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Can endoscopic submucosal dissection be safely performed in a smaller specialized clinic?

World Journal of Gastroenterology 2013年第4期19卷 528-535页

作者： Naondo Sohara Satoshi Hagiwara riki arai Haruhisa Iizuka Yasuhiro Onozato Satoru Kakizaki Department of Endoscopy and Endoscopic Surgery Shirakawa ClinicMaebashiGunma 371-0051Japan Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan

AIM:To investigate whether endoscopic submucosal dissection(ESD) can be safely performed at small clinics,such as the Shirakawa ***:One thousand forty-seven ESDs to treat gastrointestinal tumors were performed at the Shirakawa Clinic from April 2006 to March *** efficacy,technical feasibility and associated complications of the procedures were *** ESD procedures were performed by five *** was induced with propofol for esophagogastorduodenal ***:One thousand forty-seven ESDs were performed to treat 64 patients with esophageal cancer(E),850 patients with gastric tumors(G:764 patients with cancer,82 patients with adenomas and four others),four patients with duodenal cancer(D) and 129 patients with colorectal tumors(C:94 patients with cancer,21 patients with adenomas and 14 others).The en bloc resection rate was 94.3%(E:96.9%,G:95.8%,D:100%,C:79.8%).The median operation time was 46 min(range:4-360 min) and the mean size of the resected specimens was 18 mm(range:2-150 mm).No mortal complications were observed in association with the ESD *** occurred in 12 cases(1.1%,E:1 case,G:9 cases,D:1 case,C:1 case) and postoperative bleeding occurred in 53 cases(5.1%,G:51 cases,D:1 case,C:1 case);however,no case required either emergency surgery or blood *** of the perforations and postperative bleedings were resolved by endoscopic clipping or *** other problematic complication observed was pneumonia,which was treated with conservative ***:ESD can be safely performed in a clinic with established therapeutic methods and medical services to address potential complications.

关键词： Endoscopic submucosal dissection Complication Perforation Clinic

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Applications of human hepatitis B virus preS domain in bio-and nanotechnology

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World Journal of Gastroenterology 2015年第24期21卷 7400-7411页

作者： riki Toita Takahito Kawano Jeong-Hun Kang Masaharu Murata Department of Biomaterials Faculty of Dental Science Kyushu University Department of Advanced Medical Initiatives Faculty of Medical Sciences Kyushu University Innovation Center for Medical Redox Navigation Kyushu University Division of Biopharmaceutics and Pharmacokinetics Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute

Human hepatitis B virus(HBV) is a member of the family Hepadnaviridae, and causes acute and chronic infections of the liver. The hepatitis B surface antigen(HBs Ag) contains the large(L), middle(M), and small(S) surface proteins. The L protein consists of the S protein, pre S1, and pre S2. In HBs Ag, the pre S domain(pre S1 + pre S2) plays a key role in the infection of hepatocytic cells by HBV and has several immunogenic epitopes. Based on these characteristics of pre S, several pre S-based diagnostic and therapeutic materials and systems have been developed. Pre S1-specific monoclonal antibodies(e.g., MA18/7 and KR127) can be used to inhibit HBV infection. A myristoylated pre S1 peptide(amino acids 2-48) also inhibits the attachment of HBV to Hepa RG cells, primary human hepatocytes, and primary tupaia hepatocytes. Antibodies and antigens related to the components of HBs Ag, pre S(pre S1 + pre S2), or pre S1 can be available as diagnostic markers of acute and chronic HBV infections. Hepatocyte-targeting delivery systems for therapeutic molecules(drugs, genes, or proteins) are very important for increasing the clinical efficacy of these molecules and in reducing their adverse effects on other organs. The selective delivery of diagnosticmolecules to target hepatocytic cells can also improve the efficiency of diagnosis. In addition to the full-length HBV vector, pre S(pre S1 + pre S2), pre S1, and pre S1-derived fragments can be useful in hepatocyte-specific targeting. In this review, we discuss the literature concerning the applications of the HBV pre S domain in bio- and nanotechnology.

关键词： Hepatitis B virus Hepatocyte deliverysystem Vaccine Hepatitis B surface antigen Diagnosis

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Invasive ductal carcinoma of the pancreas showing exophytic growth

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 97-102页

作者： Yuichi Sanada Kazuhiro Yoshida Masaoki Itoh riki Okita Morihito Okada Department of Surgical Oncology Research Institution for Radiation Biology and MedicineHiroshima University

BACKGROUND:Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative *** aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth. METHODS:A 67-year-old woman presented with a mass of 5.0 cm in diameter in the pancreatic *** computed tomography revealed a well-demarcated, primarily solid mass with a central low-density area. Magnetic resonance cholangiopancreatography revealed neither encasement nor dilation of the main pancreatic *** incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the *** serum carcinoembryonic antigen(CEA)levels and abnormal FDG positron emmission tomography accumulation suggested that the tumor had malignant potential requiring a pancreatoduodenectomy. RESULTS:The head of the pancreas contained a well- circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50%adenocarcinoma,with mucinous carci- noma in the center and anaplastic carcinoma at the *** anaplastic carcinoma comprised pleo- morphic cells(PCs)and pleomorphic giant cells(PGCs). The PGCs phagocytozed mononuclear PCs and lymphocytes adjacent to the capsule without infiltrating the capsule *** revealed that the anaplastic carcinoma cells including PGCs were positive for the tumor antigen Mucin 1 and CEA but negative for vimentin. CONCLUSION:Our observations suggest anaplastic carcinoma components in the present tumor have a ductal origin and that the exophytic tumor growth is associated with the phagocytotic activity of PGCs.

关键词： pancreatic carcinoma anaplastic carcinoma mucinous carcinoma Mucin 1 carcinoembryonic antigen

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Nationalist-Religious Ideology and Civic Education:The Israeli Case

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International Relations and Diplomacy 2021年第2期9卷 51-68页

作者： riki Tesler The Hebrew University JerusalemIsrael

Are we riding the fourth wave of democracy,as predicted by Toffler(1984)and Huntington(1991),a post-capitalist,post-global wave?Western liberal democracy is currently responding to the dramatic change in the economic system after capitalism,the coronavirus pandemic,and the growing power of nationalist and fundamentalist *** this process indicates a change in Western democracy or is it the end of democracy and what is the role of civic education within it?In Israel,as in other Western countries,the nationalist and fundamentalist ideologies(gained strength,undermining liberalism)threaten the conception of global citizenship and strive to shape a model of an illiberal *** Israel,contrary to other Western countries,they also threaten civic equality and the very existence of the democratic *** the absence of a constitution and consensus,Israel is experiencing culture and religious war over values,identity and the concept of“citizenship”as a legal,political,and social ***,the struggle over civic education reflects the struggle over educational hegemony,as well as over national *** this process,nationalists and fundamentalists initiate anti-democratic legislation,violate human rights,obstruct government supervisory mechanisms,and expand ideological education in order to change Israel‟s character to a Jewish state rather than a Jewish and democratic state.

关键词： Liberalism Nationalism Fundamentalism Civic Education.Ideological Education Global Citizen Digital Citizen

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Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

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World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita riki Asakura Keisuke arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

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Supramolecular liquid crystals from the dimer of L-shapedmolecules with tertiary amide end groups

Aggregate

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Aggregate 2024年第3期5卷 299-307页

作者： Yuki Sawatari Yoshimichi Shimomura Masato Takeuchi riki Iwai Takuya Tanaka Eiji Tsurumaki Masatoshi Tokita Junji Watanabe Gen-ichi Konishi Department of Chemical Science and Engineering Tokyo Institute of TechnologyMeguro-kuTokyoJapan Department of Applied Chemistry Osaka Metropolitan UniversitySakaiOsakaJapan Department of Chemistry Tokyo Institute of TechnologyMeguro-kuTokyoJapan Department of Polymer Chemistry Tokyo Institute of TechnologyMeguro-kuTokyoJapan

Supramolecular liquid crystals(SLCs)are attractive materials for fabricating devices with new optoelectronic *** SLCs are made from hydrogen-bonded ***,these mesogens suffer from high melting points,and the types of formable aggregates are limited owing to the directionality of the hydro-gen ***,to fabricate non-hydrogen-bonded SLCs,we hypothesized that the introduction of tertiary amide groups into calamitic molecules would be advantageous because they have an L-shaped structure with N-or C-alkyl side chains not aligned along the long axis and theﬂexibility to undergo cis–trans *** this study,we developed a novel non-hydrogen-bonded SLC by assembling an L-shaped dimer composed of calamitic molecules(phenyltolanes)with tertiary amides at their *** molecules exhibited a smectic B *** phase tran-sition temperature of the SLCs from crystal to liquid crystal phase was low despite the longπ-conjugated ***-angle X-ray diffraction and variable-temperature Fourier-transform infrared measurements revealed dimer formation by weak inter-molecular interactions,that is,the molecular recognition of L-shaped molecules,and mobility of the alkyl groups attached to amide driven by cis–trans isomerization in the liquid crystal ***,cis–trans isomerization of tertiary amides contributed enormously to the formation and lower clearing points of this *** developed method can be used not only to develop non-hydrogen-bonded SLCs but also to develop novel soft matter with controlled properties by incorporating the SLCs,as the aggregates can be controlled to impart desired functionalities.

关键词： mesogen self-assembly semectic phase supramolecular liquid crystal tertiary amide variable-

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Structures of Stoichiometric Sodium Oxide Cluster Cations Studied by Ion Mobility Mass Spectrometry

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Chinese Journal of Chemical Physics 2019年第2期32卷 193-199,I0002页

作者： Motoyoshi Nakano Yudai Ishimura riki Hotta Daiki Hebiguchi Toshiaki Nagata Fuminori Misaizu Institute for Excellence in Higher Education Tohoku University 41 Kawauchi Aoba-ku Sendai 980-8576 Japan Department of Chemistry Graduate School of Science Tohoku University 6-3 Aoba Aramaki Aoba-ku Sendai 980-8578 Japan

Structures of stable compositions of sodium oxide cluster cations (NanOm+,n≤11) have been investigated by ion mobility mass spectrometry. Stoichiometric compositions series, Na(Na2O)(n-1)/2^+(n=3, 5, 7, 9, and 11), were observed as stable composition series, and NaO(Na2O)(n-1)/2^+ series (n=5, 7, 9, and 11) were observed as secondary stable series in the mass spectra. To assign the structures of these cluster ion series, collision cross sections between the ions and helium buffer gas were determined experimentally from the ion mobility measurements. Theoretical collision cross sections were also calculated for optimized structures of these compositions. Finally, the structures of Na(Na2O)(n-1)/2^+ and NaO(Na2O)(n-1)/2^+ were assigned to those having similar structural frames for each n except for n=9. All bonds in the assigned structures of Na(Na2O)(n-1)/2^+ were between sodium and oxygen. On the other hand, there was one O-O bond in addition to Na-O bonds in NaO(Na2O)(n-1)/2^+. This result indicates that NaO(Na2O)(n-1)/2^+ have a peroxide ion (O22-) as a substitute for an oxide ion (O2-) of Na(Na2O)(n-1)/2^+. As a result, both stable series, Na(Na2O)(n-1)/2^+ and NaO(Na2O)(n-1)/2^+, are closed-shell compositions. These closed-shell characteristics have a strong influence on the stability of sodium oxide cluster cations.

关键词： Sodium oxide cluster Structure Ion mobility mass spectrometry

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Reachability-Based Packet Scheduler of Multipath QUIC for Heterogeneous Mobile Networks

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Communications and Network 2022年第4期14卷 200-209页

作者： riki Okunishi Rui Teng Kenya Sato Graduate School of Science and Engineering Doshisha University Kyoto Japan Mobility Research Center Doshisha University Kyoto Japan

In recent years, we need more bandwidth to enjoy entertainment contents such as video streaming, music and online gaming. To gain enough bandwidth, technologies that combine bandwidth by using multiple interfaces at same time are desired. Multipath transport protocols which combine multiple paths for packet delivery at the transport layer are a promising technology. Such protocols have a mechanism, called “packet scheduler”, to select the interface to send a packet. However, existing studies of the packet scheduler have not explicitly considered the compatibility of mobility with bonding of bandwidth. Therefore, when smartphone users move out of coverage of communication networks such as wireless Local Area Network (LAN) and Long Term Evolution (LTE) by vehicle, packet loss occurs, leading to a decrease of throughput. In this study, we propose a packet scheduler that selects an appropriate communication path so that packets can reach the peer before it moves out of the coverage. Based on routes of a vehicle and the position and communication range of the access point, the time at which a communication path will be lost is predicted. In addition, we employ MPQUIC (Multipath QUIC (Quick UDP Internet Connections)), which is a multipath transport protocol proposed as the extension of QUIC protocol, to reduce the ACK packet loss in multipath communication, and to reduce the time until the starts of retransmission. We evaluated the number of packet losses, the throughput and the time until starts of retransmission using a simulator and show the superiority of proposed method.

关键词： Mobility Multipath Transport Protocol Multipath QUIC

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时间轴上的徘徊——北京西城区城市更新探索

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世界建筑 2004年第2期 58-64页

作者： riki Nishimura,Rachel Jaffe MAUD MUP

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地震预报的经验方法

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世界地震译丛 1989年第1期20卷 8-17页

作者： riki.,T. 吕春来

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