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Provenance and Paleoclimate of the Triassic to Middle Jurassic Adigrat Sandstone,Blue Nile Basin,Central Ethiopia

Acta Geologica Sinica(English Edition) 2024年第4期98卷 1007-1020页

作者： Bekele BARSISA Ayalew DEREJE Kidanemariam GIlAMICHAEl Atnafu BAlEMWAl Raphaël PIK Department of Earth Sciences Wollega UniversityNekemteEthiopia Department of Earth Sciences Addis Ababa UniversityAddis AbabaEthiopia Departments of Anthropology Geography and GeologyEast Los Angeles CollegeLos AngelesCaliforniaUSA CRPG(UMR 7358 CNRS&Universitéde lorraine) 15 rue ND des pauvres BP2054501 Vandoeuvre-Lès-Nancy CedexFrance

Mineralogical and geochemical studies have been undertaken on the Triassic to lower Jurassic Adigrat Sandstone of the Blue Nile Basin of central Ethiopia to infer its source rock type,paleoweathering,and paleoclimatic *** Adigrat Sandstone occurs at the basal section of the Mesozoic sedimentary formation and unconformably overlays the Neoproterozoic–Paleozoic crystalline rocks,or locally,the Karroo sediments in the northern Blue Nile Basin.A mineralogical study reveals that quartz(Q),feldspars(F),and lithic fragments(l)are the framework grains of the *** the QFl diagram,the plot of the modal composition of the sandstone mainly falls within the feldspathic arenite and quartzose arenite *** geochemical data of the lower section of the sandstone mainly falls within the arkose and subarkose fields,whereas the upper section data falls within the quartzose and sublithic arenite *** and geochemical weathering indices indicate that the provenances of the Adigrat Sandstone were exposed to pronounced weathering intensity,where the lower part of the sandstone was controlled by arid to semi-arid conditions,whereas the upper section was linked to humid to semi-humid(tropical to subtropical)climatic *** and geochemical data also indicate that mafic to intermediate basement rocks were the primary source rocks of the *** the sediment was assumed to have been reworked by multi-cyclic sedimentary *** discriminant function diagram,the REE pattern,la/Th ***/Yb,and the Th–Hf–Co plot are consistent.A comparison of provenance studies for the Adigrat Sandstone in the Blue Nile Basin and the Mekele outlier of northern Ethiopia indicates that the sediment of the former is highly sorted,experienced higher weathering intensity,and compositionally derived from mafic to intermediate crystalline *** the other hand,the sediment of the latter is essentially a weathering product of felsic rocks.

关键词： mineralogical geochemical paleoweathering humid provenance Adigrat Sandstone

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Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.Nicácio lucas K.Anzolin Josél.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto richard l.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

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Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn E.Hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven l.Spitalnik Vassilis l.Tzounakas Department of Biochemistry School of MedicineUniversity of Patras26504 PatrasGreece Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA laboratory of Reliability and Quality Control in laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA Present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain

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SANC Monte Carlo programs for small-angle Bhabha scattering

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Chinese Physics C 2024年第4期48卷 14-19页

作者： A.B.Arbuzov S.G.Bondarenko I.R.Boyko l.V.Kalinovskaya A.A.Kampf R.R.Sadykov V.l.Yermolchyk Bogoliubov laboratory of Theoretical Physics JINRDubna141980 Russia Dzhelepov laboratory of Nuclear Problems JINRDubna141980 Russia Dubna State University Dubna141982 Russia

luminosity monitoring at e^(+)e^(−)colliders was investigated using SANC Monte Carlo event generator ReneSANCe and integrator MCSANC for simulation of Bhabha scattering at low *** are presented for center-of-mass energies of the Z boson resonance and at 240 GeV for the conditions of typical luminosity *** is shown that bremsstrahlung events with extremely low electron scattering angles are relevant to match the precision tags of future electron-positron colliders.

关键词： luminosity Bhabha scattering QED Monte Carlo simulation

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langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： WONG Yeong Yi F l Supian A Radzwan M Musa N F N Abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and PABA using the langmuir method and first-principle density functional theory(DFT).Using the langmuir-Schaefer(lS)technique,an ultrathin film composed of calix[n]arenes and their complexes with PABA was deposited on various *** on the langmuir study,the PABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the lS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHNS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of PABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory langmuir-Schaefer PABA sensor

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A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

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Microsystems & Nanoengineering 2024年第1期10卷 115-128页

作者： Jongcheon lim Peter A.Zoss Terry l.Powley Hyowon lee Matthew P.Ward Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Center for Implantable Devices Purdue UniversityWest LafayetteINUSA Department of Psychological Sciences Purdue UniversityWest LafayetteINUSA Purdue Institute of Integrative Neuroscience Purdue UniversityWest LafayetteINUSA Indiana University School of Medicine IndianapolisINUSA

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the *** better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication *** several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel *** microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µ*** thick design can potentially harm the delicate tissue structures,including the nerve *** this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a *** demonstrated recording evoked compound action potentials(ECAP)from a transected nerve ending that has multiple nerve ***,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

关键词： electrode recording film

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Portable dielectrophoresis for biology:ADEPT facilitates cell trapping,separation,and interactions

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Microsystems & Nanoengineering 2024年第2期10卷 193-205页

作者： lourdes Albina Nirupa Julius Dora Akgül Gowri Krishnan Fabian Falk Jan Korvink Vlad Badilita Department Institute of Microstructure TechnologyKarlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 1Eggenstein-Leopoldshafen76344Baden-WürttembergGermany

Dielectrophoresis is a powerful and well-established technique that allows label-free,non-invasive manipulation of cells and particles by leveraging their electrical *** practical implementation of the associated electronics and user interface in a biology laboratory,however,requires an engineering background,thus hindering the broader adoption of the *** order to address these challenges and to bridge the gap between biologists and the engineering skills required for the implementation of DEP platforms,we report here a custom-built,compact,universal electronic platform termed ADEPT(adaptable dielectrophoresis embedded platform tool)for use with a simple microfluidic chip containing six *** versatility of the open-source platform is ensured by a custom-developed graphical user interface that permits simple reconfiguration of the control signals to address a wide-range of specific applications:(i)precision positioning of the single bacterium/cell/particle in the micrometer range;(ii)viability-based separation by achieving a 94%efficiency in separating live and dead yeast;(iii)phenotype-based separation by achieving a 96%efficiency in separating yeast and Bacillus subtilis;(iv)cell–cell interactions by steering a phagocytosis process where a granulocyte engulfs *** RGB-S ***,the set of experiments and the platform form a complete basis for a wide range of possible applications addressing various biological questions exploiting the plug-and-play design and the intuitive GUI of ADEPT.

关键词： Together separation separating

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Factors Associated with Mortality in Diabetic Patients with End-Stage Renal Failure Starting Emergency Hemodialysis

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Open Journal of Nephrology 2024年第1期14卷 17-24页

作者： Gaël Honal Mahoungou Daniel Tony Eyeni Sinomono Farel Elilié Mawa Ongoth Éric Ngandzali-Ngabé Nestor Andzouana Raissa laure Mayanda Aymande Okoumou-Moko Francky Ambounou Précieux Ngoma Berline Ndinga Héléna Botokoto Bothard Hardy Ibovi richard loumingou Department of Nephrology University Hospital of Brazzaville Brazzaville Congo Faculty of Health Sciences University Marien Ngouabi Brazzaville Congo Department of Metabolic Diseases University Hospital of Brazzaville Brazzaville Congo

Background: Diabetic nephropathy is the leading cause of end-stage chronic kidney disease with poor prognosis in resource-limited settings. This study aimed to determine factors associated with mortality in patients starting dialysis treatment for end-stage chronic renal disease in an emergency context. Patients and Methods: This was a retrospective study from January 2020 to December 2022 at CHU-B. Data from 79 diabetic patients requiring emergency dialysis were compared with those of 79 non-diabetic patients with an end-stage renal disease requiring emergency dialysis. Data were collected from the Nephrology Department registry. We studied their initial clinical and biological profiles and factors related to mortality. Results: Out of 545 compiled records, 79 diabetic chronic kidney disease patients needing dialysis were included (group 1). A control group of 79 non-diabetic chronic kidney disease patients requiring emergency dialysis was also included (group 2). The average age of patients was 53.5 ± 17 years, and the duration of diabetes at dialysis initiation was 14.8 ± 4.3 years. Twenty-three percent were hypertensive. Fifty-two percent of patients experienced intra-dialytic hypotension. Death occurred in 22% of patients. Results show that age (adjusted OR 1.955;CI: 1.025 - 1.086;p-value: Conclusion: Emergency dialysis in diabetics is associated with unfavorable outcomes in terms of mortality. Despite follow-up, renal involvement remains poorly explored, emphasizing the need for physician awareness.

关键词： Diabetic Nephropathy Emergency Dialysis Republic of the Congo

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Prevalence of Helicobacter pylori infection among patients with esophageal carcinoma

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World Journal of Gastroenterology 2024年第29期30卷 3479-3487页

作者： Miriam lópez-Gómez Maria Morales Rebeca Fuerte Marta Muñoz Pedro-David Delgado-lópez Jorge Francisco Gómez-Cerezo Enrique Casado Department of Medical Oncology Precision Oncology LaboratoryInfanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain Department of Medical Oncology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Internal Medicine Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain Department of Pathology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Neurosurgery Burgos University HospitalBurgos 09006Spain Department of Internal Medicine Infanta Sofía University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain Department of Medical Oncology Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain

BACKGROUND Helicobacter pylori(***)is a widespread microorganism related to gastric adenocarcinoma(AC).In contrast,it has been reported that an inverse association exists between *** infection and esophageal *** mechanisms underlying this supposedly protective effect remain *** To determine the prevalence of *** infection in esophageal carcinoma patients,we performed a retrospective observational study of esophageal tumors diagnosed in our *** We retrospectively reviewed the prevalence of *** infection in a cohort of patients diagnosed with esophageal *** or previous proton pump inhibitor(PPI)usage was also *** A total of 89 patients with esophageal carcinoma(69 males,77.5%),with a mean age of 66 years(range,26-93 years)were *** was the most frequent pathological variant(n=47,52.8%),followed by squamous cell carcinoma(n=37,41.6%).Fourteen ACs(29.8%)originated in the gastroesophageal junction and 33(70.2%)in the esophageal ***,54 patients(60.7%)presented at stages III and *** *** infection occurred only in 4 patients(4.5%),3 with AC(6.3%of all ACs)and 1 with squamous cell carcinoma(2.7%of all squamous cell tumors).All patients with previous *** infection had stage *** one patient had received prior *** eradication therapy,whereas 86(96.6%)had received previous or concomitant PPI *** In our cohort of patients,and after histologic evaluation of paraffin-embedded primary tumors,we found a very low prevalence of previous *** *** also reviewed the medical history of the patients,concluding that the majority had received or were on PPI *** minimal prevalence of *** infection found in this cohort of patients with esophageal carcinoma suggests a protective role.

关键词： Helicobacter pylori Eradication Esophageal tumor Dysbiosis Proton pump inhibitors Carcinogenesis Microbiota Incidence

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Water-soluble brown carbon in atmospheric aerosols from the resource-dependent cities:Optical properties,chemical compositions and sources

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Journal of Environmental Sciences 2024年第4期138卷 74-87页

作者： Haoji Wang Yue Su Yangzheng liu Fei Xie Xingjun Zhou Ruihong Yu Changwei lü Jiang He School of Ecology and Environment Inner Mongolia UniversityHohhot 010021China Institute of Environmental Geology Inner Mongolia UniversityHohhot 010021China Environmental Monitoring Center of Inner Mongolia Hohhot 010011China

As a vital type of light-absorbing aerosol,brown carbon(BrC)presents inherent associations with atmospheric photochemistry and climate ***,the understanding of the chemical and optical properties of BrC is limited,especially in some resource-dependent cities with long heating periods in northwest *** study showed that the annual average abundances of Water-soluble BrC(WS-BrC)were 9.33±7.42 and 8.69±6.29μg/m^(3)in Baotou and Wuhai and the concentrations,absorption coefficient(Abs_(365)),and mass absorption efficiency(MAE365)of WS-BrC presented significant seasonal patterns,with high values in the heating season and low values in the non-heating season;while showing opposite seasonal trends for the Absorption Angstr?m exponent(AAE_(300-400)).Comparatively,the levels of WS-BrC in developing regions(such as cities in Asia)were higher than those in developed regions(such as cities in Europe and Australia),indicating the significant differences in energy consumption in these *** combining fluorescence excitation-emission matrix(EEM)spectra with the parallel factor(PARAFAC)model,humic-like(C1 and C2)and proteinlike(C3)substances were identified,and accounted for 61.40%±4.66%and 38.6%±3.78%at Baotou,and 60.33%±6.29%and 39.67%±4.17%at Wuhai,*** results of source apportionment suggested that the potential source regions of WS-BrC varied in heating ***-heating seasons and that the properties of WS-BrC significantly depended on primary emissions(e.g.,combustion emissions)and secondary formation.

关键词： Water-soluble brown carbon Atmospheric aerosols Optical properties PARAFAC Source apportionment

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