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Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： Kiyoto Takehara Hideki Aoki Yuko Takehara rie yamasaki Kohji Tanakaya Hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词：原发性直肠癌肝癌肉瘤病理组织学检查肝脏肿瘤化疗药物氟尿嘧啶

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Synchronous coexistence of liver metastases from cecal leiomyosarcoma and rectal adenocarcinoma: A case report

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World Journal of Gastroenterology 2017年第9期23卷 1725-1734页

作者： Hideki Aoki Takashi Arata Masashi Utsumi Yutaka Mushiake Tomoyoshi Kunitomo Isao Yasuhara Fumitaka Taniguchi Koh Katsuda Kohji Tanakaya Hitoshi Takeuchi rie yamasaki Department of Surgery Iwakuni Clinical Center Department of Pathology Iwakuni Clinical Center

Multiple liver tumors represent a challenging condition for abdominal surgeons both in the selection of technique and the rarity of diagnosis. There are no case reports on co-existence of liver metastases from both intestinal leiomyosarcoma and adenocarcinoma. The patient described in this report successfully underwent resection of both primary lesions and liver metastases in combination with chemotherapy. As for the leiomyosarcoma, the primary cecal lesion was revealed more than three years after the patient's first visit. Peritoneal, lymph-node, and lung recurrences were observed afterward, and thus surgeries on those regions were performed. Pathologically, the peritoneal and lung recurrences comprised leiomyosarcoma and the lymphnode recurrence was diagnosed as adenocarcinoma. Despite newly discovered multiple lung recurrences and regional lymph-node metastases, the patient lived a normal life for 73 mo after the initial operation based on multidisciplinary therapy. He ultimately died of liver failure due to invasive lymph-node recurrence from the rectal adenocarcinoma, in addition to multiple lung recurrences from the leiomyosarcoma. Hepatic recurrence did not occur in this patient's case, which appears to be one reason for his long-term survival.

关键词： Leiomyosarcoma 化疗多重肝肿瘤肝转移腺癌

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A GLOBAL VIEW OF THE LANDFALL CHARACTERISTICS OF TROPICAL CYCLONES

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Tropical Cyclone Research and Review 2014年第3期3卷 178-192页

作者： HIRONORI FUDEYASU SHUN HIROSE HIROAKI YOSHIOKA rie KUMAZAWA SHOTA yamasaki Yokohama National University

This report presents a climatology of the landfall characteristics of tropical cyclones(TCs) by country. Landfalling TCs can produce strong winds, storm surges and severe flooding that may result in loss of life and widespread damages. Although historically many governments have estimated the frequency of TC landfall for their own country, less work has been undertaken from a global viewpoint. This report addresses that gap by presenting a comparative assessment that may assist global efforts toward disaster risk reduction through improved understanding of the relative level of exposure of countries to TCs. The various aspects of the climatology of TC landfalls for each country are provided. Using the definition of a TC landfall as the intersection of the TC track with a coastline, eleven countries were detected as having an average of at least one landfall per year. China has the highest rate of TC landfalls. The Philippines ranks second and Japan third. A lot of countries that face the North Western Pacific were included in TC-Landfall countries, which is attributed to the high rate of TC formation over the basin.

关键词： landfall climatology of landfall characteristics ranking of TC landfall country

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