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Mixtures of tetrakis hydroxymethyl phosphonium chloride and ammonium influence plankton community structure in blackwater pond mesocosms

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Emerging Contaminants 2020年第1期6卷 62-71页

作者： Marina N.Osier risa A.Cohen Department of Biology Georgia Southern UniversityPO Box 8042-1StatesboroGA30460USA

Mixtures of chemicals from human sources are pervasive in aquatic systems,yet their effects on aquatic communities are relatively *** contaminants such as organophosphorus flameretardants(*** hydroxymethyl phosphonium chloride(THPC)),are toxic to planktonic species at environmentally relevant ***,inorganic ammonium from agriculture and industry is likely to enter surface waters simultaneously with flame retardant *** effects of ammonium on plankton are known,its presence has the potential to influence the toxicity of other *** study mixture effects on plankton communities,floating mesocosms were dosed with THPC(0.08 or 0.8 mg L^-1)with or without ammonium(0.3 mg L^-1).Weekly measurements of zooplankton community composition and phytoplankton abundance(as chlorophyll a)were *** factor alone had no effect on zooplankton abundance or species ***,the mixture decreased the proportion of calanoid copepods and increased rotifers during weeks *** a was unaffected by treatments,but concentrations were highly variable for the duration of the *** interaction between THPC and ammonium suggests that the contaminants together reduce abundance of large zooplankton,releasing smaller zooplankton from predation and competitive pressure while potentially limiting food availability to planktivorous fish.

关键词： Emerging contaminant Flame retardant Freshwater Nitrogen Phytoplankton Zooplankton Ecotoxicology

Machine Learning for Cataract Classification/Grading on Ophthalmic Imaging Modalities:A Survey

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Machine Intelligence Research 2022年第3期19卷 184-208页

作者： Xiao-Qing Zhang Yan Hu Zun-Jie Xiao Jian-Sheng Fang risa Higashita Jiang Liu Research Institute of Trustworthy Autonomous Systems Southern University of Science and TechnologyShenzhen 518055China Department of Computer Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Tomey Corporation Nagoya 4510051Japan Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315300China Guangdong Provincial Key Laboratory of Brain-inspired Intelligent Computation Southern University of Science and TechnologyShenzhen 518055China

Cataracts are the leading cause of visual impairment and blindness *** the years,researchers have achieved significant progress in developing state-of-the-art machine learning techniques for automatic cataract classification and grading,aiming to prevent cataracts early and improve clinicians′diagnosis *** survey provides a comprehensive survey of recent advances in machine learning techniques for cataract classification/grading based on ophthalmic *** summarize existing literature from two research directions:conventional machine learning methods and deep learning *** survey also provides insights into existing works of both merits and *** addition,we discuss several challenges of automatic cataract classification/grading based on machine learning techniques and present possible solutions to these challenges for future research.

关键词： Cataract classification and grading ophthalmic image machine learning deep learning

Optical nature of non-substituted triphenylmethyl cation:Crystalline state emission,thermochromism,and phosphorescence

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Aggregate

Aggregate 2021年第6期2卷 99-108页

作者： Tomohiko Nishiuchi Hikaru Sotome risa Fukuuchi Kenji Kamada Hiroshi Miyasaka Takashi Kubo Department of Chemistry Graduate School of ScienceOsaka UniversityToyonakaOsakaJapan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(ICS-OTRI)Osaka UniversitySuitaOsakaJapan Division of Frontier Materials Science and Center for Advanced Interdisciplinary Research Graduate School of Engineering ScienceOsaka UniversityToyonakaOsakaJapan Nanomaterial Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaOsakaJapan Department of Chemistry Graduate School of Science and TechnologyKwansei Gakuin UniversitySandaHyogoJapan

Since the discovery of the triphenylmethyl(trityl)cation 120 years ago,a variety of aromatic cations having various colors and luminescence properties have been rigorously ***,differently substituted trityl cations have been synthesized,and their optical properties have been ***,the optical properties of the parent,non-substituted and highly reactive trityl cation,which was observed to be very weakly luminescent,have not been subjected to detailed *** the effort described herein,we explored the optical nature of non-substituted trityl hexafluorophosphate(PF_(6))in the crystalline *** PF_(6) was found to exist as two crystal polymorphs including a yellow(Y)and an orange(O)***,we observed that these crystalline forms display crystalline-state emission with different *** results of X-ray crystallographic analysis showed that the two polymorphs have totally different molecular packing ***,an investigation of their optical properties revealed that the O-crystal undergoes a distinct color change to yellow upon cooling as a consequence of a change in the nature of the charge transfer interaction between the cation and PF6 anion,and that both the Y-and O-crystal exhibit phosphorescence.

关键词： aggregation induced emission carbocation phosphorescence crystal phase transition thermochromism

Development and Future Trends of Traditional Kampo Medicine in Japan

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Chinese Medicine and Culture 2022年第1期5卷 58-64页

作者： risa Shibata Gui-Xiang Chu Xun Lin Jin-Rong Fu Gynaecology Department of TCM Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China International Office Shanghai University of Traditional Chinese MedicineShanghai 201203China

Traditional Kampo medicine is based on traditional Chinese medicine,which spread to Japan via the Korean Peninsula in the 5th *** practice of Kampo developed gradually under the influence of local Japanese culture and prospered until the Meiji *** appeared in schools successively,such as the School of Later Developments,the School of Classic Methods,the School of Textual Research,and the Integrated ***,the practice of Kampo gradually declined after the Meiji ***,through the continuous efforts of knowledgeable Japanese Kampo practitioners,the practice of Kampo has entered a new era as an indispensable aspect of contemporary Japanese medicine.

关键词： Medical history History Japan Kampo Traditional Chinese medicine

A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method

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International Journal of Oral Science 2017年第2期9卷 80-86页

作者： Hiroyuki Yamaguchi Yuji Ishida Jun Hosomichi Jun-ichi Suzuki risa Usumi-Fujita Yasuhiro Shimizu Sawa Kaneko Takashi Ono Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Advanced Clinical Science and Therapeutics Graduate School of MedicineThe University of TokyoTokyoJapan

The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B(NF-κB) decoy oligodeoxynucleotide(ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6J mice by ultrasound radiation at low(LUM-Sc) and high(HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble *** inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation(A-Sc). Then, an NF-κB decoy was transfected into the periodontal tissue using the highintensity ultrasound-microbubble(HUM-NF) technique to examine the anti-inflammatory effects of the decoy ODN. Western blot analysis was performed to investigate the expression of interleukin(IL)-1β, IL-6 and intercellular adhesion molecule-1(ICAM-1)in the gingival tissues in the HUM-Sc, the HUM-NF and control groups. The fluorescence microscopy results showed that the fluorescent intensity in the periodontal tissues in the LUM-Sc and HUM-Sc groups was significantly higher than that in the A-Sc and the control groups. The fluorescent intensity in the HUM-Sc group, especially in the gingival connective tissue,was the highest of all groups. Western blot analysis indicated that the protein expression levels of IL-1β, IL-6 and ICAM-1 in the HUM-NF group were significantly lower than those in the HUM-Sc and the control groups. These findings suggest that the high-intensity ultrasound-microbubble technique is an effective tool for decoy transfection into the periodontal tissue.

关键词： decoy oligodeoxynucleotide gene therapy periodontal tissue ultrasound

Duodenal stenosis resulting from a preduodenal portal vein and an operation for scoliosis

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World Journal of Gastroenterology 2009年第31期15卷 3950-3953页

作者： Kouji Masumoto risa Teshiba Genshiro Esumi Kouji Nagata Takanori Nakatsuji Yuko Nishimoto Sadako Yamaguchi Kenzo Sumitomo Tomoaki Taguchi Department of Pediatric Surgery Reproductive and Developmental MedicineGraduate School of Medical SciencesKyushu University Department of Clinical Nutrition Kyushu University Hospital Department of Pediatric Surgery Shimonoseki City Central Hospital

A preduodenal portal vein （PDPV） is known to be a rare cause of duodenal stenosis. We treated a 22-yearold male patient with malnutrition as a result of PDPV and a previously performed operation for scoliosis, who showed an improvement in quality of life after being treated with a combination of nutritional support and surgery. The patient with PDPV had been admitted to our department with duodenal stenosis, ranging from the first to third portions. He had suffered from vomiting since 1 year of age, and he developed malnutrition during the last 6-too period after orthopedic surgery for scoliosis. The stenosis was related to both the PDPV and the previously performed operation for scoliosis. After receiving nutritional support for 6 mo, a gastrojejunostomy with Braun＇s anastomosis for the first portion and a duodenojejunostomy for the second and third portions were performed. The postoperative course was almost uneventful. Three months later, he was discharged and able to attend university. In patients with widespread duodenal stenosis, there may be a complicated cause,such as PDPV and duodenal stretching induced by previous spinal surgery.

关键词： Preduodenal portal vein Duodenum Malnutrition Gastrojejunostomy Nutritional support Stenosis

Obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli, Tsukamurella tyrosinosolvens: Minireview of a rare opportunistic pathogen

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World Journal of Clinical Cases 2022年第24期10卷 8443-8449页

作者： Daisuke Usuda risa Tanaka Makoto Suzuki Shintaro Shimozawa Hayabusa Takano Yuta Hotchi Shungo Tokunaga Ippei Osugi risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Department of Medicine Juntendo UniversityBunkyo-ku 113-8421TokyoJapan

Tsukamurella species are obligate aerobic,gram-positive,weak acid-fast,nonmotile *** are found in various environments,such as soil,water,sludge,and petroleum reservoir wastewater,and belong to the order *** 2016,there was a reclassification of species within the genus Tsukamurella,merging the species Tsukamurella tyrosinosolvens(***)and Tsukamurella *** species are clinically considered to be a rare opportunistic pathogen,because most reported cases have been related to bacteremia and intravascular prosthetic devices and *** date,it has been isolated only from human specimens,and has always been associated with clinical disease;human infections are very *** infections have included pneumonia,brain abscesses,catheter-related bloodstream infections,ocular infections,bacteremia,and sepsis presenting with septic pulmonary emboli in patients who are *** date,there is no commercially available test for *** the other hand,sequence-based identification,including matrix-assisted laser desorption ionization time-of-flight mass spectrometry,is an alternative method for identifying clinical isolates that are either slow growers or difficult to identify through biochemical *** golden standards for diagnosis and optimal management still remain to be ***,newer molecular biological techniques can provide accurate identification,and contribute to the appropriate selection of definitive therapy for infections caused by this *** of several antimicrobial agents have been proposed for treatment,though the length of treatment for infections has yet to be determined,and should be individualized according to clinical *** patients often experience severe cases due to infection,and life-threatening *** events associated with dissemination and/or failure of source control have ***

关键词： Tsukamurella tyrosinosolvens Gram-positive bacilli Opportunistic infection Sequence-based identification Matrix-assisted laser desorption ionization time-of-flight mass spectrometry Combination antibiotic therapy

Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience

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World Journal of Hepatology 2018年第1期10卷 88-94页

作者： Rena Kaneko Natsuko Nakazaki risa Omori Yuichiro Yano Masazumi Ogawa Yuzuru Sato Department of Gastroenterology Japan Organization of Occupational Health and Safety Kanto Rosai Hospital

AIM To evaluate the efficacy of direct-acting antivirals(DAAs) in Kanto Rosai Hospital. METHODS All patients with hepatitis C virus(HCV) who underwent DAA prescription were enrolled in this study. The present study was a single center retrospective analysis using patients infected with HCV genotype 1 or 2. Resistance analysis was performed by using direct sequencing and cycleave PCR in genotype 1 patients treated with interferon(IFN)-free DAA. The primary endpoint was sustained virologic response at 12 wk after therapy(SVR12).RESULTS A total of 117 patients participated in the study, including 135 with genotype 1 and 42 with genotype 2. Of the 135 patients with genotype 1, 16 received protease inhibitor + IFN + ribavirin and all achieved SVR. Of the 119 patients who received IFN-free DAA(in different combinations), 102 achieved SVR and 9 failed(7/9 were on daclatasvir/asunaprevir and 2/9 on ledipasvir/sofosbuvir). Efficacy analysis was done only for 43 patients who received daclatasvir/asunaprevir. From this analysis, Y93 resistance-associated substitutions were significantly correlated with *** The SVR rate was 98% for genotype 1 and 100% for genotype 2. However, caution is needed for HCV NS5 A resistance-associated substitutions that are selected by HCV NS5 A inhibitors because cerebrovascular adverse events are induced by some DAA drugs.

关键词： Resistance-associated substitutions Directacting antivirals Sustained viral response Hepatitis C

Professional identities of occupational therapy practitioners in Japan

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Health 2013年第6期5卷 64-71页

作者： risa Takashima Kazuko Saeki Department of Rehabilitation Megumino Care Support-Elderly Care Nursing Facility Eniwa Japan Faculty of Health Sciences Hokkaido University Sapporo Japan

To aim to inductively clarify the professional identity of occupational therapists who work in a clinical setting, the researchers interviewed the 22 occupational therapists who had a minimum of 5 years or more of practice in the field. The professional identities of the practicing occupational therapists were constructed by the following two core categories: “harmonizing with a client’s life and the characteristic of a client’s disability”, and “giving clients sovereignties as a mission of the occupational therapists”. The occupational therapist can carry the role of coordinator in an interdisciplinary team for the clients with disability by understanding them. This is achieved based on the core category called “giving clients sovereignties as a mission of the occupational therapists”. Furthermore, in order to achieve the clients’ sovereignties, the occupational therapist can be an operational unit by planning practical strategies and practicing them based on the core category called “harmonizing with a client’s life and the characteristic of a client’s disability”. The fact is often difficult for these clients that they are concerned with how he/she lived actively. It is through unique ways of contributing for the clients in a team of professionals that the occupational therapists try to understand the clients not as “patients” but as “human beings”, and try to harmonize with their life and the characteristics of their disability, then try to support and empower them to reach a stage in which they have the sovereignties of their lives.

关键词： Occupational Therapist Professional Identity Grounded Theory Approach