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Disparate outcomes in Hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study

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World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko Esteban Arroyave Akshata Moghe Michael L Kueht Omar AbdulSaldarriaga Kevin H McKinney Heather L Stevenson monique R Ferguson Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino *** mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease Hepatocellular carcinoma

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Evaluation of Acute Toxicity, Antioxidant and Antibacterial Potential of Leaves Extracts from Two Anacardiaceae’s Species: Lannea microcarpa Engl. &K. Krause and Mangifera indica L.

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Journal of Biosciences and Medicines 2022年第10期10卷 125-134页

作者： monique Brigitte Ouattara Jean Hubert Bationo Martin Kiendrebeogo Odile Germaine Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de formation et de recherche en sciences de la vie et de la terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Background: Leaves of Mangifera indica L or Lannea microcarpa Engl. & K. Krause are used in traditional medicine in Burkina Faso to treat bacterial, parasitic or metabolic diseases. Objective: The aim of this study is to evaluate the acute general toxicity, antioxidant potential and antibacterial activitiy of leave’s aqueous extracts from Lannea microcarpa Engl. and K. Krause and Mangifera indica L. The use of these plants in traditional medicine motivated our choice to lead scientific studies. Methods: The aqueous decoction of the leaves is the form of use recommended by traditional healers. We used the same type of extracts for studies. Acute toxicity was studied in NMRI strain mice, with the dose of 2000 mg/kg body weight, for each plant species. The antioxidant activity is evaluated by the method of reduction of radical DPPH. The phytochemical compounds were detected with specific reagent: Alcaloids with Dragendorff’s reagent, Flavonoids with ammonia (NH4OH), Polyphenols and tannins are revelated by ferric chloride (FeCl3). Saponosides were revelated by their foaming power property. Bacterial inhibiting activity is tested by measuring the diameters’ inhibition of extracts on reference strains. Results: The aqueous extracts were not toxic at the maximum dose of 2000 mg/kg body weight, for each plant species. The extracts showed an antioxidant activity with an IC50, 20 μg/ml for Lannea microcarpa and 18 μg/ml for Mangifera indica. The extracts showed no bacterial activity on three strains of bacteria tested: Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The phytochemicals we have identified are for L. microcarpa: tannins and phenolics compounds, triterpenes, saponosides. We identified in M. indica’s extracts: tannins and phenolics compounds, triterpenes, saponosides and flavonoids.

关键词： Lannea microcarpa Mangifera indica Toxicity Antioxidant Activity DPPH Antibacterial Activity Phytochemical Compounds

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Phytochemical Screening and Acute Toxicity Evaluation of Leaves Extract of Two Fabaceae’s Species: <i>Sesbania pachycarpa</i>DC. and <i>Indigofera berhautiana</i>Gillett

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Journal of Biosciences and Medicines 2020年第7期8卷 28-34页

作者： monique Brigitte Ouattara Jean Hubert Bationo Martin Kiendrebeogo Odile Germaine Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de Formation et de Recherche en Sciences de la Vie et de la Terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Objective: The aim of this study is to screen chemical composition and to evaluate the acute general toxicity of leaves aqueous extracts from Sesbania pachycarpa DC. (Fabaceae), used in traditional medicine in Burkina Faso to treat malaria, helminthiasis, and aqueous extracts of the leaves from Indigofera berhautiana Gillet (Fabaceae) used to treat hepatitis and typhoid fever. Methods: Aqueous decoction of leaves from Sesbania pachycarpa DC. or Indigofera berhautiana Gillett which are the form of use recommended by traditional health practitioners, were used for tests. Aqueous extracts used to evaluate the acute toxicity, were studied on mice of strain NMRI. For the toxicity study, the doses of the aqueous extracts were respectively 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg of body weight. Phytochemical screening was done to identify the phytochemicals contained in extracts. Results: Aqueous extracts of two species: Sesbania pachycarpa DC., Indigofera berhautiana Gillet were not toxic at the maximum dose of 2000 mg/kg of body weight. Phytochemical screening, showed coumarins, flavonoids, tannins, polyphenols compounds, steroids and/or triterpenes and saponosides in the aqueous extracts of the two species. Alkaloids were identified in Sesbania pachycarpa aqueous extract.

关键词： Sesbania pachycarpa DC. Indigofera bergautiana Gillet Aqueous Extracts Acute General Toxicity NMRI Strain Phytochemicals Compounds

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The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men

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Asian Journal of Andrology 2023年第6期25卷 674-679页

作者： Peter KF Chiu Thomas YT Lam Chi-Fai Ng Jeremy YC Teoh Carmen CM Cho Hiu-Yee Hung Cindy Hong monique J Roobol Winnie CW Chu Samuel YS Wong Joseph JY Sung SH Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong SARChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong Kong SARChina Erasmus MC Cancer Institute Erasmus Medical UniversityRotterdam 3015The Netherlands Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent *** aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening *** aged 50–75 years were prospectively recruited from a community-based PSA screening *** with PSA 4.0–10.0 ng ml^(−1) had PHI result *** prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥*** significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic *** total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI *** them,28.3%(53/187)had PI-RADS≥3 ***,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received *** the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,*** with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),*** benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<*** them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary *** benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 *** was an important risk stratification step for PCa

关键词： magnetic resonance imaging prostate prostate cancer prostate health index prostate-specific antigen screening

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Chemical abundance analysis of 19 barium stars

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Research in Astronomy and Astrophysics 2016年第1期16卷 159-174页

作者： Guo-Chao Yang Yan-Chun Liang monique Spite Yu-Qin Chen Gang Zhao Bo Zhang Guo-Qing Liu Yu-Juan Liu Nian Liu Li-Cai Deng Francois Spite Vanessa Hill Cai-Xia Zhang College of Physics and Information Engineering Hebei Normal University Shijiazhuang 050024 China Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China University of Chinese Academy of Sciences Beijing 100049 China GEPI Observatoire de Paris-Meudon 92195 Meudon France Physics Department and Tsinghua Center for Astrophysics Tsinghua University Beijing 100084 China Astronomy Department Beijing Normal University Beijing 100875 China Department of Physics Shijiazhuang University Shijiazhuang 050035 China

We aim at deriving accurate atmospheric parameters and chemical abundances of 19 barium（Ba） stars, including both strong and mild Ba stars, based on the high signal-to-noise ratio and high resolution Echelle spectra obtained from the 2.16 m telescope at Xinglong station of National Astronomical Observatories, Chinese Academy of Sciences. The chemical abundances of the sample stars were obtained from an LTE, plane-parallel and line-blanketed atmospheric model by inputting the atmospheric parameters（effective temperatures Teff, surface gravities log g, metallicity [Fe/H] and microturbulence velocity ξt） and equivalent widths of stellar absorption lines. These samples of Ba stars are giants as indicated by atmospheric parameters, metallicities and kinematic analysis about UVW velocity. Chemical abundances of 17 elements were obtained for these Ba stars. Their Na, Al, α- and iron-peak elements（O, Na, Mg, Al, Si, Ca,Sc, Ti, V, Cr, Mn, Ni） are similar to the solar abundances. Our samples of Ba stars show obvious overabundances of neutron-capture（n-capture） process elements relative to the Sun. Their median abundances of[Ba/Fe], [La/Fe] and [Eu/Fe] are 0.54, 0.65 and 0.40, respectively. The Y I and Zr I abundances are lower than Ba, La and Eu, but higher than the α- and iron-peak elements for the strong Ba stars and similar to the iron-peak elements for the mild stars. There exists a positive correlation between Ba intensity and [Ba/Fe].For the n-capture elements（Y, Zr, Ba, La）, there is an anti-correlation between their [X/Fe] and [Fe/H]. We identify nine of our sample stars as strong Ba stars with [Ba/Fe]〉0.6 where seven of them have Ba intensity Ba=2-5, one has Ba=1.5 and another one has Ba=1.0. The remaining ten stars are classified as mild Ba stars with 0.17〈[Ba/Fe]〈0.54.

关键词： methods: observational - stars: abundances - stars: atmospheres - stars: chemically peculiar- stars: kinematics and dynamics - stars: late-type

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Application of Selected Natural Antimicrobial Formulations for the Control of Food Pathogens in Fresh-Cut Cauliflower

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Journal of Food Science and Engineering 2014年第6期4卷 261-270页

作者： Pamphile Tawema Jaejoon Han Stephane Salmieri Khanh Dang Vu monique Lacroix Research Laboratories in Sciences Applied to Food Nutraceutical and Functional Food Institute (INAF) Canadian Irradiation Center (CIC) 1NRS-Institute Armand-Frappier University of Quebec 531 Boulevard des Prairies Laval Quebec H7V 1B7 Canada Department of Food Bioscience and Technology Korea University Seoul 136-701 Korea

In recent years, research on biopolymer based-coating containing natural antimicrobial agents is developing significantly. The objective of this study was to evaluate the antimicrobial efficiency of six formulations containing pre-selected natural antimicrobial compounds against Listeria monocytogenes, Escherichia coli O 157：H7, Salmonella typhimurium, the total bacteria and total yeasts and molds in cauliflower. Each formulation was subjected to a sensory test in parallel to microbiological analysis and the efficiency during storage at 5 ℃ was evaluated for the two best formulations, based on their ability to eliminate the target microorganisms. Both formulations were able to reduce all pathogens and total flora below detectable levels after 24 h of storage at 5 ℃. Using washing or spraying treatments, the two formulations were able to reduce Listeria to undetectable levels for 3 d. This efficiency was extended to 7 d when the formulations were incorporated into an edible coating. Washing treatment with the two formulations was also able to limit the growth of yeast and molds at levels lower than 2 log, for more than 7 d. The population of E. coli was reduced to below the detection limit during 14 d of storage, after washing treatment with the two formulations. The spraying treatment of cauliflower with the formulations allowed the use of very small amounts of antimicrobials while maintaining a fairly good efficiency, greatly reducing the potential costs of implementing this method in the industry. Future research may focus on development of nanoemulsion of antimicrobial formulations based on the developed antimicrobial formulations in this study to improve the better coating efficiency.

关键词： Natural antimicrobials organic acids essential oils food pathogens shelf life.

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Beliefs and Practices Regarding Spirituality as a Healthcare Strategy

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Open Journal of Preventive Medicine 2022年第3期12卷 59-72页

作者： monique S. White Clifton C. Addison Brenda W. Jenkins Department of Public Policy and Administration Jackson State University Jackson MS USA Jackson Heart Study Graduate Training and Education Center Jackson State University Jackson MS USA College of Health Sciences Jackson State University Jackson MS USA School of Public Health Department of Epidemiology and Biostatistics Jackson State University Jackson MS USA

Objective: This study examined the perceptions and practices of medical personnel regarding the spirituality in the treatment management plan of their patients. Methods: A spirituality survey was administered to doctors and nurses, soliciting responses about their beliefs and willingness to include spirituality practices in treating patients within their facility. Respondents were asked to give their views on daily practices regarding the use of spirituality in patient care and patient response to treatment. Results: The doctors’ responses suggest that they believe that solutions to medical problems, patient recovery, and coping are related to mind and body stress issues that surgery and drugs may not necessarily cure. The emphasis on self-care for some of these medical problems can put the patient back in control and eliminate the use of excessive drugs in the treatment process. Chances for health and well being of patients are improved if good medical practices are combined with a strong mental and psychological disposition to provide a vital foundation for directly confronting diseases. Conclusion: Spiritual engagement helps to support a psychological outlook that is necessary for fighting diseases and coping adequately with life’s tragedies. This approach provides a well-balanced attack on disease and increases the patient’s chances of coping and surviving.

关键词： Mississippi Spirituality Healthcare Providers Illness Beliefs

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绅士出街

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汽车生活 2007年第9期 80-83页

作者： monique

有些穿衣习惯很难坚持,特别对于贪爱舒适的男士,比如袖扣、领带。在极简风当道的今时,这些配饰似乎越来越淡出了视野。偶尔瞥见一位穿戴齐整,衬衣、领带、袖扣、皮鞋一样不拉,光鲜出街的男士,竟叫人视为稀有品种,刻薄者更会评判其过于... 详细信息

有些穿衣习惯很难坚持,特别对于贪爱舒适的男士,比如袖扣、领带。在极简风当道的今时,这些配饰似乎越来越淡出了视野。偶尔瞥见一位穿戴齐整,衬衣、领带、袖扣、皮鞋一样不拉,光鲜出街的男士,竟叫人视为稀有品种,刻薄者更会评判其过于雕饰。事实上,能够花心思修饰自己,代表他的生活态度也一定严谨。就像绅士的穿戴仪式,看似繁复,贯穿始终的却是稳重高雅的不凡气度。

关键词：领带仪式搭配含蓄美男人稳重品位建议代表简约

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Isotope Dating of the Potash and Rock Salt Deposit at Bamnet Narong, NE-Thailand

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Open Journal of Geology 2016年第8期6卷 875-894页

作者： Bent T. Hansen Klaus Wemmer monique Eckhardt Prinya Putthapiban San Assavapatchara Geoscience Center Gottingen University of Gottingen Gottingen Germany Geoscience Programme Kanchanaburi Campus Mahidol University Kanchanaburi Thailand Department of Mineral Resources Bureau of Geological Survey Bangkok Thailand

Bamnet Narong is located in northeastern Thailand (Chaiyaphum Province). It is the largest salt mine in the country and has been mined for decades. The landscape in this part of Thailand is characterised by a low plateau, which is called the Khorat Plateau. The plateau is divided into two basins by the Phu Phan Range, the Sakhon Nakhon Basin in the north and the Khorat Basin in the south. The analysed potashes and rock salts are deposited in the Maha Sarakham Formation, which represents the salt-bearing strata of the Khorat Basin. The stratigraphic age of this deposit has been debated since the late 1960’s. The assigned ages range from Mid-Cretaceous to Late Cretaceous and up to the Eocene. In this study different isotopic dating systems (Rb-Sr, Sr-Sr, K-Ar and K-Ca) were applied. The stratigraphic age for the time of deposition was confirmed to be Mid Cretaceous (Cenomanian). Furthermore, the homogeneity of the carnallites was investigated in order to trace a possible redistribution of rubidium.

关键词： Isotope Dating Salt Deposits Mid-Cretaceous Asian Potash Mine Thailand

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WILHELMY平板法及拉开液膜法测定界面张力的原理

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无锡轻工业学院学报 1985年第1期 69-78页

作者： monique Dupeyrat 法国巴黎第六大学物理化学实验室

测定界面或表面张力的方法很多,使用时最重要的是对测量原理有透彻理解,否则不可能得到准确的测定值。本文讨论Wilhelmy平板法及拉开液膜法测定界面张力(或表面张力)的基本原理,并向读者推荐U形环法(一种拉开液膜法)。

关键词：界面张力 WILHELMY 弯月面弯液面液膜法平板法

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