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Pituitary apoplexy secondary to dengue fever-induced-thrombocytopenia:A case report and review of literature

Journal of Acute Disease 2023年第1期12卷 39-42页

作者： rishi Agarwal Hardeva Ram Nehara Babulal Meena RP Agrawal Departments of Medicine SP Medical CollegeBikanerRajasthanIndia Endocrinology SP Medical CollegeBikanerRajasthanIndia

Rationale:Pituitary apoplexy(pa)is a rare endocrine emergency that requires prompt diagnosis and *** fever-induced-thrombocytopenia may rarely predispose to ***’s Concern:A 58-year-old male patient having known pituitary macroadenoma presented to the emergency department with fever,a sudden onset severe headache,and altered ***:Pituitary apoplexy caused by dengue ***:Conservative management with fluids,mannitol,dexamethasone and symptomatic ***:The patient responded well to the treatment and was discharged ***:Although dengue hemorrhagic fever is a rare cause of pituitary apoplexy,it should be considered if a patient presents with headache and altered sensorium,and prompt initiation of treatment is crucial to prevent fatality and neuro-ophthalmic deficits.

关键词： Dengue hemorrhagic fever Pituitary adenoma Apoplexy Thrombocytopenia Endocrine emergency

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Assessment of Safety and Effectiveness of Glaritus<sup>®</sup>(Wockhardt’s Insulin Glargine) in a Prospective, Multi-Centric Post Marketing Observational Study in Nepalese Having Type 2 Diabetes Mellitus

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Open Journal of Endocrine and Metabolic Diseases 2019年第2期9卷 21-33页

作者： Ansumali Joshi Bhojraj Adhikari Basant Tamrakar Gaurav Puppalwar Agam Shah rishi Jain Kathmandu Diabetes & Thyroid Centre Pvt. Ltd. Kathmandu Nepal Pushpanjali Hospital Bharatpur Nepal Fishtail Hospital & Research Centre Pvt. Ltd. Pokhara Nepal Medical Affairs Wockhardt Ltd. Mumbai India

Background: Nepal is one of the fastest urbanizing countries in South Asia and is facing the consequences of urban lifestyle leading to obesity and metabolic syndrome. Type 2 diabetes mellitus (T2DM) is currently a high-burden disease in Nepal with a prevalence of 8.4%. Of these 8% - 18% patients are on insulin and 42% patients were reported to have uncontrolled diabetes in the past year. This suggests a need for better therapy options in terms of efficacy and safety. The current study was designed to investigate the effects of Insulin glargine-based therapy in Nepalese with T2DM who could not achieve adequate glycemic control with oral and non-glargine-insulin therapy. Methods: This is a prospective, multi-centric, single arm and post marketing observational study to assess the safety and effectiveness of Glaritus®(Wockhardt’s Insulin Glargine) in 52 T2DM patients from 3 (three) different study sites in Nepal (Bharatpur, Kathmandu and Pokhra) from September 2015 to December 2016. The primary objective of the study was to evaluate the safety of Glaritus®, mainly in terms of hypoglycemia, renal function tests and liver function tests. The secondary objectives were to evaluate the effectiveness of Glaritus®in terms of percentage of patients achieving HbA1c goal of less than 7%, mean changes in HbA1c & fasting plasma glucose (FPG) levels from baseline till the end of study. Results: 3.85% of subjects experienced hypoglycemia during first 3 months of therapy whereas 1.92% had similar experience in next 3 months of therapy. The mean HbA1c values reduced from 9.16% to 7.15% at the end of study. 21.05% of the enrolled subjects achieved the goal of HbA1c ®was well tolerated by the study patients. Conclusion: In patients with type 2 diabetes mellitus inadequately controlled on oral hypoglycemic agents and/or insulin, initiation with Glaritus®significantly improved glycemic control with good tolerability and acceptability. This analysis in T2DM Nepalese pa

关键词： Insulin Glargine Type 2 Diabetes Nepalese patients Hypoglycemia Basal Insulin HbA1c Fasting Plasma Glucose Post Marketing Surveillance

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机械血栓切除术综合性卒中中心的要求和卒中血管内治疗医疗体系：血管和介入神经病学学会（SVIN）卒中血管内治疗标准委员会的推荐意见

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国际脑血管病杂志 2017年第6期25卷 498-505页

作者： Joey D. English Dileep R. Yavagal rishi Gupta Vallabh Janardhan Osama O. Zaidat Andrew R. Xavier Raul G. Nogueira Jawad F. Kirmani Tudor G. Jovin 刘晓昀许岩孙文 From the Neurointerventional Surgery California Pacific Medical Center San Francisco Calif. Neurology and Neurosurgery University of Miami School of Medicine Miami Fla. Neurosurgery WellStar Medical Group Marietta Ga. Neurology Medical City Dallas Hospital Dallas Tex. Medical College of Wisconsin Milwaukee Wis. Neurology Detroit Medical Center Detroit Mich. Emory University School of Medicine Atlanta Ga. Stroke and Neurovascular Center JFK Medical Center Edison N.J. Neurology University of Pittsburgh Medical Center Pittsburgh Pa. 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002

最近，5项具有里程碑意义的多中心、前瞻性、随机、开放标签、盲法终点的临床试验证实，在伴有颅内大血管闭塞的急性缺血性卒中（acute ischemic stroke，AIS）患者中，应用机械血栓切除术进行血管内治疗具有显著的临床获益。血管和介... 详细信息

最近，5项具有里程碑意义的多中心、前瞻性、随机、开放标签、盲法终点的临床试验证实，在伴有颅内大血管闭塞的急性缺血性卒中（acute ischemic stroke，AIS）患者中，应用机械血栓切除术进行血管内治疗具有显著的临床获益。血管和介入神经病学学会（Society of Vascular and Interventional，SVIN）任命了一个专业写作委员会来总结这些新证据，并就如何应用这些数据指导AIS患者的急诊血管内治疗提出了推荐意见。

关键词：急性缺血性卒中大血管闭塞机械取栓术医疗体系

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