检索结果-南通市图书馆

Evaluation of the chemical profile from four germplasms sources of Pruni Semen using UHPLC-LTQ-Orbitrap-MS and multivariate analyses

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Journal of Pharmaceutical Analysis 2022年第5期12卷 733-742页

作者： Zihan Zhao Yue Liu Yushi Zhang Zeyu Geng Rina Su Lipeng Zhou Chao Han Zhanjun Wang Shuangcheng Ma Weidong Li School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Institute of Forestry and Grassland Ecology Ningxia Academy of Agricultural and Forestry SciencesYinchuan750002China Institute for Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing100050China

Pruni Semen,the seed of several unique Prunus plants,is a traditional purgative herbal material.To determine the authentic sources of Pruni Semen,46 samples from four species were collected and analyzed.Ten compounds including multiflorin A(Mul A),a notable purative compound,were isolated and identified by chemical separation and nuclear magnetic resonance spectroscopy.Seventy-six communal components were identified by ultra-high performance liquid chromatography with linear ion trap-quadrupole Orbitrap mass spectrometry,and acetyl flavonoid glycosides were recognized as characteristic constituents.The flavonoids were distributed in the seed coat and cyanogenic glycosides in the kernel.Based on this,methods for identifying Pruni Semen from different sources were established using chemical fingerprinting,quantitative analysis of the eight principal compounds,hierarchical cluster analysis,principal component analysis,and orthogonal partial least squares discriminant analysis.The results showed that the samples were divided into two categories:one is the small seeds from Prunus humilis(Ph)and Prunus japonica(Pj),and the other is the big seeds from Prunus pedunculata(Pp)and Prunus triloba(Pt).The average content of Mul A was 3.02,6.93,0.40,and 0.29 mg/g,while the average content of amygdalin was 18.5,17.7,31.5,and 30.9 mg/g in Ph,Pj,Pp,and Pt,respectively.All the above information suggests that small seeds might be superior sources of Pruni Semen.This is the first comprehensive report on the identification of chemical components in Pruni Semen from different species.

关键词： Pruni semen Acetyl flavonoids Amygdalin Multivariate analyses Authentic sources

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Incidence and Clinical Risk Factors for Preeclampsia and Its subtypes:A Population-Based Study in Beijing,China

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Maternal-Fetal Medicine 2021年第2期3卷 91-99页

作者： Li Lin Jing Huai Rina Su Chen Wang Boya Li Huixia Yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus Beijing 100034China

Objective:This study aimed to evaluate the incidence and associated clinical risk factors for preeclampsia(PE)and its subtypes in a large multicentre retrospective study of Beijing,China.Methods:This study was conducted as a secondary analysis from the Gestational diabetes mellitus Prevalence survey(GPS),a multicentre retrospective cohort study,which included 15 hospitals in Beijing,China.This analysis included 15,003 pregnant women who delivered in Beijing from June 20th to November 30th,2013.The incidence of PE was calculated.Risk factors for PE,including maternal age,pre-gestational body mass index(BMI),parity,chronic hypertension,pre-existing diabetes,and gestational diabetes mellitus,were assessed.PE was defined as early-or late-onset PE based on clinical manifestations during the week of delivery,and mild or severe PE based on the severity of the disease.Logistic regression analysis was used to quantify the association with the risk factors,and data were displayed as odds risks(OR)and 95%confidence interval(CI).Results:The overall incidence of PE was 2.65%(397/15,003).The prevalence of early-onset and late-onset PE was 0.36%(54/15,003)and 2.29%(343/15,003),respectively.The prevalence of mild and severe PE was 0.91%(137/15,003)and 1.73%(260/15,003),respectively.Risk factors including high BMI considered overweight(adjusted odds risk(aOR):1.48;95%CI:1.06-2.05;P=0.02)and obesity(aOR:2.15;95%CI:1.50-3.08;P<0.001),nulliparity(aOR:1.73;95%CI:1.32-2.25;P<0.001),multiple gestation(aOR:4.58;95%CI:2.86-7.32;P<0.001),and chronic hypertension(aOR:34.95;95%CI:26.60-45.93;P<0.001),were associated with increased risk for PE.Only chronic hypertension(aOR:13.75;95%CI:4.78-39.58;P<0.001)was a significant risk factors for early-onset PE,whereas high BMI considered both overweight(aOR:1.54;95%CI:1.09-2.18;P=0.01)and obesity(aOR:2.23;95%CI:1.53-3.27;P<0.001),nulliparity(aOR:2.00;95%CI:1.49-2.68;P<0.001),multiple gestation(aOR:4.11;95%CI:2.40-7.05;P<0.001),and chronic hypertension(aOR:35.57;95%CI:26.66-47.47;P<0.001)were more re

关键词： Pre-eclampsia Early-onset preeclampsia Late-onset preeclampsia Mild preeclampsia Severe preeclampsia Prevalence Risk factor

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Inosine:A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation

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Journal of Pharmaceutical Analysis 2023年第1期13卷 11-23页

作者： Ningning Wang Entao Li Huifang Deng Lanxin Yue Lei Zhou Rina Su Baokun He Chengcai Lai Gaofu Li Yuwei Gao Wei Zhou Yue Gao Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing100850China Tianjin University of Traditional Chinese Medicine Tianjin301617China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130022China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease 19(COVID-19)progression,severity,criticality,and death.Glucocorticoid and anti-cytokine therapies are frequently administered to treat COVID-19,but have limited clinical efficacy in severe and critical cases.Nevertheless,the weaknesses of these treatment modalities have prompted the development of anti-inflammatory therapy against this infection.We found that the broad-spectrum anti-inflammatory agent inosine downregulated proinflammatory interleukin(IL)-6,upregulated anti-inflammatory IL-10,and ameliorated acute inflammatory lung injury caused by multiple infectious agents.Inosine significantly improved survival in mice infected with SARS-CoV-2.It indirectly impeded TANK-binding kinase 1(TBK1)phosphorylation by binding stimulator of interferon genes(STING)and glycogen synthase kinase-3β(GSK3β),inhibited the activation and nuclear translocation of the downstream transcription factors interferon regulatory factor(IRF3)and nuclear factor kappa B(NF-κB),and downregulated IL-6 in the sera and lung tissues of mice infected with lipopolysaccharide(LPS),H1N1,or SARS-CoV-2.Thus,inosine administration is feasible for clinical anti-inflammatory therapy against severe and critical COVID-19.Moreover,targeting TBK1 is a promising strategy for inhibiting cytokine storms and mitigating acute inflammatory lung injury induced by SARS-CoV-2 and other infectious agents.

关键词： Cytokine stormInterleukin 6 (IL-6)InosineSARS-CoV-2TANK-binding kinase 1 (TBK1)

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半自动机制桑蚕丝绵片含胶率检验装置的设计探索

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丝绸 2019年第4期56卷 8-11页

作者：苏日娜浙江出入境检验检疫局丝类检测中心杭州310012

蚕丝被作为中国最古老并沿袭至今的传统寝被,在中国已有5 500余年历史,也是中国传统丝绸产品和重要出口商品。但由于蚕丝被生产工艺相对简单,行业进入门槛低,市场上蚕丝被的品质良莠不齐,以假乱真、以次充好的现象时有发生。在蚕丝被使... 详细信息

蚕丝被作为中国最古老并沿袭至今的传统寝被,在中国已有5 500余年历史,也是中国传统丝绸产品和重要出口商品。但由于蚕丝被生产工艺相对简单,行业进入门槛低,市场上蚕丝被的品质良莠不齐,以假乱真、以次充好的现象时有发生。在蚕丝被使用过程中,残留的丝胶逐渐发生变性,导致蚕丝被板结发黄,直接影响到了蚕丝被的品质。因此,机制桑蚕丝绵片的含胶量为贸易所重视,与消费者的切身利益息息相关。目前,中国的含胶率检测大多沿用传统装置,需要检验员手动操作,检验效率低,风险性高。文章通过改进传统含胶率检验装置的弊端,探索设计一种半自动机制桑蚕丝绵片含胶率检验装置,以提高检验效率,增强检验的安全性。

关键词：丝绵片含胶率蚕丝被脱胶半自动检验装置

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图书馆建设 2019年第2期 148-157页

作者：苏日娜中山大学资讯管理学院

社区图书馆是保障城市公民实现文化权利的基本阵地。本文基于文献研究和实践研究基础上,分析除社区图书馆用户之外的利益相关者的态度与诉求,包括基层文化官员、所在区域重要图书馆、资助方志愿组织/志愿者、所在区域学校、图书馆员。... 详细信息

社区图书馆是保障城市公民实现文化权利的基本阵地。本文基于文献研究和实践研究基础上,分析除社区图书馆用户之外的利益相关者的态度与诉求,包括基层文化官员、所在区域重要图书馆、资助方志愿组织/志愿者、所在区域学校、图书馆员。图书馆若要获得良性的发展,这些利益相关者必须在某种层面上形成合力,在很多时候还需要相互妥协与合作,尤其是必要性的退让或争取。

关键词：社区图书馆公益图书馆利益相关者留守儿童

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先秦至两汉服饰文化交融对建构中华文化象征体系的意义

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西南民族大学学报（人文社会科学版） 2023年第9期44卷 18-28页

作者：苏日娜王悦中央民族大学民族学与社会学学院北京100081

先秦至两汉时期,中原农耕地区与北方游牧地区拥有数量众多的文化亚形态,不同文化间的转化和解读相当繁复,以服饰文化为代表的非语言符号是文化亚形态之间交流的重要媒介。北方游牧民的不断迁徙及其与中原农耕民的频繁往来,推动双方不同... 详细信息

先秦至两汉时期,中原农耕地区与北方游牧地区拥有数量众多的文化亚形态,不同文化间的转化和解读相当繁复,以服饰文化为代表的非语言符号是文化亚形态之间交流的重要媒介。北方游牧民的不断迁徙及其与中原农耕民的频繁往来,推动双方不同服饰文化元素、服饰制度以服饰文化符号的形式汇聚和交融。服饰文化符号的形象性与意向性,是加速服饰文化凝聚性结构形成的前提。通过战争、礼仪、和亲、礼物馈赠等交往情境下服饰符号意象的再生产,服饰从地域性、族群性符号转变为双方共同使用、共同享有的文化符号与视觉形象,成为建构中华文化象征体系的重要文化来源。

关键词：服饰文化融合先秦至两汉中华文化象征体系象征符号文化记忆

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半自动生丝含胶率测试仪的研制

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现代纺织技术 2019年第3期27卷 87-90页

作者：苏日娜浙江出入境检验检疫局丝类检测中心杭州310012

为了提高生丝含胶率检验效率,通过分析传统含胶率检测方法及原理的异同,改进传统生丝含胶率检验装置,设计了一种半自动生丝含胶率测试仪。经过对比实验发现,使用半自动生丝含胶率测试仪检验得到的数据较传统检验方法绝对误差在±0.4%以... 详细信息

为了提高生丝含胶率检验效率,通过分析传统含胶率检测方法及原理的异同,改进传统生丝含胶率检验装置,设计了一种半自动生丝含胶率测试仪。经过对比实验发现,使用半自动生丝含胶率测试仪检验得到的数据较传统检验方法绝对误差在±0.4%以内,但效率提高了4倍以上。结果表明:该设计的半自动生丝含胶率测试仪克服了传统测试方法中手工搅拌脱胶的不足,检验结果可靠,检验效率高,同时提高了含胶率检验的安全性。

关键词：生丝含胶率检验脱胶半自动

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Risk Factors for Gestational Diabetes Mellitus(GDM)in subsequent Pregnancy Among Women Without GDM History in China:A Multicenter Retrospective Study

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Maternal-Fetal Medicine 2023年第1期5卷 9-15页

作者： Geng Song Yumei Wei Juan Juan Rina Su Jianying Yan Mei Xiao Xianlan Zhao Meihua Zhang Yuyan Ma Haiwei Liu Jingxia sun Kejia Hu Huixia Yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus Beijing 100034China Department of Obstetrics and Gynecology Fujian Province Maternal and Child Health HospitalFuzhou 350005China Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Hubei ProvinceWuhan 430064China Department of Obstetrics and Gynecology Zhengzhou University First Affiliated HospitalZhengzhou 450052China Department ofObstetrics and Gynecology Taiyuan Maternal and Child Health HospitalTaiyuan 030012China Department of Obstetrics and Gynecology Shandong University Qilu HospitalJinan 250063China Department of Obstetrics and Gynecology Hainan General HospitalHaikou 570311China Department of Obstetrics and Gynecology First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Obstetrics and Gynecology Beijing Shunyi District HospitalBeijing 101312China

Objective:This study aimed to determine the likelihood of gestational diabetes mellitus(GDM)in subsequent pregnancy among women without GDM history and to identify risk factors for GDM in subsequent pregnancy.Methods:This retrospective cohort study involved participants who delivered twice in same hospital of 18 research centers when delivered the second baby from January 2018 to December 2018.Finally 6204 women were enrolled and 5180 women without GDM history were analyzed further.Women were categorized as non-GDM or GDM based on the blood glucose values of the subsequent pregnancy,and the characteristics and GDM risk of these groups were compared.A univariate analysis of potential risk factors was performed using the Chi-squared test and/ort-test for qualitative or quantitative variables,respectively.Associations withP valuessults:In primary analysis of 6204 women,the incidence of GDM in subsequent pregnancy is 48.9%(490/1002)in women with GDM history and 16.1%(835/5202)in women without GDM history.In a further analysis for 5180 women without GDM at index pregnancy,compared with the non-GDM group,the GDM group had a significantly higher age,prepregnancy body mass index,and blood glucose value at each oral glucose tolerance test(OGTT)timepoint(fasting,1 h and 2 h)during the index and subsequent pregnancies,as well as higher weight retention during the interval between the two pregnancies(Psubsequent pregnancy(odds ratio(OR)=1.540,95%confidence interval(CI)=1.257-1.886,Psubsequent pregnancy.Conclusion:For women without GDM history,GDM risk factors including age,macros

关键词： Diabetes gestational Without GDM history Risk factors subsequent pregnancy.

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Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China

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Chinese Medical Journal 2022年第6期135卷 665-671页

作者： Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang Huixia Yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics Tianjin Central Obstetrics and Gynecology HospitalTianjin 300199China Department of Obstetrics Jinan Maternal and Child Health HospitalJinanShandong 250000China Department of Obstetrics Dalian Maternity HospitalDalianLiaoning 116033China Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Obstetrics Shenzhen Peking University HospitalShenzhenGuangdong 518036China Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Huazhong University of Science and TechnologyWuhanHubei 430030China Department of Obstetrics and Gynecology Suzhou Jiulong Hospital Affiliated to Shanghai Jiaotong UniversitySuzhouJiangsu 320571China Department of Obstetrics Affiliated Hospital of Inner Mongolia Medical UniversityHuhhotInner Mongolia 010050China Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Epidemiology Branch Division of Intramural Population Health ResearchEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMD 20817USA

Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM management.It was shown that a history of GDM was significantly associated with a higher maternal risk for GDM recurrence.The incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in China.We aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in China.Methods:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research centers.All participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed further.All participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were analyzed.Results:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of GDM.There are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal women.Moreover,it seems so important in the degree of abnormal glucose

关键词： Gestational diabetes mellitus Recurrence Risk factors Multipara Primipara

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“赤脚图书馆员”形象解构——东南亚图书馆服务精神探析

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图书馆 2016年第7期 38-42页

作者：苏日娜中山大学资讯管理学院广州510006

"Barefoot Librarian"概念首次出现在1973年12月马尼拉举办的第二届东南亚图书馆员会议的开幕式上,进而在整个东南亚地区开始了"赤脚图书馆员"的图书馆服务运动。东南亚在全球的图书馆事业发展中并非发达地区,但是依靠一群默默贡献并立... 详细信息

"Barefoot Librarian"概念首次出现在1973年12月马尼拉举办的第二届东南亚图书馆员会议的开幕式上,进而在整个东南亚地区开始了"赤脚图书馆员"的图书馆服务运动。东南亚在全球的图书馆事业发展中并非发达地区,但是依靠一群默默贡献并立志于图书馆事业的人们,用特殊的方式支撑和推动东南亚文化事业的发展。文章在简要梳理东南亚图书馆事业发展史的基础上,对近些年来东南亚图书馆事业取得的进步以及图书馆人所作的努力进行归纳和分析,探论"赤脚图书馆员"如何一步步将"鞋"穿在脚上,脚踏实地,服务读者。

关键词：东南亚图书馆事业赤脚图书馆员图书馆社区运动图书馆服务

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