检索结果-南通市图书馆

Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target

Neural Regeneration Research 2020年第6期15卷 1030-1032页

作者： Karan Govindpani Chitra Vinnakota Henry J.waldvogel richard l.faull Andrea Kwakowsky Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the predominant form of *** its initial description by Alois Alzheimer in 1906,several advances have been made in our understanding of the progression of the disease and its clinical consequences,yet the underlying etiology remains *** the stereotyped patterns of cortical and hippocampal neuronal loss and the progressive degeneration of key neurotransmitter pathways,research has traditionally been focused on factors affecting neuronal viability,including the contribution of glial dysfunction to neuronal *** a clinical perspective,the fruits of this work have been *** pathological markers of the disease,includingβ-amyloid(Aβ)plaque formation and tau hyperphosphorylation,have yielded no effective therapies,highlighted by the recent discontinuations of several high profile Aβimmunotherapy *** few current symptomatic therapies for AD are predicated on the amelioration of cholinergic or glutamatergic *** from underscoring the inadequacy of current therapeutic approaches,this also points to the importance of alternative contributors to AD *** recent years,there has been a growing appreciation for the multimodal and multifactorial nature of the condition;the case for combinatorial therapies is thus strong.

关键词： Alzheimer degeneration dysfunction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic potential of alpha 5 subunit containing GABA_(A) receptors in Alzheimer's disease

引用

Neural Regeneration Research 2021年第8期16卷 1550-1551页

作者： Andrea Kwakowsky Henry J.Waldvogel richard l.M.faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

Alheimer's disease(AD) is a common neurodegenerative disorder and the leading cause of dementia. It has been estimated that over 50 million people worldwide were affected by dementia in 2019, and the prevalence of dementia is expected to double approximately once every 20 years(Govindpani et al., 2017). Most people who die with AD require high levels of care for long periods of time.

关键词： al. Alzheimer Therapeutic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gamma-aminobutyric acid A receptors in Alzheimer＇s disease： highly localized remodeling of a complex and diverse signaling pathway

引用

Neural Regeneration Research 2018年第8期13卷 1362-1363页

作者： Andrea Kwakowsky Beatriz Calvo-Flores Guzman Karan Govindpani Henry J. Waldvogel richard l. faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health Sciences University of Auckland AucklandNew Zealand

Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.

关键词： AD highly localized remodeling of a complex and diverse signaling pathway Gamma-aminobutyric acid A receptors in Alzheimer’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：