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IFIH1 and DDX58 gene variants in pediatric rheumatic diseases

World Journal of Clinical Pediatrics 2023年第3期12卷 107-114页

作者： rinat raupov.ev.eny suspitsin Konstantin Belozerov Tatiana Gabrusskaya Mikhail Kostik Department of Pediatry Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Genetics Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Gastrointestinal Diseases Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia

BACKGROUND The IFIH1 gene codes the MDA5 protein and the DDX58 gene codes the RIG-I *** proteins are parts of the interferon(IFN)I signaling pathway and are responsible for antiviral defense and innate immune ***1 and DDX58 polymorphisms are associated with a spectrum of autoimmune *** gain-of-function IFIH1 mutations have been found in Singleton-Merten and Aicardi-Goutières syndrome,while DDX58 mutation can cause atypical Singleton-Merten *** To characterize children with pediatric rheumatic diseases(PRD)carrying DDX58 or IFIH1 *** Clinical exome sequencing was performed on 92 children with different ***1 and DDX58 variants have been detected in 14 ***-I score has been analyzed and the clinical characteristics of patients have been *** A total of seven patients with systemic lupus erythematosus(SLE)(n=2),myelodysplastic syndrome with SLE features at the onset of the disease(n=1),mixed connective tissue disease(MCTD)(n=1),undifferentiated systemic autoinflammatory disease(uSAID)(n=3)have 5 different variants of the DDX58 gene.A common non-pathogenic variant p.D580E has been found in five children.A rare variant of uncertain significance(VUS)p.N354S was found in one patient with uSAID,a rare likely non-pathogenic variant p.E37K in one patient with uSAID,and a rare likely pathogenic variant ***864fs in a patient with *** IFN-I score was detected in 6 of 7 patients with DDX58 *** patients had six different IFIH1 *** were presented with uSAID(n=2),juvenile dermatomyositis(JDM)(n=1),SLElike disease(n=1),Periodic fever with aphthous stomatitis,pharyngitis,and adenitis syndrome(n=1),and systemic onset juvenile idiopathic arthritis(n=1).Three patients have VUS p.E627X,one patient has benign variant *** VUS p.R595H was detected in the JDM *** rare VUS p.L679Ifs*2 and previously not reported variant p.V599Ffs*5 were detected in the patient with uS

关键词： IFIH1 DDX58 Undifferentiated systemic autoinflammatory disease Systemic lupus erythematosus Interferon-I score©The Author(s)2023.Published by Baishideng

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BIOMEDICAL OPTOACOUSTICS

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 39-44页

作者： rinat O.ESENALIev Laboratory for Optical Sensing and Monitoring Center for Biomedical Engineering Department of Neuroscience and Cell Biology and Department of Anesthesiology University of Texas Medical Branch Galveston TX 77555-1156USA

Optoacoustics is a promising modality for biomedical imaging,sensing,and monitoring with high resolution and *** this paper,we present an overview of our studies for the last two decades on optoacoustic effects in tissues and imaging capabilities of the optoacoustic *** our earlier optoacoustic works we studied laser ablation of tissues and tissue-like media and proposed to use optoacoustics for imaging in *** mid-90s we demonstrated detection of optoacoustic signals from tissues at depths of up to several centimeters,well deeper than the optical diffusion *** then obtained optoacoustic images of tissues both in vitro and in *** late 90s we studied optoacoustic monitoring of thermotherapy:hyperthermia,coagulation,and *** we proposed and studied optoacoustic monitoring of blood oxygenation,hemoglobin concentration,and other physiologic parameters.

关键词： Optoacoustics imaging monitoring laser ablation nanoparticles

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Outcomes of a 12-month course of early and late rituximab BCD020 biosimilar administration in juvenile systemic lupus erythematosus:A retrospective study

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World Journal of Nephrology 2024年第4期13卷 81-90页

作者： Elvira Kalashnikova Eugenia Isupova Ekaterina Gaidar Natalia Lubimova Lyubov Sorokina Irina Chikova Maria Kaneva rinat raupov Olga Kalashnikova Damir Aliev Inna Gaydukova Mikhail Kostik Hospital Pediatry Saint-Petersburg State Pediatric Medical UniversitySaint Petersburg 194100Sankt-PeterburgRussia Research Laboratory of Autoimmune and Autoinflammatory Diseases World-Class Research Centre for Personalized MedicineAlmazov National Medical Research CentreSaint Petersburg 197341Sankt-PeterburgRussia Pediatric Rheumatology H.Turner National Medical Research Center for Children’s Orthopedics and Trauma SurgerySaint Petersburg 196603Sankt-PeterburgRussia Department of Internal Medicine RheumatologyExamination of Temporary Disability Examination and Quality of Medical Care named after E.E.EichwaldI.I.Mechnikov North-Western State Medical UniversitySaint Petersburg 191015Sankt-PeterburgRussia Department of Rheumatology Clinical Rheumatological Hospital#25Saint Petersburg 190068Sankt-PeterburgRussia

BACKGROUND Juvenile systemic lupus erythematosus(SLE)is a severe,life-threatening ***,the role of rituximab in managing juvenile SLE remains undefined,although early biological intervention may improve disease *** To assess the differences in the outcomes of different types of rituximab administration(early and late).METHODS In this retrospective cohort study,the information of 36 children with SLE with administration(LRA)was *** compared initial disease characteristics at onset,at baseline(start of rituximab),and at the end of the study(EOS)at 12 months,as well as outcomes and treatment *** The main differences at baseline were a higher daily median dose of corticosteroids,increased MAS frequency,and a higher Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)in the ERA *** differences in the main SLE outcomes between groups at the EOS were *** part of lupus nephritis patients who achieved remission changed from 44%to 31%in ERA and 32%to 11%in the LRA *** with ERA had a shorter time to achieve low daily corticosteroid dose(≤0.2 mg/kg)at 1.2(0.9;1.4)years compared to 2.8(2.3;4.0)years(P=0.000001)and higher probability to achieve this low dose[hazard ratio(HR)=57.8(95%confidence interval(CI):7.2-463.2),P=0.00001 and remission(SLEDAI=0);HR=37.6(95%CI:4.45-333.3),P=0.00001].No differences in adverse events,including severe adverse events,were *** ERA demonstrated a better steroid-sparing effect and a possibility of earlier remission or low disease activity,except for lupus *** investigations are required.

关键词： Systemic lupus erythematosus Rituximab Rituximab BCD020 biosimilar Anti-CD-20 Biologic Children

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BCD020 rituximab bioanalog compared to standard treatment in juvenile systemic lupus erythematosus: The data of 12 months casecontrol study

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World Journal of Clinical Pediatrics 2024年第1期13卷 52-61页

作者： Elvira Kalashnikova Eugenia Isupova Ekaterina Gaidar Lyubov Sorokina Maria Kaneva Vera Masalova Margarita Dubko Tatiana Kornishina Natalia Lubimova Ekaterina Kuchinskaya Irina Chikova rinat raupov Olga Kalashnikova Mikhail Kostik Hospital Pediatry Department Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CentreSaint Petersburg 197341Russia Department of Rheumatology Turner National Medical Research Center forСhildren’s Orthopedics and Trauma SurgerySaint-Petetrsburg 197136Russia

BACKGROUND Systemic lupus erythematosus(SLE)is the most frequent and serious systemic connective tissue *** there is no clear guidance on its treatment in *** are a lot of negative effects of standard-of-care treatment(SOCT),including steroid ***(RTX)is the biological B-lymphocyte-depleting agent suggested as a basic therapy in pediatric *** To compare the benefits of RTX above *** The data from case histories of 79 children from the Saint-Petersburg State Pediatric Medical University from 2012 to 2022 years,were *** diagnosis of SLE was established with SLICC *** compared the outcomes of treatment of SLE in children treated with and without *** data,doses of glucocorticosteroids,disease activity measured with SELENA-SLEDAI,RESULTS Patients,treated with RTX initially had a higher degree of disease activity with prevalence of central nervous system and kidney involvement,compared to patients with *** year later the disease characteristics became similar between groups with a more marked reduction of disease activity(SELENA-SLEDAI activity index)in the children who received RTX[-19 points(17;23)since baseline]compared to children with SOCT[-10(5;15.5)points since baseline,P=0.001],the number of patients with active lupus nephritis,and daily *** RTX therapy,infectious diseases had three patients;one patient developed a *** RTX can be considered as the option in the treatment of severe forms of SLE,due to its ability to arrest disease activity compared to SOCT.

关键词： Systemic lupus erythematosus Children Rituximab Anti-B-cell therapy Glucocorticosteroids

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A comparison of emissive and cold floating probe techniques for electric potential measurements in rf inductive discharge

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Plasma Science and Technology 2019年第4期21卷 94-98页

作者： Yaroslav MURZAev Gen nadii LIZIAKIN An drey GAVRIKOV rinat TIMIRKHANOV Valentin SMIRNOV Joint Institute for High Temperatures of the Russian Academy of Sciences 125412Izhorskaya 13Bd 2MoscowRussia

A cold floating probe method was compared with the emissive floating probe method in terms of a low-pressure radio-frequency inductive *** dependences of difference between the plasma potential and the floating potential on the electron temperature 1-8 ev,plasma density 109-1012 cm 3 and magnetic field 100-650 G were *** was demonstrated that the difference between the potentials that obtained by these two methods can differ significantly from the expected value of 5.2 kTe/e for argon.

关键词： emissive probe floating probe rf inductive discharge plasma potential measurement

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Multimodal bioimaging based on gold nanorod and carbon dot nanohybrids as a novel tool for atherosclerosis detection

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Nano Research 2018年第3期11卷 1262-1273页

作者： Xiaojing Liu Luting Liu Xiujie Hu Shuyun Zhou rinat Ankri Dror Fixler Zheng Xie Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Faculty of Engineering and Institute of Nanotechnology and Advanced Materials Bar-Ilan University Ramat-Gan 52900 Israel

Advanced biocompatible and robust platforms equipped with diverse properties are highly required in biomedical imaging applications for the early detection of atherosclerotic vascular disease and cancers. Designing nanohybrids composed of noble metals and fluorescent materials is a new way to perform multimodal imaging to overcome the limitations of single-modality counterparts. Herein, we propose the novel design of a multimodal contrast agent; namely, an enhanced nanohybrid comprising gold nanorods （GNRs） and carbon dots （CDs） with silica （SiO2） as a bridge. The nanohybrid （GNR@SiO2@CD） construction is based on covalent bonding between SiO2 and the silane-functionalized CDs, which links the GNRs with the CDs to form typical core-shell units. The novel structure not only retains and even highly improves the optical properties of the GNRs and CDs, but also possesses superior imaging performance in both diffusion reflection （DR） and fluorescence lifetime imaging microscopy （FLIM） measurements compared with bare GNRs or fluorescence dyes and CDs. The superior bioimaging properties of the GNR@SiOa@CD nanohybrids were successfully exploited for in vitro DR and FLIM measurements of macrophages within tissue-like phantoms, paving the way toward a theranostic contrast agent for atherosclerosis and cancer.

关键词： nanohybrids multimodal imagingcontrast agent diffusion reflection fluorescence lifetimeimaging atherosclerosis macrophages

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Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration

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Regenerative Biomaterials 2023年第1期10卷 1248-1260页

作者： rinat Nigmatullin Caroline STaylor Pooja Basnett Barbara Lukasiewicz Alexandra Paxinou Lorena RLizarraga-Valderrama John WHaycock Ipsita Roy Higher Steaks Ltd. 25 Cambridge Science Park RdMiltonCambridge CB40FWUK School of Life Sciences College of Liberal Arts and SciencesUniversity of WestminsterLondon W1B 2HWUK Department of Materials Science&and Engineering The University of SheffieldSheffield S37HQUK Foundation of Research and Technology Hellas Institute of Chemical Engineering and High Temperature Chemical Processes(FORTH/ICE-HT)P.O.Box 1414GR 26504RionPatrasGreece School of Life Sciences Queen’s Medical CentreUniversity of NottinghamNottingham NG72UHUK

Polyhydroxyalkanoates are natural,biodegradable,thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue *** describe a comparative evaluation of three medium chain length polyhydroxyalkanoates(mcl-PHAs),namely poly(3-hydroxyoctanoate),poly(3-hydroxyoctanoate-co-3-hydoxydecanoate)and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate),one short chain length polyhydroxyalkanoate,poly(3-hydroxybutyrate),P(3HB)and synthetic aliphatic polyesters(polycaprolactone and polylactide)with a specific focus on nerve regeneration,due to mechanical properties of mcl-PHAs closely matching nerve *** vitro biological studies with NG108-15 neuronal cell and primary Schwann cells did not show a cytotoxic effect of the materials on both cell *** mcl-PHAs supported cell adhesion and *** the three mcl-PHAs,P(3HO-co-3HD)exhibited superior properties with regards to numbers of cells adhered and viable cells for both cell types,number of neurite extensions from NG108-15 cells,average length of neurite extensions and Schwann ***,similar characteristics were observed for flat P(3HB)surfaces,high rigidity of this biomaterial,and FDA-approved polymers such as PLLA,limits their applications in peripheral nerve ***,we have designed,synthesized and evaluated these materials for nerve tissue engineering and regenerative medicine,the interaction of mcl-PHAs with neuronal and Schwann cells,identifying mcl-PHAs as excellent materials to enhance nerve regeneration and potentially their clinical application in peripheral nerve repair.

关键词： peripheral nerve injury nerve regeneration biomaterials mcl-polyhydroxyalkanoates Schwann cells NG108-15

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Deep Learning-Enabled Brain Stroke Classification on Computed Tomography Images

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Computers, Materials & Continua 2023年第4期75卷 1431-1446页

作者： Azhar Tursynova Batyrkhan Omarov Natalya Tukenova Indira Salgozha Onergul Khaaval rinat Ramazanov Bagdat Ospanov Al-Farabi Kazakh National University AlmatyKazakhstan International University of Tourism and Hospitality TurkistanKazakhstan Zhetisu University Named After I.Zhansugurov TaldykorganKazakhstan Abai Kazakh National Pedagogical University AlmatyKazakhstan Brunch Center of Excellence in Taldykorgan TaldykorganKazakhstan

In the field of stroke imaging, deep learning (DL) has enormousuntapped *** clinically significant symptoms of a cerebral strokeare detected, it is crucial to make an urgent diagnosis using available imagingtechniques such as computed tomography (CT) scans. The purpose of thiswork is to classify brain CT images as normal, surviving ischemia or cerebralhemorrhage based on the convolutional neural network (CNN) model. In thisstudy, we propose a computer-aided diagnostic system (CAD) for categorizingcerebral strokes using computed tomography images. Horizontal flip datamagnification techniques were used to obtain more accurate *** Data Generator to magnify the image in real time and apply anyrandom transformations to each training image. An early stopping method toavoid overtraining. As a result, the proposed methods improved several estimationparameters such as accuracy and recall, compared to other machinelearning methods. A python web application was created to demonstrate theresults of CNN model classification using cloud development techniques. Inour case, the model correctly identified the drawing class as normal with 79%accuracy. Based on the collected results, it was determined that the presentedautomated diagnostic system could be used to assist medical professionals indetecting and classifying brain strokes.

关键词： Ischemic stroke hemorrhage CNN deep learning classification

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Must We Release All Sinners Because of Our Sins？ Clemency Power in Shakespeare＇s Measure for Measure

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Journal of Literature and Art Studies 2017年第5期7卷 500-512页

作者： rinat Kitai-Sangero Cannel Academic Center and College of Law and Business Ramat Gan Israel

The paper examines the concepts of justice and mercy in Shakespeare＇s play Measure for Measure. As opposed to the strict meaning of the term ＂Measure for Measure＂, analysis of the play demonstrates that it endorses for various reasons the ideas of mercy and clemency, and the conception that every person is entitled to and is capable of redemption.

关键词： retribution clemency mercy Measure for Measure

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Communicating Different and Higher across the Praxis of Bloom’s Taxonomy While Shifting toward Health at every Size (HAES)

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Health 2015年第6期7卷 788-799页

作者： Ofra Walter rinat Ezra Tel-Hai Academic College Kiryat Shemona Iseral Independent Researcher University College London London UK

The majority of recent studies on prevention and control of childhood obesity focus on methods for achieving weight loss. In contrast, the Health at every Size (HAES) paradigm fosters improved health behaviors for people of all sizes by emphasizing natural diversity of body type and attention to social, emotional, and spiritual factors in addition to physical ones. This study examined introduction of the HAES paradigm to student teachers using different communication models while moving across the learning domains of Bloom’s Taxonomy. The qualitative research tested a face-to-face verbal communication model and a Computer-Mediated Communication (CMC) module and its blog. It was also based upon reflection diaries recorded by participants using both models. Participants included Druze, Jewish, and Bedouin students at a teacher training program in northern Israel. The student teachers succeeded in developing the HAES concepts further while demonstrating the higher domain levels across Bloom’s Taxonomy. These higher levels emerged when engaging with theoretical concepts and practical dilemmas relating to the HAES concepts of health promotion, body image, well-being, and self-worth. Challenging the appreciation of HAES using different communication models can be translated into diverse contexts of Health Education Practices.

关键词： Health at every Size Bloom’s Taxonomy Communication Health Promotion Body Image Well-Being and Self-Worth Health Education Practices

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