were quantified by enzyme-linked immunosorbent assay. Nitric oxide levels were detected by Griess reagent. Results： Compared with the CIA model group, a remarkable reduction in various angiogenic （VEGF and IL-8） and inflammatory mediators （TNF-α, IL-4 and COX-2） after treatment with DDB either alone or combined with mTX （P〈0.05 or P〈0.01）. Histopathological and X-ray findings were confirmatory to the observed DDB anti-arthritic effect. The DDB-treated group showed amelioration in signs of arthritis which appeared essentially similar to normal. Conclusion： Our data shed light on the therapeutic efficacy of DDB in experimental rheumatoid arthritis （RA） compared with a choice drug （mTX） and it may be offered as a second-line drug in the treatment of RA.

关键词： rheumatoid arthritis collagen-induced arthritis dimethyl dimethoxy biphenyl dicarboxylate angiogenesis inflammation

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Circulating Levels of Hypoxia-regulating microRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia

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Current medical Science 2022年第6期42卷 1231-1239页

作者： Amira m.Gamal-Eldeen Cinderella A.Fahmy Bassem m.Raafat Fayez Althobaiti Iman H.Bassyouni roba m.talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia High Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective microRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(HIF-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the HIF-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the HIF-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased HIF-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/HIF-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

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Tumor necrosis factor-alpha -308G/A polymorphism and risk of hepatocellular carcinoma in hepatitis C virus-infected patients

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Chinese Journal of Cancer 2012年第1期31卷 29-35页

作者： roba m.talaat Ahmed A.Esmail Reda Elwakil Adel A.Gurgis mahmoud I.Nasr molecular Biology Departments Genetic Engineering and Biotechnology Research Institute(GEBRI)Menofia UniversitySadat 22857Egypt Roche Diagnostics Ain Shams UniversityCairo 11522Egypt Department of Tropical medicine Ain Shams UniversityCairo 11522Egypt

Tumor necrosis factor-alpha (TNF-α) is an important cytokine in generating an immune response against infection with hepatitis C virus (HCV). The functions of TNF-α may be altered by single-nucleotide polymorphisms (SNPs) in its gene structure. We hypothesized that SNPs in TNF-α may be important in determining the outcome of an HCV infection. To test this hypothesis, we investigated the role of the polymorphism -308G/A, which is located in the promoter region of the TNF-α gene, in the progression of HCV infection in Egyptian patients using a quantitative real-time polymerase chain reaction (qRT-PCR). The distribution of this polymorphism and its impact on the serum level of TNF-α was compared between 90 HCV-infected patients [45 with HCV-induced cirrhosis and 45 with HCV-related hepatocellular carcinoma (HCC)] and 45 healthy Egyptian volunteers without any history of liver disease. Our results showed that at the TNF-α -308 position, the G/G allele was most common (78.5% ) in the study population, with the G/A and A/A alleles occurring less frequently (13.3% and 8.1% , respectively). Frequencies of G/G, G/A, and A/A genotypes were 87%, 7%, and 6% in patients with liver cirrhosis and were 94% , 4% , and 2% in patients with HCC, respectively. Serum levels of TNF-α were significantly higher in HCV-infected patients than in healthy controls, indicating that the TNF-α -308 polymorphism does not influence the production of TNF-α. The serum level of TNF-α was positively correlated with HCV infection. Taken together, these findings suggest that the TNF-α -308 polymorphism may not be a host genetic factor associated with the severity of HCV infection, but may be an independent risk factor for HCC.

关键词：肿瘤坏死因子-α 单核苷酸多态性丙型肝炎病毒病毒感染患者肝癌风险聚合酶链反应

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Rapid immunodiagnostic assays for mycobacterium Tuberculosis infection

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Health 2010年第3期2卷 171-176页

作者： roba m. talaat Gamal S. Radwan Abdelaziz A. mosaad Saleh A. Saleh Kalied Bassiouny ministry of Health minufiya University

Purpose: There is a need for a continued effort to develop rapid immunodiagnostic assays for tuberculosis (TB) infection with greater sensitivity and specificity that can be used in the field and in the laboratory and that can be formatted for use with multiple species. This would help to obtain definitive early diagnosis of TB. The present study was developed to determine the role of using early secreted antigenic target-6 (ESAT-6) in immunodiagnosis of mycobacterium tuberculosis. methods: Serum samples were obtained from TB infected patients and normal healthy controls. Two rapid immunodiagnostic assays (Enzyme-linked immunosorbent assay (ELISA) and Immunoblotting) were performed. Results: The sensitivity of immunoblotting assay was 100%;however, ESAT-6 antigen was not able to discriminate between patients and normal controls. Application of direct ELISA using ESAT-6 antigen yielded 97.6% sensitivity and 75% specificity for the diagnosis of TB infection. Conclusion: In conclusion, the detection of antibodies against ESAT-6 antigen in the sera of TB patients by direct ELISA could be used as a preliminary assay for diagnosis of human m. tuberculosis infection. A combination of the ELISA with either radiological or microscopic examination is required to overcome the low specificity of the assay for negative results.

关键词： Tuberculosis Diagnosis ESAT-6 ELISA Immunoblotting

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Rapid immunodiagnostic assays for mycobacterium Tuberculosis infection

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Health（健康） 2010年第3期

作者： roba m. talaat Gamal S. Radwan Abdelaziz A. mosaad Saleh A. Saleh Kalied Bassiouny

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Structural and Tectonic Evolution of El-Faiyum Depression,North Western Desert,Egypt Based on Analysis of Landsat ETm+,and SRTm Data

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Journal of Earth Science 2011年第1期22卷 75-100页

作者： Timothy m Kusky talaat m Ramadan mahmoud m Hassaan Safwat Gabr Three Gorges Research Center for Geo-hazard State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences The Geological Applications and mineral Resources Division National Authority for Remote Sensing and Space Sciences (NARSS) Cairo Egypt

False color Landsat ETm＋（bands 7, 4, 2 in RGB） and SRTm images of the EI-Faiyum depression, Egypt, highlights major NE-SW faults and other lineaments trending NW-SE and N-S. Airborne magnetic data reveal some E-W subsurface faults which are not recognized on Landsat ETm＋ and SRTm images. Ratio images （5/7, 3/1, 4/3） and （5/7, 5/1, 4） were used for lithological discrimination of different rock types. The EI-Faiyum area is occupied by sedimentary rocks of middle Eocene, Upper Eocene, Oligocene, Lower miocene, Pliocene, Pleistocene and Holocene. Understanding the structural regime of EI-Faiyum depression in the Western Desert of Egypt is significant in relation to the neotectonics of the Nile Delta and to the development of new communities west of the delta. The area is covered by Late Cretaceous, middle to Late Eocene deposits, Oligocene deposits （comprising fluviatile sediments and basalt sheets） and Pliocene and Quaternary alluvium and sand deposits. New geological and structural maps were prepared at a scale of 1 ： 100 000 using Landsat ETm＋ and SRTm images coupled with extensive field work. The major structural trends are E-W, ENE, NS and NW--the same trends observed elsewhere in North Africa from NW Sudan to NE Egypt including north and central Sinai. EI-Faiyum depression is a structurally-controlled tectonic basin, marked by northeast-striking faults along its northern margin. These faults are parallel to similar faults of the Syrian arc fold belt, which includes a group of related faults, folds, push-up structures, and basins. Qarun Lake is located in the northern part of EI-Faiyum depression, at a right-step between two strands of the NE striking fault system. We have suggested elsewhere that EI-Faiyum depression is a pull-apart basin related to extension between these mismatched strands of strike-slip faults. The E-W structures are probably related to the relative motion between south Europe and north Egypt and closure of the Neotethys. The continuation of t

关键词： Egypt EI-Faiyum Syrian arc fold belt pull-apart basin Western Desert of Egypt.

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A New Reliable System For managing Virtual Cloud Network

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Computers, materials & Continua 2022年第12期73卷 5863-5885页

作者： Samah Alshathri Fatma m.talaat Aida A.Nasr Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Faculty of Artificial Intelligence Kafrelsheikh UniversityKafrelsheikhEgypt Faculity of Computers and Informatics Tanta UniversityTantaEgypt

Virtual cloud network(VCN)usage is popular today among large and small organizations due to its safety and ***,it makes all resources in the company work as one *** also facilitates sharing of files and applications without ***,cloud providers face many issues in managing the VCN on cloud computing including these issues:Power consumption,network failures,and data *** issues often occur due to overloaded and unbalanced load *** this paper,we propose a new automatic system to manage VCN for executing the *** new system calledmulti-User Hybrid Scheduling(mUSH)can solve running issues and save power during workflow *** consists of three phases:Initialization,virtual machine allocation,and task scheduling *** mUSH system focuses on the execution of the workflow with deadline ***,it considers the utilization of virtual *** new system can save makespan and increase the throughput of the execution operation.

关键词： Virtual network scheduling reliability Vm allocation cloud computing

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Dissipation of chlorpyrifos, pendimethalin, and thiophanate-methyl pesticides in compost based-versus peat-moss based-biomixture of biobeds

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Waste Disposal and Sustainable Energy 2023年第4期5卷 461-470页

作者： talaat N.m.El-Sebai Wafaa m.H.Zidan Alaa marzouk marion Divers Fabrice martin-Laurent Agricultural microbiology Dept.Agricultural and Biology Research Institute National Research CentreCairoEgypt Laboratory of Pesticide Analysis Agriculture Research CentreCairoEgypt Laboratory of Soil microbiology National Institute of Agricultural ResearchDijonFrance

Biobed is a smart bioremediation system used to treat point-source pesticide *** is the main component of biobeds,and pesticide dissipation is affected by its *** study aimed to compare the effectiveness of compost-based(C)versus peat-moss-based(P)biomixtures of biobeds on tested pesticide *** concentrations(25,50,and 75 mg/kg)of chlorpyrifos,pendimethalin,and thiophanate methyl were added separately and as a mix to both biomixtures C and *** data showed the effect of biomixture type on the dissipation of the tested *** chlorpyrifos,its dissipation rate in biomixture P was more rapid than that in biomixture *** result was confirmed by the mineralization kinetic experiment,since 25%of the initial ^(14)C-chlorpyrifos concentration accumulated in the form ^(14)CO_(2) in biomixture P compared to only 14%in biomixture *** addition,the chlorpyrifos dissipation rate was influenced by the initial concentration when applied individually in biomixture *** contrast,biomixture C was more effective at pendimethalin dissipation than biomixture P,since>76%of pendimethalin was dissipated in biomixture C versus 67%in biomixture P at the same incubation *** thiophanate-methyl,the abilities of both biomixtures C and P were similar and less efficient than those of the other tested *** addition of the three tested pesticides to biomixture C only had a positive effect on both chlorpyrifos and thiophanate-methyl dissipation,while pendimethalin dissipation was similar when applied separately or as a *** activity was stimulated by the addition of separately or mixed pesticides to biomixtures C and P as measured by dehydrogenase activity.

关键词： Biopurification system Pesticides Contamination Point-source Bioremediation Biomixture

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Facial Expression Recognition model Depending on Optimized Support Vector machine

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Computers, materials & Continua 2023年第7期76卷 499-515页

作者： Amel Ali Alhussan Fatma m.talaat El-Sayed m.El-kenawy Abdelaziz A.Abdelhamid Abdelhameed Ibrahim Doaa Sami Khafaga mona Alnaggar Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia machine Learning&Information Retrieval Department Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Communications and Electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Department of Computer Science College of Computing and Information TechnologyShaqra University11961Saudi Arabia Department of Computer Science Faculty of Computer and Information SciencesAin Shams UniversityCairo11566Egypt Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Robotics and Intelligent machines Department Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikh33516Egypt

In computer vision,emotion recognition using facial expression images is considered an important research *** learning advances in recent years have aided in attaining improved results in this *** to recent studies,multiple facial expressions may be included in facial photographs representing a particular type of *** is feasible and useful to convert face photos into collections of visual words and carry out global expression *** main contribution of this paper is to propose a facial expression recognitionmodel(FERm)depending on an optimized Support Vector machine(SVm).To test the performance of the proposed model(FERm),AffectNet is *** uses 1250 emotion-related keywords in six different languages to search three major search engines and get over 1,000,000 facial photos *** FERm is composed of three main phases:(i)the Data preparation phase,(ii)Applying grid search for optimization,and(iii)the categorization *** discriminant analysis(LDA)is used to categorize the data into eight labels(neutral,happy,sad,surprised,fear,disgust,angry,and contempt).Due to using LDA,the performance of categorization via SVm has been obviously *** search is used to find the optimal values for hyperparameters of SVm(C and gamma).The proposed optimized SVm algorithm has achieved an accuracy of 99%and a 98%F1 score.

关键词： Facial expression recognition machine learning linear dis-criminant analysis(LDA) support vector machine(SVm) grid search

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Robust Deep Learning model for Black Fungus Detection Based on Gabor Filter and Transfer Learning

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Computer Systems Science & Engineering 2023年第11期47卷 1507-1525页

作者： Esraa Hassan Fatma m.talaat Samah Adel Samir Abdelrazek Ahsan Aziz Yunyoung Nam Nora El-Rashidy machine Learning and Information Retrieval Department Faculty of Artificial IntelligenceKafrelsheikh UniversityKafrelsheikhEgypt Electronics and Communication Engineering Department Faculty of Engineering Horus UniversityDamiettaEgypt Information Systems Department Faculty of Computers and InformationMansoura UniversityMansoura35516Egypt Department of ICT Convergence Soonchunhyang UniversityAsanKorea

Black fungus is a rare and dangerous mycology that usually affects the brain and lungs and could be life-threatening in diabetic ***,some COVID-19 survivors,especially those with co-morbid diseases,have been susceptible to black ***,recovered COVID-19 patients should seek medical support when they notice mucormycosis *** paper proposes a novel ensemble deep-learning model that includes three pre-trained models:reset(50),VGG(19),and *** approach is medically intuitive and efficient compared to the traditional deep learning *** image dataset was aggregated from various resources and divided into two classes:a black fungus class and a skin infection *** the best of our knowledge,our study is the first that is concerned with building black fungus detection models based on deep learning *** proposed approach can significantly improve the performance of the classification task and increase the generalization ability of such a binary classification *** to the reported results,it has empirically achieved a sensitivity value of 0.9907,a specificity value of 0.9938,a precision value of 0.9938,and a negative predictive value of 0.9907.

关键词： Black fungus COVID-19 Transfer learning pre-trained models medical image

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