检索结果-南通市图书馆

Investigation of Interaction of Some chalcones and cyclic chalcone Analogues with Outer Mitochondrial Membrane by UV-VIS and Fluorescence Spectroscopy

引用

Spectral Analysis Review 2013年第1期1卷 1-9页

作者： Vladimíra tomecková Miroslava Stefanisinová Beáta Veliká Krisztina Fodor Pal Perjési Marek Stupák Juraj Guzy Stefan tóth Jr tímea Pekárová Department of Medical chemistry Biochemistry and Clinical BiochemistryFaculty of MedicinePavol Jozef Safárik University in KosiceKosiceSlovakia Institute of Pharmaceutical chemistry Faculty of MedicineUniversity of PécsPécsHungary

Interaction of the synthetic chalcones (1b,1c) and their cyclic analogues (2b,2c) with bovine (BSA) and human serum albumin (HSA) as well as with rat liver mitochondria (RLM) was studied by fluorescence spectroscopy. the maxima of emission fluorescence spectra were changed only in the case of 2b and 2c during interaction with BSA, HSA as well as mitochondrial outer membrane showing a slight hypsochromic shift and decrease of fluorescence. Interaction of the methoxy-(1b,2b) and the dimethylamino-substituted (1c,2c) compounds with outer mitochondrial membrane were studied by fluorescence polarization. Fluorescence polarization of 1b in the presence of the two proteins and mitochondria was found to be unchanged. Under similar conditions (2b,1c,2c) showed continuously increasing fluorescence polarization signal during the 30 minute period of investigations. Since fluorescence polarization supposes that as a result of binding these substances to proteins and lipids. compound 2c displayed a continuous increase of fluorescence polarization signal in the presence of proteins (BSA, HSA), yeast c.t.plasm (Yc) and mitochondria (YM and RLM). this compound displayed a significant c.t.toxic effect. this pattern of interaction with proteins might be one of the contributing vectors of the observed c.t.toxic.t. against several human carcinoma cell lines.

关键词： chalcones Yeast c.t.plasm Yeast Mitochondria Rat Liver Mitochondria Fluorescence Polarization? Fluorescence Synchronous Fingerprint

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stress-Induced Flowering in Pharbitis—A Review

引用

American Journal of Plant Sciences 2013年第12期4卷 74-79页

作者： Kaede c. Wada Mizuki Yamada Kiyotoshi takeno Department of Applied Biological chemistry Faculty of Agriculture Niigata University Niigata Japan Graduate School of Science and technology Niigata University Niigata Japan Graduate School of Science and technology Niigata University Niigata Japan Department of Biology Faculty of Science Niigata University Niigata Japan

Many plant species are induced to flower by stress. Stress-induced flowering has been studied mostly in the short-day plant pharbitis (also called Japanese morning glory;Ipomoea nil, formerly Pharbitis nil). In this article, physiological characteristics, the regulation by salicylic acid (SA) and the expression of flowering-related genes in stress-induced flowering in pharbitis are reviewed. Pharbitis flowered under long-days in response to poor nutrition or low temperature. the pharbitis plants induced to flower by stress reached anthesis, fruited and produced fertile seeds. the progeny of the stressed plants developed normally. Grafting experiments indic.t.d that a transmissible flowering stimulus is involved in poor nutrition stress-induced flowering. Aminooxyac.t.c acid (AOA), a phenylalanine ammonia-lyase (PAL) inhibitor, inhibited the stress-induced flowering, and this inhibition was overcome by SA. Stress induced PAL activity and SA biosynthesis. PnFt2, a pharbitis ortholog of the flowering gene FLOWERING LOcUS t of Arabidopsis thaliana, was expressed when the plants were induced to flower by stress. the overexpression of PnFt2 induced flowering, and PnFt2RNAi inhibited it. AOA inhibited PnFt2 expression induced by stress, and SA eliminated this inhibitory effect. SA enhanced PnFt2 expression under poor nutrition but not under non-stressful conditions. therefore, stress may induce the production of SA and other unknown factor(s) that may work in combination to induce PnFt2 expression and flowering.

关键词： Flowering Pharbitis PnFt Salicylic Acid Stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacogenetics of response to simvastatin in chinese patients with hyperlipidaemia

引用

沈阳药科大学学报 2008年第S1期25卷 1-1页

作者： tOMLINSON B MAK V W L cHU t t W tSUI t LEE V W Y Department of Medicine & therapeutics Chinese University of Hong Kong Department of chemical Pathology Chinese University of Hong Kong School of Pharmacy Faculty of MedicineChinese University of Hong Kong

Objective to examine the relationship of single-nucleotide polymorphisms(SNPs)in candidate genes with the lipid responses to *** chinese patients were treated with simvastatin 40 mg daily for at least 6 weeks.20 SNPs in 11 genes were *** 95 patients age(mean±SD)57.5±10.6 years completed the *** Adiponectin 45t>G polymorphism was significantly related to absolute reductions in total cholesterol(tc)and LDL-cholesterol with a trend(P=0.053)for percentage reductions in tc.t.∶tG∶GG=-38.4%∶-35.6%∶-32.6%).Similar findings were seen with LDL-Receptor(LDLR)SNPs(2052t>c and 1866c.t.with absolute reductions in tc and LDL-cholesterol significantly *** Breast cancer Resistance Protein(ABcG2)421c>A polymorphism was related(Pto HDL-cholesterol response(cc∶cA∶AA=+0.50%∶-5.73%∶-11.41%).conclusions Adiponectin,LDLR and ABcG2 SNPs had some influence on the lipid responses to simvastatin.

关键词： pharmacogenetics simvastatin Adiponectin LDL-Receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胸部ct对弥漫性特发性骨肥厚的诊断:观察者间一致性

引用

国际医学放射学杂志 2017年第2期 230-231页

作者： S.F.Oudkerk P.A.de Jong M.Attrach t.Luijkx c.F.Buckens W.P.t.M.Mali 杜倩妮 Department of Radiology and Nuclear Medicine University Medical Center Utrecht

摘要目的评估和改善基于ct对弥漫性特发性骨肥厚(DISH)诊断观察者间的一致性。方法将600例接受ct检查行肺癌筛查的病人随机分为2组。根据Resnick对X线表

关键词：弥漫性特发性骨肥厚病人胸部躯干 ct

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

computational Study of the cyclization of 5-Hexenyl, 3-Oxa-5-Hexenyl and 4-Oxa-5-Hexenyl Radicals

引用

International Journal of Organic chemistry 2013年第3期3卷 169-175页

作者： Albert R. Matlin Matthew c. Leyden Department of chemistry and Biochemistry Oberlin College Oberlin USA

the intramolecular cyclization of 5-hexenyl radicals continues to be an important synthetic method for the construction of five-membered rings. the synthetic utility arises from the high degree of regioselectivity to give predominantly cyclopentyl products in high yield under mild conditions. Recently we reported product cyclization studies on 4-oxa perturbed 5-hexenyl radical. In this paper, we report our results from a computational study (UB3LYP and UccSD (t)) of the cyclization of a series of 5-hexenyl and 3-and 4-oxa-5-hexenyl radicals. three highly conserved cyclization tran-sitions states (exo-chair, exo-boat and endo-chair) were loc.t.d for 10 acyclic radicals. Activation energies were calcu-lated for the three modes of cyclization for each radical. calculated values for the exo/endo cyclization ratios had a high level of agreement with experiment and predictions were offered for two cases that have not been experimentally tested. the increased percentage of exo-cyclization with 3-and 4-oxa substitution is the result of an increase in the energy dif-ference between the exo-and endo-chair transition states compared to the hydrocarbon systems. the decreased rate of cyclization of the 4-oxa compounds is primarily due to the stabilization of the initial acyclic radical by the vinyl ether linkage. the increase in the rate of cyclization with 3-methyl substitution is due to the increased conformational energy of the starting acyclic radical.

关键词： Radical cyclizations Activation Energies UB3LYP UccSD (t)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

压电材料裂纹顶端条状电饱和区模型的力学分析

引用

力学学报 1999年第3期31卷 311-319页

作者：王自强中国科学院力学研究所

在线性压电本构方程框架下，对裂纹顶端条状电饱和区模型进行了严格的数学分析．完整地考虑了各向异性力电耦合效应．建立了电饱和区尺寸与外加电场的依赖关系．证实了当裂纹垂直极化轴时，压电材料的断裂应力随着外加正电场的增加而减... 详细信息

在线性压电本构方程框架下，对裂纹顶端条状电饱和区模型进行了严格的数学分析．完整地考虑了各向异性力电耦合效应．建立了电饱和区尺寸与外加电场的依赖关系．证实了当裂纹垂直极化轴时，压电材料的断裂应力随着外加正电场的增加而减小，随着外加负电场的增加而增加．当裂纹平行于极化轴时。

关键词：压电材料裂纹电饱和极化力学分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Purific.t.on, crystallization and Preliminary X-Ray Diffraction Analysis of Exodeoxyribonuclease III from crenarchaeon <i>Sulfolobus tokodaii</i>Strain 7

引用

crystal Structure theory and Applic.t.ons 2013年第4期2卷 155-158页

作者： Shuichi Miyamoto chieko Naoe Masaru tsunoda Kazuo t. Nakamura Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan Faculty of Pharmacy Iwaki Meisei University Iwaki Japan School of Pharmacy Showa University Tokyo Japan

Exodeoxyribonuclease III (EXOIII) acts as a 3’→5’ exonuclease and is homologous to purinic/apyrimidinic (AP) endonuclease (APE), which plays an important role in the base excision repair pathway. to structurally investigate the reaction and substrate recognition mechanisms of EXOIII, a crystallographic study of EXOIII from Sulfolobus tokodaii strain 7 was carried out. the purified enzyme was crystallized by using the hanging-drop vapor-diffusion method. the crystals belonged to space group c2, with unit-cell parameters a = 154.2, b = 47.7, c = 92.4 ?, β = 125.8° and diffracted to 1.5 ? resolution.

关键词： crenarchaeon crystallization Exodeoxyribonuclease Sulfolobus tokodaii X-Ray Diffraction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Study of cardiac Profile in Patients with Snake Envenomation and Its complic.t.ons

引用

International Journal of clinical Medicine 2017年第3期8卷 167-177页

作者： Ramakrishna c. D. Placid Sebastian Kanattu Department of cardiology Pariyaram Medical College Kannur India

Background: Snake bite is a common and frequently devastating environmental and occupational disease, especially in rural areas of tropical developing countries. the present study was undertaken to evaluate the effect on cardiac profile in patients with snake envenomation and its complic.t.ons. Methods: A total of 200 patients with snake envenomation were enrolled in this study excluding patients having history of any cardiovascular disease, renal disease, coagulopathy, liver disease, neuromuscular disease and those cases who bitten by non-poisonous snakes. All patients underwent physical examination, laboratory, Electrocardiogram (EcG), X-ray of chest and echocardiogram investigations. Results: A total of 200 cases had envenomation having 116 (58%) of male subjects. Most common local signs were edema 187 (93.5%), tenderness 141 (70.5%), skin necrosis 81 (40.5%) and blistering 12 (6%). Severity of local envenomation was graded into mild 66 (33%), moderate 120 (60%) and severe 14 (7%) cases. Systemic manifestations were present in 83 patients of venomous bites. It includes that majorly 53 (26.5%) cases had vomiting, 44 (22%) cases had abdominal pain and 9 (4.5%) cases of hypotension. EcG manifestation showed 27 (13.5%), 6 (3%) and 1 (0.5%) patients had sinus tachycardia, sinus bradycardia and ventricular tachycardia respectively. While, 9 (4.5%) cases had t inversion alone in precordial leads. Mortality (3%) was observed in intracranial bleed, neurotoxic.t. and capillary leak syndrome. However, cardiovascular involvement was not responsible for mortality in any cases. conclusion: In conclusion, ventricular tachycardia is one of the manifestations of snake envenomation. Moreover, sinus tachycardia is common cardiovascular sign which may not be due to cardiac causes. Mortality results conclude that, cardiovascular involvement could not be responsible for mortality in snake envenomation.

关键词： Snake Envenomation cardiac complic.t.ons Sinus tachycardia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肝恶性肿瘤射频消融术后黏附电极的组织的组织病理学与免疫组化特点有助于预测局部肿瘤进展:初步结果

引用

国际医学放射学杂志 2008年第A6期31卷 507-508页

作者： c.t.Sofocleous R.G.Nascimento L.M.Petrovic D.S.Klimstra M.Go-nen K.t.Brown 谭小月 Section of Interventional Radiology Memorial Sloan-Kettering Cancer Center

目的探讨肝恶性肿瘤射频消融术后黏附电极的组织的组织病理学与免疫组化特点是否有助于预测局部肿瘤进展(LtP)。

关键词：肝恶性肿瘤免疫组化特点肿瘤进展射频消融术组织病理学学术审查凝固性坏死肝脏肿瘤肿瘤平均

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

cALcULAtION OF GOLD SOLUBILItIES IN tHE WINDOW OF t & P

引用

Geotectonica et Metallogenia 1999年第1期23卷 58-83页

作者： D.c.McPhail D.R.Gray

calculations based on the newest thermodynamic properties and supposed ore-fluid conditions suggest that gold solubilities in aqueous hydrosulphide and chloride fluids wi1l change with both temperature and *** given 100 MPa, the gold solubility in aqueous hydrosulphide fluids will increase as the temperature increases, and reach the peak at 400℃, then decrease as the temperature increases;at 150 MPa, the peak of gold solubility is loc.t.d at 500℃. At 100 MPa, however, the gold solubility in aqueous chloride fluids will also increase as the temperature increases, and reach the peak at 500℃, then decrease as the temperature increases ; at 150 MPa, the peak of gold solubility is shifted to 600℃ or higher. On the other hand, at given 300℃ and below 300℃,the gold solubility in aqueous hydrosulphide and chloride fluids changes very little as the pressure increases ; however, above 400℃ the gold solubility will increase sharply with pressure. this certifies that the pressure plays a very important role on the gold solubility at high temperature, At some content,the influence of pressure on the gold solubility is the same as that of temperature. Peaks of gold solubilities in aqueous hydrosulphide and chloride fluids in the window of t & P will form a trajectory respectively in the crust. the two trajectories will form a belt which is a favorite region for gold transportation in ore-forming fluids. Outside of this region, gold will be deposited from the ore-forming fluids. It is possible that the positions of gold deposits wou1d be inferred with this diagram in the future.

关键词： Ore-forming fluid gold solubility temperature & pressure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：