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Elucidation of neural circuit mechanism integrating noxious stimulus and ambient temperature sensation in Drosophila

Elucidation of neural circuit mechanism integrating noxious ...

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中国神经科学学会第十二届全国学术会议

作者： Kai Li Koun Onodera risa nishimura Akira Murakami Tadashi Uemura Tadao Usui Uemura Lab. Graduate School of Biostudies Kyoto University

Avoidance of harmful stimuli is essential for animals’ survival. Such a nociceptive response is a protective mechanism to escape from damage to the tissue. Previously, we are interested in Class IV dendritic arborization neurons(Class IV neurons) in Drosophila larvae, which are polymodal nociceptors responsible for thermal, mechanical and light sensation. The activation of these neurons leads to distinct behaviors, depending on the inputs. For example, the noxious thermal stimulation triggers a stereotyped avoidance response named rolling escape behavior. However, the downstream processing mechanism of harmful stimuli is still elusive. Interestingly, in our and other’s behavior tests, we found a group of thermosensory neurons in larval brain can also induce the rolling behavior, which indicated that there is a second input for the behavior(Luo et al., Nature Neurosci., 2016). Based on our behavior test, this central thermosensors might not only be the primary sensory neurons but also the Class IV neurons’ downstream interneurons. Why larva has such thermosensory neurons deep in the brain? How is this second input transduced to the downstream? How such descending input from brain affect the peripheral nociceptive sensation? How are two input integrated by the downstream circuits and contribute to the behavioral decision. We believe such integration of multiple inputs will bring the animal certain ecological benefits. The Drosophila larva is an excellent model system to study such structural and functional patterns of circuits and how such neural circuits make the behavioral selection. It has a relatively small size of nervous system with 00,000 neurons. Its transparent tissue makes it amenable to neuronal activation using optogenetic tools. Moreover, powerful genetic toolkit in Drosophila allow us to anatomically and functionally map circuits. By investigating these particular circuits in Drosophila, we expect that certain universal mechanism underlying integration o

关键词： Drosophila nociception avoidance behavior neural circuit

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