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农场

Breath Biopsy^(®) to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection

作者： (英)汤姆·罗伯·史密斯(Tom rob smith)

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 638-648页

作者： Giuseppe Ferrandino Giovanna De Palo Antonio Murgia Owen Birch Ahmed Tawfike rob smith Irene Debiram-Beecham Olga Gandelman Graham Kibble Anne Marie Lydon Alice Groves Agnieszka Smolinska Max Allsworth Billy Boyle Marc P.van der Schee Michael Allison Rebecca C.Fitzgerald Matthew Hoare Victoria K.Snowdon Owlstone Medical CambridgeUK Department of Oncology University of CambridgeHutchison/MRC Research CentreCambridgeUK Department of Pharmacology and Toxicology School for Nutrition and Translational Research in Metabo-lism(NUTRIM)Maastricht University Medical Centerthe Netherlands Department of Medicine University of CambridgeAddenbrooke’s HospitalCambridgeUK Addenbrookes Hepatology and Liver Transplantation Unit Addenbrookes Hospi-talCambridgeUK MRC Cancer Unit Hutchison/MRC Research CentreUniversity of CambridgeCambridgeUK CRUK Cambridge Institute CambridgeUK

Background and Aims:The prevalence of chronic liver dis-ease in adults exceeds 30%in some countries and there is significant interest in developing tests and treatments to help control disease progression and reduce healthcare *** is a rich sampling matrix that offers non-invasive so-lutions suitable for early-stage detection and disease *** previously investigated targeted analysis of a single biomarker,here we investigated a multiparametric approach to breath testing that would provide more robust and reliable results for clinical ***:To identify can-didate biomarkers we compared 46 breath samples from cir-rhosis patients and 42 from *** and analysis used Breath Biopsy OMNI™,maximizing signal and contrast to background to provide high confidence biomarker detec-tion based upon gas chromatography mass spectrometry(GC-MS).Blank samples were also analyzed to provide de-tailed information on background volatile organic compounds(VOCs)***:A set of 29 breath VOCs differed significantly between cirrhosis and controls.A classification model based on these VOCs had an area under the curve(AUC)of 0.95±0.04 in cross-validated test *** seven best performing VOCs were sufficient to maximize classifica-tion performance.A subset of 11 VOCs was correlated with blood metrics of liver function(bilirubin,albumin,prothrom-bin time)and separated patients by cirrhosis severity using principal component ***:A set of seven VOCs consisting of previously reported and novel candidates show promise as a panel for liver disease detection and mon-itoring,showing correlation to disease severity and serum biomarkers at late stage.

关键词： Breath Biopsy Non-invasive Biomarker Cirrhosis Liver function test.

近20年英国职教师资培养变革趋势及其特征研究

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比较教育研究 2016年第8期38卷 95-102页

作者：汤霓张蔚然罗伯.史密斯石伟平教育部职业技术教育中心研究所北京100029 华东师范大学职业教育与成人教育研究所上海200062 英国伍尔弗汉普顿大学终身教育研究与发展中心

英国政府对职教师资培养的正式关注始于20世纪90年代后期,在近20年的发展过程中经历了尝试监管、强化监管和弱化监管三个阶段。英国职教师资培养的专业标准、资格认证以及课程设置反映了英国职教师资培养体系的三大核心要素,体现出了鲜... 详细信息

英国政府对职教师资培养的正式关注始于20世纪90年代后期,在近20年的发展过程中经历了尝试监管、强化监管和弱化监管三个阶段。英国职教师资培养的专业标准、资格认证以及课程设置反映了英国职教师资培养体系的三大核心要素,体现出了鲜明的特征:宽泛通用的专业标准、分层级的资格证书体系、螺旋式的课程结构设计。

关键词：英国职教师资培养专业标准资格认证课程设置

Separation of Fault Tolerance and Non-Functional Concerns: Aspect Oriented Patterns and Evaluation

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Journal of Software Engineering and Applications 2010年第4期3卷 303-311页

作者： Kashif Hameed rob Williams Jim smith University of the West of England Bristol Institute of Technology Bristol UK.

Dependable computer based systems employing fault tolerance and robust software development techniques demand additional error detection and recovery related tasks. This results in tangling of core functionality with these cross cutting non-functional concerns. In this regard current work identifies these dependability related non-functional and cross-cutting concerns and proposes design and implementation solutions in an aspect oriented framework that modularizes and separates them from core functionality. The degree of separation has been quantified using software metrics. A Lego NXT robot based case study has been completed to evaluate the proposed design framework.

关键词： Aspect Oriented Design and Programming Separation of Concerns Executable Assertions Exception Handling Fault Tolerance Software Metrics

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计算机游戏宝典 G

Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

丛书名：美国IDG“宝典”丛书

2001年

作者：（美）Mark L.Chambers （美）rob smith 牛力等译

本书系统介绍了计算机游戏的种类、玩法及所用的外围设备，本书分为三部分，主要包括：硬件基础、游戏世界和高级游戏。

ISBN: (纸本)7505366637

本书系统介绍了计算机游戏的种类、玩法及所用的外围设备，本书分为三部分，主要包括：硬件基础、游戏世界和高级游戏。

关键词：游戏应用软件

来源：畅想之星图书光盘版（南... 评论

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee rob Myers robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin Blake David A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh Dina Attia Steven Bollipo Alastair D.smith Bradley Freilich robert G.Gish Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA Division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum Diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA Division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD *** hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLD MAFLD NASH Fatty liver disease Liver Fibrosis

Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen

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Open Journal of Medicinal Chemistry 2013年第1期3卷 16-25页

作者： David C. Pryde Thien-Duc Tran Mark Gardner Chris Pickford Stephen M. Shaw Mike Westby Tanya Parkinson Caroline smith-Burchnell rob Webster Satish Dayal Anti-Infectives Research Unit Pfizer Global Research and Develoapment Sandwich UK Anti-Infectives Research Unit Pfizer Global Research and Development Sandwich UK Pharmacokinetics Dynamics and Metabolism Pfizer Global Research and Development Sandwich UK Worldwide Medicinal Chemistry Pfizer Global Research and Development Sandwich UK

A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.

关键词： HCV Replicon Antiviral Cell-Based Screen

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外科手术学第3卷

外科手术学第3卷

1964年

作者：（英）洛勃（C.rob）（英）斯密茨（R.smith）赵连壁等译

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外科手术学第6卷

外科手术学第6卷