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Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury

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Journal of Biomedical Research 2025年第1期39卷 61-75页

作者： Xuejun Xu Kaineng Sun Hao Chang Chunxiang Shen Xiangdong li Yangyue Ni Yuxiao Zhu Huiquan Wang Ruiyan Xiong Jon rob Padde Zhipeng Xu lin Chen lu Chen Min Hou liyong Pu Minjun Ji Department of Pathogen Biology National Vaccine Innovation PlatformJiangsu Province Engineering Research Center of Antibody DrugSchool of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Hepatobiliary Center Jiangsu Province Hospital and Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210029China

Ischemia-reperfusion injury(IRI)remains an unavoidable challenge in liver surgery,with macrophages playing a critical role in its ***,the mechanisms by which macrophages regulate the pathogenesis of IRI are not well *** a target-guided screening approach,we identified a small 3 k Da peptide(Sj DX5-271)from various schistosome egg-derived peptides that induced M2 macrophage ***5-271 treatment protected mice against liver IRI by promoting M2 macrophage polarization,and this protective effect was abrogated when the macrophages were *** sequencing showed that the TlR signaling pathway was significantly inhibited in macrophages from the SjDX5-271 treatment *** further identified that SjDX5-271 promoted M2 macrophage polarization by inhibiting the TlR4/My D88/NF-κB signaling pathway and alleviated hepatic inflammation in liver ***,SjDX5-271 exhibited some promising therapeutic effects in IRI and represented a novel therapeutic approach,potentially applicable to other immune-related *** current study demonstrates the potential of new biologics from the parasite,enhances our understanding of host-parasite interplay,and provides a blueprint for future therapies for immunerelated diseases.

关键词： schistosome-derived peptide liver ischemia-reperfusion injury macrophage toll-like receptor-4

Effects of Electric Field on the Electronic Structures in Electroluminescent Polymers

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Journal of Materials Science & Technology 1999年第4期15卷 354-356页

作者： Fu, Rl Chu, JH Fu, rt li, l Sun, X Chinese Acad Sci Shanghai Inst Tech Phys Natl Lab Infrared Phys Shanghai 200083 Peoples R China Fudan Univ Dept Phys Shanghai 200433 Peoples R China

The effects of the electric field on the electronic structures in electroluminescent polymers were studied with the tight-binding model including electron-phonon interactions plus an applied electric field. It is found that the applied electric field changes both the energy levels and the electronic wavefunctions in electroluminescent polymers: applied field induces two localized electronic states near the midgap, and also polarizes these localized electronic states, so the polarization occurs at weak or moderate fields. In addition, the strong field will dissociate a bipolaron exciton and lead to photoluminescence quenching.

关键词： Polymers

Genomic Mutations Within the Host Microbiome: Adaptive Evolution or Purifying Selection

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Engineering 2023年第1期20卷 96-102页

作者： Jiachao Zhang rob Knight School of Food Science and Engineering Hainan UniversityHaikou 570228China Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Center for Microbiome Innovation Jacobs School of EngineeringUniversity of California San DiegoLa JollaCA 92093USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Department of Computer Science and Engineering University of California San DiegoLa JollaCA 92093USA

Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.

关键词： Gut microbiota Genomic mutations Adaptive evolution Purifying selection Single-nucleoti de variants

Poles of l-Functions on Quaternion Groups

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Chinese Annals of Mathematics,Series B 2014年第4期35卷 519-526页

作者： ?etin ürtS Department of Mathematics TOBB University of Economics and Technology Ankara Turkey

The author shows that the(partial) standard langlands l-functions on quarternion groups have at most simple poles at certain positive integers.

关键词： Siegel Eisenstein series l-Functions Quaternion groups RegularizedSiegel-Weil formula

Novel　Type　CO_2　Methanation　Catalysts　over　Ni／Sepiolite　and　Ru／Sepiolite　System

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Chinese Chemical letters 1996年第10期7卷 956-959页

作者： Deng, GC Xu, l Mu, RC Chen, rt lu, W NANKAI UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA TIANJIN ENVIRONM PROTECT BUR TIANJIN 300191PEOPLES R CHINA

A Novel type single-component catalyst in which small amounts of nickel of ruthenium supported on sepiolite nas found to be a very efficient methanation catalyst for carbon dioxide at high space velocity.

关键词： Ru and Type over Methanation Novel Sepiolite System CO2 Catalysts 二氧化碳 Ni

Poverty reduction through the development of inclusive food value chains

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Journal of Integrative Agriculture 2021年第4期20卷 964-978页

作者： rob VOS Andrea CATTANEO International Food Policy Research Institute(IFPRI) WashingtonD.C.20007USA Food and Agriculture Organization of the United Nations(FAO) Rome 00153Italy

Propelled by urbanization,rising incomes,and changing diets,food markets have been expanding in Africa and South Asia,creating the vast potential for job and income opportunities along food supply chains and,hence,for poverty *** novel coronavirus(COVID-19)that spread to a pandemic in early 2020 provokes enormous setbacks to this ***,however,should provide lessons regarding the importance of resilient and inclusive food *** responses to COVID-19 should consider interventions towards that end and leverage the opportunities provided by food markets growth as economies recover from the present economic *** paper assesses options of how this could be done by facilitating the better functioning and interconnectedness of the many small and medium-sized enterprises that are proliferating along the"hidden middle"of food value chains in storage,logistics,transportation,and wholesale and retail *** also explores how policies can help smallholder farmers connect to this"hidden middle"in more gainful ways and help them climb out of poverty as well.

关键词： poverty food security and hunger food supply chains South Asia sub-Saharan Africa

Ecological networks and greenways in Europe: reasoning and concepts

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Journal of Environmental Sciences 2003年第2期15卷 173-181页

作者： rob H.G. Jongman Wageningen UR Expertise Group on Environmental Sciences

The paper gives an overview of approaches towards ecological networks throughout Europe. It does not intend to present a complete picture, but to highlight common developments within countries and regions and show common principles and differences between countries and regions that have to be taken into account when developing a joint European initiative. Countries or regions that have not been included can be active in the same way, but information was not accessible to the authors for different reasons. This overview shows the comparable trends in decline of landscapes and the diversity in approaches to biodiversity conservation and nature conservation planning. Understanding the differences and common issues are of utmost importance to generalise common principles and to understand the way neighbours and other European partners approach problems.

关键词： ecological networks greenways biodiversity land use change homogenisation fragmentation

Oxygen and Iron-and Steelmaking:Best Friends and Arch-Enemies

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Journal of Iron and Steel Research International 2011年第S2期18卷 16-27页

作者： BOOM rob Materials innovation institute M2i Department of Materials Science and EngineeringDelft University of TechnologyDelftThe Netherlands

Ironmaking is the art of removal the arch-enemy oxygen from iron ore by means of carbon reduction and thus producing hot *** is the art of removing carbon from liquid hot metal by means of best friend pure oxygen,followed by alloying and deoxidation-where oxygen returns to be the ***-metallic particles in steel such as oxides can have a detrimental effect on the steel product properties in terms of formability,strength and surface *** overview of the battle for clean steel production is given based on the experience of the author in industry as well as university research.

关键词： ironmaking carbon-oxygen equilibrium steelmaking deoxidation tundish metallurgy casting clean steel

Hunting for a viral proxy in bioaerosols of swine buildings using molecular detection and metagenomics

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Journal of Environmental Sciences 2025年第2期148卷 69-78页

作者： Valérie létourneau Marie-Josée Gagné Jonathan M.Vyskocil Vincent Brochu Kim robitaille Martin Gauthier Julie Brassard Caroline Duchaine Quebec Heart and lung Institute Research Centre-Universitélaval 2725 Chemin Sainte-FoyQuebecG1V 4G5Canada Saint-Hyacinthe Research and Development Centre Agriculture and Agri-Food Canada3600 Casavant Boulevard WestSaint-HyacintheJ2S 8E3Canada Department of Biochemistry Microbiologyand Bio-informaticsFaculty of Science and EngineeringUniversitéLaval1045 Avenue de la MédecineQuebecG1V 0A6Canada The Swine and Poultry Infectious Diseases Research Centre Faculty of Veterinary Medicine of Universitéde Montréal3200 Rue SicotteSaint-HyacintheJ2S 2M2Canada

There are limited biosecurity measures directed at preventing airborne transmission of viruses in *** effectiveness of dust mitigation strategies such as oil sprinkling,to decrease risk of airborne virus transmission are *** and qPCR for common fecal viruses were used to hunt for a ubiquitous virus to serve as a proxy when evaluating the efficiency of mitigation strategies against airborne viral infectious *** particles were collected from swine buildings using high-volume air *** DNA and RNA were used to perform specific rt-qPCR and qPCR and analyzed by highthroughput *** astroviruses group 2 were common(from 102 to 105 genomic copies per cubic meter of air or gc/m^(3),93%positivity)while no norovirus genogroup II was recovered from air *** torque teno sus virus were detected by qPCR in low concentrations(from 101 to 102 gc/m^(3),47%positivity).Among the identified viral families by metagenomics analysis,Herelleviridae,Microviridae,Myoviridae,Podoviridae,and Siphoviridae were *** phage vB_AviM_AVP of Aerococcus was present in all air samples and a newly designed qPCR revealed between 101 and 105 gc/m^(3) among the samples taken for the present study(97%positivity)and banked samples from5-and 15-year old studies(89%positivity).According to the present study,both the porcine astrovirus group 2 and the phage vB_AviM_AVP of Aerococcus could be proxy for airborne viruses of swine buildings.

关键词： Bioaerosols Viral metagenomics Astrovirus Aerococcus phage Swine buildings