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A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

Neuroscience Bulletin 2024年第3期40卷 310-324页

作者： Man Yuan sen Jin Gao Tan Siyuan Song Yizong Liu Huadong Wang Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430060China The Brain Cognition and Brain Disease Institute Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNational Medical Products Administration Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen518055China jan and Dan Duncan Neurological Research Institute Baylor College of MedicineHouston77030USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyCASWuhan430071China Frontier Science Center of Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan430071China

Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various ***,their role in transmitting visual information remains ***,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual *** applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole ***,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual ***,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic ***,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual *** results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.

关键词： Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway

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金果榄质量HPLC评价研究

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中国新药杂志 2024年第4期33卷 400-406页

作者：陈帅袁崇均罗森汤依娜向缅周先建王笳杨玉霞四川省中医药科学院成都610041 中药材品质及创新中药研究四川省重点实验室成都610041

目的:建立同时测定金果榄药材中古伦宾、蜕皮激素和生物碱类成分的含量的方法,并寻找金果榄药材中的质量差异标志物。方法:采用HPLC法同时测定古伦宾、蜕皮激素、非洲防己碱、药根碱和巴马丁的含量,并以检测出的含量为指标,结合聚类分... 详细信息

目的:建立同时测定金果榄药材中古伦宾、蜕皮激素和生物碱类成分的含量的方法,并寻找金果榄药材中的质量差异标志物。方法:采用HPLC法同时测定古伦宾、蜕皮激素、非洲防己碱、药根碱和巴马丁的含量,并以检测出的含量为指标,结合聚类分析和偏最小二乘判别分析进一步确定金果榄药材中的质量差异标志物。结果:测定方法精密度、稳定性和重复性良好,聚类分析和偏最小二乘判别分析结果均显示20批样品可分为三大类,变量权重结果证实非洲防己碱、古伦宾、巴马汀为金果榄药材主要质量差异标志物。结论:所建方法利用DAD检测器特性,同时监测多个波长,方便快捷,能显著提高药材质量控制效率;聚类分析和偏最小二乘判别分析结果也可为金果榄药材种植、栽培提供依据。

关键词：金果榄古伦宾蜕皮激素非洲防己碱药根碱巴马丁聚类分析偏最小二乘判别分析

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Littoral landforms of Lake Hulun and Lake Buir(China and Mongolia):Wind-driven hydro-sedimentary dynamics and resulting clastics distribution

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Journal of Palaeogeography 2024年第2期13卷 309-326页

作者： Li Wang Mathieu Schuster Shi-Wei Xin Florin Zainescu Xin-Yu Xue Joep Storms jan-Hendrik May Alexis Nutz Helena van der Vegt Guilherme Bozetti Zai-Xing Jiang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Universite de Strasbourg CNRSENGEESInstitut Terre et Environnement de StrasbourgUMR 70635 Rue DescartesStrasbourgFrance Tamsag Mongolia(XIX)Ltd. PetroChinaDaqing 163000China CEREGE Aix-Marseille UniversitéCNESIRDCollege de FranceINRAAix en ProvenceFrance School of Marine Science Sun Yat-sen UniversityZhuhai 519083China Delft University of Technology Department of Geoscience and EngineeringDelfthe Netherlands School of Geography Earth and Atmospheric SciencesUniversity of Melbourne253 Elgin St.CarltonVIC 3053Australia Deltares Delfthe Netherlands SCMF Faculty of GeographyUniversity of Bucharest1 N.Balcescu Blv.BucharestRomania

Two rectangular-shaped lakes,Lake Hulun and Lake Buir,located at the boundary between China and Mongolia,only c.75 km apart and therefore experiencing similar wind fields,have been studied based on satellite images and field surveys in order to compare their geomorphological and sedimentological *** wind-driven hydrodynamics,which have a significant effect on the development of littoral landforms and on sediment distribution,have been discussed for the two similar lakes that experienced a prevailing wind perpendicular to their long axis.A conceptual model related to wind-driven water bodies and sediment distribution is ***-influenced to wave-dominated deltas,beaches,spits,and eolian dune deposits develop around these two lakes,with a strikingly similar distribution *** features locally inform the longshore drift and help reconstruct the water circulation induced by wind *** the NW prevailing wind regime,the spits developed on the SW coast with a NW—SE extension,which was influenced by the NW—SE longshore *** same influence was observed in the delta extension in the NE *** differences lie in the presence of fan deltas in the NW region of Lake Hulun,but not in Lake ***,the width of the beach and eolian deposits on the downwind coast of Lake Hulun is three times greater than that of Lake Buir which were caused by the differences in sediment supply and wind fetch between the two *** Hulun and Lake Buir provide two reliable examples to understand the relationship among the wind field,provenance,hydrodynamics,landforms,and asymmetrical distribution of clastics in elongated *** also represent relevant modern analogs,which may also be of guiding significance to wind-driven sand body prediction in lacustrine basins.

关键词： Wind-driven lakes Fetch Sedimentary facies Hydrodynamics Geomorphology Spits Shoreline Lake Hulun Lake Buir

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Corrosion and mechanical properties of a novel biomedical WN43magnesium alloy prepared by spark plasma sintering

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Journal of Magnesium and Alloys 2021年第3期9卷 853-865页

作者： Michal Knapek Mária Zemková Adam Gres Eva Jablonská Frantisek Lukác Robert Král jan Bohlen Peter Minárik Charles University Faculty of Mathematics and PhysicsKe Karlovu 512116 PragueCzech Republic Nuclear Physics Institute of CAS Řež13025068ŘežCzech Republic University of Chemistry and Technology Department of Biochemistry and MicrobiologyTechnická5Prague16628 PragueCzech Republic Institute of Plasma Physics of CAS Za Slovankou 318200 PragueCzech Republic Helmholtz-Zentrum Geesthacht Magnesium Innovation Centre(MagIC)D21502 GeesthachtGermany

Alloying of Mg with rare-earth(RE)elements proved to be beneficial for their in-vitro and in-vivo *** this work,a novel WN43(Mg-4 wt%Y-3 wt%Nd)alloy with a well-defined composition was prepared,where,unlike in the commercial WE43 alloy,the possibly harmful RE mischmetal was substituted by less toxic Nd.A modern spark plasma sintering(SPS)technique was used to effectively produce WN43 samples from atomized *** temperatures of 400℃-550℃ and holding times of 3 or 10 min were used and wellcompacted final materials were successfully *** was shown that a superior combination of corrosion and mechanical properties was attained in the samples sintered at 500℃ and 550℃,while the effect of sintering time was rather *** performance of this material was exceptional within the group of Mg alloys prepared by powder metallurgy and comparable with conventionally prepared ***,it was shown that a great variety of mechanical and corrosion characteristics can be obtained by altering the SPS parameters so as to fulfill case-specific requirements typical of biomedical ***,the novel WN43 alloy prepared by SPS seems to be a particularly suitable material for biomedical use.

关键词： Magnesium Biocompatibility Powder Sintering Corrosion Rare earth element

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Prognostic analysis of surgical treatment of peripheral cholangiocarcinoma: Two decades of experience at Chang Gung Memorial Hospital

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World Journal of Gastroenterology 2005年第12期11卷 1779-1784页

作者： Yi-Yin jan Chun-Nan Yeh Ta-sen Yeh Tse-Ching Chen Department of Surgery Department of Pathology

AIM: To analyze the prognostic factors influencing the overall survival of peripheral cholangiocarcinoma (PCC) patients undergoing surgical treatment during 25 years at a single institution. METHODS: This study retrospectively reviewed prospectively collecting data about 373 patients with historically proven PCC who underwent surgical treatment between 1977 and 2001. RESULTS: Three hundred and seventy-three PCC patients (159 men and 214 women) underwent surgical treatment from 1977 to 2001. Among them, 187 PCC patients underwent hepatectomy and 135 had curative resection (curative resectability rate: 36.2%). The follow-up duration ranged from 1.05 to 167.6 mo (mean/median = 14.1/7.2 mo). Overall cumulative survival rates at 1, 3, and 5 years were 32.5%, 9.2%, and 4.1%, respectively. Univariate log-rank analysis identified the following as adverse influences on overall survival: presence of symptoms, absence of mucobilia, elevated CEA and CA 19-9 levels, non-papillary tumor type, receiving non-hepatectomy, advanced tumor staging, lack of post-operative chemotherapy, and radiotherapy. Meanwhile, multivariate Cox's proportional hazard analysis demonstrated that absence of mucobilia, non-papillary tumor type, advanced tumor staging, non-hepatectomy, and lack of post-operative chemotherapy were the five independent prognostic factors that adversely affected overall survival. CONCLUSION: Favorable overall survival of PCC patients undergoing surgical treatment depends on early tumor stage, presence of mucobilia, papillary tumor type, hepatic resection, and post-operative chemotherapy.

关键词： Prognostic factor Surgical treatment Peripheral cholangiocarcinoma

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Three-dimensional modeling in complex liver surgery and liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 318-324页

作者： Jian-Peng Liu jan Lerut Zhe Yang Ze-Kuan Li Shu-sen Zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China Starzl Unit of Abdominal Transplantation University Hospitals Saint LucUniversitécatholique LouvainBrusselsBelgium Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China National Clinical Research Center of Infectious Diseases Hangzhou 310003China

Liver resection and transplantation are the most effective therapies for many hepatobiliary tumors and ***,these surgical procedures are challenging due to the anatomic complexity and many anatomical variations of the vascular and biliary ***-dimensional(3D)printing models can clearly locate and describe blood vessels,bile ducts and tumors,calculate both liver and residual liver volumes,and finally predict the functional status of the liver after resection *** 3D printing models may be particularly helpful in the preoperative evaluation and surgical planning of especially complex liver resection and transplantation,allowing to possibly increase resectability rates and reduce postoperative *** the continuous developments of imaging techniques,such models are expected to become widely applied in clinical practice.

关键词： 3D printing models Liver surgery Liver transplantation

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Surgical management of gallbladder sarcomatoid carcinoma

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World Journal of Gastroenterology 2009年第15期15卷 1876-1879页

作者： Keng-Hao Liu Ta-sen Yeh Tsann-Long Hwang Yi-Yin jan Miin-Fu Chen Department of General Surgery Chang Gung Memorial HospitalChang Gung University

AIM:To study the behavior as well as optimal treatment of gallbladder sarcomatoid carcinoma, we reviewed the results of treatment of gallbladder sarcomatoid carcinoma from Chang Gung Memorial Hospital. METHODS:From 1987 to 2005,six patients were diagnosed with gallbladder sarcomatoid carcinoma and treated at our *** staging was based on 2002 revised tumor-node-metastasis(TNM)staging for gall bladder cancer from the American Joint Committee on *** clinical presentation,laboratory data and preoperative workup were reviewed retrospectively. RESULTS:Five patients were female and one was *** age ranged from 51 to 66 years(median, 58 years).Surgical procedures included three curative resections,two palliative resections and one biopsy. There were two surgical complications(33.3%)and one case of surgical mortality(16.7%).The followup time ranged from 30 d to 5 *** median survival was 2.5 *** prognosis was extremely poor,even after curative resection and postoperative chemotherapy. CONCLUSION:The prognosis of gallbladder sarcomatoid carcinoma was not dependent on TNM stage and was always *** clinicopathological features were different from those of gall bladder cancer.

关键词： Gallbladder Carcinoama Sarcomatoidcarcinoma Surgery Therapy

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Alpha-fetoprotein and 18F-FDG standard uptake value predict tumor recurrence after liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis:Preliminary experience

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 229-234页

作者： Zhe Yang Fang-Zhou Luo Shuo Wang jan Lerut Li Zhuang Qi-Yong Li Xiao Xu Shu-sen Zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhouChina Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhouChina National Clinical Research Center of Infectious Diseases HangzhouChina Starzl Unit of Abdominal Transplantation University Hospitals Saint LucUniversitécatholique LouvainBrusselsBelgium

Background:Portal vein tumor thrombosis(PVTT)is regarded as a contraindication for liver transplantation(LT)in hepatocellular carcinoma(HCC).However,some of these patients may have a favorable prognosis after *** this study,we evaluated the biological behavior of HCC with PVTT using tumor biomarker(alpha-fetoprotein,AFP)and 18 F-FDG positron emission tomography(tumor standard uptake value)to identify a subset of patients who may be suitable for ***:Seventy-five HCC-PVTT liver recipients transplanted during February 2016 and June 2018 were *** pre-transplant prognostic factors were identified by univariate and multivariate *** status was identified following Vp classification(Vp1-Vp4).Results:Three-year recurrence-free survival and overall survival rates were 40%and 65.4%in Vp2-Vp3 PVTT patients,21.4%and 30.6%in Vp4 PVTT patients(P8 cm,pretransplant AFP level>1000 ng/m L and intrahepatic tumor maximal standard uptake value(SUVmaxtumor>5)were independent risk factors for HCC recurrence and overall survival after LT in Vp2-3 PVTT *** risk patients were defined as total tumor diameter≤8 cm;or if total tumor diameter more than 8 cm,with both pre-transplant AFP level less than 1000 ng/m L and intrahepatic tumor SUVmax less than 5,***-two Vp2-3 PVTT HCC patients(46.8%)were identified as low risk patients,and their 3-year recurrence-free and overall survival rates were 67.6%and 95.2%,***:Patients with segmental or lobar PVTT and biologically favorable tumors defined by AFP and 18 F-FDG SUVmax might be suitable for LT.

关键词： Hepatocellular carcinoma Liver transplantation Portal vein tumor thrombosis Alpha-fetoprotein Standard uptake value

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Gastrointestinal tract post-transplant lymphoproliferative disorder after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 556-558页

作者： Qin-Fen Xie Ping Chen Xin-Hua Chen Ji-Min Liu jan Lerut Shu-sen Zheng Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou) Hospital (Zhejiang University International Hospital) Hangzhou 310000 China Pancreatic Surgery and Department of Infectious Disease Shulan(Hangzhou) Hospital (Zhejiang University International Hospital) Hangzhou 310000 China Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Department of Pathology and Molecular Medicine Faculty of Health Science McMaster UniversityHamilton Ontario Canada Starzl Unit of Abdominal Transplantation Université catholique Louvain (UCL) Brussels Belgium

To the Editor:Post-transplant lymphoproliferative disorder（PTLD）is a rare and potentially fatal complication occurring after all types of solid organ transplantation.;PTLD accounts for 20%of all de novo post-transplant tumors.;The most important risk factors for PTLD are prolonged intense immunosuppression and Epstein-Barr virus（EBV）

关键词： DLBCL EBV Gastrointestinal tract post-transplant lympho proliferative disorder after liver transplantation HBV MOP BPR GI OLT

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Local anesthesia with ropivacaine for patients undergoing laparoscopic cholecystectomy

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World Journal of Gastroenterology 2009年第19期15卷 2376-2380页

作者： Chun-Nan Yeh Hsiang-Lin Lee Chun-Yi Tsai Chih-Chung Lin Tzu-Chieh Chao Ta-sen Yeh Yi-Yin jan Department of Surgery Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuan 33375TaiwanChina Department of Anesthesiology Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuan 33375TaiwanChina

AIM:To investigate the effect of pain relief after infu-sion of ropivacaine at port sites at the end of ***:From October 2006 to September 2007,72 patients undergoing laparoscopic cholecystectomy(LC) were randomized into two groups of 36 *** group received ropivacaine infusion at the port sites at the end of LC and the other received normal saline.A visual analog scale was used to assess postoperative pain when the patient awakened in the operating room,6 and 24 h after surgery,and before *** amount of analgesics use was also *** demographics,laboratory data,hospital stay,and perioperative complications were compared between the two ***:There was no difference between the two groups preoperatively in terms of demographic and lab-oratory *** surgery,similar operation time,blood loss,and no postoperative morbidity and mortality were observed in the two ***,a significantly lower pain score was observed in the patients undergo-ing LC with local anesthesia infusion at 1 h after LC and at *** analgesic use,the amount of meperidine used 1 h after LC and the total used during admission were lower in patients undergoing LC with local anesthesia *** group also had a shorter hospital ***:Local anesthesia with ropivacaine at the port site in LC patients signif icantly decreased post-operative pain *** explains the lower meperidine use and earlier discharge for these patients.

关键词： Prospective randomized trial Localanesthesia Ropivacaine Normal saline Laparoscopic cholecystectomy

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