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Dracunculiasis eradication-Finishing the job before surprises arise

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 505-510页

作者： Benjamin Jelle visser Academic Medical Centre University of AmsterdamMeibergdreef 91105AZAmsterdamThe Netherlands

Dracunculiasis(Guinea worm disease) is a preventable waterborne parasitic disease that affects the poorest people living in remote rural areas in sub-Saharan African countries,who do not have access to safe drinking *** Guinea Worm Eradication Program,a 25-year old campaign to rid the world of Guinea Worm disease has now reached its final stage accelerating to zero cases in all endemic *** the 19th and 20th centuries,dracunculiasis was common in much of Southern Asia and the African *** overall number of cases has been reduced tremendously by≥99%,from the 3.32 million cases estimated to have occurred in 1986 in Africa to only I 797 cases reported in 2010 reported in only five countries(Sudan,Mali,Ethiopia,Chad and Ghana) and Asia free of the *** achievement is unique in its kind - the only previously eradicated disease is smallpox,a viral infection for which vaccination was possible - and it has been achieved through primary community-based prevention and health education *** efforts need to be taken in two countries,South Sudan(comprising 94%or I 698 out of 1 797 of the cases reported world-wide in 2010) and Mali because of frequent movements of nomads in a vast area inside and outside Mali’s *** factors favourable to dracunculiasis eradication are available including adequate financial resources,community and political support and high levels of *** there is no reason that this disabling parasitic disease cannot be eradicated soon before surprises arise such as new civil conflicts in currently endemic countries.

关键词： Dracunculiasis Guinea worm disease Eradication

Folate Biofortification of Potato by Tuber-Specific Expression of Four Folate Biosynthesis Genes

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Molecular Plant 2018年第1期11卷 175-188页

作者： Jolien de Lepeleire Simon Strobbe Jana Verstraete Dieter Blancquaert Lars Ambach Richard G.F. visser Christophe Stove Dominique Van der Straeten Laboratory of Functional Plant Biology Department of Biology Ghent University K.L. Ledeganckstraat 35 9000 Ghent Belgium Laboratory of Toxicology Department of BioanalysisGhent University Ottergemsesteenweg 460 9000 Ghent Belgium Plant Breeding Wageningen University & Research Droevendaalsesteeg 16700 Wageningen the Netherlands These authors contributed equally to this article.

Insufficient dietary intake of micronutHents, known as ＂hidden hunger＂, is a devastating global burden, affecting two billion people. deficiency of folates （vitamin B9）, which are known to play a central role in Cl metabolism, causes birth defects in at least a quarter million people annually. Biofortification to enhance the level of naturally occurring folates in crop plants, proves to be an efficient and cost-effective tool in fighting folate deficiency. Previously, introduction of folate biosynthesis genes GTPCHI andADCS, proven to be a successful biofortification strategy in rice and tomato, turned out to be insufficient to adequately increase folate levels in potato tubers. Here, we provide a proof of concept that additional introduction of HPPK/DHPS and/or FPGS, downstream genes in mitochonddal folate biosynthesis, enables augmenta- tion of folates to satisfactory levels （12-fold） and ensures folate stability upon long-term storage of tubers. In conclusion, this engineering strategy can serve as a model in the creation of folate-accumulating potato cultivars, readily applicable in potato-consuming populations suffedng from folate deficiency.

关键词： folate vitamin Bg malnutrition biofortification potato metabolic engineering

Scalable Jet-Based Fabrication of PEI-Hydrogel Particles for CO_(2) Capture

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Energy & Environmental Materials 2024年第6期7卷 351-358页

作者： Jieke Jiang Eline van Daatselaar Hylke Wijnja Tessa de Koning Gans Michel Schellevis Cornelis H.Venner derk W.F.Brilman Claas Willem visser Engineering Fluid Dynamics Group Department of Thermal and Fluid EngineeringFaculty of Engineering TechnologyUniversity of Twente7500AEEnschedeThe Netherlands Sustainable Process Technology Faculty of Science and TechnologyUniversity of Twente7500AEEnschedeThe Netherlands

The capture,regeneration,and conversion of CO_(2) from ambient air and flue gas streams are critical aspects of mitigating global *** sorbents for CO_(2) absorption are very promising as they have high mass transfer areas without energy input and reduce emissions and minimize corrosion as compared to liquid ***,precisely tunable solid CO_(2) sorbents are difficult to ***,we demonstrate the high-throughput production of hydrogel-based CO_(2)-absorbing particles via liquid *** wrapping a liquid jet consisting of an aqueous solution of cross-linkable branched polyethylenimine(PEI)with a layer of suspension containing hydrophobic silica nanoparticles,monodisperse droplets with a silica nanoparticle coating layer was formed in the air.A stable Pickering emulsion containing PEI droplets was obtained after these ejected droplets were collected in a heated oil *** droplets turn into mm-sized particles after thermal curing in the *** diameter,PEI content,and silica content of the particles were systematically varied,and their CO_(2) absorption was measured as a function of *** regeneration of the particles enabled cyclic testing,revealing a CO_(2) absorption capacity of 6.5±0.5 mol kg^(−1)solid PEI in pure CO_(2) environments and 0.7±0.3 mol kg^(−1)solid PEI for direct air *** thousands of particles were produced per second at a rate of around 0.5 kg per hour,with a single *** process can be further scaled by *** complete toolbox for the design,fabrication,testing,and regeneration of functional hydrogel particles provides a powerful route toward novel solid sorbents for regenerative CO_(2) capture.

关键词： CO_(2) capture droplet hydrogel liquid jet particle steam regeneration

Multimodal Fused deep Learning Networks for Domain Specific Image Similarity Search

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Computers, Materials & Continua 2023年第4期75卷 243-258页

作者： Umer Waqas Jesse Wiebe visser Hana Choe Donghun Lee Research and development AItheNutrigeneSeoul06132Korea

The exponential increase in data over the past fewyears,particularly in images,has led to more complex content since visual representation became the new norm.E-commerce and similar platforms maintain large image catalogues of their *** image databases,searching and retrieving similar images is still a challenge,even though several image retrieval techniques have been proposed over the *** of these techniques work well when querying general image ***,they often fail in domain-specific image databases,especially for datasets with low intraclass *** paper proposes a domain-specific image similarity search engine based on a fused deep learning *** network is comprised of an improved object localization module,a classification module to narrow down search options and finally a feature extraction and similarity calculation *** network features both an offline stage for indexing the dataset and an online stage for *** dataset used to evaluate the performance of the proposed network is a custom domain-specific dataset related to cosmetics packaging gathered from various online *** proposed method addresses the intraclass variance problem with more precise object localization and the introduction of top result reranking based on object ***,quantitative and qualitative experiment results are presented,showing improved image similarity search performance.

关键词： Image search classification image retrieval deep learning

Potential of South African road technology for application in China

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第2期4卷 113-117页

作者： Alex T. visser department of Civil Engineering University of Pretoria Pretoria South Africa School of Highways Chang'an Uniuersity Xi'an 710064 China

One of the main problems with roads and highways in China is the reflection cracking caused by the cement stabilized subbase layers passing through the overlying asphaltic layers. The cracks permit the ingress of moisture which softens the layers below the subbase resulting in loss of support and accelerated breakdown of the subbase layer and reduction in the tiding quality. The aim of this paper is to present the use of South African pavement design approach of deep structure and thin surfacing to overcome the existing problems. The deep pavement structure provides good long-term support and avoids the influence of moisture ingress, which means that only surfacing damage needs to be repaired. An unbound crushed stone base layer which is an integral component of the pavement structure limits reflection cracking. The paper first deals with the South African pavement design procedure and contrast this with the Chinese pavement design method. The inherent weaknesses of these methods are discussed and flowing from this discussion proposals for adapting the South African approach to China is presented. The resultant proposals have a high likelihood of success and will counteract the influences of extreme climate and rampant overloading that occurs on the Chinese roads.

关键词： Pavement design Reflection crack Performance Overloading deep structure

Programmed Cell death in Relation to Petal Senescence in Ornamental Plants

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Journal of Integrative Plant Biology 2005年第6期47卷 641-650页

作者： YuanZHOU Cai-YunWANG HongGE FrankA.HOEBERICHTS PETERB.visser StateKeyLaboratoryforBiologyofHorticulturalPlants HuazhongAgriculturalUniversityWuhan430070China StateKeyLaboratoryforBiologyofHorticulturalPlants HuazhongAgriculturalUniversityWuhan430070China／／CollegeofLandscapeArchitectureBeijingForestryUniversityBeijing100083China InstituteofVegetablesandFlowers ChineseAcademyofAgriculturalSciencesBeijing100081China InstitutodeBiologfaMolecularyCelulardePlantas UniversidadPolit~cnicadeValencia-CSICAvdadelosNaranjoss／n46022ValenciaSpain InstitutoAgroforestalMediterrdneo UniversidadPolitdcnicadeValenciaCaminodeVeras／n46022ValenciaSpain

Abstract: Cell death is a common event in all types of plant organisms. Understanding the phenomenon of programmed cell death (PCD) is an important area of research for plant scientists because of its role in senescence and the post-harvest quality of ornamentals, fruits, and vegetables. In the present paper, PCD in relation to petal senescence in ornamental plants is reviewed. Morphological, anatomical, physiological, and biochemical changes that are related to PCD in petals, such as water content, sink-source relationships, hormones, genes, and signal transduction pathways, are discussed. Several approaches to improving the quality of post-harvest ornamentals are reviewed and some prospects for future research are given.

关键词： ornamental plants petal senescence post-harvest quality programmed cell death

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单晶CeB6发射性能及磁电阻各向异性研究

物理学报 2017年第18期66卷 173-179页

作者：包黎红陶如玉特古斯黄颖楷冷华倩 Anne de visser 内蒙古自治区功能材料物理与化学重点实验室内蒙古师范大学呼和浩特010022 Van der Waals-Zeeman Institute University of AmsterdamScience Park 9041098 XH AmsterdamThe Netherlands

采用X射线劳厄定向法对单晶CeB_6的(110),(111),(210)和(310)晶面进行了定向.系统研究了不同晶面热发射性能及磁场对电阻率的影响规律.结果表明,当阴极温度为1873 K时(110),(111),(210)和(310)晶面最大发射电流密度分别为38.4,11.54,50.... 详细信息

采用X射线劳厄定向法对单晶CeB_6的(110),(111),(210)和(310)晶面进行了定向.系统研究了不同晶面热发射性能及磁场对电阻率的影响规律.结果表明,当阴极温度为1873 K时(110),(111),(210)和(310)晶面最大发射电流密度分别为38.4,11.54,50.4和20.8 A/cm^2,表现出了发射性能的"各向异性".RichardsonDushman公式计算逸出功结果表明,上述晶面中(210)晶面具有最低的逸出功,为2.4 eV.从实际应用来看,该晶面有望替代商业化的钨灯丝成为新一代的场发射阴极材料.磁电阻率测量结果显示,当晶体从[001]方向旋转至[011]方向时电阻率从73μ?·cm变化至69μ?·cm,表明电阻率在磁场中沿不同方向同样具有"各向异性"的特点.

关键词： CeB6 逸出功磁电阻

Surgery in (pre)malignant celiac disease

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World Journal of Gastroenterology 2015年第43期21卷 12403-12409页

作者： Jolanda MW van de Water Petula Nijeboer Laura R de Baaij Jessy Zegers Gerd Bouma Otto J visser Donald L van der Peet Chris JJ Mulder Wilhelmus JHJ Meijerink department of Gastroenterology and Hepatology Coeliac Center AmsterdamVU University Medical Center department of Haematology Coeliac Center AmsterdamVU University Medical Center department of Surgery Coeliac Center Amsterdam VU University Medical Center

AIM: To report the outcome of surgery in patients with(pre)malignant conditions of celiac disease(CD) and the impact on ***: A total of 40 patients with(pre)malignant conditions of CD,ulcerative jejunitis(n = 5) and enteropathy associated T-cell lymphoma(EATL)(n = 35),who underwent surgery between 2002 and 2013 were retrospectively evaluated. Data on indications,operative procedure,post-operative morbidity and mortali ty,adjuvant therapy and overal l survival(OS) were collected. Eleven patients with EATL who underwent chemotherapy without resection were included as a control group for survival analysis. Patients were followed-up every three months during the first year and at 6-mo intervals ***: Mean age at resection was 62 years. The majority of patients(63%) underwent elective laparotomy. Functional stenosis(n = 1 3) and perforation(n = 12) were the major indications for surgery. In 70% of patients radical resection wasperformed. Early postoperative complications,mainly due to leakage or sepsis,occurred in 14/40(35%) of patients. Eight patients required reoperation. More patients who underwent resection in the acute setting(n = 3,20%) died compared to patients treated in the elective setting. With a median follow-up of 20 mo,seven patients(18%) required reoperation due to long-term complications. Significantly more patients who underwent acute surgery could not be treated with adjuvant chemotherapy. Patients who first underwent surgical resection showed significantly better OS than patients who received chemotherapy without ***: Although the complication rate is high,the preferred first step of treatment in(pre)malignant CD consists of local resection as early as possible to improve survival.

关键词： Enteropathy associated T-cell lymphoma Ulcerative

A novel forecasting approach to schedule aggregated electric vehicle charging

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Energy and AI 2023年第4期14卷 522-535页

作者： Nico Brinkel Lennard visser Wilfried van Sark Tarek AlSkaif Copernicus Institute of Sustainable development Utrecht UniversityPrincetonlaan 8aUtrecht3584 CBThe Netherlands Information Technology Group(INF) Wageningen University and Research(WUR)Hollandseweg 1Wageningen6706 KNThe Netherlands

To be able to schedule the charging demand of an electric vehicle fleet using smart charging,insight is required into different charging session characteristics of the considered fleet,including the number of charging sessions,their charging demand and arrival and departure *** use of forecasting techniques can reduce the uncertainty about these charging session characteristics,but since these characteristics are interrelated,this is not ***,forecasting frameworks that cover all required characteristics to schedule the charging of an electric vehicle fleet are absent in scientific *** cover this gap,this study proposes a novel approach for forecasting the charging requirements of an electric vehicle fleet,which can be used as input to schedule their aggregated charging *** the first step of this approach,the charging session characteristics of an electric vehicle fleet are translated to three parameter values that describe a virtual ***,optimal predictor variable and hyperparameter sets are *** serve as input for the last step,in which the virtual battery parameter values are *** approach has been tested on a real-world case study of public charging stations,considering a high number of predictor variables and different forecasting models(Multivariate Linear Regression,Random Forest,Artificial Neural Network and k-Nearest Neighbors).The results show that the different virtual battery parameters can be forecasted with high accuracy,reaching R^(2) scores up to 0.98 when considering 400 charging *** addition,the results indicate that the forecasting performance of all considered models is somehow similar and that only a low number of predictor variables are required to adequately forecast aggregated electric vehicle charging characteristics.

关键词： Forecasting Electric vehicle smart charging Electric vehicle aggregation Virtual battery method