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Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

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Materials Futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius Alec P LaGrow Haiyan Jin Zhipeng Yu Ana Araujo rita marques.adélio mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon Science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain Scientific Imaging Section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan Songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange membrane(PEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

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SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

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Neural Regeneration Research 2022年第2期17卷 266-270页

作者： rita F.marques Kent E.Duncan Institute for Biochemistry and Molecular Biology Department of ChemistryUniversity of HamburgHamburgGermany Neuronal Translational Control Research Group Center for Molecular Neurobiology Hamburg(ZMNH)University Medical Center Hamburg-EppendorfHamburgGermany

Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death. Despite major advances in identifying genes that can cause disease when mutated and model the disease in animals and cellular models, it still remains unclear why motor symptoms suddenly appear after a long pre-symptomatic phase of apparently normal function. One hypothesis is that age-related deregulation of specific proteins within key cell types, especially motor neurons themselves, initiates disease symptom appearance and may also drive progressive degeneration. Genome-wide in vivo cell-type-specific screening tools are enabling identification of candidates for such proteins. In this minireview, we first briefly discuss the methodology used in a recent study that applied a motor neuron-specific RNASeq screening approach to a standard model of TAR DNA-binding protein-43(TDP-43)-driven amyotrophic lateral sclerosis. A key finding of this study is that synaptogyrin-4 and pleckstrin homology domain-containing family B member 1 are also deregulated at the protein level within motor neurons of two unrelated mouse models of mutant TDP-43 driven amyotrophic lateral sclerosis. Guided by what is known about molecular and cellular functions of these proteins and their orthologs, we outline here specific hypotheses for how changes in their levels might potentially alter cellular physiology of motor neurons and detrimentally affect motor neuron function. Where possible, we also discuss how this information could potentially be used in a translational context to develop new therapeutic strategies for this currently incurable, devastating disease.

关键词： amyotrophic lateral sclerosis glucagon-like peptide-1 receptor motor neuron disease mouse model neurodegeneration phosphatidylserine pleckstrin homology domain synaptogyrin TAR DNA-binding protein-43 vesicle transport

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On the canonical map of surfaces with q≥6

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Science China Mathematics 2011年第8期54卷 1725-1739页

作者： mendes LOPES Margarida PARDINI rita PIROLA Gian Pietro Departamento de Matem'atica Instituto Superior TcnicoUniversidade Tcnica de LisboaAv.Rovisco PaisLisboa 1049-001Portugal Dipartimento di Matematica Università di PisaLargo B.Pontecorvo 5Pisa 56127Italy Dipartimento di Matematica Università di PaviaVia Ferrata 1Pavia 27100Italy

We carry out an analysis of the canonical system of a minimal complex surface S of general type with irregularity q > *** this analysis,we are able to sharpen in the case q > 0 the well-known Castelnuovo inequality KS2≥3pg(S) + q(S)-*** we turn to the study of surfaces with pg=2q-3 and no fibration onto a curve of genus > *** prove that for q≥6 the canonical map is *** this result with the analysis of the canonical system,we also prove the inequality:KS2≥7χ(S) + *** improves an earlier result of mendes Lopes and Pardini (2010).

关键词：地图表面复杂曲面曲线曲面普通型纤维化不等式系统

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Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza mendes dos Santos Gabriel Lima Correa Santos Hanna Santos marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

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葡萄牙阿威罗大学孔子学院小学汉语教学现况调查分析

葡萄牙阿威罗大学孔子学院小学汉语教学现况调查分析

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作者： rita ISABEL marques PEREIRA（丽达）大连外国语大学

学位级别：硕士

本文主要分析当前阿威罗大学孔子学院管理体系下中文课程的特点、中文教学的开展情况和教学成果,概括总结孔子学院在海外汉语教学活动中所起到的作用。本项调查研究主要通过归纳目前在葡萄牙参与对外汉语教育的这一群体(学生、老师)的特... 详细信息

本文主要分析当前阿威罗大学孔子学院管理体系下中文课程的特点、中文教学的开展情况和教学成果,概括总结孔子学院在海外汉语教学活动中所起到的作用。本项调查研究主要通过归纳目前在葡萄牙参与对外汉语教育的这一群体(学生、老师)的特点,分析当前葡萄牙小学汉语教学的特殊性,对目前阿威罗大学孔子学院小学汉语教学项目提出建设性的教学建议并提供促进其教学管理工作发展的可行性数据信息。作者以葡萄牙阿威罗大学孔子学院小学汉语教学项目为调查对象,针对教学项目中的教学规模、学生人群、教师备课、课堂教学、教学效果、教辅人员反馈以及孔子学院的管理等方面,对项目进行全方位的调查研究。通过实地访谈、参与课程、调查问卷、文献研究以及数据分析等多种调研方法,以教师、学生及教学管理者为研究对象,对于课程的开展、运行及效果进行阶段性的考查。我们的调查主要是将语言与文化放在同样的高度审视,在语言教学的同时追溯其文化内涵。对外汉语教学中文化教学研究的问题从二十世纪八十年代开始逐渐得到了中国对外汉语教学界的重视。所以本文所阐述的大部分教学方法,均来自于实践教学课堂的数据和信息搜集,也是最接近目前葡萄牙小学汉语教学实际情况的信息。

关键词：葡萄牙孔子学院小学汉语教学

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<i>In Situ</i>Hydroxyapatite Synthesis: Influence of Collagen on Its Structural and Morphological Characteristic

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Materials Sciences and Applications 2012年第8期3卷 580-586页

作者： Luis C. mendes Geysy L. Ribeiro Raphaella C. marques Instituto de Macromoléculas Professora Eloísa Mano (IMA) Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil

Hydroxyapatite (HA) was synthesized in situ by the precipitation method, with and without the presence of collagen (COLL), to study its influence on HA’s structural and morphological characteristics. The material was characterized by energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), wide-angle X-ray diffraction (WAXD), thermogravimetric analysis (TG) and scanning electron microscopy (SEM). The Ca/P molar ratio was influenced by collagen addition—1.89 and 2.38 for samples without and with collagen, respectively. The WAXD pattern revealed better resolution and intensity besides higher crystallinity degree of the HA in the presence of collagen. The photomicrographs showed a strong influence of collagen on the HA morphology.

关键词： Hydroxyapatite Collagen In Situ Precipitation Method Morphology

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Amprolium exposure alters mice behavior and metabolism in vivo

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Animal Models and Experimental Medicine 2018年第4期1卷 272-281页

作者： Juliana Oliveira Moraes Samara Dias Cardoso Rodrigues Leidiano Martins Pereira rita de Cássia Noronha Medeiros Clarissa Amorim Silva de Cordova Fabiano mendes de Cordova Programa de Pós-Gradua??o em Sanidade Animal e Saúde Pública nos Trópicos Universidade Federal do Tocantins Curso de Medicina Veterinária Universidade Federal do Tocantins Curso de Medicina Universidade Federal do Tocantins

Background: Thiamine deficiency(TD) models have been developed, mainly using the thiamine analog pyrithiamine. Other analogs have not been used in rodents. We aimed to evaluate the effects and mechanisms of intraperitoneal(ip) amprolium-induced TD in mice. We also evaluated the associated pathogenesis using antioxidant and anti-inflammatory compounds(Trolox, dimethyl sulfoxide).Methods: Male mice were separated into two groups, one receiving a standard diet(control animals), and the other a TD diet(deficient groups) for 20 days. Control mice were further subdivided into three groups receiving daily ip injections of saline(NaCl0.9%; Cont group), Tolox(Tr group) or dimethyl sulfoxide(DMSO; Dmso group). The three TD groups received amprolium(Amp group), amprolium and Trolox(Amp+Tr group), or amprolium and DMSO(Amp+Dmso group). The animals were subjected to behavioral tests and then euthanized. The brain and viscera were ***: Amprolium exposure induced weight loss with hyporexia, reduced the behavioral parameters(locomotion, exploratory activity, and motor coordination), and induced changes in the brain(lower cortical cell viability) and liver(steatosis). Trolox co-treatment partially improved these conditions, but to a lesser extent than ***: Amprolium-induced TD may be an interesting model, allowing the deficiency to develop more slowly and to a lesser extent. Amprolium exposure also seems to involve oxidative stress and inflammation, suggested as the main mechanisms of cell dysfunction in TD.

关键词： brain dimethyl sulfoxide thiamine deficiency Trolox

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Only Spondylodiscitis? A Clinical Case of Multiple Septic Embolization

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Case Reports in Clinical Medicine 2016年第10期5卷 353-357页

作者： rita Aguiar Manuel Ferreira Gomes Elisabete Bento Guerreiro Tiago marques Carla Santos Department of Immunoallergology Hospital de Santa Maria Centro Hospitalar Lisboa Norte Lisbon Portugal Department of Internal Medicine Hospital de Santa Maria Centro Hospitalar Lisboa Norte Lisbon Portugal Department of Infectious Diseases Hospital de Santa Maria Centro Hospitalar Lisboa Norte Lisbon Portugal

Background: Spondylodiscitis and spinal epidural abscesses are rare pathologic entities, but increasing in incidence. Group G beta hemolytic Streptococcus has been recently described associated with human infections. They often present clinically in a non-specific fashion, a fact which can lead to diagnostic delay, with serious consequences for the patient. Case Report: An 80-year-old man was admitted to the hospital with complaints of fever for three days, dysuria, hematuria, and back pain. Both septic embolizations and spondylodiscitis due to Group G beta hemolytic Streptococcus were detected. The patient was successfully treated with intravenous penicillin G for eight weeks, followed by oral amoxicillin for five months. Discussion: In all patients with spondylodiscitis, infective endocarditis should be considered, particularly in patients with heart valve disease history, since spondylodiscitis may be the presenting sign of an infective endocarditis. A high level of suspicion is therefore necessary in order correctly diagnose such entities as quickly as possible. The present case illustrates the pathogenic potential of group G streptococci in spondylodiscitis and native valve endocarditis.

关键词： Spondylodiscitis Group G Beta Hemolytic Streptococcus Epidural Abscess Embolization

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The Development of a Loop-Mediated Isothermal Amplification (LAMP) Procedure for Plague Diagnostic

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American Journal of Analytical Chemistry 2014年第16期5卷 1069-1077页

作者： Mariana de Lira Nunes Carina Lucena mendes-marques Alzira Maria Paiva de Almeida Nilma Cintra Leal Departamento de Microbiologia Centro de Pesquisas Aggeu Magalh&atilde es FIOCRUZ-PE Recife Brazil

Plague caused by Yersinia pestis is one of the infectious diseases subject to the International Health Regulations (IHR). Permanent monitoring of the focal plague areas is mandatory in order to enable prompt control measures to prevent the spread of the disease. Therefore, the availability of efficient diagnosis tests is of paramount importance. Here, we describe a loop-mediated isothermal amplification (LAMP)-based procedure for rapid Y. pestis detection. We constructed a set of LAMP primers, which were used in assays to establish the reaction conditions that would lead to the quick visualization of the results by evaluating the test tube with the naked eye. The primers were specifically designed to target the caf1 gene located on pFra/Tox (pMT), a prototypical plasmid of Y. pestis. The LAMP procedure was performed at 65°C for 45 min in a water bath and allowed for the detection of at least 10 pg of bacterial DNA. Due to its simplicity, specificity, sensitivity and rapidity, the LAMP technique is an additional tool that may be implemented in routine plague diagnoses, especially in emergencies.

关键词： Plague Yersinia pestis Diagnosis Tests Loop-Mediated Isothermal Amplification (LAMP)

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Immunotherapy in glioblastoma treatment:Current state and future prospects

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World Journal of Clinical Oncology 2023年第4期14卷 138-159页

作者： Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Hanna Santos marques Marcel Silva Luz Luís Guilherme de Oliveira Silva Clara Faria Souza mendes dos Santos Karolaine da Costa Evangelista Mariana Santos Calmon Matheus Sande Loureiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Glioblastoma remains as the most common and aggressive malignant brain tumor,standing with a poor prognosis and treatment *** the aggressive standard care,such as surgical resection and chemoradiation,median survival rates are *** this regard,immunotherapeutic strategies aim to become more attractive for glioblastoma,considering its recent advances and *** this review,we provide an overview of the current status and progress in immunotherapy for glioblastoma,going through the fundamental knowledge on immune targeting to promising strategies,such as Chimeric antigen receptor T-Cell therapy,immune checkpoint inhibitors,cytokine-based treatment,oncolytic virus and vaccine-based *** last,it is discussed innovative methods to overcome diverse challenges,and future perspectives in this area.

关键词： Glioblastoma Immunotherapy Tumor microenvironment Chimeric antigen receptor T cell Oncolytic viruses Immune-checkpoint inhibitors Brain cancer

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