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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1453-1465页

作者： Laurent Quéro Mouna Labidi Marc Bollet côme Bommier Sophie Guillerm christophe Hennequin catherine Thieblemont Department of Radiation Oncology AP-HPSaint Louis HospitalParis 75010France Faculty of Medicine Universitéde ParisParis 75005France Department of Radiation Oncology Hartmann Oncology Radiotherapy GroupLevallois-Perret 92044France Hemato-Oncology DMU DHIAP-HPSaint Louis HospitalParis 75010France

Gastric mucosa-associated lymphoid tissue(MALT)lymphoma is a rare disease which is often associated with Helicobacter pylori(***)***-line treatment of stage IE and IIE localized gastric MALT lymphoma is based on the eradication of *** presence of *** resistance factors such as translocation t(11;18),peri-gastric lymph node involvement and the degree of tumor infiltration of the gastric wall;or lack of response to antibiotic therapy are two main indications to treat with definitive radiotherapy(rt).rt is an effective treatment in localized gastric MALT lymphoma.A moderate dose of 30 Gy allows a high cure rate while being well *** treatment,regular gastric endoscopic follow-up is necessary to detect a potential occurrence of gastric adenocarcinoma.

关键词： Radiotherapy Mucosa-associated lymphoid tissue MALT Helicobacter pylori Lymphoma Review

Solidification pathway and phase transformation behavior in a beta-solidified gamma-TiAl based alloy

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Journal of Materials Science & Technology 2019年第11期35卷 2652-2657页

作者： H.Xu X.B.Li W.W.Xing L.Shu Y.c.Ma K.Liu Institute of Metal Research Chinese Academy of SciencesShenyang 110016China MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology Engineering Research Center of Materials Behavior and DesignMinistry of EducationNanjing University of Science and TechnologyNanjing 210094China

The phase transformation behavior of an as-cast Ti-42Al-5 Mn(at.%)alloy after subsequent quenching from 1380℃to 1000℃was investigated based on the differential thermal analysis(DTA),electron probe micro analyzer-backscattered electrons(EPMA-BSE),transmission electron microscope(TEM)and X-ray diffraction(XRD).The results show that,the solidification path can be summarized as follows:Liquid→Liquid+β→β→β→α→β+α+γ→βo+α2+γ→βo+γ+α2/γ→βo+γ+α2/γ+βo,sec,with the phase transformationα→βtemperature(Tβ)=1311℃,phase transformationγ→βtemperature of(Tγsolv)=1231℃,phase transformationα2→αorβo→βtemperature(Tα2→α/Tβo→β)=1168 c,eutectoid temperature(Teut)=1132℃and T(α2/γ→βo,sec)≈1120℃.In comparison with Ti-42 Al alloy,the Teut and Tγsolv are slightly increased while both the Tp is decreased obviously by 5%Mn *** quenched from the temperature of 1380-1260℃,the martensitic transformationβ→α'could occur to form the needlelike martensite structure inβ*** kind of martensitic structure is much obvious with the increase of temperature from 1260℃to 1380℃.When the temperature is below Tγsolv(1231℃),theγgrains would nucleate directly from theβ*** the temperature slightly lower than T(eut)(1132℃),the dottedβ(o,sec)phases could nucleate in the lamellar colonies besides theγlamellae precipitated withinα2 ***,at room-temperature(rt),the alloy exhibits(po+α2+γ)triple phase with microstructure ofβo+lamellae+γ,of which the lamellar structure consists ofα2,γandβo,sec *** phase transformation mechanisms in this alloy,involvingβ→α',β→γ,α2→α2/γandα2→βo,sec were discussed.

关键词： Titanium aluminides Quenching Phase transformation Microstructure βphase

HTR-10放射性石墨粉尘取样回路中过滤元件的效率研究

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原子能科学技术 2014年第S1期48卷 511-516页

作者：皮月谢锋曹建主 c.chadwick 清华大学核能与新能源技术研究院先进反应堆工程与安全教育部重点实验室北京100084 中国核电工程有限公司北京100840 Porvair Filtration Group Hampshire PO15 5RT United Kingdom

10MW高温气冷实验堆(HTR-10)中石墨构件摩擦磨损不可避免地会产生石墨粉尘,其上可吸附固体裂变核素,可能影响反应堆安全正常运行。为研究石墨粉尘的粒径分布、微观形貌以及其表面的吸附特性,在HTR-10一回路氦净化系统入口建造了配置高... 详细信息

10MW高温气冷实验堆(HTR-10)中石墨构件摩擦磨损不可避免地会产生石墨粉尘,其上可吸附固体裂变核素,可能影响反应堆安全正常运行。为研究石墨粉尘的粒径分布、微观形貌以及其表面的吸附特性,在HTR-10一回路氦净化系统入口建造了配置高性能烧结金属粉末过滤元件的放射性石墨粉尘取样回路。为对放射性石墨粉尘的取样过滤结果进行研究,首先对过滤元件的过滤机理、压降特征以及过滤效率进行分析。设计并搭建实验装置对烧结金属粉末过滤元件的过滤效率进行测量,实验结果表明过滤元件能去除气流中的大部分粉尘,实现对HTR-10一回路氦气中放射性石墨粉尘等悬浮物的高效过滤取样。

关键词： HTR-10 放射性石墨粉尘烧结金属粉末过滤元件过滤效率

Tenecteplase Reperfusion therapy in Acute ischaemic cerebrovascular Events-Ⅱ (TRAcE Ⅱ): rationale and design

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Stroke & Vascular Neurology 2022年第1期7卷 71-76页

作者： Shuya Li Bruce c V campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang china National clinical Research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Medicine and Neurology University of MelbourneMelbourneVictoriaAustralia Department of Neurology and comprehensive Stroke center Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology Liverpool HospitalSouth Western Sydney Clinical SchoolSydneyNew South WalesAustralia

Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke *** and design Tenecteplase Reperfusion therapy in Acute ischemic cerebrovascular Events(TRAcE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority *** eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 *** considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day *** outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 *** efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke *** outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any *** There is no completed registration study of TNK in AIS *** Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in china.

关键词： infusion acute rational

cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays

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World Journal of Gastroenterology 2006年第29期12卷 4646-4651页

作者： Paul W Anderson Bud c Tennant Zhenghong Lee Department of Radiology University Hospitals of Cleveland Cleveland OH 44106United States Department of clinical Sciences College of Veterinary Medicine Cornell UniversityIthaca NY 14853 United States

AIM： To demonstrate the feasibility of using woodchuck samples on human microarrays, to provide insight into pathways involving positron emission tomography （PET） imaging tracers and to identify genes that could be potential molecular imaging targets for woodchuck hepatocellular carcinoma. METHODS： Labeled cRNA from woodchuck tissue samples were hybridized to Affymetrix U133 plus 2.0 Genechips. Ten genes were selected for validation using quantitative rt-PcR and literature review was made. RESULTS： Testis enhanced gene transcript （BAX Inhibitor 1）, alpha-fetoprotein, isocitrate dehydrogenase 3 （NAD＋） beta, acetyI-coA synthetase 2, carnitine palmitoyltransferase 2, and N-myc2 were up-regulated and spermidine/spermine N1-acetyltransferase was down-regulated in the woodchuck Hcc. We also found previously published results supporting 8 of the 10 most up-regulated genes and all 10 of the 10 most downregulated genes. cONcLUSION： Many of our microarray results were validated using rt-PcR or literature search. Hence, we believe that woodchuck Hcc and non-cancerous liver samples can be used on human microarrays to yield meaningful results.

关键词： cross-species hybridization Gene expression Woodchuck hepatitis virus Hepatocellular carcinoma Woodchuck Marmota monax

computing Paradigms in Emerging Vehicular Environments:A Review

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IEEE/cAA Journal of Automatica Sinica 2021年第3期8卷 491-511页

作者： Lion Silva Naercio Magaia Breno Sousa Anna Kobusińska António casimiro constandinos X.Mavromoustakis George Mastorakis Victor Hugo c.de Albuquerque Department of computer Science Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal Laboratory of computing Science PoznańUniversity of TechnologyPoznan 60-965Poland Department of computer Science University of NicosiaNicosia CY-2417Cyprus Department of Management Science and Technology Hellenic Mediterranean UniversityAgios Nikolaos 72100Greece LAPIScO Federal Institute of EducationScience and Technology of CearáFortaleza 60750-740 ARMTEc Tecnologia em robótica Fortaleza 60150000Brazil

Determining how to structure vehicular network environments can be done in various ***,we highlight vehicle networks’evolution from vehicular ad-hoc networks(VANET)to the internet of vehicles(Io Vs),listing their benefits and *** also highlight the reasons in adopting wireless technologies,in particular,IEEE 802.11 p and 5 G vehicle-toeverything,as well as the use of paradigms able to store and analyze a vast amount of data to produce intelligence and their applications in vehicular *** also correlate the use of each of these paradigms with the desire to meet existing intelligent transportation systems’*** presentation of each paradigm is given from a historical and logical *** particular,vehicular fog computing improves on the deficiences of vehicular cloud computing,so both are not exclusive from the application point of *** also emphasize some security issues that are linked to the characteristics of these paradigms and vehicular networks,showing that they complement each other and share problems and *** these networks still have many opportunities to grow in both concept and application,we finally discuss concepts and technologies that we believe are *** this work,we emphasize the crucial role of these concepts for the well-being of humanity.

关键词： computing paradigm cloud edge fog internet of vehicle(IoV) vehicular networks

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

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Translational Neurodegeneration 2022年第1期11卷 845-858页

作者： Ivan Martinez-Valbuena Naomi P.Visanji Ain Kim Heather H.c.Lau Raphaella W.L.So Sohaila Alshimemeri Andrew Gao Michael A.Seidman Maria R.Luquin Joel c.Watts Anthony E.Lang Gabor G.Kovacs Tanz centre for Research in Neurodegenerative Diseases University of TorontoTorontoONCanada Edmond J.Safra Program in PD and the Morton and Gloria Shulman Movement Disorders clinic Toronto Western HospitalTorontoONCanada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Krembil Brain Institute University Health NetworkTorontoONCanada Department of Biochemistry University of TorontoTorontoONCanada Laboratory Medicine Program University Health NetworkTorontoONCanada Department of Neurology Clinica Universidad de NavarraPamplonaNavarraSpain Division of Neurology Department of MedicineKing Saud UniversityRiyadhSaudi Arabia.

Background: Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy correlates with the predominant clinical features, the burden of pathology does not fully explain observed differences in clinical presentation and rate of disease progression. We hypothesized that the clinical heterogeneity in MSA is a consequence of variability in the seeding activity of α-synuclein both between different patients and between different brain regions. Methods: The reliable detection of α-synuclein seeding activity derived from MSA using cell-free amplification assays remains challenging. Therefore, we conducted a systematic evaluation of 168 different reaction buffers, using an array of pH and salts, seeded with fully characterized brain homogenates from one MSA and one PD patient. We then validated the two conditions that conferred the optimal ability to discriminate between PD- and MSA-derived samples in a larger cohort of 40 neuropathologically confirmed cases, including 15 MSA. Finally, in a subset of brains, we conducted the first multi-region analysis of seeding behaviour in MSA. Results: Using our novel buffer conditions, we show that the physicochemical factors that govern the in vitro amplification of α-synuclein can be tailored to generate strain-specific reaction buffers that can be used to reliably study the seeding capacity from MSA-derived α-synuclein. Using this novel approach, we were able to sub-categorize the 15 MSA brains into 3 groups: high, intermediate and low seeders. To further demonstrate heterogeneity in α-synuclein seeding in MSA, we conducted a comprehensive multi-regional evaluation of α-synuclein seeding in 13 different regions from 2 high seeders, 2 intermediate seeders and 2 low seeders. conclusions: We have identified unexpected differences in seed-competent α-synuclein across a coho

关键词： Alpha-synuclein Multiple system atrophy rt-QuIc Seeding behavior

MR IMAGING ASSESSMENT OF IRREGULAR SHRINKAGE OF TUMOR MORPHOLOGY AND VOLUME IN cERVIcAL cANcER DURING RADIATION THERAPY

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chinese Journal of cancer Research 2004年第2期16卷 137-141,149页

作者：李文彬李明华崔雪娥 WilliamT.c.Yuh NinaA.Mayr Department of Radiology Affiliated Sixth People'S Hospital Shanghai Jiaotong University Shanghai 200233 China Department of Radiology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA Radiation Oncology center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

To study the clinical significance of the morphological and volume changes in cervical cancer during an ongoing course of radiation therapy (rt) using MR imaging. Methods: Serial MR imaging examinations were performed in 60 advanced cervical cancer patients. MR imaging was obtained at the start of rt, at 20-25 Gy (2-2.5 weeks of rt), at 45-50 Gy (4-5 weeks of rt), and 1-2 month post-rt. Tumor morphology was classified qualitatively as well-defined (round/oval with a well-demarcated smooth margin) vs. lobulated vs. irregular and tumor volume was assessed in each serial MR examination independently by ROI volumetry and diameter volumetry. ROI volumetry was traced on the computer workstation with a trackball in each sagittal T2-weighted image and calculated by the summation of all tumor areas in each slice and multiplication by the slice profile. Diameter volumetry was to measure the largest three orthogonal tumor diameters in each orthogonal measurement plane and calculate as an ellipsoid formula (V=d1 x d2 x d3 x p/6). Serial tumor volume was compared between the two measurement methods. Results: The proportion of lobulated and irregular tumors increased early during rt and declined lately post-rt (68% pre-rt, 80% at 2-2.5 weeks of rt, 72% at 4-5 weeks of rt, 33% post-rt). Accordingly, ROI volumetry and diameter volumetry correlated well pre-rt (r1=0.89) and post-rt (r4=0.80), but poorly during rt (r2 = 0.17 at 2-2.5 weeks of rt, r3 = 0.69 at 4-5 weeks of rt). conclusions: cervical cancers regress in a non-uniform fashion during rt and undergo increasingly irregular shrinkage. Measurement with ROI volumetry techniques, which can optimally measure irregular volumes, provides better assessment of radiation response during treatment than diameter volumetry.

关键词： cervical cancer MR imaging Tumor volume Radiation therapy Tumor regression

On the solar activity dependence of midnight equatorial plasma bubbles during June solstice periods

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Earth and Planetary Physics 2021年第5期5卷 378-386页

作者： K.K.Ajith S.Tulasi Ram GuoZhu Li M.Yamamoto K.Hozumi c.Y.Yatini P.Supnithi Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Indian Institute of Geomagnetism MumbaiIndia Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China college of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Research Institute for Sustainable Humanosphere Kyoto UniversityUjiJapan National Institute of Information and communications Technology TokyoJapan Space Science center Indonesian National Institute of Aeronautics and SpaceIndonesia School of Engineering King Mongkut’s Institute of Technology LadkrabangChalongkrung RdLadkrabang10520 BangkokThailand

The occurrence of midnight Equatorial Plasma Bubbles(EPBs)during the June solstice period of the ascending phase of solar cycle 24,from 2010 to 2014,was studied using data from the 47 MHz Equatorial Atmosphere Radar(EAR)at Kototabang,*** analysis shows that the occurrence of midnight hour EPBs was at its maximum during the low solar activity year 2010 and monotonically decreased thereafter with increasing solar *** of the dependence of midnight hour EPB occurrence on solar activity were investigated using SAMI2 model simulation with a realistic input of E×B drift velocity data obtained from the cINDI-IVM onboard the c/NOFS *** obtained from term-by-term analysis of the flux tube integrated linear growth rate of rt instability indicate that the formation of a high flux tube electron content height gradient(steep vertical gradient)region at higher altitudes,due to the elevated F layer,is the key factor enhancing the growth rate of rt instability during low solar activity June *** factors are discussed in light of the relatively weak westward zonal electric field in the presence of the equatorward neutral wind and north-to-south transequatorial wind around the midnight hours of low solar activity June *** discussed are the initial seeding of rt instability by MSTIDs and how the threshold height required for EPB development varies with solar activity.

关键词： equatorial plasma bubbles equatorial ionosphere ionospheric instabilities and irregularities