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1997 International Symposium on Electromagnetic Compatibility

作者： Masaharu UCHINO Yoshinobu HAYASHI Takashi SHINOZUKA risaburo sato Electromagnetic Compatibility Research Laboratories Co.Ltd.

Given that amplitude probability distribution(APD) is an effective means of estimating the effects of electromagnetic disturbance on digital communications,we are now testing low-cost equipment for measuring APD at high resolution. The equipment combines multiple M-sequence counters having relatively prime periods and makes use of residue number systems(RNS) so that most circuits can be formed on one IC chip and a low-cost configuration can be achieved. In addition,the size of the discrete logarithm table here, which is essential to restoring the enumerated value from the bit pattern output of M-sequence counters,need be only 10 the size of a single M-sequence *** therefore arranging n units of this APD measuring equipment into a parallel configuration,processing speed can be increased by n times.

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Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis

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World Journal of Gastroenterology 2018年第38期24卷 4384-4392页

作者： Jun Urushikubo Shunichi Yanai Shotaro Nakamura Keisuke Kawasaki risaburo Akasaka Kunihiko sato Yosuke Toya Kensuke Asakura Takahiro Gonai Tamotsu Sugai Takayuki Matsumoto Division of Gastroenterology Department of Internal Medicine School of Medicine Iwate Medical University Division of Molecular Diagnostic Pathology Department of Pathology School of Medicine Iwate Medical University

AIM To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis(UC). METHODS We performed a cross-sectional observational study of 131 Japanese patients with UC and measured fecal calprotectin levels by fluorescence enzyme immunoassay. The clinical activity of UC was assessed with the partial Mayo score(PMS). Relapse was defined as increase of PMS by 2 points or more in stool frequency or rectal bleeding subscore. The endoscopic and histologic activities of UC were evaluated in 50 patients within a 2-mo period from fecal sampling. Endoscopic activity was determined by Mayo endoscopic subscore, Rachmilewitz endoscopic index, and ulcerative colitis endoscopic index of severity. The histologic grade of inflammation was evaluated with biopsy specimens obtained from the endoscopically most severely inflamed site, according to the scheme by Matts grade and Riley's *** Fecal calprotectin levels varied from 1-20783 μg/g. There was a significant correlation between the partial Mayo score and fecal calprotectin levels(r = 0.548, P < 0.001). In 50 patients who underwent colonoscopy with biopsy, levels were significantly correlated with the Mayo endoscopic subscore(r = 0.574, P < 0.001), Rachmilewitz endoscopic index(r = 0.628, P < 0.001), ulcerative colitis endoscopic index of severity(r = 0.613, P < 0.001), Riley's histologic score(r = 0.400, P = 0.006), and Matts grade(r = 0.586, P < 0.001). Receiver-operating characteristic analyses identified the best cut-off value for the prediction of endoscopic remission as 288 μg/g, with an area under the curve of 0.777 or 0.823, while that for histologic remission was 123 or 125 μg/g, with an AUC of 0.881 or 0918, respectively. Of the 131 study patients, 88 patients in clinical remission were followed up 6 mo. During the follow-up period, 19 patients relapsed. The best fecal calprotectin cut-off value for predicting relapse

关键词： Ulcerative colitis Remission Mucosal healing Colonoscopy Histology Biomarker Feces Calprotectin

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