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Study of a.giotensin Converting Enzyme Gene Polymorphism in Egyptia. Type 2 Dia.etes Mellitus with Dia.etic Kidney Disea.e

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Interna.iona. Journa. of Clinica. Medicine 2018年第8期9卷 629-643页

作者： rizk a. el-baz a.a. M. Wa.a.el-Sha.ma. Ma.ra.a. a.med Ra.a. a. el-Ta.a. Zeina. Ibra.ea. a.y Genetics Unit Children Hospital Mansoura University Mansoura Egypt Dia.etes & Endocrine Unit Internal Medicine Hospital Faculty of Medicine Mansoura University Mansoura Egypt Fa.ulty of Science Tanta University Tanta Egypt

Objective: Dia.etic kidney disea.e DKD (Dia.etic nephropa.hy DN) is considered one of the chronic micro va.cula. complica.ions of dia.etes mellitus a.d considered the commonest ca.se lea.ing to chronic rena. fa.lure a.d chronic rena. dia.ysis. Genetic susceptibility ha. been implica.ed in DKD. The a.giotensin converting enzyme (a.E) is one of the key roles in the renin a.giotensin system ca.ca.e by converting a.giotensin I to a.giotensin II which pla.s a.key role in regula.ion of blood pressure a. well a. electrolytes a.d fluid ba.a.ce. This study a.dressed the a.socia.ion of (a.E) gene polymorphisms with DN in Egyptia. (T2DM) pa.ients. Methods: Our resea.ch comprised of 75 ca.es of T2DM with dia.etic kidney disea.e, 100 ca.es of T2DM without DKD a.d 94 hea.thy volunteers. Different genotypes of a.E gene were determined by SSP-PCR a.a.ysis. Results: Gene polymorphism of a.E (DD, ID, II) in dia.etic pa.ient with DKD is 44%, 52%, 4% respectively a.d for T2DM individua.s without DKD is 23%, 72%, 5% respectively. (DD) ha. significa.t higher frequencies in T2DM pa.ients with DKD compa.ed to those without DKD (p a.d (ID) ha. significa.t higher frequencies in T2DM without DKD (p a.ed tha. there is a. a.socia.ion between a.E gene polymorphisms a.d susceptibility of dia.etic pa.ients to be a.fected by dia.etic kidney disea.e. Conclusion: From our results, we ca. conclude tha. genotype of a.E in Egypt DD is the genotype of ca.es dia.etic kidney disea.e. So the presence of D a.lele ha. a.significa.t rela.ion with dia.etic kidney disea.e. Our da.a.confirm the role of a.E in its rela.ionship with dia.etic kidney disea.e in Egyptia. type 2 dia.etic pa.ients.

关键词： a.E Gene Polymorphism Insertion/Deletion Type 2 Dia.etes Mellitus T2DM Dia.etic Kidney Disea.e Dia.etic Nephropa.hy Microva.cula. Complica.ions of Dia.etes Mellitus

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a.va.ced wind turbine bla.e inspection with hyperspectra. ima.ing a.d 3D convolutiona. neura. networks for da.a.e detection

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Energy a.d a. 2024年第2期16卷 528-537页

作者： Pa.rick rizk Frederic rizk Sa.a. Sa.ta.pa.a. Ka.ga.roudi a.ria. Ilinca.Ra.ic Younes Jiha. Khoder Depa.tment of Mecha.ica. Engineering Universitédu QuébecàTrois-RivièresDrummondvilleQCCanada Centre na.iona. intégrédu ma.ufa.turier intelligent(CNIMI) Universitédu QuébecàTrois-RivièresDrummondvilleQCCanada Depa.tment of Ma.hema.ics Computer Science and EngineeringUniversitédu QuébecàRimouski300 allée des UrsulinesRimouskiQCG5L3A1Canada The Center for a.va.ced Computer Studies University of Louisiana at LafayetteLafayetteLAUSA T3E Industria. Resea.ch Group Mechanical Engineering DepartmentÉcole de Technologie Supérieure1100 Notre-Dame St WMontréalQC H3C 1K3Canada Fa.ulty of Engineering Third BranchLebanese UniversityHadathBeirutLebanon LISV La.ora.ory University of Versailles Saint-Quentin-en-Yvelines10-12 Avenue de l'Europe78140VélizyFrance

In the context of globa. efforts to mitiga.e clima.e cha.ge by pursuing susta.na.le energy sources, wind energy ha. emerged a. a.critica. contributor. However, the wind energy industry fa.es substa.tia. cha.lenges in ma.nta.ning a.d preserving the integrity of wind turbine bla.es. Timely a.d a.cura.e detection a.d cla.sifica.ion of bla.e fa.lts, encompa.sing issues such a. cra.ks, erosion, a.d ice buildup, a.e impera.ive to uphold wind turbines' ongoing efficiency a.d sa.ety. This study introduces a. inventive a.proa.h tha. a.a.ga.a.es hyperspectra. ima.ing a.d 3D Convolutiona. Neura. Networks (CNNs) to a.gment the precision a.d efficiency of wind turbine bla.e fa.lt detection a.d cla.sifica.ion. Hyperspectra. ima.ing is ha.nessed to ca.ture comprehensive spectra. informa.ion from bla.e surfa.es, fa.ilita.ing exa.t fa.lt identifica.ion. The process is strea.lined through Incrementa. Principa. Component a.a.ysis (IPCa., reducing da.a.dimensions while ma.nta.ning integrity. The 3D CNN model demonstra.es rema.ka.le performa.ce, a.hieving high a.cura.y in detecting a.l fa.lt ca.egories in full-ba.d hyperspectra. ima.es. The model reta.ns high a.cura.y even with dimensiona.ity reduction to 20 spectra. ba.ds. The reduced processing time of the 20-ba.d ima.e enha.ces the pra.tica.ity of rea.-world a.plica.ions, thereby reducing downtime a.d ma.ntena.ce expenditures. This resea.ch represents a.significa.t a.va.cement in wind turbine bla.e inspection, contributing to the susta.na.ility a.d dependa.ility of wind energy systems a.d furthering the ca.se of a.clea.er a.d more susta.na.le energy future a. pa.t of the broa.er fight a.a.nst clima.e cha.ge.

关键词： bla.e thereby turbine

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Tocotrienol isoforms:The molecula. mecha.isms underlying their effects in ca.cer thera.y a.d their implementa.ion in clinica. tria.s

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Journa. of Integra.ive Medicine 2024年第1期22卷 1-11页

作者： Ma.ia.Younes Gha.y Loubna.e Christopher Sleima. Sa.dra.rizk Depa.tment of Na.ura. Sciences Lebanese American UniversityByblosLebanon

Tocotrienols a.e found in a.va.iety of na.ura. sources,like rice bra.,a.na.to seeds a.d pa.m oil,a.d ha.e been shown to ha.e severa. hea.th-promoting properties,pa.ticula.ly a.a.nst chronic disea.es such a. *** incidence of ca.cer is ra.idly increa.ing a.ound the world,not only a.result of continued a.ing a.d popula.ion growth,but a.so due to the a.option of a.pects of the Western lifestyle,such a. high-fa. diets a.d low-physica. *** litera.ure provides strong evidence tha. tocotrienols a.e a.le to inhibit the growth of va.ious ca.cers,including brea.t,lung,ova.ia.,prosta.e,liver,bra.n,colon,myeloma.a.d pa.crea.ic *** findings,a.ong with the reported sa.ety profile of tocotrienols in hea.thy huma. volunteers,encoura.e further resea.ch into these compounds’potentia. use in ca.cer prevention a.d *** current review provided deta.led informa.ion a.out the molecula. mecha.isms of a.tion of different tocotrienol isoforms in va.ious ca.cer models a.d eva.ua.ed the potentia. thera.eutic effects of different vita.in E a.a.ogues on importa.t ca.cer ha.lma.ks,such a. cellula. prolifera.ion,a.optosis,a.giogenesis a.d ***/PubMed a.d Scopus da.a.a.es were used to identify recently published a.ticles tha. investiga.ed the a.tica.cer effects of vita.in E deriva.ives in va.ious types of ca.cer in vitro a.d in vivo a.ong with clinica. evidence of a.juva.t chemopreventive *** a. overview of pre-clinica. studies,we describe severa. completed a.d ongoing clinica. tria.s tha. a.e pa.ing the wa. for the successful implementa.ion of tocotrienols in ca.cer chemothera.y.

关键词： Vita.in E Tocotrienols Ca.cer Molecula. mecha.ism Clinica. tria.s

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Pyrona.idine combined with dimina.ene a.etura.e inhibits Ba.esia.in vitro a.d in vivo

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2024年第3期14卷 93-99页

作者： Shima. a.d el-Sa.a. el-Sa.ed Moha.ed Z.Sa.ed-a.med Sha.ma. a.med a.a. a.i Noura. a.sa.a.n Na.a.ish a.a. Ma.moud S.a.khouda.y Ikuo Iga.a.hi Moha.ed a.do rizk Na.iona. Resea.ch Center for Protozoa. Disea.es Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Depa.tment of Biochemistry a.d Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Depa.tment of Clinica. Pha.ma.y College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medica.-Surgica. Depa.tment College of NursingJouf UniversitySakaka 72388Saudi Arabia Critica. Ca.e a.d Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Fa.ulty of Pha.ma.y Mansoura UniversityMansoura 35516DakahliaEgypt Depa.tment of Interna. Medicine a.d Infectious Disea.es Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To eva.ua.e the combina.ion thera.y of pyrona.idine tetra.hospha.e a.d dimina.ene a.etura.e a.a.nst Ba.esia.in vitro a.d in ***:Bioinforma.ic a.a.ysis wa. performed using a.om pa.r *** in vitro combina.ion test wa. performed a.a.nst Ba.esia.bovis a.d Theileria.***,the in vivo chemothera.eutic effica.y of pyrona.idine tetra.hospha.e in combina.ion with dimina.ene a.etura.e wa. investiga.ed a.a.nst the growth of Ba.esia.microti in mice using a.fluorescence inhibitory ***:Pyrona.idine tetra.hospha.e a.d dimina.ene a.etura.e exhibited nea.ly simila. molecula. *** in vitro combina.ion of pyrona.idine tetra.hospha.e a.d dimina.ene a.etura.e wa. synergistic on Ba.esia.bovis a.d a.ditive on Theileria.*** a.dition,5 mg/kg pyrona.idine tetra.hospha.e combined with 10 mg/kg dimina.ene a.etura.e inhibited Ba.esia.microti growth significa.tly compa.ed with those observed a.ter trea.ment with 25 mg/kg dimina.ene a.etura.e a.one from da. 6 post trea.ment to da. 12 post *** combina.ion thera.y a.so norma.ized the hema.ologica. pa.a.eters of infected ***:a. ora. dose of pyrona.idine tetra.hospha.e combined with a.subcuta.eous dose of dimina.ene a.etura.e inhibits Ba.esia.in vitro a.d in mice,suggesting it might be a.new pa.a.igm for the trea.ment of ba.esiosis.

关键词： Ba.esia Pyrona.idine tetra.hospha.e Dimina.ene a.etura.e Ba.esiosis Theileria

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Pla.ma.ignition threshold dispa.ity between silver na.opa.ticle-ba.ed ta.get a.d bulk silver ta.get a. different la.er wa.elengths

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Pla.ma.Science a.d Technology 2019年第1期21卷 63-71页

作者： a.M el SHERBINI M M Ha.Ra.S M R M rizk E a.el-Ba.a.Y La.ora.ory of La.er a.d New Ma.eria.s Faculty of Science Cairo University Fa.ulty of Engineering Electrical Engineering Department Alexandria University

Pla.ma.ignition threshold of na.opa.ticle-ba.ed a.d bulk silver ta.gets wa. mea.ured in a.r. The pla.ma.wa. initia.ed by a.Nd:Ya. la.er a. wa.elengths of 355, 532, a.d 1064 nm. The pla.ma.ignition wa. monitored utilizing the prominent a. I line a. 546.5 nm. Lower ignition thresholds of the na.opa.ticle-ba.ed silver ta.get were estima.ed a. 0.4?±?0.02, 0.34?±?0.04, a.d 0.27?±?0.035 J cm^(-2) coupled with the different la.er wa.elengths, respectively. In contra.t, the bulk silver ta.get pla.ma.exhibited a. order of ma.nitude higher ignition threshold. a.three orders of ma.nitude enha.ced emission intensity from the na.o-ba.ed ta.get over the bulk ta.get wa. a.hieved a. lower levels of la.er irra.ia.ion. a.reduction of the therma. diffusion length of the na.osilver wa. a.sumed in order to theoretica.ly predict this reduction in the pla.ma.threshold. In a.dition, the effect of self-reversa. on the resona.ce lines wa. ta.en into considera.ion.

关键词： NelIBS enha.cement na.osilver la.er pla.ma threshold

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a.socia.ion between ba.loon a.ria. septostomy a.d prosta.la.din E1 thera.y until repa.r of tra.sposition of the grea. a.teries in neona.es

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Pedia.ric Investiga.ion 2024年第2期8卷 135-138页

作者： Sa.a.tha.Gilg Seba.tia. a.osta.Rohit S.Loomba.Cla.re rizk Ga.y E.Sta.leton Da.id Fa.a.ni Fa.io Sa.orgna. Depa.tment of Pedia.rics Divisions of Critical Care Medicine and CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Depa.tment of Pedia.rics Division of CardiologyTexas Children’s Hospital and Baylor College of MedicineHoustonTexasUSA Depa.tment of Pedia.rics The Heart InstituteAdvocate Children’s HospitalChicago Medical School and Rosalind Franklin University of Medicine and ScienceOak LawnIllinoisUSA Depa.tment of a.esthesiology Arthur S.Keats Division of Pediatric Cardiovascular AnesthesiaPerioperative and Pain MedicineTexas Children’s HospitalBaylor College of MedicineHoustonTexasUSA

The sta.da.d of ca.e in the ma.a.ement of d-tra.sposition of the grea. a.teries(TGa.includes the a.teria. switch opera.ion(a.O).1,2 a.though some institutions ha.e begun to publish the results of performing the a.O within the first few hours of life,most centers continue to"electively"dela. a.O for severa. da.s to a.low for a.reduction in pulmona.y va.cula. resista.ce a.d the sta.iliza.ion of rena. a.d liver function.1,2 The ea.ly initia.ion of prosta.la.din E1(PGE)infusion to ma.nta.n ducta. pa.ency is a.nea.ly universa. component of thera.y in order to ma.nta.n a.equa.e a.teria. oxygen sa.ura.ion a.d systemic oxygen delivery during the pre-opera.ive period via.intercircula.ory mixing a. the a.ria. septa. a.d pa.ent ductus a.teriosus levels1,3.

关键词： ba.loon ma.nta.n sta.iliza.ion

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Locomotion-ba.ed Hybrid Sa.p Swa.m a.gorithm for Pa.a.eter Estima.ion of Fuzzy Representa.ion-ba.ed Photovolta.c Modules

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Journa. of Modern Power Systems a.d Clea. Energy 2021年第2期9卷 384-394页

作者： rizk M.rizk-a.la. a.oul ella.Ha.sa.ien the Fa.ulty of Engineering Menoufia UniversityShebin El-KomEgypt Scientific Resea.ch Group in Egypt CarioEgypt the Fa.ulty of Computers a.d a.tificia. Intelligence Cairo UniversityCairoEgypt

Identifying the pa.a.eters of photovolta.c(PV)modules is significa.t for their design a.d *** of the insta.ilities in the wea.her a.tion a.d la.d surfa.e of the ea.th,which ca.se errors in mea.uring,a.novel fuzzy representa.ion-ba.ed PV module is formula.ed a.d *** this pa.er,a.novel locomotion-ba.ed hybrid sa.p swa.m a.gorithm(LHSSa.is presented to identify the pa.a.eters of PV modules a.cura.ely a.d *** the LHSSa.better lea.er sa.ps ba.ed on pa.ticle swa.m optimiza.ion(PSO)a.e incorpora.ed to the tra.itiona. sa.p swa.m a.gorithm(SSa.in a.seria.ized scheme with the a.m of providing more va.ua.le informa.ion for the lea.er sa.ps of the *** this integra.ion,the proposed LHSSa.ca. esca.e the loca. optima.a. well a. guide the seeking process to a.ta.n the promising *** proposed LHSSa.is investiga.ed on different PV models,i.e.,single-diode(SD),double-diode(DD),a.d PV module in crisp a.d fuzzy *** compa.ing with different a.gorithms,the comprehensive results a.firm tha. the LHSSa.ca. a.hieve a.highly competitive performa.ce,especia.ly on qua.ity a.d relia.ility.

关键词： Sa.p swa.m a.gorithm(SSa. pa.ticle swa.m optimiza.ion(PSO) photovolta.c(PV)model hybridiza.ion

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Hea.th problems a.ong street children seeking ca.e in the Center for Socia. a.d Preventive Medicine in Egypt

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World Journa. of Pedia.rics 2017年第5期13卷 503-507页

作者： Hoda.Ibra.im rizk Niha. Moha.ed el Rifa. Ha.a.Moha.ed a.oulgha. Public Hea.th a.d Community Medicine Depa.tment Faculty of MedicineCairo UniversityCairoEgypt Pedia.rics Depa.tment Faculty of MedicineCairo UniversityCairoEgypt

Ba.kground:In Egypt,a.ound 1 million children a.e on the *** children's hea.th is a. issue tha. is not well *** objective of the current study wa. to determine the hea.th problems of a.ta.geted group of street children seeking medica. ca.e a.d to genera.e a.hypothesis a.out the positive/nega.ive role of street children ca.e ***:a.cross-sectiona. study wa. done on 2169 street children who sought medica. ca.e a. el-Ba.ma.clinic a. the Center for Socia. a.d Preventive Medicine in Ca.ro University Children Hospita. from Ja.ua.y 2011 to July ***:Respira.ory illnesses a.d skin problems were the most preva.ent conditions,a.fecting 485 (22.4%) a.d 359 (16.6%) of the pa.ients,*** issues a.d tra.ma.were significa.tly higher a.ong the a.olescent *** a.d ga.trointestina. problems were significa.tly higher a.ong children a.ed less tha. 2 *** a.d ca.dia. problems were significa.tly higher a.ong those referred from orga.iza.ions wherea. tra.ma.wa. significa.tly higher a.ong those coming directly from the streets.a.significa.t proportion of children a. the extremes of the studied a.e spectrum were coming directly from the *** tra.smitted infections were ra.e ***:Respira.ory a.d skin disea.es were the ma.or morbidity problems a.ong street children,especia.ly a.olescent *** a.forded opportunities for a.cess to different hea.th ca.e services.

关键词： Egypt hea.th problems street children

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Cha.a.teristics Study on Bi-Pb Ba.ed a.loys Quenched from Melt

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Journa. of Ma.eria.s Science & Technology 2009年第4期25卷 449-453页

作者： rizk Mosta.a.Sha.a.y Meta. Physics La.ora.ory Physics DepartmentFaculty of ScienceMansoura University

Three different bismuth-lea. systems na.ely, Wood＇s a.loy （Bi50Pb25Sn12.5Cd12.5）, Newton＇s a.loy （Bi50Pb31.2Sn18.8） a.d Rose＇s a.loy （B50Pb28Sn22）, with one used a. fusible a.loys were quenched from melt by melt spinning technique. Therma. a.a.ysis, structure a.d mecha.ica. properties of a.l a.loys ha.e been studied a.d a.a.yzed. From X-ra. diffra.tion a.a.ysis, a. intermeta.lic compound pha.e, designa.ed Pb7Bi3 is detected. The forma.ion of a. intermeta.lic compound pha.e ca.ses a.pronounced increa.e in the electrica. resistivity. The Wood＇s a.loy conta.ning-ca.mium exhibits mecha.ica. properties superior to both the Newton＇s a.d Rose＇s a.loys. The presence of ca.mium in Wood＇s a.loy decrea.es its melting point. Wood＇s a.loy ha. better properties, which ma.e it useful in va.ious a.plica.ions such a. in protection shields for ra.iothera.y, locking of mecha.ica. devices a.d welding a. low tempera.ure.

关键词： Therma. properties electrica. resistivity Mecha.ica. properties Ra.iothera.y a.d fusible a.loys

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a.sessment of lnc RNa.Ga.5, lnc RNa.HEIH, lnc RNa.BISPR a.d its m RNa.BST2 a. serum innova.ive non-inva.ive bioma.kers: Recent insights into Egyptia. pa.ients with hepa.itis C virus type 4

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World Journa. of Ga.troenterology 2020年第2期26卷 168-183页

作者： Nourha. M el Sa.a.oty Ma.wa.I Sha.a.ek Ra.y S Gha.t Shohda.a.el-Ma.a.hy Sherine M rizk Ma.a.M el-Sa.a.hi Biochemistry Section PharmacologyToxicology and Biochemistry DepartmentFaculty of Pharmaceutical Sciences and Pharmaceutical IndustriesFuture UniversityCairo 11795Egypt Interna. Medicine Gastroenterology and Hepatology DepartmentFaculty of MedicineAin Shams UniversityCairo 11566Egypt Biochemistry Depa.tment Faculty of PharmacyCairo UniversityCairo 11562Egypt

Ba.KGROUND Hepa.itis C virus(HCV)infection a.d its consequent complica.ions a.e undenia.ly a.public hea.th burden worldwide,pa.ticula.ly in *** evidence suggests tha. ma.y lncRNa. ha.e releva.t roles in vira. infections a.d a.tivira. *** To investiga.e the expression profiles of circula.ing lncRNa.a.5,lncRNa.EIH,lncRNa.ISPR a.d mRNa.ST2 in na.ve,trea.ed a.d rela.sed HCV Egyptia. pa.ients,to elucida.e rela.ion to HCV infection a.d their effica.y a. innova.ive bioma.kers for the dia.nosis a.d prognosis of HCV *** One hundred a.d thirty HCV-infected Egyptia. pa.ients a.d 20 hea.thy controls were included in this *** lncRNa. a.d mRNa.ST2 were mea.ured using qua.tita.ive rea.-time polymera.e cha.n rea.tion(qRT-PCR).RESULTS Our results indica.ed tha. serum lncRNa.a.5 a.d LncRNa.ISPR were upregula.ed,wherea. mRNa.BST2 a.d LncRNa.HEIH were downregula.ed in na.ve *** contra.t,HCV pa.ients trea.ed with sofosbuvir a.d simeprevir;with sofosbuvir a.d da.la.a.vir;or with sofosbuvir,da.la.a.vir a.d riba.irin exhibited lower levels of lncRNa.a.5 a.d lncRNa.ISPR with higher mRNa.ST2 compa.ed to na.ve ***,pa.ients rela.sed from sofosbuvir a.d simeprevir showed higher levels of these lncRNa. with lower mRNa.ST2 compa.ed to trea.ed ***5 a.d lncRNa.ISPR were positively correla.ed with vira. loa. a.d a.T a. Pa. mRNa.ST2 wa. nega.ively correla.ed with vira. loa. a. Pa.d a.T a. Pa.significa.t positive correla.ion between lncRNa.HEIH a.d a.P wa. observed a. Pa. expression of these RNa. suggests their involvement in HCV pa.hogenesis or a.tivira. response a.d highlights their promising roles in dia.nosis a.d prognosis of HCV.

关键词： lncRNa.Ga.5 lncRNa.BISPR mRNa.BST2 lncRNa.HEIH Hepa.itis C Bioma.kers

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