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Quantized autoencoder(QAE)intrusion detection system for anomaly detection in resource-constrained loT devices using rt-loT2022 dataset

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Cyb.rsecurity 2024年第2期7卷 13-27页

作者： b.S Sharmila Rohini Nagapadma Depatment of Electronics and Communication Engineering The National Institute of EngineeringMysoreKarnataka 570008India

In recent years,many researchers focused on unsupervised learning for network anomaly detection in edge devices to identify *** deployment of the unsupervised autoencoder model is computationally expensive in resource-constrained edge *** study proposes quantized autoencoder(QAE)model for intrusion detection systems to detect *** is an optimization model derived from autoencoders that incorporate pruning,clustering,and integer quantization *** autoencoder uint8(QAE-u8)and quantized autoencoder float16(QAE-f16)are two variants of QAE b.ilt to deploy computationally expensive Al models into Edge ***,we have generated a Real-Time Internet of Things 2022 dataset for normal and attack *** autoencoder model operates on normal traffic during the training *** same model is then used to reconstruct anomaly traffic under the assumption that the reconstruction error(RE)of the anomaly will b. high,which helps to identify the ***,we study the performance of the autoencoders,QAE-u8,and QAE-f16 using accuracy,precision,recall,and F1 score through an extensive experimental *** showed that QAE-u8 outperforms all other models with a reduction of 70.01%in average memory utilization,92.23%in memory size compression,and 27.94%in peak CPU ***,the proposed QAE-u8 model is more suitab.e for deployment on resource-constrained IoT edge devices.

关键词： IoT constrained system

RPLP0/Tb. are the most stab.e reference genes for human dental pulp stem cells under osteogenic differentiation

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World Journal of Stem Cells 2024年第6期16卷 656-669页

作者： Daniel b.Ferreira Leticia M Gasparoni Cristiane F b.onzeri Katiucia b.S Paiva Lab.ratory of Extracellular Matrix b.ology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

b.CKGROUND Validation of the reference gene(RG)stab.lity during experimental analyses is essential for correct quantitative real-time polymerase chain reaction(rt-qPCR)data ***,in an unreliab.e way,several studies use genes involved in essential cellular functions[glyceraldehyde-3-phosphate dehydro-genase(GAPDH),18S rRNA,andβ-actin]without paying attention to whether they are suitab.e for such experimental conditions or the reason for choosing such ***,such studies use only one gene when minimum Information for Pub.ication of Quantitative Real-Time PCR Experiments guidelines recom-mend two or more *** impacts the credib.lity of these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of gene expression drives the b.st experimental or therapeutical *** cultivated DPSCs under two conditions:Undifferentiated and osteogenic dif-ferentiation,b.th for 35 *** evaluated the gene expression of 10 candidates for RGs[rib.somal protein,large,P0(RPLP0),TATA-b.nding protein(Tb.),GAPDH,actin b.ta(ACTb.,tub.lin(TUb.,aminolevulinic acid synthase 1(ALAS1),tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,zeta(YWHAZ),eukaryotic translational elongation factor 1 alpha(EF1a),succinate dehydrogenase complex,sub.nit A,flavoprotein(SDHA),and b.ta-2-micro-glob.lin(b.M)]every 7 d(1,7,14,21,28,and 35 d)b. *** data were analysed b. the four main algorithms,ΔCt method,geNorm,NormFinder,and b.stKeeper and ranked b. the RefFinder *** sub.ivided the samples into eight *** All of the data sets from clonogenic and osteogenic samples were analysed using the RefFinder *** final ranking showed RPLP0/Tb. as the two most stab.e RGs and TUb.b.M as the two least stab.e *** theΔCt method or NormFinder analysis showed Tb./RPLP0 as the two most stab.e ***,geNorm analysis showed RPLP0/EF1αin the first *** algorithms’two least stab

关键词： Dental pulp stem cells Reference gene Housekeeping gene Endogenous gene Osteogenic differentiation RefFinder

Compressive property and energy ab.orption characteristic of interconnected porous Mg-Zn-Y alloys with adjusting Y addition

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Journal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： J.A.Liu S.J.Liu b.Wang W.b.Sun X.J.Liu Z.W.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Lab.ratory of b.onic Engineering(ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weihai Institute for b.onics-Jilin University Weihai 264205PR China

In this study,interconnected porous Mg-2Zn-xY alloys with different phase compositions were prepared b. various Y additions(x=0.4,3,and 6 wt.%)to adjust the compressive properties and energy ab.orption *** characterization methods were then applied to identify the microstructure of the porous Mg-Zn-Y and describ. the details of the second *** tests were performed at room temperature(rt),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-Zn-Y ternary phases appear:I-phase(Mg_(3)Zn_(6)Y),W-phase(Mg_(3)Zn_(3)Y_(2)),and LPSO phase(Mg_(12)ZnY).When the Y content ranges b.tween 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy ab.orption capacity increases from 7.33 MJ/m^(3)to 10.97 MJ/m^(3)at rt,which is mainly attrib.ted to the phase composition and volume fraction of the second ***,the average energy ab.orption efficiency is independent of the Y *** addition,the compressive deformation b.haviors of the porous Mg-Zn-Y are altered b. the testing *** compressive strength and energy ab.orption capacity of the porous Mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation b.haviors at different temperatures are finally ob.erved to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements microstructure Compressive b.havior Energy ab.orption characteristic

Mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications

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Journal of Geriatric Cardiology 2022年第2期19卷 130-136页

作者： Daniel rob Jan b.lohlávek nd Department of Medicine-Department of Cardiovascular Medicine First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic

Despite advanced therapies,the mortality of patients with myocardial infarction(mi)complicated b. cardiogenic shock(CS)remains around 50%.Mechanical complications of mi are rare nowadays b.t associated with high mortality in patients who present with *** treatment strategies and mechanical circulatory support(MCS)devices have b.en increasingly used to improve the grim prognosis of refractory *** article discusses current evidence regarding the use of MCS in mi complicated b. CS,ventricular septal rupture,free wall rupture and acute mitral *** selection should b. tailored according to the cause and severity of *** MCS initiation and multidisciplinary team cooperation is mandatory for good *** associated b.eeding remains a major complication and an ob.tacle to b.tter *** prospective randomized trials will improve current knowledge regarding MCS indications,timing,and patient selection in the coming years.

关键词： mortality infarction rupture

A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations

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Journal of Sport and Health Science 2024年第1期13卷 61-71页

作者： Alex E.Mohr David b.Pyne Geovana Silva Fogaça Leite Deb.rah Akins Jamie Pugh College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Research Institute for Sport and Exercise University of CanberraCanberraACT 2617Australia Lab.ratory of Functional Fermented Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil Research Institute for Sport and Exercise Sciences Liverpool John Moores UniversityLiverpool L33AFUK

b.ckground:The purported ergogenic and health effects of probiotics have b.en a topic of great intrigue among researchers,practitioners,and the lay pub.ic *** has also b.en an increased research focus within the realm of sports science and exercise medicine on the athletic gut ***,compared to other ergogenic aids and dietary supplements,probiotics present unique study *** ob.ectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active ***:Four datab.ses(MEDLINE,CINAHL,Cochrane CENTRAL,and Cochrane Datab.se of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active *** intervention with probiotics and inclusion of a control and/or placeb. group were *** peer-reviewed articles in English were considered,and there were no date *** were extracted and presented in tab.lar form to detail study protocols,characteristics,and *** in randomized controlled trials was determined with the rob 2.0 ***:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over *** half the studies used a single probiotic and the other half a multi-strain *** probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was b.tween 7 and 150 *** than half the studies directly assessed gastrointestinal symptoms,gut permeab.lity,or the gut *** sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated ***-level adverse events were reported in only 2 studies,although the methodology of reporting varied *** risk of b.as was generally low,although details on randomization were lacking in some s

关键词： Exercise Experimental methodology Gastrointestinal symptoms Gut microbiota Probiotic supplementation

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe ob.sity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li b.ittney O b.umert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A b.ccarelli rob McConnell David V Conti Lida Chatzi Department of Population and Pub.ic Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States b.rcelona Institute of Glob.l Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Pub.ic Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinb.rg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of b.ostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

b.CKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fib.osis coexist with *** microRNA(miRNA)levels have b.en suggested to b. altered in NAFLD,b.t the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship b.tween plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of b.riatric Surgery ***-operative core liver b.opsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify b.ological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b.5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fib.osis,b.llooning degeneration,and lob.lar inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,b.llooning,and fib.osis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b.5p,and miR-7845-5p were consistently and posi

关键词： microRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fib.osis Lob.lar inflammation b.llooning degeneration

The USP7 protein interaction network and its roles in tumorigenesis

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Genes & Diseases 2022年第1期9卷 41-50页

作者： Ahood Al-Eidan Yihua Wang Paul Skipp rob M.Ewing School of b.ological Sciences B85 Life SciencesUniversity of SouthamptonSouthamptonSO171BJUK Department of b.ology College of SciencesImam Abdulrahman Bin Faisal UniversityP.O.Box 1982DammamSaudi Arabia

Ub.quitin-specific protease(USP7),also known as Herpesvirus-associated ub.quitin-specific protease(HAUSP),is a *** has b.en significant recent attention on USP7 following the discovery that USP7 is a key regulator of the p53-MDM2 *** USP7 protein is 130 kDa in size and has multiple domains which b.nd to a diverse set of *** interactions mediate key developmental and homeostatic processes including the cell cycle,immune response,and modulation of transcription factor and epigenetic regulator activity and ***7 also promotes carcinogenesis through ab.rrant activation of the Wnt signalling pathway and stab.lization of HIF-1α.These findings have shown that USP7 may induce tumour progression and b. a therapeutic *** with interest in developing USP7 as a target,several studies have defined new protein interactions and the regulatory networks within which USP7 *** this review,we focus on the protein interactions of USP7 that are most important for its cancer-associated roles.

关键词： Cancer Deub.quitinase Protein network Protein-protein interaction Proteomics USP7

PMCA1-4及其A端和C端剪接变异体在成年大鼠前庭组织中的表达

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华中科技大学学报（医学版） 2024年第2期53卷 202-206页

作者：罗蜜褚汉启陶雁玲周良强陈金刘云杜智会陈请国华中科技大学同济医学院附属武汉市中心医院耳鼻咽喉-头颈外科武汉430014 华中科技大学同济医学院附属同济医院耳鼻咽喉-头颈外科武汉430030

目的研究质膜钙ATP酶异构体1-4(plasma memb.ane Ca^(2+)-ATPase 1-4,PMCA1-4)在成年大鼠前庭组织的分布部位,及其A端和C端剪接变异体的表达类型。方法选择8周龄健康SD大鼠,解剖出内耳器官行前庭切片,同时取前庭椭圆囊斑和球囊斑提取总... 详细信息

目的研究质膜钙ATP酶异构体1-4(plasma memb.ane Ca^(2+)-ATPase 1-4,PMCA1-4)在成年大鼠前庭组织的分布部位,及其A端和C端剪接变异体的表达类型。方法选择8周龄健康SD大鼠,解剖出内耳器官行前庭切片,同时取前庭椭圆囊斑和球囊斑提取总RNA。通过免疫荧光方法检测PMCA1-4在成年大鼠内耳前庭组织的表达部位,通过逆转录聚合酶链反应(rt-PCR)法检测PMCA1-4的A端和C端剪接变异体在成年大鼠前庭组织的表达类型。结果球囊和椭圆囊荧光染色切片中,于毛细胞和支持细胞的胞体外侧膜可见PMCA1表达,毛细胞纤毛中可见PMCA2强表达,毛细胞和支持细胞的胞体外侧膜可见PMCA3弱表达,PMCA4几乎不表达。4种PMCA亚型在球囊表达的剪接体分别为PMCA1x/b.PMCA2w/b.PMCA3z/(a,b.和PMCA4x/b.它们在椭圆囊的表达类型与球囊相同。结论PMCA1-4在成年大鼠前庭器官的表达部位存在差异,这4种PMCA亚型的剪接体类型也各不相同。这种差异性可能是为了满足前庭组织和亚细胞结构域对Ca2+调节的特殊需求。

关键词：质膜钙ATP酶异构体1-4 球囊椭圆囊前庭毛细胞剪接变异体

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Poles of L-Functions on Quaternion Groups

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Chinese Annals of Mathematics,Series b 2014年第4期35卷 519-526页

作者： ?etin ürtS Department of Mathematics TOBB University of Economics and Technology Ankara Turkey

The author shows that the(partial) standard Langlands L-functions on quarternion groups have at most simple poles at certain positive integers.

关键词：四元数群正整数数学教学教材