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Depletion of the Ozone Layer and Its Consequences: A Review

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American Journal of Plant Sciences 2013年第10期4卷 1990-1997页

作者： Anjali Aggarwal Reeta Kumari Neeti Mehla Deepali rishi pal singh Sonal Bhatnagar Kameshwar Sharma Kuldeep Sharma Vashishtha Amit Brijesh Rathi Department of Biochemistry Sri Venkateswara College University of Delhi New Delhi India Department of Botany Deshbandhu College University of Delhi New Delhi India Department of Botany Sri Venkateswara College University of Delhi New Delhi India Department of Botany Uni- versity of Delhi New Delhi India. Department of Chemistry Sri Venkates- wara College University of Delhi New Delhi India

Ozone (O3) is a stratospheric layer that plays important role in providing support to humans for their survival. It is an essential factor for many global, biological and environmental phenomena. The ultra-violet (UV) rays emitted from sun are captured by ozone and thereby provide a stable ontological structure in the biosphere. Various anthropogenic activities such as emissions of CFCs, HCFCs and other organo-halogens lead to the depletion of ozone. The ozone depletion resulted in secondary production of an ozone layer near the ground (terrestrial ozone layer), which is responsible for adverse effects on plants, humans and environment with increased number of bronchial diseases in humans. The mutations caused by UV rays result in variation in morphogenic traits of plants which ultimately decreases crop productivity. However, UV radiation is required in optimum intensity for both plants and animals. This review takes into an account the wide ranging effects of ozone depletion with a majority of them being detrimental to the plant system.

关键词： Ozone Depletion Ultra-Violet Radiation Chlorofluorocarbons Plants Ecosystem

Sodium glucose cotransporter 2 inhibitors in the management of heart failure:Veni,Vidi,and Vici

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World Journal of Cardiology 2024年第10期16卷 550-563页

作者： Monika Bhandari Akshyaya Pradhan Pravesh Vishwakarma Abhishek singh rishi Sethi Department of Cardiology King Georg’s Medical UniversityLucknow 226003Uttar PradeshIndia

Heart failure(HF)is a chronic disease associated with high morbidity and mortality ***-angiotensin-aldosterone system blockers(including angiotensin receptor/neprilysin inhibitors),beta-blockers,and mineralocorticoid receptor blockers remain the mainstay of pharmacotherapy for HF with reduced ejection fraction(HFrEF).However,despite the use of guideline-directed medical therapy,the mortality from HFrEF remains *** with preserved ejection fraction(HFpEF)comprises approximately half of the total incident HF cases;however,unlike HFrEF,there are no proven therapies for this *** glucose cotransporter-2 inhibitors(SGLT-2is)represent a new class of pharmacological agents approved for diabetes mellitus(DM)that inhibit SGLT-2 receptors in the kidney.A serendipitous finding from seminal trials of SGLT-2is in DM was the significant improvement in renal and cardiovascular(CV)*** importantly,the improvement in HF hospitalization(HHF)in the CV outcomes trials of SGLT-2is was *** mechanisms have been proposed for the pleiotropic effects of SGLT-2is beyond their glycemic ***,as patients with HF were not included in any of these trials,it can be considered as a primary ***,two landmark studies of SGLT-2is in patients with HFrEF,namely,an empagliflozin outcome trial in patients with chronic HF and a reduced ejection fraction(EMPEROR-Reduced)and dapagliflozin and prevention of adverse outcomes in HF(DAPA-HF),demonstrated significant improvement in HHF and CV mortality regardless of the presence of *** impressive results pitchforked these drugs as class I indications in patients with HFrEF across major ***,empagliflozin outcome trial in patients with chronic HF with preserved ejection fraction(EMPEROR-Preserved)and dapagliflozin evaluation to improve the lives of patients with preserved ejection fraction HF(DELIVER)trials successively confirmed that SGLT-2is also benefit patients w

关键词： Heart failure with preserved ejection fraction Gliflozins Diuresis Natriuresis N terminal-pro brain natriuretic peptide Heart failure hospitalization

Plant based metabolomics:a future prospective and versatile tool for metabolite databases of Curcuma longa

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未来食品学报(英文) 2024年第1期4卷 37-47页

作者： Shuvendhu Gupta Amrat pal singh Gurpreet singh Xianting Ding Alok Sharma Department of Pharmacognosy ISF College of PharmacyMoga 142001India Department of Pharmaceutical Chemistry ISF College of PharmacyMoga 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the market ***,increase in demand of Curcuma longa has led to a high swing in small and medium food *** present review is devoted to an in-depth information on metabolite database of *** from different analytical techniques such as high-performance thin-layer chromatography(HPTLC),liquid chromatography-mass spectrometry,gas chromatography-mass spectrometry and nuclear magnetic *** work highlights different extraction methods,phytochemistry along with structure activity relationship,nutritional profiling,market viability and pharmacology of *** bioactives of *** depends on various factors such as plants growth,temperature,humidity,soil type,collection,drying and extraction *** factors can contribute in quality evaluation of the food supplements if need to be *** introduction of omics approaches can helpful to explore the quality and identification of potential lead of *** results could play an essential role in the area of food-phyto based ***,metabolomics techniques may provide a analytical platfom by combination of different"omics"data souces for future esearch to food sand herbal based products.

关键词： Curcuma longa Omics approaches Multidisciplinary method Quality control Metabolomics

Dust-Holding Capacity and Bio-Chemical Changes of Plant Species Growing in an Around Opencast Mining Area of Bundelkhand Region of Uttar Pradesh, India

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American Journal of Plant Sciences 2024年第8期15卷 677-698页

作者： Priyanka singh Amit pal Institute of Environment and Development Studies Bundelkhand University Jhansi India

The present study has been carried out on a total of 50 available plant species to assess their dust-capturing capacity and biochemical performances in and around open cast granite mine areas of Jhansi district and Bundelkhand University campus treated as control site. Plant species existing under a polluted environment for a long time may be considered as potentially resistant species and recommended for green belt design in mining areas, especially to cope with dust pollution. Results showed the pollution level, especially of mining-originated dust particles holding capacity of leaves and effects of different biochemical parameters (Total Chlorophyll, Protein and Carotenoid) of existing plant species both from mining areas as well as from Bundelkhand University campus. Based on their performances, Tectona grandis L., Ficus hispida L., Calotropis procera Aiton., Butea monosperma Lam. and Ficus benghalensis L., etc. are highly tolerant species while Ficus infectoria L., Artocarpus heterophyllus Lam., Ipomoea purpurea L., Allianthus excelsa Roxb. and Bauhinia variegata L. are intermediate tolerant species. T. grandis had shown the highest dust-holding capacity (2.566 ± 0.0004 mg/cm2) whereas Albizia procera (0.018 ± 0.0002 mg/cm2) was found to be the lowest dust-holding capacity. Our findings also showed that the T. grandis and F. hispida have significant dust deposition with minimal effect of dust on their leaf chlorophyll (17.447 ± 0.019 mg/g and 14.703 ± 0.201 mg/g), protein (0.699 ± 0.001 mg/g and 0.604 ± 0.002 mg/g) and carotenoid (0.372 ± 0.003 mg/g and 0.354 ± 0.003 mg/g) content respectively among all selected plant species. Therefore, in the present investigation, plant species with high tolerance to high dust-holding capacity on their leaf surfaces are preferable for green corridors as open cast granite mines and their adjacent areas.

关键词： Bundelkhand Region Biochemical Changes Dust-Holding Capacity Chlorophyll Content Open Cast Granite Mining

Current evidence on artificial intelligence in regional anesthesia

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World Journal of Clinical Cases 2024年第33期12卷 6613-6619页

作者： Bhanu Pratap Swain Deb Sanjay Nag rishi Anand Himanshu Kumar Pradip Kumar Ganguly Niharika singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

The recent advancement in regional anesthesia(RA)has been largely attributed to ultrasound ***,the safety and efficiency of ultrasound-guided nerve blocks depend upon the skill and experience of the *** with adequate training,experience,and knowledge,human-related limitations such as fatigue,failure to recognize the correct anatomical structure,and unintentional needle or probe movement can hinder the overall effectiveness of *** amalgamation of artificial intelligence(AI)to RA practice has promised to override these human *** learning,an integral part of AI can improve its performance through continuous learning and experience,like the human *** enables computers to recognize images and patterns specifically useful in anatomic structure identification during the performance of *** can provide real-time guidance to clinicians by highlighting important anatomical structures on ultrasound images,and it can also assist in needle tracking and accurate deposition of local *** future of RA with AI integration appears promising,yet obstacles such as device malfunction,data privacy,regulatory barriers,and cost concerns can deter its clinical *** current mini review deliberates the current application,future direction,and barrier to the application of AI in RA practice.

关键词： Artificial intelligence Regional anesthesia Machine learning Ultrasonography Nerve block

Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock:An Indian perspective

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World Journal of Critical Care Medicine 2024年第1期13卷 65-75页

作者： Yatin Mehta Abdul Samad Ansari Amit Kumar Mandal Dipanjan Chatterjee Gauri Shankar Sharma Prachee Sathe Purvesh V Umraniya Rajib Paul Sachin Gupta Vinod singh Yogendra pal singh Institute of Critical Care and Anesthesiology Medanta The MedicityGurgaon 122001HaryanaIndia Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Pulmonology Sleep and Critical CareFortis HospitalMohaliPunjabMohali 160062PunjabIndia Department of Cardio-Puimonary Critical Care Medica Superspecialty HospitalKolkata 700099India Department of Critical Care Medicine Fortis HospitalNew Delhi 110070India Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Bhailal Amin General HospitalVadodara 390003GujaratIndia Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Anaesthesiology Narayana Superspeciality HospitalGurugram 122002India Department of Critical Care Medicine Institute of Critical Care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Department of Critical Care Medicine Max Super Speciality HospitalDelhi 110092India

BACKGROUND Septic shock is a severe form of sepsis characterised by deterioration in circulatory and cellular-metabolic *** standard therapy,the outcomes are *** adjuvant therapy,such as CytoSorb®extracorporeal haemoadsorption device,has been investigated and shown promising ***,there is a lack of some guidance to make clinical decisions on the use of CytoSorb®haemoadsorption as an adjuvant therapy in septic shock in Indian ***,this expert consensus was *** To formulate/establish specific consensus statements on the use of CytoSorb®haemoadsorption treatment based on the best available evidence and contextualised to the Indian *** We performed a comprehensive literature on CytoSorb®haemoadsorption in sepsis,septic shock in PubMed selecting papers published between January 2011 and March 20232021 in English *** statements for a consensus document were developed based on the summarised literature analysis and identification of knowledge *** a modified Delphi approach combining evidence appraisal and expert opinion,the following topics related to CytoSorb®in septic shock were addressed:need for adjuvant therapy,initiation timeline,need for Interleukin-6 levels,duration of therapy,change of adsorbers,safety,prerequisite condition,efficacy endpoints and management *** expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** Eleven expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** 11 experts in the consensus group(100%)participated in the first,second and third round of *** three iterative voting rounds and adapting two statements,consensus was achieved on nine statements out of nine *** consensus expert panel also recognised the necessity to form an associatio

关键词： Consensus CytoSorb Cytokine Hemoadsorption Refractory Sepsis Septic shock

Fabrication of core-shell PLGA/PLA-pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs

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Particuology 2018年第5期16卷 169-176页

作者： Tanushree Basu Bonamali pal Satnam singh School of Chemistry and Biochemistry Thapar lnstitute of Engineering and TechnologyPatiala 147004Punjablndia

Polylactic acid (PLA)and poly(lactic-co-glycolic)acid (PLGA)are two commonly applied biodegrad- able polymers for the preparation of nanocomposites used in drug-delivery ***,these polymers lack desirable attributes such as resistance to aggregation during long-term storage due to *** improve their efficacy,in this work,PLA and PLGA were encapsulated within a shell of poly(N-isopropylacrylamide)(pNIPAM)using a single emulsion technique followed by an aqueous free radical precipitation polymerisation process,yielding core-shell PLA/PLGA-pNIPAM nanocomposites. The nanocomposites were cbaracterised using zeta potential,dynamic light scattering,and transmission electron microscopy analyses and were further applied as a delivery system for ramipril,an antihypertensive *** drug-loaded PLGA-pNIPAM core-shell nanoparticles exhibited a higher drug content (91%)and entrapment efficiency (78%)than their PLA *** in vitro release study of the formulations at pH 7.3in phosphate-buffered saline indicated that PLGA was more efficient than PLA with a sustained release of 86% of ramipril from the polymer matrix within ***,to determine the release kinetics,the data were fitted to Korsmeyer-Peppas and Higuchi models;the release of ramipril from the polymer matrix followed zero-order rate kinetics and an anomalous (non-Fickian)diffusion mechanism.

关键词： Poly(lactic-co-glycolic)acid Polylactic acid Poly(N-isopropylacrylamide) Antihypertensive drug Entrapment efficiency Drug release

Lucrative pectinase production by novel strain Pseudozyma sp. SPJ with statistical optimization techniques using agro-industrial residues

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Frontiers in Biology 2014年第4期9卷 317-323页

作者： Sampriya SHARMA Jitender SHARMA rishi pal MANDHAN Department of Biotechnology Kurukshetra University Kurukshetra 136119 India

Production of high titers of an alkaline, extracellular and thermo-tolerant pectinase by a newly isolated yeast Pseudozyma sp. SPJ was carried out under solid state fermentation. Citrus peel, the inexpensive agro-industrial residue used as substrate, was experienced to be unsurpassed. Response surface methodology was conducted to optimize the culture conditions for Pseudozyma sp. SPJ for hyper production of pectinase. Plackett Burman design was applied to identify the most effective culture variables. Out of nine variables studied, incubation time, moisture content and ammonium sulfate were detected as most important. A full factorial Central Composite Design was used to optimize the levels of these variables, which resulted in 17-fold increase （71.19 IU/g to 1215.66 IU/g dry substrate） in the enzyme yield. The results of analysis of variance and multiple regression analysis implies that the effect of incubation time （p 〈 0.000） and moisture content （p 〈 0.018） is more than ammonium sulfate. And also the interaction of moisture content with ammonium sulfate （p 〈 0.002） is more significant.

关键词： pectinase Pseudozyma sp. SPJ response surface methodology solid state fermentation

Joint routing and rate allocation for multiple video streams in ad-hoc wireless networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 727-736页

作者： singh Jatinder pal GIROD Bernd Deutsche Telekom Laboratories Ernst-Reuter-Platz 7 Berlin 10587 Germany Information System Laboratory Stanford University California 94305 USA

The support for multiple video streams in an ad-hoc wireless network requires appropriate routing and rate allocation measures ascertaining the set of links for transmitting each stream and the encoding rate of the video to be delivered over the chosen links. The routing and rate allocation procedures impact the sustained quality of each video stream measured as the mean squared error (MSE) distortion at the receiver, and the overall network congestion in terms of queuing delay per link. We study the trade-off between these two competing objectives in a convex optimization formulation, and discuss both centralized and dis- tributed solutions for joint routing and rate allocation for multiple streams. For each stream, the optimal allocated rate strikes a balance between the selfish motive of minimizing video distortion and the global good of minimizing network congestions, while the routes are chosen over the least-congested links in the network. In addition to detailed analysis, network simulation results using ns-2 are presented for studying the optimal choice of parameters and to confirm the effectiveness of the proposed measures.

关键词： Ad-hoc wireless networks, Video streaming, Rate allocation, Multi-path routing