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Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration

Regenerative Biomaterials 2023年第1期10卷 1248-1260页

作者： rinat Nigmatullin Caroline STaylor Pooja Basnett Barbara Lukasiewicz Alexandra Paxinou Lorena RLizarraga-valderrama John WHaycock Ipsita Roy Higher Steaks Ltd. 25 Cambridge Science Park RdMiltonCambridge CB40FWUK School of Life Sciences College of Liberal Arts and SciencesUniversity of WestminsterLondon W1B 2HWUK Department of Materials Science&and Engineering The University of SheffieldSheffield S37HQUK Foundation of Research and Technology Hellas Institute of Chemical Engineering and High Temperature Chemical Processes(FORTH/ICE-HT)P.O.Box 1414GR 26504RionPatrasGreece School of Life Sciences Queen’s Medical CentreUniversity of NottinghamNottingham NG72UHUK

Polyhydroxyalkanoates are natural,biodegradable,thermoplastic and sustainable polymers with a huge potential in fabrication of bioresorbable implantable devices for tissue *** describe a comparative evaluation of three medium chain length polyhydroxyalkanoates(mcl-PHAs),namely poly(3-hydroxyoctanoate),poly(3-hydroxyoctanoate-co-3-hydoxydecanoate)and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate),one short chain length polyhydroxyalkanoate,poly(3-hydroxybutyrate),P(3HB)and synthetic aliphatic polyesters(polycaprolactone and polylactide)with a specific focus on nerve regeneration,due to mechanical properties of mcl-PHAs closely matching nerve *** vitro biological studies with NG108-15 neuronal cell and primary Schwann cells did not show a cytotoxic effect of the materials on both cell *** mcl-PHAs supported cell adhesion and *** the three mcl-PHAs,P(3HO-co-3HD)exhibited superior properties with regards to numbers of cells adhered and viable cells for both cell types,number of neurite extensions from NG108-15 cells,average length of neurite extensions and Schwann ***,similar characteristics were observed for flat P(3HB)surfaces,high rigidity of this biomaterial,and FDA-approved polymers such as PLLA,limits their applications in peripheral nerve ***,we have designed,synthesized and evaluated these materials for nerve tissue engineering and regenerative medicine,the interaction of mcl-PHAs with neuronal and Schwann cells,identifying mcl-PHAs as excellent materials to enhance nerve regeneration and potentially their clinical application in peripheral nerve repair.

关键词： peripheral nerve injury nerve regeneration biomaterials mcl-polyhydroxyalkanoates Schwann cells NG108-15

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IFIH1 and DDX58 gene variants in pediatric rheumatic diseases

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World Journal of Clinical Pediatrics 2023年第3期12卷 107-114页

作者： rinat raup.v Evgeny Suspitsin Konstantin Belozerov Tatiana Gabrusskaya Mikhail Kostik Department of Pediatry Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Genetics Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Gastrointestinal Diseases Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia

BACKGROUND The IFIH1 gene codes the MDA5 protein and the DDX58 gene codes the RIG-I *** proteins are parts of the interferon(IFN)I signaling pathway and are responsible for antiviral defense and innate immune ***1 and DDX58 polymorphisms are associated with a spectrum of autoimmune *** gain-of-function IFIH1 mutations have been found in Singleton-Merten and Aicardi-Goutières syndrome,while DDX58 mutation can cause atypical Singleton-Merten *** To characterize children with pediatric rheumatic diseases(PRD)carrying DDX58 or IFIH1 *** Clinical exome sequencing was performed on 92 children with different ***1 and DDX58 variants have been detected in 14 ***-I score has been analyzed and the clinical characteristics of patients have been *** A total of seven patients with systemic lupus erythematosus(SLE)(n=2),myelodysplastic syndrome with SLE features at the onset of the disease(n=1),mixed connective tissue disease(MCTD)(n=1),undifferentiated systemic autoinflammatory disease(uSAID)(n=3)have 5 different variants of the DDX58 gene.A common non-pathogenic variant p.D580E has been found in five children.A rare variant of uncertain significance(vUS)p.N354S was found in one patient with uSAID,a rare likely non-pathogenic variant p.E37K in one patient with uSAID,and a rare likely pathogenic variant ***864fs in a patient with *** IFN-I score was detected in 6 of 7 patients with DDX58 *** patients had six different IFIH1 *** were presented with uSAID(n=2),juvenile dermatomyositis(JDM)(n=1),SLElike disease(n=1),Periodic fever with aphthous stomatitis,pharyngitis,and adenitis syndrome(n=1),and systemic onset juvenile idiopathic arthritis(n=1).Three patients have vUS p.E627X,one patient has benign variant *** vUS p.R595H was detected in the JDM *** rare vUS p.L679Ifs*2 and previously not reported variant p.v599Ffs*5 were detected in the patient with uS

关键词： IFIH1 DDX58 Undifferentiated systemic autoinflammatory disease Systemic lupus erythematosus Interferon-I score©The Author(s)2023.Published by Baishideng

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The Influence of Ceric Oxide on Phase Composition and Activity of Iron Oxide Catalysts

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Advances in Chemical Engineering and Science 2012年第1期2卷 28-33页

作者： Aleksandr A. Lamberov Ekaterina v. Dementyeva Dmitriy I. vavilov Olga v. Kuzmina rinat R. Gilmullin Ekaterina A. Pavlova 不详

The process of dehydrogenation of methyl butenes to isoprene is conducted in the presence of iron oxide catalysts whose composition may include oxides of alkaline metals, alkaline earth metals, and transition metals. Catalysts of latest generation can also contain oxides of rare earth elements, particularly cerium oxide. However there is no any common opinion concerning its effect on catalytic properties of iron oxide catalysts. It is well known that ceric oxide has a positive effect on the quantity and stability of active centers and can play a critical role in a redox cycle of the dehydrogenation process. By means of differential thermal analysis, dispersion analysis and X-ray phase analysis, it was found in present study that introducing of ceric oxide promotes the decrease in hematite crystallite sizes. At the same time, it prevents potassium polyferrites formation, with the equilibrium of topochemical reaction between ferric oxide and po tassium carbonates moving predominantly to the formation of intermediate products–monoferrite systems, having greater catalytic activity. The increase in potassium monoferrite content results in dispersion of particles in the Fe2O3-K2CO3-СеО2 system that is accompanied by modification of texture characteristics. For this catalyst composition, the optimum concentration of ceric oxide (8.7 wt.%), leading to the formation of a certain ratio of mono- and polyferrite phases, was found. If more than 8.7 wt.% of СеО2 is introduced, the modification of texture characteristics of catalyst samples takes place, that negatively affects their selectivity.

关键词： Process of Dehydrogenation Ferric Oxide Ceric Oxide Monoferrite and Polyferrite Systems

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Search for Molecular Markers of Wheat Resistance to Fungal Pathogens

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Agricultural Sciences 2014年第8期5卷 722-729页

作者： Liubov G. Yarullina Svetlana v. veselova rinat I. Ibragimov Irina A. Shpirnaya Rita I. Kasimova Albina R. Akhatova vyacheslav O. Tsvetkov Igor v. Maksimov Bashkir State University Ufa Russia Institute of Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Sciences Ufa Russia

Functional traits, potentially associated with resistance to infection, were investigated in cultivars of bread wheat. Plant responses to infection by hemibiotrophic fungus Stagonospora (Septoria) nodorum were studied under laboratory conditions. Infection-induced up-regulation of genes coding for class III peroxidase, oxalate oxidase and protease inhibitor was greater in leaves with reduced disease symptoms (percentage of chlorotic or necrotic leaf area). Similar association was detected between activity of pectinase inhibitors and disease severity. Resistant cultivar also differed from the susceptible one by increased content of Н2О2 in infected tissues and more intensive deposition of lignin. We discuss possibility of using these functional traits in plant breeding for increased stress tolerance.

关键词： Infection Peroxidase Oxalate Oxidase Protease Inhibitor Pectinase Inhibitor PR-Gene Expression Н2О2 Lignin Wheat

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