检索结果-南通市图书馆

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell(cDC1)activation and tumor infiltration

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2804-2818页

作者： Fenglian He Zhongen Wu Chenglong Liu Yuanyuan Zhu Yan Zhou Enming Tian rina rosin-arbesfeld Dehua Yang Ming-Wei Wang Di Zhu Department of Pharmacology Minhang Hospitaland Key Laboratory of Smart Drug DeliveryShanghai Engineering Research Center of Immune TherapySchool of PharmacyFudan UniversityShanghai 201203China The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai 201203China Department of Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources SanyaChina Department of Chemistry School of ScienceThe University of TokyoTokyoJapan Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education School of PharmacyHainan Medical UniversityHaikouChina Shandong Academy of Pharmaceutical Science JinanChina

Conventional type 1 dendritic cells(cDC1)are the essential antigen-presenting DC subset in antitumor *** B-cell lymphoma 9 and B-cell lymphoma 9-like(BCL9/BCL9L)inhibits tumor growth and boosts immune responses against ***,whether oncogenic BCL9/BCL9L impairs antigen presentation in tumors is still not completely ***,we show that targeting BCL9/BCL9L enhanced antigen presentation by stimulating cDC1 activation and infiltration into *** inhibition of BCL9/BCL9L with a novel inhibitor hsBCL9z96 or Bcl9/Bcl9l knockout mice markedly delayed tumor growth and promoted antitumor CD8^(+)T cell ***,targeting BCL9/BCL9L promoted antigen presentation in *** is due to the increase of cDC1 activation and tumor infiltration by the XCL1-XCR1 ***,using single-cell transcriptomics analysis,we found that Bcl9/Bcl9l deficient cDC1 were superior to wild-type(WT)cDC1 at activation and antigen presentation via NF-κB/IRF1 ***,we demonstrate that targeting BCL9/BCL9L plays a crucial role in cDC1-modulated antigen presentation of tumor-derived antigens,as well as CD8^(+)T cell activation and tumor *** BCL9/BCL9L to regulate cDC1 function and directly orchestrate a positive feedback loop necessary for optimal antitumor immunity could serve as a potential strategy to counter immune suppression and enhance cancer immunotherapy.

关键词： immunity Targeting markedly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ChatGPT is a Remarkable Tool—For Experts

引用

Data Intelligence 2024年第1期6卷 240-296页

作者： Amos Azaria rina Azoulay Shulamit Reches School of Computer Science Ariel UniversityIsrael Department of Computer Science Jerusalem College of TechnologyIsrael Department of Mathematics Jerusalem College of TechnologyIsrael

This paper investigates the capabilities of ChatGPT as an automated assistant in diverse domains,including scientific writing,mathematics,education,programming,and *** explore the potential of ChatGPT to enhance productivity,streamline problem-solving processes,and improve writing ***,we highlight the potential risks associated with excessive reliance on ChatGPT in these *** limitations encompass factors like incorrect and fictitious responses,inaccuracies in code,limited logical reasoning abilities,overconfidence,and critical ethical concerns of copyright and privacy *** outline areas and objectives where ChatGPT proves beneficial,applications where it should be used judiciously,and scenarios where its reliability may be *** light of observed limitations,and given that the tool's fundamental errors may pose a special challenge for non-experts,ChatGPT should be used with a strategic *** drawing from comprehensive experimental studies,we offer methods and flowcharts for effectively using *** recommendations emphasize iterative interaction with ChatGPT and independent verification of its *** the importance of utilizing ChatGPT judiciously and with expertise,we recommend its usage for experts who are well-versed in the respective domains.

关键词： limitations utilizing Tool

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of Blade-Flapping Vibration on Aerodynamic Characteristics of Wind Turbines under Yaw Conditions

引用

Energy Engineering 2024年第8期121卷 2213-2229页

作者： Shaokun Liu Zhiying Gao rina Su Mengmeng Yan Jianwen Wang College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010051China Key Laboratory of Wind and Solar Energy Utilization Technology Ministry of EducationHohhot010051China

Although the aerodynamic loading of wind turbine blades under various conditions has been widely studied,the radial distribution of load along the blade under various yaw conditions and with blade flapping phenomena is poorly *** study aims to investigate the effects of second-order flapwise vibration on the mean and fluctuation characteristics of the torque and axial thrust of wind turbines under yaw conditions using computational fluid dynamics(CFD).In the CFD model,the blades are segmented radially to comprehensively analyze the distribution patterns of torque,axial load,and tangential *** following results are obtained.(i)After applying flapwise vibration,the torque and axial thrust of wind turbines decrease in relation to those of the rigid model,with significantly increased fluctuations.(ii)Flapwise vibration causes the blades to reciprocate along the axial direction,altering the local angle of attack and velocity of the blades relative to the incoming wind *** results in the contraction of the torque region from a circular shape to a complex“gear”shape,which is accompanied by evident oscillations.(iii)Compared to the tangential load,the axial load on the blades is more sensitive to flapwise vibration although both exhibit significantly enhanced *** study not only reveals the impact of flapwise vibration on wind turbine blade performance,including the reduction of torque and axial thrust and increased operational fluctuations,but also clarifies the radial distribution patterns of blade aerodynamic characteristics,which is of great significance for optimizing wind turbine blade design and reducing fatigue risks.

关键词： Wind turbine CFD numerical simulation aerodynamic characteristics yaw flapping vibration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots

引用

Chinese Herbal Medicines 2024年第3期16卷 392-400页

作者： Lin Shi Tong Cui Xinyue Wang rina Wu Junrui Wu Yanqun Wang Weiming Wang College of Food Science Shenyang Agricultural UniversityShenyang 110866China Institute of Chinese Materia Medica Heilongjiang Academy of Chinese Medicine SciencesHarbin 150036China

In Northeast China,Goubao pickle is a popular food fermented from the roots of Platycodon grandiflorum as the main material,offering a unique flavor and rich nutritional *** in roots of *** may play a crucial role in determining the quality of Goubao pickle through microorganism ***,biotransfermation of platycosides has not been reviewed during *** this study,we reviewed platycosides in chemical diversity,metabolic processes in vivo,biotransformation of platycosides in vitro,and pharmacological ***,we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.

关键词： biotransformation Goubao pickle microorganisms pharmacological activities platycosides Platycodon grandiflorum(Jacq.)A.DC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on the quality deterioration of UHT milk products during shelf life:core microorganisms and related characteristics

引用

Food Science and Human Wellness 2024年第5期13卷 2866-2875页

作者： Ruixue Ding Kairu He rina Wu Mengxue Lou Zhili Liu Yuqiong Piao Xiaoyan Liu Zhishen Mu Junrui Wu College of Food Science Shenyang Agricultural UniversityShenyang 110866China Shenyang Key Laboratory of Microbial Fermentation Technology Innovation Shenyang 110866China Liaoning Engineering Research Center of Food Fermentation Technology Shenyang 110866China Inner Mongolia Mengniu Dairy Grp.Co. Ltd.Hohhot 010000China

Commercial sterility does not guarantee the sustained stability of ultrahigh temperature(UHT)milk over 6 months shelf *** explore the microbiota presented in normal(SZ)and quality deteriorated UHT milk(QY and WY)products from the same *** on high-throughput sequencing research results,11 phyla and 54 genera were identified as dominant ***,Streptococcus,and Acinetobacter as core functional microbiota significantly influenced the UHT milk quality ***,principal component analysis(PCA)and multivariate analyses were used to examine the quality characteristics,including 11 physicochemical parameters,10 fatty acids,and 2 enzyme activities,in normal and quality deteriorated UHT *** found that the abundance of Pseudomonas increased in quality deteriorated milk(WY)and showed a significant positive correlation with heat-resistant protease *** in quality deteriorated milk(QY)also considerably contributed to the content of heat-resistant lipase,which resulted in spoilage deterioration of UHT milk.

关键词： Ultrahigh temperature(UHT) Quality deterioration High-throughput sequencing Core functional microbiota Lipase Protease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

海上丝路与中国天文历法在日本的传播及影响研究

引用

自然辩证法通讯 2024年第4期46卷 57-65页

作者：萨日娜上海交通大学科学史与科学文化研究院上海200240

经过海上丝路有大量汉文科学典籍传入日本并产生了重要的影响,天文历法知识是其中重要的一个方面。文中通过史料调查和实证考察,探索了魏晋南北朝时期,中国天文知识传日背景;研究隋唐时期,随着海上丝路的发展,日本留学生(僧)把中国天文... 详细信息

经过海上丝路有大量汉文科学典籍传入日本并产生了重要的影响,天文历法知识是其中重要的一个方面。文中通过史料调查和实证考察,探索了魏晋南北朝时期,中国天文知识传日背景;研究隋唐时期,随着海上丝路的发展,日本留学生(僧)把中国天文知识传至日本的详情,尤其考察了唐历《宣明历》在日本使用八百多年之久的缘由;继而分析了宋元明时期,中国传统天文历法持续传日,并对其传统学术建构产生的深远影响。结论认为研究中日传统天文历法的关联性,不仅有助于认识海上丝路文明对日本传统科技的影响,对提升中华传统文化的国际传播力和影响力也有一定的借鉴意义。

关键词：海上丝路天文历法传统科技中日交流

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

引用

Chinese Medical Journal 2024年第13期137卷 1563-1575页

作者： Jie Ning Jing Huai Shuxian Wang Jie Yan rina Su Muqiu Zhang Mengtong Liu Huixia Yang Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Foetal Medicine of Gestational Diabetes Mellitus Beijing 100034China Peking University Beijing 100034China

Background:Alterations in the placental expression of glucose transporters(GLUTs),the crucial maternal-fetal nutrient transporters,have been found in women with hyperglycemia in pregnancy(HIP).However,there is still uncertainty about the underlying effect of the high-glucose environment on placental GLUTs expression in ***:We quantitatively evaluated the activity of mammalian target of rapamycin(mTOR)and expression of GLUTs(GLUT1,GLUT3,and GLUT4)in the placenta of women with normal pregnancies(CTRL,n=12)and pregnant women complicated with poorly controlled type 2 diabetes mellitus(T2DM,n=12)by *** addition,BeWo cells were treated with different glucose concentrations to verify the regulation of ***,changes in the expression of GLUTs following the activation or suppression of the mTOR pathway were also assessed using MHY1485/rapamycin(RAPA)treatment or small interfering RNA(siRNA)-mediated silencing ***,we further explored the alteration and potential upstream regulatory role of methyltransferase-like 3(METTL3)when exposed to ***:mTOR,phosphorylated mTOR(p-mTOR),and GLUT1 protein levels were upregulated in the placenta of women with T2DM compared with those *** BeWo cells,mTOR activity increased with increasing glucose concentration,and the expression of GLUT1,GLUT3,and GLUT4 as well as GLUT1 cell membrane translocation were upregulated by hyperglycemia to varying *** the drug-mediated and genetic depletion of mTOR signaling in BeWo cells suppressed GLUTs expression,whereas MHY1485-induced mTOR activation upregulated GLUTs ***,high glucose levels upregulated METTL3 expression and nuclear translocation,and decreasing METTL3 levels suppressed GLUTs expression and mTOR activity and vice ***,in METTL3 knockdown BeWo cells,the inhibitory effect on GLUTs expression was eliminated by activating the mTOR signaling pathway using ***:High-g

关键词： Glucose transporters Hyperglycemia Type 2 diabetes mellitus Pregnancy Mammalian target of rapamycin Methyltransferase-like 3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stresses in the Scapular Fossa Do Not Exceed the Yield Stress When Elevated up to 135 Degrees of Abduction after Reverse Shoulder Arthroplasty

引用

Journal of Biomedical Science and Engineering 2024年第2期17卷 35-40页

作者： rina Sakai Tomonori Kenmoku Ryo Tazawa Kazuhiro Yoshida Tomomi Mizuhashi Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Department of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Kitasato University Graduate School of Medical Sciences Sagamihara Japan

Reverse shoulder arthroplasty (RSA) is an effective treatment for rotator cuff tears. Despite its advantages, complications occur at a high rate. Complications requiring revision include a high rate of base plate failure, 38% of which are due to instability. The primary stability the base plate ensures is a crucial factor and, thus, is the subject of much debate in clinical studies and biomechanical research. This study is aimed to provide data that will contribute to the base plate’s pri-mary stability and glenoid longevity by clarifying the stresses at the scapular fossa and base plate interface associated with elevation after RSA. A 3D finite element model was created from the DICOM data for the scapulohumeral joint and SMR shoulder system. For loading conditions, 30 N was applied for each posi-tion with abduction angles of 0, 45, 90, and 135 degrees. A three-dimensional fi-nite element analysis was performed using the static implicit method with LS-DYNA. The von Mises stresses in the scapular fossa were found not to exceed the yield stress on the bone even after elevation to an abduction angle of 135 de-grees after RSA. It is rough to uniformly compare the yield stress and the von Mises stress, but it was inferred that the possibility of fracture is low unless a large external force is applied. A maximum von Mises stress showed 0 degrees of abduction, suggesting that the lowered position is in a more severe condition than the elevated position. If better improvement is desired, it may be necessary to devise ways to reduce the stress on the upper screw. .

关键词： Reverse Shoulder Arthroplasty Finite Element Analysis Yield Stress Glenoid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flow Rate Measurement of Gravity Infusion Set and Functional Evaluation of Drop Counter: A Pilot Study

引用

Journal of Biomedical Science and Engineering 2024年第7期17卷 129-135页

作者： rina Sakai Shuichi Tanaka Kaya Murakami Tomomi Mizuhashi Kazuhiro Yoshida Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Faculty of Medical Engineering Gunma University of Health and Welfare Maebashi Japan Kitasato University Graduate School of Medical Sciences Sagamihara Japan

Developing a novel drop counter by introducing the Internet of Things concept has been vigorously conducted in recent years. Understanding the newly introduced drop counter’s flow rate control accuracy and flow rate count feature is essential for improving safety in infusion management. This study aimed to verify if the new drop counters could secure accurate flow rate and drip count by conducting actual flow rate measurements using gravimetry and functional evaluation. A drop counter was attached to each drip chamber of the infusion set, and an IV drip was conducted at the 100 ml/h flow rate. The weight of discharged physiological saline was measured to plot trumpet curves. Next, three different types of drop counters were evaluated to determine if they maintained drip count accuracy according to the changes in their position angles. The flow rate errors in all conditions indicated trumpet-like curves, exhibiting an overall error range within ±10% in all observation windows. Although every drop counter successfully detected and measured dripping, it was challenging in some counters to detect dripping when the drip chamber was tilted. In comparing adult and pediatric IV sets, the adult IV set was found to be less likely to detect dripping in the angled position. No significant differences in results were confirmed between high and low flow rates, suggesting that the drop count function would not be affected by the flow rate in the ranges of typical infusion practices. Doppler sensors have a wide range of measurements and high sensitivity;the dripping was detected successfully even when the drip chamber was tilted, probably due to the advantages of these sensors. In contrast, miscounts occurred in those equipped with infrared sensors, which could not detect light intensity changes in tilted positions. Understanding the tendencies in flow rate errors in infusion can be valuable information for infusion management.

关键词： Gravity Infusion Set Drop Counter IV Fluids Flow Rate Trumpet Curves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

激光散射特性的红外瞄准镜基线检测方法

引用

激光杂志 2024年第7期45卷 227-232页

作者：李波莎日娜内蒙古医科大学呼和浩特010110 中国人民解放军32302部队50分队北京101400

为提升武器射击精度,设计激光散射特性的红外瞄准镜基线检测方法。通过固定瞄准镜并利用黑体发射红外激光,在镜子反射后形成红外平行光束,并在瞄准镜视场内生成靶标的像。通过调整瞄准镜分划中心与靶标像中心重合,实现基线检测。采用双... 详细信息

为提升武器射击精度,设计激光散射特性的红外瞄准镜基线检测方法。通过固定瞄准镜并利用黑体发射红外激光,在镜子反射后形成红外平行光束,并在瞄准镜视场内生成靶标的像。通过调整瞄准镜分划中心与靶标像中心重合,实现基线检测。采用双向反射分布函数和基尔霍夫近似理论的驻留相位近似法,分析红外激光的散射特性及波长与散射角对成像精度的影响,从而提高基线检测的精度。实验证明:当入射波长在9.5μm左右时,射击目标粗糙度为8μm时,双站极化散射系数最低,在1.0左右;当散射角在29°左右时,射击目标粗糙度为8μm时,双站极化散射系数最低在0.146左右;校正后目标位置偏差平均为0.01 m。

关键词：激光散射特性红外瞄准镜基线检测反射分布函数基尔霍夫驻留相位近似法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：