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Synthetic lethal approaches to target cancers with loss of PTEN function

Genes & Diseases 2023年第6期10卷 2511-2527页

作者： Ayse Ertay rob mewing Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3 ) into phosphatidylinositol 4,5-bisphosphate (PIP2 ). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes such as PTEN has been challenging as it is difficult to restore the tumor suppressor functions. Therefore, focusing on the downstream signaling pathways to discover a targeted therapy for inactive tumor suppressor genes has highlighted the importance of synthetic lethality studies. This review focused on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.

关键词： Cancer PTEN Synthetic lethality Tumour suppressor gene WDHD1

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Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes

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Virologica Sinica 2020年第6期35卷 853-856页

作者： Xiaojun Wu Tong Wang Yilu Zhou Xiaofan Liu Hong Zhou Yang Lu Weijun Tan Mingli Yuan Xuhong Ding Jinjing Zou Ruiyun Li Hailing Liu rob mewing Yi Hu Hanxiang Nie Yihua Wang Department of Respiratory and Critical Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK Department of Pulmonary and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK

Dear Editor,The pandemic of COVID-19,a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2;previously known as 2019-n Co V),has placed an enormous burden on health authorities in 213 countries and *** the time of writing,over 26 million cases have been recorded across the world,with more than 870 k associated deaths(***/coronavirus/).World Bank warns COVID-19 pandemic risks dramatic rise in poverty,with the majority of economies expecting to suffer from falling levels of GDP in 2020.

关键词： acute respiratory authorities

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