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Chinese Journal of Chemistry 2011年第4期29卷 745-750页

作者： Kamboj, Ramesh C Kumar, Dinesh Sharma, Geeta Arora, rita Department of Chemistry Kurukshetra University Kurukshetra 136119 India

Photo-irradiation of 2-（5-methylthiophen-2-yl）-3-[（naphthalen-2-yl）methoxy]-4H-chromen-4-ones yielded the fascinating angular tetracyclic products via cyclization involving both 2-thienyl ring and naphthylmethoxy group via 1,4-biradical generated in the Norrish type-II process. The stereochemical dispositions of the products were determined by MM2 energy minimized programme and spectroscopic analysis.

关键词： type-II reaction radicals thienylchromone sigmatropic rearrangement substituent effects

Optimal load frequency control through combined state and control gain estimation for noisy measurements

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Protection and Control of Modern Power Systems 2020年第1期5卷 268-279页

作者： Anju G.Pillai Elizabeth rita Samuel A.Unnikrishnan Department of Electrical&Electronics Engineering Rajagiri School of Engineering&TechnologyErnakulamKerala 682037India APJ Abdul Kalam Technological University ThiruvananthapuramKeralaIndia

Combined estimation of state and feed-back gain for optimal load frequency control is *** frequency control(LFC)addresses the problem of controlling system frequency in response to disturbance,and is one of main research areas in power system operation.A well acknowledged solution to this problem is feedback stabilization,where the Linear Quadratic Regulator(LQR)based controller computes the feedback gain K from the known system parameters and implements the control,assuming the availability of all the state ***,this approach restricts control to cases where the state variables are readily available and the system parameters are ***,by estimating the states continuously from available measurements of some of the states,it can accommodate dynamic changes in the system *** paper proposes the technique of augmenting the state variables with controller *** introduces a non-linearity to the augmented system and thereby the estimation is performed using an Extended Kalman *** results in producing controller gains that are capable of controlling the system in response to changes in load demand,system parameter variation and measurement noise.

关键词： Load frequency control State feedback control Linear quadratic regulator Extended Kalman filter Single area power system

Role of chemotherapy in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 221-229页

作者： rita Nader Joelle El Amm Jeanny B Aragon-Ching Department of Internal Medicine Lebanese American University Beirut 1102 2801 Lebanon Department of Internal Medicine Division of Hematology and Oncology Lebanese American University Beirut 1102 2801 Lebanon Genitourinary Medical Oncology Inova Schar Cancer Institute Fairfax VA 22031 USA

Chemotherapy in prostate cancer （PCa） has undergone dramatic landscape changes. While earlier studies utilized varying chemotherapy regimens which were found to be largely palliative in nature and hardly resulted in durable or meaningful responses, docetaxel resulted in the first chemotherapy agent that showed improvement in overall survival in metastatic castration-resistant prostate cancer （mCRPC）. However, combination chemotherapy or any agents added to docetaxel have failed to yield incremental benefits. The improvement in overall survival as well as secondary endpoints of prostate-specific antigen （PSA） and time to recurrence when using docetaxel in the metastatic hormone-sensitive state has changed the standard of care for treatment of newly diagnosed de novo metastatic PCa. There are also promising results in locally advanced PCa and high-risk PCa in both the neoadjuvant and adjuvant settings. This review summarizes the historical as well as the more contemporary use of chemotherapeutic agents in PCa in varying states and phases of disease.

关键词： docetaxel metastatic castration-resistant prostate cancer prostate cancer

MULTIOBJECTIVE ROUTING IN MULTISERVICE MPLS NETWORKS WITH TRAFFIC SPLITTING-A NETWORK FLOW APPROACH

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Journal of Systems Science and Systems Engineering 2015年第4期24卷 389-432页

作者： rita Girao-Silva Jose Craveirinha Joao Climaco M.Eugenia Captivo Department of Electrical and Computer Engineering University of Coimbra Polo ⅡPinhal de Marrocos P-3030-290 Coimbra Portugal Institute of Computers and Systems Engineering of Coimbra(INESC-Coimbra)R.Antero de Quental 199 P-3000-033 Coimbra Portugal Centro de Investigacao Operacional Faculdade de CienciasUniversidade de Lisboa Campo GrandeBloco C6Piso 4 P-1749-016 Lisboa Portugal

A multiobjective routing model for Multiprotocol Label Switching networks with multiple service types and traffic splitting is presented in this paper. The routing problem is formulated as a multiobjective mixed-integer program, where the considered objectives are the minimization of the bandwidth routing cost and the minimization of the load cost in the network links with a constraint on the maximal splitting of traffic trunks. Two different exact methods are developed for solving the formulated problem, one based on the classical constraint method and another based on a modified constraint method. A very extensive experimental study, with results on network performance measures in various reference test networks and in randomly generated networks, is also presented and its results are discussed.

关键词： Routing models multiobjective optimization telecommunication networks network flowapproach traffic splitting

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology

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Neural Regeneration Research 2022年第2期17卷 266-270页

作者： rita F.Marques Kent E.Duncan Institute for Biochemistry and Molecular Biology Department of ChemistryUniversity of HamburgHamburgGermany Neuronal Translational Control Research Group Center for Molecular Neurobiology Hamburg(ZMNH)University Medical Center Hamburg-EppendorfHamburgGermany

Amyotrophic lateral sclerosis is the most common adult-onset neurodegenerative disease affecting motor neurons. Its defining feature is progressive loss of motor neuron function in the cortex, brainstem, and spinal cord, leading to paralysis and death. Despite major advances in identifying genes that can cause disease when mutated and model the disease in animals and cellular models, it still remains unclear why motor symptoms suddenly appear after a long pre-symptomatic phase of apparently normal function. One hypothesis is that age-related deregulation of specific proteins within key cell types, especially motor neurons themselves, initiates disease symptom appearance and may also drive progressive degeneration. Genome-wide in vivo cell-type-specific screening tools are enabling identification of candidates for such proteins. In this minireview, we first briefly discuss the methodology used in a recent study that applied a motor neuron-specific RNASeq screening approach to a standard model of TAR DNA-binding protein-43(TDP-43)-driven amyotrophic lateral sclerosis. A key finding of this study is that synaptogyrin-4 and pleckstrin homology domain-containing family B member 1 are also deregulated at the protein level within motor neurons of two unrelated mouse models of mutant TDP-43 driven amyotrophic lateral sclerosis. Guided by what is known about molecular and cellular functions of these proteins and their orthologs, we outline here specific hypotheses for how changes in their levels might potentially alter cellular physiology of motor neurons and detrimentally affect motor neuron function. Where possible, we also discuss how this information could potentially be used in a translational context to develop new therapeutic strategies for this currently incurable, devastating disease.

关键词： amyotrophic lateral sclerosis glucagon-like peptide-1 receptor motor neuron disease mouse model neurodegeneration phosphatidylserine pleckstrin homology domain synaptogyrin TAR DNA-binding protein-43 vesicle transport

A network of sex and competition： The promiscuous mating system of an invasive weevil

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Current Zoology 2015年第1期61卷 85-97页

作者： Alberto Francesco INGHILESI Giuseppe MAZZA rita CERVO Alessandro CINI Department of Biology University of Florence Via Romana 17 50125 Florence Italy Agricultural Research Council Research Centre for Agrobiology and Pedology via Lanciola 12/A Cascine del Riccio 50125 Florence Italy Department of Biology University of Florence Via Madonna del Piano 6 50019 Sesto Fiorentino Florence Italy Corpo Forestale dello Stato Centro Nazionale Biodiversit~t Forestale "Bosco Fontana"Via C. Ederle 16/a 37100 Verona Italy

Invasive alien pest insect species represent a major threat for agriculture and biodiversity. Because chemical treatments employed to contrast such pests elicit serious environmental and human health problems, a great effort is currently directed to develop long term and environmentally friendly biological control strategies. However, the successful application of some promising techniques, such as the Sterile Insect Technique （SIT）, requires a deep knowledge of the pest basic biology. Here, we argue that understanding pest sexual biology using a social network approach can significantly improve the performance of con- trol strategies. For example, SIT may benefit from understanding how individuals interact and how males accede to reproduction, in order to target the most reproductively active and polygamic males. In this paper we studied the socio-sexual networks of the Asian red palm weevil （RPW） Rhynchophorusferrugineus, a worldwide invader which is causing heavy economic impacts on several palm species. We found that the RPW has a highly promiscuous mating system, characterized by forced interruptions of pair copulations by additional males. The social network is highly non-random nor regular： few males almost monopolize repro- duction, behaving as key-players in the network of matings. Additionally, males have a stable pattern of sexual behaviour over time. We use RPW social network as a case study to direct the development of management techniques such as SIT strategy [Current Zoology 61 （1）： 85-97, 2015].

关键词： Social network analysis Pest management Mating system Reproductive skew Alien pest Rhynchophorusferrugineus

Perception and Higher Education in China

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Perception and Higher Education in China

作者： rita Nagy 华东师范大学

学位级别：硕士

本文探究了留学经历对在华留学生对东道国认知的影响。近年来,来华学习的留学生日益增多,其对东道国的认知及影响这些认知的因素十分值得关注。基于对现有文献的研究,我们可知“认知”是一种内在的固有文化约束。因此,本文的研究范围仅... 详细信息

本文探究了留学经历对在华留学生对东道国认知的影响。近年来,来华学习的留学生日益增多,其对东道国的认知及影响这些认知的因素十分值得关注。基于对现有文献的研究,我们可知“认知”是一种内在的固有文化约束。因此,本文的研究范围仅限于匈牙利的在华留学生。为了了解他们对中国文化和政治价值观的看法,本文采取了问卷调查和半结构化访谈的方式。结果表明,在华留学生对中国的总体印象明显高于普通大众,在中国的留学经历对他们对中国的认知起到了积极的影响。本文认为,留学经历及在高等学府所受教育促使留学生对东道国——中国形成更加积极正面的看法。

关键词：认知留学生文化价值观政治价值观

Overview of hepatitis B virus mutations and theirimplications in the management of infection

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World Journal of Gastroenterology 2016年第1期22卷 145-154页

作者： Patrizia Caligiuri rita Cerruti Giancarlo Icardi Bianca Bruzzone Department of Health Sciences University of Genoa16132 GenoaItaly Hygiene Unit I.R.C.C.S.A.O.U.San Martino-IST16132 GenoaItaly

Hepatitis B virus(HBV)affects approximately two billion people worldwide and more than 240 million people in the world are currently chronic carrier that could develop serious complications in the future,like liver cirrhosis and hepatocellular *** an extended HBV immunization program is being carried out since the early‘80s,representing effective preventive measure,leading to a dramatic reduction of HBV hepatitis incidence,globally HBV infection still represents a major public health *** HBV virus is a DNA virus belongs to the Hepadnaviridae *** HBV-DNA is a circular,partial double strand *** coding information is on the minus DNA strand and it is organized into four open reading *** hepatitis B virus is a DNA virus,it has a high mutation rate due to its replicative strategy,that leads to the production of many nonidentical variants at each cycle of *** fact,it contains a polymerase without the proofreading activity,and uses an RNA intermediate(pg RNA)during its replication,so error frequencies are comparable to those seen in retroviruses and other RNA viruses rather than in more stable DNA *** to the low fidelity of the polymerase,the high replication rate and the overlapping reading frames,mutations occur throughout the genome and they have been identified both in the structural and not structural *** arise of mutations being to develop of a whole of viral variants called"quasi-species"and the prevalent population,which favors virus replication,was selected by viral fitness,host’s immune pressure and external pressure,i.e.,vaccination or antiviral *** occurring mutations were found both in acute and chronic *** the present review we examine and discuss the most recent available data about HBV genetic variability and its significance.

关键词： Hepatitis B virus Mutations Open readingframes Molecular biology tools Liver disease

GASTROINTESTINAL ABNORMALITIES IDENTIFIED BY FLUORESCENCE ENDOMICROSCOPY

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 33-38页

作者： HONGCHUN BAO ALEX BOUSSIOUTAS MCGEAREY ALEIXANDRIA rita BUSUTTIL MIN GU Center for Micro-Photonics Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Victoria 3122Australia Research-Peter MacCallum Cancer Center 1 St Andrews Place East Melbourne Victoria 3002Australia Department of Medicine(RMH)University of Melbourne Royal Melbourne HospitalParkvilleVictoria 3050Australia

Real-tine in vivo microscopic imaging has becomne a reality with the advent of confocal and nonlinear *** devices are best utilized in conjunction with standard white light *** evaluated the use of fuorescence endomicroscopy in detecting microscopic abnormalities in colonic *** of C57bl/6 strain had intraperitoneal injection with azoxymethane once every week for five weeks and littermates,not exposed to azoxymethane served as *** 14 weeks,intestines were imaged by fuorescence *** images show obvious cellular structural diferences between those two groups of *** difference in endomicroscopy imaging can be used for identifying tissues suspicious for neoplasia or other changes,leading to early diagnosis of gastrointestinal track of cancer.

关键词： Endomicroscopy fuorescence imaging one photon fluorescence imaging gastroin-testinal cancers goblet cells neoplasia

Effect of different lens status on intraocular pressure elevation in patients treated with anti-vascular endothelial growth factor injections

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 79-84页

作者： Amir Sternfeld rita Ehrlich Dov Weinberger Assaf Dotan Department of Ophthalmology Rabin Medical Center Beilinson HospitalPetach Tikva 4941402Israel Sackler Faculty of Medicine Tel Aviv UniversityRamat AvivTel Aviv 6997801Israel

AIM: To assess the effect of lens status on sustained intraocular pressure(IOP) elevation in patients treated intravitreally with anti-vascular endothelial growth factor(VEGF) agents. METHODS: Data were retrospectively collected for all patients treated with intravitreal injections of anti-VEGF medication at a tertiary medical center in July 2015. Findings were analyzed by lens status during 6 months' follow-up. The main outcome measure was a sustained increase in IOP(≥21 mm Hg or change of ≥6 mm Hg from baseline on ≥2 consecutive visits, or addition of a new IOPlowering medication during follow-up). RESULTS: A total of 119 eyes of 100 patients met the study criteria: 40 phakic, 40 pseudophakic, and 39 pseudophakic after Nd:YAG capsulotomy. The rate of sustained IOP elevation was significantly higher in the postcapsulotomy group(23.1%) than in the phakic/pseudophakic groups(8.1%;P=0.032), with no statistically significant differences among the 3 groups in mean number of injections, either total(P=0.82) or by type of anti-VEGF mediation(bevacizumab: P=0.19;ranibizumab: P=0.13), or mean follow-up time(P=0.70). CONCLUSION: Nd:YAG capsulotomy appears to be a risk factor for sustained IOP elevation in patients receiving intravitreal anti-VEGF injections. This finding has important implications given the growing use of anti-VEGF treatment and the irreversible effects of elevated IOP.

关键词： anti-VEGF injections cataract surgery intraocular pressure Nd:YAG capsulotomy