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Efficacy assessment of peracetic acid in the removal of synthetic 17α-ethinyl estradiol contraceptive hormone in wastewater

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Journal of Environmental Sciences 2020年第3期32卷 1-8页

作者： rita maurício Flávia Semedo rita Dias Joao P.Noronha Leonor Amaral Michiel A.Daam Antonio P.Mano Mário S.Diniz CENSE Center for Environmental and Sustainability ResearchNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Department of Environmental Sciences and Engineering NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal REQUIMTE/FCT NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Biotox Lab UCIBIODepartment of ChemistryNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal

Increasing concerns have been raised on endocrine disrupting chemicals like the sex hormone 17 a-ethinylestradiol(EE2),the more since traditional wastewater(WW) treatments appear to be ineffective for their *** efficacy of the relatively novel disinfectant peracetic acid(PAA) in EE2 removal was evaluated,as well as its potential effects on WW quality *** treatments tested for EE2 removal were also evaluated in terms of toxicity,through the determination of biochemical responses(antioxidant enzymes,lipid peroxidation and vitellogenin induction) using zebrafish(Danio rerio) as a biological *** contact times less than 20 min appeared insufficient regardless of the PAA dose tested,but a 100% EE2 removal was attained at a PAA concentration of 15 mg/L with a contact time of20 *** suspended solids,chemical oxygen demand and pH in PAA treatments remained well within levels set in European legislation for WW ***2 induced signific ant increased vitellogenin(VTG) levels in both female and male fish,indic ating increased estrogenic activity,especially in males suggesting an endocrine disruption *** the addition of PAA(15 mg/L),however,VTG levels in both sexes returned to control *** this PAA treatment showed increased levels of the antioxidant enzyme catalase,the lipid peroxidation levels were similar or even lower than in *** the results suggest that the use of PAA appears a promising way forward as a less toxic alternative to chlorine disinfection with high efficiency in the removal of EDC like EE2.

关键词： EE2 Wastewater treatment Zebrafish Biomarkers

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Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach

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Journal of Environmental Sciences 2010年第10期22卷 1613-1622页

作者： Mário S.Diniz rita maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana Universidade Nova de Lisboa Faculdade de Ciencias e TecnologiaREQUIMTEDep.de Quimica Universidade Nova de Lisboa Faculdade de Ciencias e TecnologiaDep.de Ciencias e Engenharia do Ambiente Department of Environmental Chemistry-IIQAB-CSIC c/Jordi Girona

The estrogenic potency of a wastewater treatment plant （WWTP） was evaluated using chemical and biological analyses, which showed that after the station treatment processes some of the selected endocrine disruptor compounds （EDCs） were still present in the treated effluent （e.g., bisphenol A, alkylphenols, estrone）. Thus, the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effluent assessed by integrating the results. Male goldfish （Carassius auratus） were used as biological indicators in a 28-day experiment. Vitellogenin （Vtg）, gonadosomatic and hepatosomatic indices, steroids （17β-estradiol and 11-ketotestosterone） and histopathology were biomarkers used in fish to evaluate WWTP treated effluent estrogenicity, in combination with instrumental analyses. The results showed a significant increase （P 〈 0.01） in plasma and liver Vtg, which were significantly correlated （r = 0.66; P 〈 0.01）. The gonadosmatic index was significantly （P 〈 0.01） reduced in exposed fish. The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations. The histological examinations show changes in exposed fish gonads, such as regressed testes and in some cases （43% to 75%） the development of ovo-testis in fish exposed to 50% and 100% treated effluent.

关键词： Carassius auratus endocrine disruptors vitellogenin steroids intersex

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Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第9期20卷 2594-2595页

作者： Carmela rita Balistreri Roberto Monastero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhages,white matter lesions,atherosclerosis,and arteriolosclerosis have also been significantly described in the preclinical stages of cognitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardiovascular

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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： rita O.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

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From the Challenges Imposed by Climate Change to the Preservation of Ecosystem Processes and Services

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Natural Resources 2017年第12期8卷 788-807页

作者： rita Anastácio Mário Jorge Pereira Departamento de Biologia e CESAM Universidade de Aveiro Aveiro Portugal

Today, especially in countries that offer a satisfactory quality of life, it is easy to forget that we depend directly and indirectly on services provided by ecosystems such as quantity and quality of water, energy, food, health, and shelter. In less developed countries, the daily struggle for essential goods makes this dependency more real, despite the lack of knowledge, organization and/or financial resources to deal with the problems imposed on ecosystems by climate and anthropogenic changes. Protecting ecosystems by ensuring the services they provide has become highly dependent on our management capacity, our understanding of its functioning, and our capacity for persuasion. Demographic pressure and individualism compromise the survival of various species, including our own, and create pressures under governments and the stability of nations. The notion of facing a global challenge has awakened in the scientific community the need to focus on developing global strategies that change the mind-sets of decision makers, industry, governments and markets. Global knowledge networks and experts are being built to mitigate problems on a global scale. In this mini review, the authors make a brief visit to documents, intergovernmental initiatives, and platforms that have been built with the aim of contributing to promote a resolution for the global problems.

关键词： Roads to Dignity Essential Biodiversity Variables Kyoto Protocol IPCC Ecosystem Services Profile SDG’s

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A Piece of a Puzzle of Haplotypes for the Indian Ocean Hawksbill Turtle

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Natural Resources 2017年第8期8卷 548-558页

作者： rita Anastácio Mário Jorge Pereira Departamento de Biologia e CESAM Universidade de Aveiro Aveiro Portugal

The Indian Ocean basin has much to reveal in what concerns marine turtles. Its regional management units (RMUs) are still lacking molecular data to define conservation strategies and priorities. Vamizi Island is one of the best known rookeries in the north of the Mozambique Channel. A mitochondrial DNA analysis revealed 14 haplotypes for the hawksbill turtle’s nesting and foraging in/near Vamizi, twelve of which were new in 2011. Though more studies inside the Channel are needed, Vamizi Island possibly contributes with hatchlings for other locations. More knowledge is important to define priorities for management units inside the Indian Ocean.

关键词： Eretmochelys imbricata mtDNA Haplotype Regional Management Unit Mozambique Channel

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Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

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World Journal of Stem Cells 2015年第6期7卷 956-975页

作者： Jorge Ribeiro Tiago Pereira Ana rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette maurício Departmento de Clínicas Veterinárias and+UPVet Instituto de Ciencias Biomedicas de Abel Salazar(ICBAS)and Centro de Estudos de Ciencia Animal(CECA)Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua de Jorge Viterbo Ferreira4050-313 PortoPortugal Centro Interdisciplinar de Estudo de Performance Humana(CIPER) Faculdade de Motricidade Humana(FMH)Universidade de Lisboa(UL)Estrada da Costa1499-002 Cruz QuebradaDafundoPortugal CECAV and Departamento de Ciencias Veterinárias Universidade de Trás-os-Montes e Alto Douro(UTAD)5001-801 Vila RealPortugal Departmento de Patologia e de Imunologia Molecular Instituto de Ciencias Biomedicas de Abel SalazarRua de Jorge Viterbo Ferreira4050-313 PortoPortugal Instituto Português de Patologia e Imunologia Molecular da Universidade do Porto(IPATIMUP) Rua Dr.Roberto Frias s/n4200-465 PortoPortugal UIS-IPL:Unidade de Investigacao em Saúde da Escola Superior de Saúde de Leiria Instituto Politécnico de Leiria2411-901 LeiriaPortugal CEMUC Departamento de Engenharia Metalúrgica e MateriaisFaculdade de Engenharia da Universidade do Porto(FEUP)Rua Dr.Roberto Frias4200-465 PortoPortugal Biosckin Molecular and Cell Therapies S.A.Tec MaiaRua Engenheiro Frederico Ulrich 26504470-605 MaiaPortugal Neuroscience Institute of the Cavalieri Ottolenghi Foundation and Department of Clinical and Biological Sciences University of Turin

AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after ***: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the "minimal Feret's diameter" respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible th

关键词： Nerve regeneration Neurotmesis Tubeguides Mesenchymal stem cells Carbon nanotubes Functional assessment Gait biomechanical analysis Histomorfometry Polyvinyl alcohol

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Deuterated dextromethorphan/quinidine for agitation in Alzheimer's disease

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Neural Regeneration Research 2022年第5期17卷 1013-1014页

作者： rita Khoury Department of Psychiatry and Clinical Psychology Saint George Hospital University Medical Center-BeirutLebanon.Adjunct FacultyDepartment of Psychiatry and Behavioral NeuroscienceSaint Louis University School of MedicineSt.LouisMIUSA

Alzheimer's disease(AD)is the most common type of neurode generative disorder;it affects around 47 million individuals worldwide(Prince et al.,2013).AD rose from the 12 th most burdensome disease in the United States ... 详细信息

关键词： Alzheimer agitation

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Insular mammalian fauna dynamics and paleogeography:A lesson from the Western Mediterranean islands

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Integrative Zoology 2018年第1期13卷 2-20页

作者： Maria rita PALOMBO Department of Earth Science Sapienza University of RomeRomaItaly CNR-IGAG Monterotondo(Roma)Italy

Since the time of Darwin(1859)and Wallace(1869),islands have been regarded by scientists as a prime target for scrutinizing the forces that may influence evolution and diversification and important elements in biogeographic *** research aims to scrutinize whether and to what extent the composition and structure of past mammal insular faunas and their changes through time may provide sound clues for inferring the paleogeographical evolution of a *** a case study,I critically analyzed the dynamics shown by the Plio-Pleistocene mammalian fauna of 3 Western Mediterranean insular districts,the Balearic Islands,Sardinia and Sicily,each characterized by its own peculiar paleobiogeographical evolutionary *** revision of faunas and the critical analysis of the dispersal ability of the ancestors of island settlers have allowed hypothesizing on the time and mode of island *** results obtained confirm that the early isolation of the Balearic Islands from the mainland led to the establishment of an endemic fauna since the pre-Messinian Miocene(?Astaracian European Land Mammal Age,MN7/8),and that Sardinia has definitely been isolated since the Pliocene,although dispersal events led to some faunal turnovers during the *** addition,the results suggest for Sicily a complex,still imperfectly disentangled history of alternate phases of complete separation and sporadic,more or less difficult connections with southern Italy.

关键词： dispersal islands mammal Plio–Pleistocene Western Mediterranean

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New few parameters differential evolution algorithm with application to structural identification

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第1期6卷 1-14页

作者： rita Greco Ivo Vanzi Department of Civil Engineering Environmental Territory Building and Chemical Polytechnic University of Bari Department of Engineering and Geology University of Chieti-Pescara "G.d'Annunzio"

Differential evolution algorithm(DEA) is a stochastic, population-based global optimization method. In this paper, we propose new schemes for both mutation and crossover operators in order to enhance the performances of the standard DEA. The advantage of these proposed operators is that they are "parameters-less", without a tuning phase of algorithm parameters that is often a disadvantage of DEA. Once the modified differential evolutions are presented, a large comparative analysis is performed with the aim to assess both correctness and efficiency of the proposed operators. Advantages of proposed DEA are used in an important task of modern structural engineering that is mechanical identification under external dynamic loads. This is because of the importance of using a "parametersless" algorithm in identification problems whose characteristics typically vary strongly case by case, needing of a continuous set up of the algorithm proposed. This important advantage of proposed optimizers, in front of other identification algorithms, is used to develop a computer code suitable for the automatic identification of a simple supported beam subject to an impact load, that has been tested both using numerical simulations and real standard tests dynamic. The results point out that this algorithm is an interesting candidate for standard applications in structural identification problems.

关键词： Differential evolution Parametric identification Structural identification Optimization

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