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Journal of Energy Chemistry 2024年第5期92卷 508-520页

作者： Riccardo Brandiele Andrea Guadagnini Mattia Parnigotto federico Pini Vito Coviello Denis Badocco Paolo Pastore Gian Andrea rizzi Andrea Vittadini Daniel forrer Vincenzo Amendola Christian Durante Department of Chemical Sciences University of PaduaVia Marzolo 135131 PadovaItaly Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia ICMATE-CNR via Marzolo 1 I-35131 PadovaItaly

The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday *** nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating *** this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ***_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in *** novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(f commercial Pt catalysts,yet resulting remarkably more active with E_(1/2)=0.943 V ***,specific activity=1095μA cm^(-2) and mass activity>1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.

关键词： Electrocatalysis GDE ORR Pt_(2)Y Pt_(3)Y LAL LfL Oxide support Pto Nanoalloys

Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic

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World Journal of Diabetes 2024年第6期15卷 1374-1380页

作者： Angelo Emilio Claro Clelia Palanza Marianna Mazza Alessandro rizzi Andrea Corsello Linda Tartaglione Giuseppe Marano Giovanna Elsa Ute Muti Schuenemann Marta Rigoni Alfredo Pontecorvi Luigi Janiri Paola Muti Dario Pitocco Diabetes Care Unit Department of Medical and Surgical SciencesFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Istituto Italiano di Antropologia ISItARome 00100Italy Unit of Psychiatry Department of NeurosciencesFondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Dipartimento di Medicina e Chirurgia Traslazionale UniversitàCattolica del Sacro CuoreRome 00168Italy Health Research Methods Evidence and Impact DepartmentMcMaster UniversityOntario 1280Canada Department of Endocrine-Metabolic and Dermo-Rheumatology Fondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

Common psychiatric disorders(CPDs)and depression contribute significantly to the global epidemic of type 2 diabetes(T2D).We postulated a possible pathophysiological mechanism that through Bridge-Symptoms present in depression and CPDs,promotes the establishment of emotional eating,activation of the reward system,onset of overweight and obesity and,ultimately the increased risk of developing *** plausibility of the proposed pathophysiological mechanism is supported by the mechanism of action of drugs such as naltrexonebupropion currently approved for the treatment of both obesity/overweight with T2D and as separate active pharmaceutical ingredients in drug addiction,but also from initial evidence that is emerging regarding glucagon-like peptide 1 receptor agonists that appear to be effective in the treatment of drug *** hope that our hypothesis may be useful in interpreting the higher prevalence of CPDs and depression in patients with T2D compared with the general population and may help refine the integrated psychiatric-diabetic therapy approach to improve the treatment and or remission of T2D.

关键词： Depression Glucagon-like peptide-1 receptor agonists Diabetes mellitus type 2 Stress psychological Sleep wake disorders food addiction

A refined frequency Domain Decomposition tool for structural modal monitoring in earthquake engineering

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 627-648页

作者： fabio Pioldi Egidio rizzi Department of Engineering and Applied Sciences (Dalmine) University of Bergamo viale G. Marconi 5 1-24044 Dalmine (BG) Italy

Output-only structural identification is developed by a refined frequency Domain Decomposition（rfDD） approach, towards assessing current modal properties of heavy-damped buildings（in terms of identification challenge）, under strong ground motions. Structural responses from earthquake excitations are taken as input signals for the identification algorithm. A new dedicated computational procedure, based on coupled Chebyshev Type Ⅱ bandpass filters, is outlined for the effective estimation of natural frequencies, mode shapes and modal damping ratios. The identification technique is also coupled with a Gabor Wavelet Transform, resulting in an effective and self-contained time-frequency analysis framework. Simulated response signals generated by shear-type frames（with variable structural features） are used as a necessary validation condition. In this context use is made of a complete set of seismic records taken from the fEMA P695 database, i.e. all 44 ＂far-field＂（22 NS, 22 WE） earthquake signals. The modal estimates are statistically compared to their target values, proving the accuracy of the developed algorithm in providing prompt and accurate estimates of all current strong ground motion modal parameters. At this stage, such analysis tool may be employed for convenient application in the realm of Earthquake Engineering, towards potential Structural Health Monitoring and damage detection purposes.

关键词： Operational Modal Analysis (OMA) modal dynamic identification refined frequency Domain Decomposition(rfDD) fEMA P695 seismic database earthquake response identification input

5-ASA in ulcerative colitis:Improving treatment compliance

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World Journal of Gastroenterology 2009年第35期15卷 4353-4355页

作者： Cosimo Prantera Marina rizzi Department of Gastroenterology Azienda Ospedaliera San Camillo-ForlaniniCirconvallazione Gianicolense 8700152 RomeItaly Department of Gastroenterology University Campus Bio Medicovia Alvaro del Portillo 20000128 Rome Italy

5-aminosalicylic acid(5-ASA)compounds are a highly effective treatment for ulcerative colitis(UC).While UC patient compliance in clinical studies is over 90%, only 40%of patients in every day life take their prescribed *** to medication has been emphasized recently by a Cochrane meta-analysis that has suggested that future trials of 5-ASA in UC should look at patient compliance rather than drug efficacy. Better compliance can be obtained by reducing the number of tablets and times of *** that the 5-ASA formulations have different delivery systems that split the active moiety in various regions of the intestine,it is particularly important that an adequate dose of the drug arrives at the inflamed part of the colon.5-ASA Multi matrix(MMx)is a novel,high strength(1.2 g),oral formulation designed for oncedaily *** releases the active moiety throughout the *** studies with this compound have shown that it is as effective as 5-ASA enema in the treatment of mild-to-moderate,left-sided UC,and is comparable to a pH-dependent,delayed release 5-ASA (Asacol ),even if given once ***,the effectiveness in the acute phase of UC has been confirmed also in *** conclusion,at present,5-ASA MMx seems theoretically the best agent for maintaining patient compliance,and consequently,treatment effectiveness.

关键词： 5-aminosalicylic acid Mesalamine Multi matrix Patient compliance Ulcerative colitis

Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up

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World Journal of Gastroenterology 2007年第39期13卷 5238-5244页

作者： Renato Caviglia Mentore Ribolsi Marina rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala Department of Digestive Diseases Campus Bio-Medico University Rome Italy

AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Infliximab therapy Steroidsparing

全基因组和基于基因的荟萃分析识别影响氢氯噻嗪血压反应的新型基因位点

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中华高血压杂志 2016年第11期24卷 1007-1007页

作者：刘莉叶鹏 Salvi E Wang Z rizzi f Gong Y McDonough CW Padmanabhan S Hiltunen TP Lanzani C Zaninello R Chittani M Bailey KR Sarin AP Barcella M Melander O Chapman AB Manunta P Kontula KK Glorioso N Cusi D Dominiczak Af Johnson JA Barlassina C Boerwinkle E Cooper-DeHoff RM Turner ST

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反... 详细信息

本研究旨在识别影响氢氯噻嗪单药治疗降压反应的新基因位点。纳入来自国际抗高血压药物基因组学研究联合会的6个临床试验中的白人高血压患者1739例,进行氢氯噻嗪降压反应的全基因组荟萃分析。此外,研究者对先前有证据表明其参与利尿反应、血压调节或高血压易感性的候选基因进行了基于基因的分析。

关键词：血压调节基因位点荟萃分析抗高血压药物基因组研究抗高血压治疗缝隙连接蛋白叉头 junction 候选基因

Surface functionalization of acrylic based photocrosslinkable resin for 3D printing applications

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Bioactive Materials 2017年第3期2卷 131-137页

作者： A.Ronca f.Maiullari M.Milan V.Pace A.Gloria R.rizzi R.De Santis L.Ambrosio Institute of Polymers Composites and Biomaterials e National Research Council(IPCB-CNR)Italy Institute of Cellular Biology and Neurobiology e National Research Council(IBCN-CNR) Italy

The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid *** this work an acrylic photocrosslinkable resin based on methyl methacrylate(MMA),butyl methacrylate(BMA)and poly(ethylene glycol)dimethacrylate(PEGDA)was developed with different composition and characterized in terms of mechanical,thermal and biological *** different systems have been developed using different amount of *** influence of every components have been evaluated on the final characteristic of the resin in order to optimize the final composition for applications in bone tissue *** crosslinked materials showed good mechanical properties and thermal stabilities and moreover cytotoxicity test confirms good biocompatibility with no cytotoxic effect on cells *** two different treatments have been proposed,using fetal bovine serum(fBS)and methanol(MeOH),in order to improve cell recognition of the *** threatened with MeOH allow cell adhesion and survival,promoting spreading,elongation and fusion of C2C12 muscle myoblast cells.

关键词： resin acrylic methacrylate

Overlap graphs and de Bruijn graphs: data structures for de novo genome assembly in the big data era

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Quantitative Biology 2019年第4期7卷 278-292页

作者： Raffaella rizzi Stefano Beretta Murray Patterson Yuri Pirola Marco Previtali Gianluca Della Vedova Paola Bonizzoni Department of Informatics Systems and CommunicationsUniversity of Milan-BicoccaMilanViale Sarca 33620126Italy

Background:De novo genome assembly relies on two kinds of graphs:de Bruijn graphs and overlap *** graphs are the basis for the Celera assembler,while de Bruijn graphs have become the dominant technical device in the last *** two kinds of graphs are collectively called assembly ***:In this review,we discuss the most recent advances in the problem of constructing,representing and navigating assembly graphs,focusing on very large *** will also explore some computational techniques,such as the Bloom filter,to compactly store graphs while keeping all functionalities ***:We complete our analysis with a discussion on the algorithmic issues of assembling from long reads(eg.,PacBio and Oxford Nanopore).finally,we present some of the most relevant open problems in this field.

关键词： overlap graphs de Bruijn graphs genome assembly long reads string graphs

Giant splenic artery aneurysm presenting with massive upper gastrointestinal bleeding:A case report and review of literature

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World Journal of Gastroenterology 2020年第22期26卷 3110-3117页

作者： francesco Panzera Riccardo Inchingolo Marina rizzi Assunta Biscaglia Maria Grazia Schievenin Emilia Tallarico Giancarlo Pacifico Beatrice Di Venere Division of Gastroenterology Department of SurgeryMadonna delle Grazie HospitalMatera 75100Italy Division of Interventional Radiology Department of RadiologyMadonna delle Grazie HospitalMatera 75100Italy Department of Intensive Care Madonna delle Grazie HospitalMatera 75100Italy Department of Pathology Madonna delle Grazie HospitalMatera 75100Italy Division of General Surgery Department of SurgeryMadonna delle Grazie HospitalMatera 75100Italy

BACKGROUND Splenic artery aneurysm(SAA)and pseudoaneurysm are rare vessel’s *** is often symptomatic and secondary to pancreatitis or *** SAA is the most common aneurysm of visceral *** contrast to pseudoaneurysm,SAA is usually asymptomatic until the rupture,with high mortality *** clinical onset of SSA’s rupture is a massive life-threatening bleeding with hemodynamic instability,usually into the free peritoneal space and more rarely into the gastrointestinal *** SUMMARY We describe the case of a 35-year-old male patient,with negative past medical history,who presented to the emergency department for massive upper gastrointestinal bleeding,severe anemia and *** esophagogastroduodenoscopy performed in emergency showed a gastric bulging in the greater curvature/posterior wall with a small erosion on its surface,with a visible vessel,but no active *** injection therapy with cyanoacrylate glue was *** contrast-enhanced computed tomography was carried out due to the clinical scenario and the unclear endoscopic aspect:The radiological examination showed a giant SAA which was adherent to posterior stomach wall,and some smaller aneurysms of the left gastric and ileocolic *** of the high risk of a two-stage rupture of the giant SAA with dramatic outcome,the patient underwent immediate open surgery with aneurysmectomy,splenectomy and distal pancreatectomy with a good postoperative *** The management of a ruptured giant SAA into the stomach can be successful with surgical approach.

关键词： Splenic artery aneurysm Upper gastrointestinal bleeding Hemorrhagic shock Computed tomography Endoscopy Case report

Pediatric spinal glioblastoma of the conus medullaris:a case report of long survival

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Chinese Journal of Cancer 2016年第6期35卷 69-72页

作者： Antonella Cacchione Angela Mastronuzzi Maria Giuseppina Cefalo Giovanna Stefania Colafati francesca Diomedi-Camassei Michele rizzi Alessandro De Benedictis Andrea Carai Department of Pediatric Hematology-OncologyBambino GesùChildren’s Hospital IRCCSPlazza Sant'Onofrio 400615 RomeItaly Neuroradiology Unit Bambino GesùChildren’s HospitalPlazza Sant'Onofrio 400615 RomeItaly Division of Pathology Bambino GesùChildren’s HospitalPlazza Sant'Onofrino 400615 RomeItaly Department of Neurosurgery Fondazione Istituto Neurologico"Carlo Besta"IRCCSMilanItaly Neurosurgery Unit Department of Neuroscience and NeurorehabilitationBambino GesùChildren’s HospitalPlazza Sant'Onofrio 400615 RomeItaly

High?grade gliomas of the spinal cord represent a rare entity in *** biology,behavior,and controversial treatment options have been discussed in a few pediatric *** tumors are associated with severe disability and poor *** report a case of a 4?year?old child diagnosed with an isolated glioblastoma multiforme of the conus *** patient underwent subtotal surgical excision,followed by adjuvant radiotherapy and oral chem?*** is alive with mild neurologic deficits at 52 months after *** describe the peculiar characteris?tics of this rare condition in pediatric *** also provide an overview of current multidisciplinary therapeutic approaches and prognostic factors for this disease.

关键词： Spinal cord cancer Glioblastoma multiforme Children Multidisciplinary treatment Prognosis