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A review of selected parasitic plants in Nigeria:converting harms to benefits

Natural Therapy Advances 2024年第3期7卷 14-28页

作者： Funmilayo I.D.Afolayan ridwan a.salaam Ebenezer S.Oladokun Samson D.Adesoye Department of Zoology University of IbadanIbadan 200132Nigeria

Parasitic plants are challenging to agricultural crops and forestry development,which are sources of major revenues in several countries,including ***,parasitic plants are important to human society as they have an abundance of bioactive compounds with pharmacological ***,it becomes expedient to know the benefits of these plants and potential means of *** review discusses four selected parasitic plants in Nigeria,namely Viscum album,Striga hermonthica,Tapinanthus bangwensis and Cuscuta *** information about their pharmacological relevance and biocontrol was obtained from credible databases,including the National Library of Medicine,SCOPUS,and Google *** review showed that all four plants have been extensively studied for their antioxidant and antitumor ***,antimicrobial and anti-inflammatory activities are common pharmacological values among parasitic *** are largely due to the presence of abundant beneficial classes of ***,there is an increasing number of biocontrol studies on the use of microorganisms,such as Phaeobotryosphaeria visci,Sphaeropsis visci,Pandoraea pulminicol,Colletotrichum gloeosporioides,and Fusarium oxysporum in controlling and managing these seemingly disastrous *** is hoped that this review will spur further studies into the conservation and proper management of parasitic plants using strategically developed biocontrol.

关键词： parasitic plants pharmacological values biocontrol plant management and control ethnopharmacology

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Antiplasmodial mechanism of Lawsonia inermis: An in silico based investigation

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Infectious Diseases Research 2024年第1期5卷 8-26页

作者： ridwan Abiodun salaam Funmilayo I.D.Afolayan Department of Zoology University of IbadanIbadan 200005Nigeria.

Background:Lawsonia inermis has been widely reported to be used as an herbal treatment for ***,despite several experimental studies about its antimalarial activities,the approach through which the herbal plant suppresses plasmodium infection is yet to be ***,this study uses computational approaches to understand the biological targets and pathways involved in the antiplasmodial activities of Lawsonia inermis ***:The Gas Chromatography-Mass Spectrometry technique identified the phytocompounds present in the herbal ***,OMIM,and NCBI databases were explored to collate target proteins for further network pharmacology *** phytocompounds were subjected to Absorption,Distribution,Metabolism,Excretion and Toxicity(ADMET)and druglikeness *** STRING algorithm and Cytoscape were employed to develop and analyze the relationships among target proteins and compounds/targets/pathways network of the putative targets of the *** computational analysis was carried out to identify potential drug ***:Based on the Network Pharmacology studies,phytocompounds in Lawsonia inermis exhibit antiplasmodial activity by interacting with therapeutic genes that play essential roles in metabolism and signaling *** among the genes are MMP9,MAPK1,HMOX1 and ***,the most influenced pathways include the metabolic pathway,PI3K-Akt signaling pathway,and HIF-1 signaling *** analysis,molecular docking analysis,and molecular dynamics simulation revealed that 3-phenyl-2-Isoxazoline and 2-Dimethylamino-3’-methoxyacetophenone are recommendable drug leads for Malaria treatment as they form stable and favorable complexes with Matrix metalloproteinase-9(MMP9)***:The 3-phenyl-2-Isoxazoline and 2-Dimethylamino-3’-methoxyacetophenone phytocompounds from Lawsonia inermis herbal plant are predicted as antimalarial drug candidates and recommended for further wet-lab studies.

关键词： Lawsonia inermis computational studies plasmodium falciparum network pharmacology molecular dynamic

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Elucidating the molecular targets of Curcuma longa for breast cancer treatment using network pharmacology,molecular docking and molecular dynamics simulation

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Precision Medicine Research 2023年第2期5卷 16-31页

作者： Christopher Terseer Tarkaa Damilare Adebayo Oyaniyi ridwan Abiodun salaam Rachael Pius Ebuh Olusola Abayomi Akangbe Sayo Ebenezer Oladokun Rodiat Omotola Sowemimo Oluwaponmile Florence Ajayi Cell Biology and Genetics Unit Department of ZoologyUniversity of IbadanIbadan 200005Nigeria Ecology and Environmental Biology Unit Department of ZoologyUniversity of IbadanIbadan 200005Nigeria

Background:To elucidate the molecular mechanisms of Curcuma longa(***)in breast cancer ***:Phytocompounds of *** were obtained from ***’s Phytochemical and Ethnobotanical *** active targets were retrieved from Bindingdb,SEA and Swiss Target Prediction *** cancer targets were retrieved from the Therapeutic Target *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were done using DAVID and KOBAS3.0 databases *** Cytoscape software was used to construct the phytocompound-target-pathway *** PyRx and Desmond software were utilized for molecular docking and molecular dynamics simulation ***:Out of one hundred and fifty-six phytocompounds,fifty-four modulated proteins involved in breast *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated *** exerts its therapeutic effect through regulating several key *** docking analysis revealed that most phytocompounds of *** had a good affinity with the key *** dynamics simulation showed that ethinylestradiol formed stable ligand-protein ***:The results of this study will enhance our understanding of the potential molecular mechanisms by which *** inhibits breast cancer and lay a foundation for future experimental studies.

关键词： Curcuma longa network pharmacology breast cancer mechanism molecular docking molecular dynamics simulation

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