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World Journal of Ophthalmology 2014年第4期4卷 130-139页

作者： rick N Nordgren Ahmed M Elkeeb Bernard F Godley Department of Ophthalmology and Visual Sciences University of Texas Medical BranchGalvestonTX 77555United States

Age-related macular degeneration(AMD) is the leading cause of irreversible blindness in the developed world. The quality of life of both patients and families is impacted by this prevalent disease. Previously, macular degeneration had no known effective treatment. Today, vitamins for non-exudative AMD and intravitreal injection of medications for its exudative form are primary forms of current treatment. Modern advances in molecular science give rise to new possibilities of disease management. In the year 2003 the sequencing of the entire human genome was completed. Since that time, genes such as complement factor H, high-temperature requirement factor A1, and age-relateed maculopathy susceptibility 2 have been discovered and associated with a higher risk of AMD. A patient's genetic make-up may dictate the effectiveness of current or future therapeutic options. In addition, utilizing genetic data and incorporating it into new treatments(such as viral vectors) may lead to longer-lasting(or permanent) VEGF blockade and specific targeting of complement related genes. There have also been considerable advances in stem cell directed treatment of AMD. Retinal pigment epithelial(RPE) cells can be derived from human embryonic stem cells, induced pluripotent stem cells, or adult human RPE stem cells. Utilizing animal models of RPE and retinal degeneration, stem cell-derived RPE cells have been successfully implanted into the subretinal space. They have been injected as a cell mass or as a pre-prepared monolayer on a thin membrane. Visual recovery has been demonstrated in a retinal dystrophic rat model. Preliminary data on 2 human subjects also demonstrates possible early visual benefit from transplantation of stem cell-derived RPE. As more data is published, and as differentiation and implantation techniques are optimized, the stabilization and possible improvement of vision in individuals with non-exudative macular becomes a real possibility. We conclude that the technologi

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Assessment of Pseudorange Multipath at Continuous GPS Stations in Mexico

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Positioning 2013年第3期4卷 253-265页

作者： G. Esteban Vázquez rick Bennett Joshua Spinler Department of Geosciences The University of Arizona Tucson USA. Faculty of the Earth and Space Sciences The Autonomous University of Sinaloa Culiacan Mexico

We conducted a study to quantify the amount of pseudorange multipath at continuous Global Positioning System (CGPS) stations in the Mexican territory. These CGPS stations serve as reference stations enabling rapid high-precision three-dimensional positioning capabilities, supporting a number of commercial and public safety applications. We studied CGPS data from a large number of publicly available networks spanning Mexico. These include the RGNA (National Active Geodetic Network) administered by INEGI (National Institute of Statistics and Geography), the PBO network (Plate Boundary Observatory) funded by the National Science Foundation (NSF) and operated by UNAVCO (University NAVstar Consortium), the Southern California Integrated GPS Network (SCIGN), which is a collaboration effort of the United States Geological Survey (USGS), Scripps Institution of Oceanography and the Jet Propulsion Laboratory (JPL), the UNAM network, operated by the National Seismological System (SSN) and the Institute of Geophysics of the National Autonomous University of Mexico (UNAM), the Suominet Geodetic Network (SNG) and the CORS (Continuously Operating Reference Station) network, operated by the Federal Aviation Administration (FAA). We evaluated a total of 53 CGPS stations, where dual-frequency geodetic-grade receivers collected GPS data continuously during the period from 1994 to 2012. Despite carefully selected locations, all GPS stations are, to some extent, affected by the presence of signal multipath. For GPS network users that rely on pseudorange observables, the existence of pseudorange multipath could be a critical source of error depending on the time scale of the application. Thus, to identify the most and the least affected GPS stations, we analyzed the averaged daily root mean square pseudorange multipath variations (MP1-RMS and MP2-RMS) for all feasible satellites tracked by the CGPS networks. We investigated the sources of multipath, including changes associated with hard

关键词： Pseudorange Multipath GPS Network

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Ice Jam Modelling of the Lower Red River

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Journal of Water Resource and Protection 2012年第1期4卷 1-11页

作者： Karl-Erich Lindenschmidt Maurice Sydor rick Carson Robert Harrison 不详

The lower reach of the Red River between Winnipeg and Lake Winnipeg is very prone to ice jam flooding. The one- dimensional ice jam model RIVICE was implemented for this reach to better understand the processes leading to such events and to provide a tool to evaluate strategies for ice jam mitigation. The most downstream portion of this river stretch flows through a delta and marsh system which poses challenges in modelling ice jams in such an area of low-lying topography and river banks. Solutions to overcome these challenges are discussed in this paper and results of one such solution using water abstractions from the main channel are also presented. Abstractions are inserted in the model to represent under-ice leakage from the main channel to side channel storage and diversions (up to 65% in the Red River delta) and spillage into the delta floodplain.

关键词： Ice Jam Modeling Netley Creek Letley-Libau Marsh Red River Delta RIVICE

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Nanostructured Materials for Energy Storage Applications

Nanostructured Materials for Energy Storage Applications

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ICAM Workshop Physics of Novel Energy Materials

作者： rick E.Williford Gordon L.Graff Pacific Northwest National Laboratory

Recent developments on nano-technology have provided new momentum on the exploration of the high energy density materials. Our recent progresses on the effect of nano-structured materials on the performance of Li-ion ...

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Routing Protocols and Concepts : CCNA Exploration Companion Guide

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1000年

作者： rick Graziani Allan Johnson

Inside the router -- CLI configuration and addressing -- Building the routing table -- Path determination and switching functions.

ISBN: (纸本)9781587132728

Inside the router -- CLI configuration and addressing -- Building the routing table -- Path determination and switching functions.

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The dynamics of color signals in male threespine sticklebacks Gasterosteus aculeatus

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Current Zoology 2016年第1期62卷 23-31页

作者： Meike HIERMES Ingolf P. rick Marion MEHLIS Theo C. M. BAKKER Institute for Evolutionary Biology and Ecology University of Bonn An der Immenburg 1 53121 Bonn Germany

Body coloration and color patterns are ubiquitous throughout the animal kingdom and vary be- tween and within species. Recent studies have dealt with individual dynamics of various aspects of coloration, as it is in many cases a flexible trait and changes in color expression may be context-de- pendent. During the reproductive phase, temporal changes of coloration in the visible spectral range （400-700 nm） have been shown for many animals but corresponding changes in the ultravio- let （UV） waveband （300-400 nm） have rarely been studied. Threespine stickleback Gasterosteus aculeatus males develop conspicuous orange-red breeding coloration combined with UV reflect- ance in the cheek region. We investigated dynamics of color patterns including UV throughout a male breeding cycle, as well as short-term changes in coloration in response to a computer- animated rival using reflectance spectrophotometry and visual modeling, to estimate how colors would be perceived by conspecifics. We found the orange-red component of coloration to vary during the breeding cycle with respect to hue （theta/R50） and intensity （achieved chroma/red chroma）. Furthermore, color intensity in the orange-red spectral part （achieved chroma） tended to be increased after the presentation of an artificial rival. Dynamic changes in specific measures of hue and intensity in the UV waveband were not found. In general, the orange-red component of the signal seems to be dynamic with respect to color intensity and hue. This accounts in particular for color changes during the breeding cycle, presumably to signal reproductive status, and with limitations as well in the intrasexual context, most likely to signal dominance or inferiority.

关键词： breeding season color change color signals stickleback structural coloration UV coloration

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全球最优秀的风险投资公司

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科学投资 2000年第12期 69-71,73-74,76,78,81-82页

作者： rick

当决定对风险投资公司进行排名时，我们意识到这并非易事。

关键词：风险投资公司排名全球决定最优优秀意识

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Ergot Alkaloid Effects on Bovine Sperm Motility <i>In Vitro</i>

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Advances in Reproductive Sciences 2019年第1期7卷 7-15页

作者： Ryan Page Toby Lester rick Rorie Charles Rosenkrans Jr. Department of Animal Science Division of Agriculture University of Arkansas System Fayetteville Arkansas USA

Cattle in some parts of the world graze pastures that consist of tall fescue that may contain ergot alkaloid contamination. Those ergot alkaloids are associated with reduced reproductive rates in cattle. Our objective was to determine if ergot alkaloids [dihydroergotamine (DHET), ergonovine (EN), and ergotamine (ET)] directly affect bovine sperm characteristics. Spermatozoa were collected from mature Angus (n = 2) and Balancer (n = 4) bulls. Within bull, treatments were structured as a 3 × 5 factorial with three alkaloids (DHET, EN, and ET) and five concentrations of each alkaloid (0, 33, 66, 100, or 200 μM). Spermatozoa (25 × 106) were incubated (39?C) in 1 mL of modified sperm medium. Sperm motility characteristics were evaluated using CASA (Hamiliton Thorne IVOS, Beverly, MA) at 0, 3, and 6 h after initial alkaloid exposure. Initial sperm motility was (69% ± 1.1%) and declined (P = 0.01) to (35% ± 2.6%) at 6 h. Sperm motility decreased (P P < 0.05) both characteristics. Our results demonstrate that ergot alkaloids (ET and DHET) can directly alter bovine sperm motility and morphology, which adds to our understanding of how ergot alkaloids may hinder cattle reproductive rates.

关键词： CASA Bull Spermatozoa Toxins

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Unicenter TNG实战第2版

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丛书名：计算机技术译林精选系列

2001年

作者：（美）rick Sturm等潇湘工作室译

本书介绍企业管理软件Unicenter TNG，其内容主要有：Unicenter TNG的体系结构和框架；利用Unicenter TNG管理网络、服务器、桌面、存储；管理并解决出现的问题；加强安全措施等。

ISBN: (纸本)7115087369

关键词：企业管理应用软件

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梁咏琪爱得起

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甲壳虫 2009年第2期 76-81页

作者： rick

你敢不敢·爱得起?从出道那天起,梁咏琪就被定义成了"玉女"。当女艺人与"玉女"的称号有了关联,未来的道路会更加艰难。可她偏偏知难而上,更要命的是,她还要在"玉女"前面加上"像才女一样的"玉女,如果没做到,那将是一败涂地,但若做到了,... 详细信息

你敢不敢·爱得起?从出道那天起,梁咏琪就被定义成了"玉女"。当女艺人与"玉女"的称号有了关联,未来的道路会更加艰难。可她偏偏知难而上,更要命的是,她还要在"玉女"前面加上"像才女一样的"玉女,如果没做到,那将是一败涂地,但若做到了,她得到的喝彩声中。

关键词：梁咏琪女艺人专业度我自己郑伊健我不知道鼓起勇气娱乐圈告诉我身份转变

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