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Absence of KHDC3L mutations in Chinese patients with recurrent and sporadic hydatidiform moles

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Absence of KHDC3L mutations in Chinese patients with recurre...

2013浙江省医学遗传学学术年会

作者： Wei Zhao ALa NuEr Muhetaer TengFei Luo Wei Zhou Cheng Qi ZhiFen Zhang Christine Dery rima slim JianHua Qian Women's Reproductive Health Laboratory Women's Hospital Zhejiang University School of Medicine Hangzhou First People's Hospital Hangzhou hospital of Nanjing Medical University Departments of Human Genetics and dObstetrics and Gynecology McGill University Health Centre

To date,two maternal-effect genes have been shown to play causal roles in recurrent hydatidiform moles (RHMs).NLRP7 ,Is a major gene for this condition,codes for a NOD-like receptor,and is mutated in 48

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中国人种葡萄胎KHDC3L基因的突变

中国人种葡萄胎KHDC3L基因的突变

Optimizing Deep Learning for Computer-Aided Diagnosis of Lung Diseases: An Automated Method Combining Evolutionary Algorithm, Transfer Learning, and Model Compression

2013浙江省医学遗传学学术年会

作者：赵微罗腾飞程琪 rima slim 钱建华杭州市第一人民医院浙江大学妇产科医院 Departments of Human Genetics and dObstetrics and Gynecology McGill University Health Centre

目的:目前已发现两个母亲效应基因与复发性葡萄胎密切相关。,研究发现NLRP7基因在48%-60%的复发性葡萄胎中存在变变与变异。KHDC3L(既往也称C6orf221)是目前新认识的与葡萄胎发生相关的基因,发现在14%的复发性葡萄胎NLRP7未突变的患者中...

目的:目前已发现两个母亲效应基因与复发性葡萄胎密切相关。,研究发现NLRP7基因在48%-60%的复发性葡萄胎中存在变变与变异。KHDC3L(既往也称C6orf221)是目前新认识的与葡萄胎发生相关的基因,发现在14%的复发性葡萄胎NLRP7未突变的患者中有KHDC3L基因突变现象。本研究筛查中国人种葡萄胎患者KHDC3L基因的突变情况。方法:研究对象:101例中国人种葡萄胎患者,其中15例既往至少有2次葡萄胎病史,16例既往至少有2次妊娠丢失病史,其中一次是葡萄胎,70例既往有1次葡萄胎病史;同时100例中国人种无不良生育史者作为对照组,用测序及比对分析方法对101例中国人种葡萄胎患者及100例中国人种无不良生育史者作为对照组筛查KHDC3L基因的突变情况。结果:101例中国人种葡萄胎患者及100例中国人种无不良生育史者中未发现KHDC3L基因的突变。结论:本次研究发现KHDC3L仅在极少数复发性葡萄胎患者的发生中有一定作用,并证实该基因与其他形式的妊娠丢失无明显相关性,同时也提示在中国人种中可能存在其他未被发现的易感基因与RHM相关。

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2519-2547页

作者： Hassen Louati Ali Louati Elham Kariri slim Bechikh College of Information Technology Kingdom UniversityRiffa40434Bahrain SMART Lab University of TunisISGTunisTunisia Department of Information Systems College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia

Recent developments in Computer Vision have presented novel opportunities to tackle complex healthcare issues,particularly in the field of lung disease *** promising avenue involves the use of chest X-Rays,which are commonly utilized in *** fully exploit their potential,researchers have suggested utilizing deep learning methods to construct computer-aided diagnostic ***,constructing and compressing these systems presents a significant challenge,as it relies heavily on the expertise of data *** tackle this issue,we propose an automated approach that utilizes an evolutionary algorithm(EA)to optimize the design and compression of a convolutional neural network(CNN)for X-Ray image *** approach accurately classifies radiography images and detects potential chest abnormalities and infections,including ***,our approach incorporates transfer learning,where a pre-trainedCNNmodel on a vast dataset of chest X-Ray images is fine-tuned for the specific task of detecting *** method can help reduce the amount of labeled data required for the task and enhance the overall performance of the *** have validated our method via a series of experiments against state-of-the-art architectures.

关键词： Computer-aided diagnosis deep learning evolutionary algorithms deep compression transfer learning

骨形态发生蛋白15基因多态性与复发性葡萄胎和习惯性流产的相关性研究

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中国妇幼保健 2017年第11期32卷 2432-2435页

作者：王鹤 Ramesh Reddy Ngoc Minh Phuong Nguyen Seang L Tan rima slim 广西医科大学附属肿瘤医院妇瘤科广西南宁530021 麦吉尔大学人类健康中心人类基因部加拿大蒙特利尔魁北克省H4A 3J1 麦吉尔大学人类健康中心妇产科加拿大蒙特利尔魁北克省H4A 3J1

目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显... 详细信息

目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMP15基因的多态性,并采用蛋白功能预测软件预测各SNPs对BMP15蛋白功能的影响。结果在BMP15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.L148P,p.A180T,p.H200Y)和1个插入突变,(***263dup)。通过预测,p.L148P突变可能会严重影响BMP15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNPs对BMP15蛋白功能基本无影响。结论 BMP15基因突变除了可能与RHMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。

关键词：骨形态发生蛋白15 基因多态性 RHMs 习惯性流产

5G Smart Mobility Management Based Fuzzy Logic Controller Unit

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Computers, Materials & Continua 2022年第6期71卷 4941-4953页

作者： Chafaa Hamrouni slim Chaoui Taif University-Khurma Univ.College-Department of Computer Sciences Khurma2935Kingdom of Saudi Arabia College of Computer and Information Sciences Dep.of Computer Engineering and NetworksJouf UniversitySkakaK.S.A

In the paper,we propose a fuzzy logic controller system to be implemented for smart mobility management in the 5G wireless communication *** management is considered as a main issue for all-IP mobile networks future *** a network-based mobility management protocol,Internet Engineering Task Force developed the Proxy Mobile IPv6(PMIPv6)in order to support the mobility of IP devices,and many other results were presented to reduce latency handover and the amount of PMIPv6 signaling,but it is not enough for the application needs in *** present paper describes an approach based on the IEEE 802.21 Media Independent Handover(MIH)standard and PMIPv6,so we present a new vertical handover algorithm for anticipating handover process *** object is to propose a smart mobility management that contribute in 5G wireless communication system network operating *** proposed dynamic thresholds were successfully made to guaranty process triggering,and a new primitive MIH is proposed for signaling a needed handover to be *** results demonstrate a significant reduction of the handover delay,packet loss,handover blocking probability and signaling *** results and tests are accomplished.

关键词： 5G proxy mobile IPv6 media independent handover wireless system QoS LTE HDM

ACOUSTIC ANALYSIS OF HYDRODYNAMIC AND ELASTO-HYDRODYNAMIC OIL LUBRICATED JOURNAL BEARINGS

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Journal of Hydrodynamics 2012年第2期24卷 250-256页

作者： BOUAZIZ slim FAKHFAKH Tahar HADDAR Mohamed Dynamic of Mechanical Systems Research Unit (UDSM) University of Sfax Mechanics Modelling and Production Research Unit (U2MP) and National School of Engineers of Sfax (ENIS) BP.11733038University of Sfax

The purpose of the present paper is to investigate the effect of elastic deformation of bearing liner on the acoustic behavior of oil lubricated journal *** is performed for hydrodynamic（HD） and elasto-hydrodynamic （EHD） *** behavior and acoustical properties are investigated through an analysis of pressure fluctuation calculated from the Reynolds equation governing the flow in the clearance space of the journal *** is solved numerically using the finite difference method with the successive over relaxation *** elasto-hydrodynamic lubrication,the finite element method with in iteration scheme is adopted to solve both Reynolds equation and the three-dimensional elasticity equation representing the displacement field in the bearing *** results show that the sound pressure level of the bearing is markedly influenced by the flexibility of the bearing liner,the viscosity of lubricant and the load applied to *** analysis shows that the journal centre＇s orbit,from a disturbed position,converges to the static equilibrium position faster than EHD *** results of the present paper could aid in the design of low-noise rotor-bearing systems supported by oil lubricated journal bearings.

关键词： vibration amplitude pressure level lubricated bearing sound pressure

Color Edge Detection Using Multidirectional Sobel Filter and Fuzzy Fusion

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Computers, Materials & Continua 2023年第2期74卷 2839-2852页

作者： slim Ben Chaabane Anas Bushnag Computer Engineering Department Faculty of Computers and Information TechnologyUniversity of TabukTabuk 47512Saudi Arabia Electrical Engineering Department University of Tunis CEREPENSIT 5 AvTaha Hussein1008TunisTunisia

A new model is proposed in this paper on color edge detection that uses the second derivative operators and data fusion *** secondorder neighborhood shows the connection between the current pixel and the surroundings of this *** connection is for each RGB component color of the input *** the image edges are detected for the three primary colors:red,green,and blue,these colors are merged using the combination ***,the final decision is applied to obtain the *** process allows different data sources to be combined,which is essential to improve the image information quality and have an optimal image ***,the segmentation results of the proposed model are ***,the classification accuracy of the tested data is assessed,and a comparison with other current models is *** comparison results show that the proposed model outperforms the existing models in image segmentation.

关键词： Segmentation edge detection second derivative operators data fusion technique fuzzy fusion classification

N4SID and MOESP Algorithms to Highlight the Ill-conditioning into Subspace Identification

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International Journal of Automation and computing 2014年第1期11卷 30-38页

作者： slim Hachicha Maher Kharrat Abdessattar Chaari Laboratory of Sciences and Techniques of Automatic Control and Computer Engineering (Lab-STA) National School of Engineering of SfaxUniversity of Sfax

In this paper,an analysis for ill conditioning problem in subspace identifcation method is *** subspace identifcation technique presents a satisfactory robustness in the parameter estimation of process model which performs *** a frst step,the main geometric and mathematical tools used in subspace identifcation are briefly *** the second step,the problem of analyzing ill-conditioning matrices in the subspace identifcation method is *** illustrate this situation,a simulation study of an example is introduced to show the ill-conditioning in subspace *** numerical subspace state space system identifcation(N4SID)and multivariable output error state space model identifcation(MOESP)are considered to study,the parameters estimation while using the induction motor model,in simulation(Matlab environment).Finally,we show the inadequacy of the oblique projection and validate the efectiveness of the orthogonal projection approach which is needed in ill-conditioning;a real application dealing with induction motor parameters estimation has been *** obtained results proved that the algorithm based on orthogonal projection MOESP,overcomes the situation of ill-conditioning in the Hankel s block,and thereby improving the estimation of parameters.

关键词： Subspace identification ill-conditioning oblique projection orthogonal projection algorithms numerical subspace state space system identification (N4SID) multivariable output error state space model identification (MOESP) induction motor

Artificial intelligence for satellite communication: A review

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Intelligent and Converged Networks 2021年第3期2卷 213-243页

作者： Fares Fourati Mohamed-slim Alouini Electrical and Mathematical Sciences and Engineering Division King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia

Satellite communication offers the prospect of service continuity over uncovered and under-covered areas,service ubiquity,and service ***,several challenges must first be addressed to realize these benefits,as the resource management,network control,network security,spectrum management,and energy usage of satellite networks are more challenging than that of terrestrial ***,artificial intelligence(AI),including machine learning,deep learning,and reinforcement learning,has been steadily growing as a research field and has shown successful results in diverse applications,including wireless *** particular,the application of AI to a wide variety of satellite communication aspects has demonstrated excellent potential,including beam-hopping,anti-jamming,network traffic forecasting,channel modeling,telemetry mining,ionospheric scintillation detecting,interference managing,remote sensing,behavior modeling,space-air-ground integrating,and energy *** work thus provides a general overview of AI,its diverse sub-fields,and its state-of-the-art *** challenges facing diverse aspects of satellite communication systems are then discussed,and their proposed and potential AI-based solutions are ***,an outlook of field is drawn,and future steps are suggested.

关键词： satellite communication wireless communication artificial intelligence machine learning deep learning reinforcement learning