检索结果-南通市图书馆

Advances in caring for the older cancer patient：a report from the 2015 conference of the International Society of Geriatric Oncology

引用

Cancer Biology & Medicine 2016年第1期13卷 150-155页

作者： rob stepney Freelance Medical Writer Charlbury OX7 3HJ UK

A paradox in cancer research is that the majority of patients enrolled in clinical trials are relatively young and fit while typical patients in daily practice are elderly and have comorbidities and impaired organ function. Given these differences, many major studies provide an imperfect guide to optimizing the treatment of the majority of patients. Since cancer incidence is highly correlated with age, and since the world's population is rapidly ageing, this problem can only increase. For this reason, oncologists and geriatricians need to collaborate in developing tools to systematically assess the health status of elderly patients and their fitness to receive cancer therapies of various intensity. Tailoring anti-cancer treatments and supportive care to individual needs should be seen as part of the move towards personalized medicine. Achieving this goal is as much of a challenge to developing and middle-income countries as it is to western nations. The 2015 annual conference of the International Society of Geriatric Oncology(SIOG) held in Prague, Czech Republic, November 2015 and had a global focus on advancing the science of geriatric oncology and supportive care. Central to this approach is the systematic assessment of life expectancy, independent functioning, and the physical and psychological health of older cancer patients. The assumption behind comprehensive geriatric assessment is that elderly cancer patients have complex needs. The implication is that effective intervention will require a multidisciplinary team. Examples of effective geriatric assessment, multidisciplinary working and supportive care were presented at the SIOG conference.

关键词： Geriatric oncology supportive care elderly geriatric assessment quality of life comorbidities

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk mapping of wildlife-vehicle collisions across thestate of Montana,USA:a machine-learning approach forimbalanced data along rural roads

引用

Transportation Safety and Environment 2024年第3期6卷 124-132页

作者： Matthew Bell Yiyi Wang rob Ament Western Transportation Institute Montana State University2327 University WayBozemanMT 59717USA School of Engineering San Francisco State University1600 Holloway AveSan FranciscoCA 94132USA

Wildlife-vehicle collisions(WVCs)with large animals are estimated to cost the USA over 8 billion USD in property damage,tens of thousands of human injuries and nearly 200 human fatalities each *** WVCs occur on rural roads and are not collected evenly among road segments,leading to imbalanced *** are a disproportionate number of analysis units that have zero WVC cases when investigating large geographic areas for collision *** units with zero WVCs can reduce prediction accuracy and weaken the coefficient estimates of statistical learning *** study demonstrates that the use of the synthetic minority over-sampling technique(SMOTE)to handle imbalanced WVC data in combination with statistical and machine-learning models improves the ability to determine seasonal WVC risk across the rural highway network in Montana,*** array of regularized variables describing landscape,road and traffic were used to develop negative binomial and random forest models to infer WVC rates per 100 million vehicle miles *** random forest model is found to work particularly well with SMOTE-augmented data to improve the prediction accuracy of seasonal WVC ***-augmented data are found to improve accuracy when predicting crash risk across fine-grained grids while retaining the characteristics of the original *** analyses suggest that SMOTE augmentation mitigates data imbalance that is encountered in seasonally divided WVC *** research provides the basis for future risk-mapping models and can potentially be used to address the low rates of WVCs and other crash types along rural roads.

关键词： wildlife-vehicle collisions machine learning SMOTE negative binomial risk mapping

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon dioxide enrichment affected flower numbers transiently and increased successful post-pollination development stably but without altering final acorn production in mature pedunculate oak (Quercus robur L.)

引用

Journal of Forestry Research 2024年第4期35卷 1-12页

作者： Ryan McClory Richard H.Ellis Martin Lukac Jo Clark Carolina Mayoral Kris M.Hart Andrew R.G.Plackett A.rob MacKenzie School of Agriculture Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Faculty of Forestry and Wood Sciences Czech University of Life Sciences PraguePrague 165000Czechia Future Trees Trust Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Birmingham Institute of Forest Research University of BirminghamEdgbastonBirmingham B152TTUK School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUK School of Geography Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Acorn production in oak(Quercus spp.)shows considerable inter-annual variation,known as masting,which provides a natural defence against seed predators but a highly-variable supply of acorns for uses such as in commercial tree planting each *** emissions of greenhouse gases have been very widely reported to influence plant growth and seed or fruit size and quantity via the‘fertilisation effect’that leads to enhanced *** examine if acorn production in mature woodland communities will be affected by further increase in CO_(2),the contents of litter traps from a Free Air Carbon Enrichment(FACE)experiment in deciduous woodland in central England were analysed for numbers of flowers and acorns of pedunculate oak(Quercus robur L.)at different stages of development and their predation levels under ambient and elevated CO_(2) ***-annual variation in acorn numbers was considerable and cyclical between 2015 and 2021,with the greatest numbers of mature acorns in 2015,2017 and 2020 but almost none in *** numbers of flowers,enlarged cups,immature acorns,empty acorn cups,and galls in the litter traps also varied amongst years;comparatively high numbers of enlarged cups were recorded in 2018,suggesting *** at this site is a fruit maturation masting species(i.e.,the extent of abortion of pollinated flowers during acorn development affects mature acorn numbers greatly).Raising the atmospheric CO_(2) concentration by 150μL L^(−1),from early 2017,increased the numbers of immature acorns,and all acorn evidence(empty cups+immature acorns+mature acorns)detected in the litter traps compared to ambient controls by 2021,but did not consistently affect the numbers of flowers,enlarged cups,empty cups,or mature *** number of flowers in the elevated CO_(2) plots’litter traps was greater in 2018 than 2017,one year after CO_(2) enrichment began,whereas numbers declined in ambient *** with CO_(2) also increased the number o

关键词： Quercus robur L. Acorns Masting Pedunculate oak Carbon dioxide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Drought Tolerance and Recovery of the Sedge Carex planostachys (Cyperaceae) from Central Texas Woodlands

引用

American Journal of Plant Sciences 2024年第9期15卷 746-765页

作者： E. rob Wayne Oscar William Van Auken Natural Sciences Department St. Philips College San Antonio USA Department of Integrative Biology The University of Texas at San Antonio San Antonio USA

Carex planostachys Kunze (Cyperaceae, Cedar sedge) is an herbaceous species in a genus commonly inhabiting mesic or hydric habitats. Carex planostachys is found in arid and semi-arid Juniperus woodlands. Arid conditions impose survival challenges to plants in dry areas. Some plants have plasticity responses to soil water content and continued normal though reduced functions through droughts, but most herbaceous plants do not survive. Limited previous studies have suggested C. planostachys is tolerant of drought. Physiological responses of C. planostachys from Juniperus woodlands was examined is this study to determine how long plants could survive without water and if they are capable of recovery from very negative water potentials beyond what is considered the permanent wilting point for most herbaceous plants. Plants were placed in pots in partial shade in this experiment. Water loss from the soil with plants was an inverse 2nd order polynomial function with soil water decreasing from 32% to 8% by day 28 of the study. Leaf water potential was also an inverse 2nd order polynomial function but did not decline significantly until 14 days without watering. Leaf water potential was −10.0 MPa after 35 days without watering. Non-watered plants Anet, (photosynthetic rate) was significantly lower compared to the water treatment by day 21 as was stomatal conductance and transpiration. When non-watered plants were watered after 21, 28 or 35 days, full recovery of physiological responses occurred within 7 days. The length of time that C. planostachys was able to withstand drought was greater than the annual trends in lack of precipitation during springtime in this area. Carex planostachys can photosynthesize at water stress between −8 and −10 MPa. Carex planostachys drought and shade tolerance enables it to occupy an understory niche devoid of other herbaceous plants.

关键词： CO2 Uptake Conductance Gas Exchange Photosynthesis Respiration Transpiration Water Stress Water Potential.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乡村旅游精英公共服务动机的结构维度研究

引用

旅游学刊 2024年第9期39卷 91-105页

作者：徐少癸韩佳钰陈思榕 rob LAW 章牧福建师范大学文化旅游与公共管理学院福建福州350117 暨南大学深圳旅游学院广东深圳518053 南洋理工大学黄金辉传播与信息学院新加坡637718 澳门大学亚太经济与管理研究所中国澳门999078 澳门大学工商管理学院中国澳门999078

乡村旅游精英在乡村振兴、消除贫困、促进乡村旅游可持续发展等方面发挥着至关重要的作用。然而,作为中国旅游研究领域的热点议题,乡村旅游精英的动机研究却往往被简单化和边缘化。因此,文章基于中国乡土文化背景,聚焦乡村旅游精英这一... 详细信息

乡村旅游精英在乡村振兴、消除贫困、促进乡村旅游可持续发展等方面发挥着至关重要的作用。然而,作为中国旅游研究领域的热点议题,乡村旅游精英的动机研究却往往被简单化和边缘化。因此,文章基于中国乡土文化背景,聚焦乡村旅游精英这一特定群体,利用扎根理论对乡村旅游精英公共服务动机的结构维度进行探索性研究。研究发现,乡村旅游精英公共服务动机由乡土情结、公共利益承诺、社会认可与支持、自我奉献精神和政策制定吸引力5个维度组成。其中,公共利益承诺、自我奉献精神和政策制定吸引力3个维度具有普适性,乡土情结和社会认可与支持则是文章基于中国乡土社会背景发现的新维度。乡村旅游精英公共服务动机是一个复杂的多维结构体系,各维度相互关联、相互影响,共同构成了乡村旅游精英公共服务动机的驱动因素。以上结论对乡村旅游精英公共服务动机研究具有一定的理论贡献,同时也为乡村旅游目的地管理、评估乡村旅游精英提供了针对性建议。

关键词：乡村旅游精英公共服务动机乡村旅游乡村振兴扎根理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

探索DNA数据驱动器

引用

科技纵览 2024年第3期 30-36,4页

作者： rob Carlson 不详

我们每天都会产生很多数据,包括电子邮件、文本、照片和社交媒体帖子等。虽然这些内容大多不值得保存,但每天我们都在默默地作出不删除这些数据的决定。我们把它们保存在某个地方,可能是手机上、电脑硬盘上或者云上,最终它们都会被存档... 详细信息

我们每天都会产生很多数据,包括电子邮件、文本、照片和社交媒体帖子等。虽然这些内容大多不值得保存,但每天我们都在默默地作出不删除这些数据的决定。我们把它们保存在某个地方,可能是手机上、电脑硬盘上或者云上,最终它们都会被存档,大多数情况下是在磁带上。此外,现在各种设备和传感器都将数据传输到网络上,汽车、飞机和其他交通工具的数据也要存储以备后用。物联网上的数十亿物品都会产生数据,所有这些信息都需要存储在某个地方。

关键词：电子邮件电脑硬盘物联网数据传输其他交通工具社交媒体传感器

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

引用

Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward rob M.Ewing Donna E.Davies Mark G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EMT LKB1 Pulmonary fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years

引用

四川生理科学杂志 2024年第7期46卷 1621-1621页

作者： Liming Li Troy J. Comi rob F. Bierman Joshua M. Akey Department of Medical Genetics and Developmental Biology School of Medicine The Key Laboratory of Developmental Genes and Human Diseases Ministry of Education Southeast University Nanjing 210009 China. The Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton NJ 08540 USA.

Although it is well known that the ancestors of modern humans and Neanderthals admixed,the effects of gene flow on the Neanderthal genome are not well *** develop methods to estimate the amount of human-introgressed s... 详细信息

关键词： flow modern apply

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomic Mutations Within the Host Microbiome: Adaptive Evolution or Purifying Selection

引用

Engineering 2023年第1期20卷 96-102页

作者： Jiachao Zhang rob Knight School of Food Science and Engineering Hainan UniversityHaikou 570228China Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Center for Microbiome Innovation Jacobs School of EngineeringUniversity of California San DiegoLa JollaCA 92093USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Department of Computer Science and Engineering University of California San DiegoLa JollaCA 92093USA

Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.

关键词： Gut microbiota Genomic mutations Adaptive evolution Purifying selection Single-nucleoti de variants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

引用

World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：