检索结果-南通市图书馆

Effects of bixin in high-fat diet-fed-induced fatty liver in C57BL/6J mice

Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1015-1021页

作者： Rosa Martha Perez Gutierrez rita valadez romero Research Laboratory of Natural Products School of Chemical Engineering and Extractive IndustriesNational Polytechnic InstituteAv.Instituto Politecnico Nacional S/NUnidad Profesional Adolfo Lopez Mateos

Objective:To evaluate the anti-obesity activity of bixin(BIX) on C57BL/6J mice which were fed a high-fat diet(HFD) and to determine the mechanism of this ***:C57BL/6J mice were separately fed a high-calorie diet or a normal diet for 8weeks,then they were treated with BIX for another 13 *** administration for 13 weeks,the animals were *** adiposity,serum lipid level,and insulin resistance were *** addition,a histological assay of pancreas and liver,an evaluation of the inhibitory properties on pancreatic lipase,and a-amylase were ***:Administration of BIX significantly decreased the body weight gain,adipocyte size,fat pad weights,hepatic lipid levels in HFD-induced obese *** addition,reduced liver weight exhibited decreased serum leptin levels,malic enzyme,glucose-6-phosphate dehydrogenase,hepatic fatty acid synthase,aspartate aminotransferase,alanine aminotransferase and hepatic phosphatidate phosphohydrolase ***,superoxide dismutase,catalase,glutathione peroxidase,and glutathione levels were increased in hepatic *** also decreased lipid and carbohydrates absorption due to inhibition of pancreatic lipase and *** term supplementation of BIX significantly decreased hyperlipidemia,insulin resistance and glucose *** levels of hepatic steatosis and the islets of Langerhans appeared less shrunken in HFD-fed ***:The antiobesity effect of BIX appears to be associated at least in part,to its inhibitory effect on lipids and carbohydrate digestion enzymes such as pancreatic lipase,a-glucosidase,and *** results suggested that BIX also act as an antioxidant and may treat visceral obesity normalizing glucose levels,improving insulin resistance and increasing energy ***,achiote which has a main component,the carotenoid BIX,could be a viable food for the treatment of obesity and diabetes.

关键词： Bixa orellana Bixin Obesity Enzymes Metabolic disturbances Diabetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：