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QT prolongation is associated with increased mortality in end stage liver disease

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World Journal of Cardiology 2017年第4期9卷 347-354页

作者： Sun Moon kim Bennet George Diego Alcivar-Franco Charles L Campbell richard Charnigo Brian Delisle Jonathan Hundley Yousef Darrat Gustavo Morales Samy-Claude Elayi Alison L Bailey Division of Cardiovascular Medicine Gill Heart InstituteUniversity of Ken-tucky Department of Cardiology Summa Health System Division of Cardiovascular Medicine Erlanger Health SystemUniversity of Tennessee College of Medicine Chattanooga Departments of Biostatistics and Statistics University of Kentucky Piedmont Transplant Institute

AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease(ESLD) patients and its association to clinical variables and *** The QT interval was measured and corrected for heart rate for each patient,with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for *** clinical variables were evaluated including sex,age,serum sodium,international normalized ratio,creatinine,total bilirubin,beta-blocker use,Model for EndStage Liver Disease(MELD),MELD-Na,and etiology of liver disease. RESULTS Among 406 ESLD patients analyzed,207(51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender(OR = 3.04,95%CI:2.01-4.60,P < 0.001). During the study period,187patients(46.1%) died. QT prolongation was a significant independent predictor of mortality(OR = 1.69,95%CI:1.03-2.77,P = 0.039). In addition,mortality was also associated with viral etiology of ESLD,elevated MELD score and its components(P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. CONCLUSION QT prolongation was commonly encountered in an ESLD population,especially in males,and served as a strong independent marker for increased mortality in ESLD patients.

关键词： Cirrhosis Electrophysiology Arrhythmias QT prolongation Mortality Liver transplantation

An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin kim Hyoun-Woo kim Seung-Lee kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

应用中国商环包皮环切手术标准化方案对328例成年男性包皮环切的临床报告

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中华男科学杂志 2009年第7期15卷 584-592页

作者：程跃彭弋峰刘毅东田龙吕年青苏新军严泽军胡嘉盛 richard LEE Howard kim David C. SOKAL 李石华宁波大学医学院附属宁波市第一医院泌尿中心浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 上海交通大学医学院附属仁济医院泌尿科上海200127 首都医科大学附属北京朝阳医院泌尿科北京100034 江苏省计划生育科学技术研究所江苏南京210036 Center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA Family Health International Research Triangle ParkNC 27709USA

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环... 详细信息

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环切手术标准化和培训制度,便于临床医生和相关医护人员学习和掌握包皮环切器的临床应用技巧,以中国商环(简称"商环,ShangRing")包皮环切技术为例,根据商环的技术特点和临床实践经验,特别制订了商环包皮环切手术标准化方案,并将其标准化操作运用于临床。方法:采用商环包皮环切手术标准化方案对328例受术者(年龄18～58岁,平均27.8岁;已婚134例,未婚194例;包茎25例,包皮过长303例)进行包皮环切手术。对手术时间、疼痛评分(视觉模拟评分法,VAS)、术后并发症、包皮创口愈合时间、术后外观满意情况进行观察和随访。结果:手术时间为(4.70±1.31)min。手术时受术者疼痛(VAS)评分为(0.24±0.59)分,术后24h疼痛评分为(1.59±0.95)分,去环前24h内疼痛评分(1.72±1.11)分,去环时疼痛评分为(2.72±1.37)分。主要并发症发生率为术后感染0.6%(2/328)、出血0.6%(2/328)、伤口裂开0.6%(2/328)和水肿4.89%(16/328)。在发生出血和伤口裂开的受术者中无1例需要缝合。术后包皮创口完全愈合时间为(20.30±6.69)d。受术者对术后外观满意率99.7%(327/328)。结论:商环包皮环切术具有手术方式易于标准化、手术时间短、术中疼痛轻、术后无须特殊护理、容易完整保留系带,并完全暴露冠状沟、术后外观满意度高、受术者易于接受等优点。初步证明了中国商环包皮环切手术标准化方案的可接受性,严格按照此方案实施手术和随访护理,能最大化地实现商环包皮环切技术的诸多临床优势,将并发症发生率控制在可接受的范围内。

关键词：包皮环切术中国商环标准化方案并发症男性成年人

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狗在急性低氧后复氧过程中的心脏功能损伤

中国应用生理学杂志 1988年第3期 197-205页

作者：宁学寒贺妙湘 Thomnas McClanahan richard A. Gerren kim P. Gallagher 中国科学院上海生理研究所中国科学院上海生理研究所 The Thoracic Surgery Research Laboratory Depts of Surgery and Physiology The University of Michigan Medical School Ann Arbor MI 48109 U. S. A. The Thoracic Surgery Research Laboratory Depts of Surgery and Physiology The University of Michigan Medical School Ann Arbor MI 48109 U. S. A. The Thoracic Surgery Research Laboratory Depts of Surgery and Physiology The University of Michigan Medical School Ann Arbor MI 48109 U. S. A.

六条在心脏上装有高精度压力传感器及微型超声测距探头的慢性实验狗,经两个星期的手术恢复期后,于Halothane麻醉下,给予低氧气体吸入,使动脉血氧饱和度从对照时的99.8±0.1％降到60.7-4.4％。低氧时,左心室功能随着动脉血氧饱和度的下降... 详细信息

六条在心脏上装有高精度压力传感器及微型超声测距探头的慢性实验狗,经两个星期的手术恢复期后,于Halothane麻醉下,给予低氧气体吸入,使动脉血氧饱和度从对照时的99.8±0.1％降到60.7-4.4％。低氧时,左心室功能随着动脉血氧饱和度的下降,表现为中度低氧时增强、严重低氧时减弱的变化。复氧时,出现与低氧时不相同的左心室功能异常,如心动过速、严重心律紊乱、后负荷增高、舒张期末室壁厚度显著增加,室壁舒-缩厚度差减小、室壁舒缩的不匀质性以及极低的心肌顺应性等。这些结果表明,在急性低氧后的复氧过程中,左心室功能存在着一种“复氧损伤”。

关键词：低氧 “复氧损伤” 左心室功能心律紊乱心肌顺应性舒缩不匀质性

中国建立男性包皮环切手术标准化和培训的重要性

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中华男科学杂志 2009年第5期15卷 390-394页

作者：李石华吕年青程跃彭弋峰田龙刘毅东贲昆龙徐建春 richard LEE Howard kim David C.SOKAL Center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA 江苏省计划生育科学技术研究所江苏南京210036 宁波大学医学院附属宁波市第一医院泌尿科浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 首都医科大学附属北京朝阳医院泌尿科北京100034 上海交通大学医学院附属仁济医院泌尿科上海200127 昆明康涛生物技术有限公司云南昆明650106 昆明医学院第一附属医院男性科云南昆明650106 Family Health International Research Triangle ParkNC 27709USA

尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(H... 详细信息

尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(HPV)、单纯疱疹病毒2型(HSV-2)和其他性传播疾病(STD)的感染率。虽然男性包皮环切技术有许多,但是没有标准化的手术方案和培训计划。研究表明,男性包皮环切技术的标准化与培训计划的实施可以大大降低并发症发生率。并发症发生率高是实施男性包皮环切服务的一个主要障碍。我们建议,在推广男性包皮环切之前应建立手术标准和培训计划。

关键词：包皮环切术 HIV感染性传播疾病

Contrasting Historical and Recent Breakup Styles on the Meade River of Arctic Alaska in the Context of a Warming Climate

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American Journal of Climate Change 2013年第2期2卷 165-172页

作者： richard A. Beck Kenneth M. Hinkel Wendy R. Eisner Douglas Whiteman Christopher D. Arp richard Machida Chris Cuomo Hongxing Liu Changjoo kim Andrew J. Rettig Chantal Ivenso Bo Yang Qiusheng Wu Haibin Su Shujie Wang Karen Frey John D. Lenters Brittany L. Potter Atmospheric Radiation Measurement Program Atqasuk USA Department of Geography Clark University Worcester USA Department of Geography University of Cincinnati Cincinnati USA Department of GeogSchool of Natural Resources University of Nebraska at Lincoln Lincoln USA raphy Clark University Worcester USA Department of Philosophy University of Georgia Athens USA Department of Physics and Geosciences Texas A&M University-Kingsville Kingsville USA Information Technology University of Alaska at Fairbanks Fairbanks USA School of Natural Resources University of Nebraska at Lincoln Lincoln USA Water and Environmental Research Center University of Alaska Fairbanks USA

Although data for temporal spring river ice breakup are available for a number of Arctic rivers, there is a paucity of information related to the type of breakup. The Arctic Climate Impact Assessment (ACIA) of 2005 predicted a transition from mechanical to thermal spring breakup of ice cover on arctic rivers, with this shift being greatest in exclusively Arctic watersheds where observed warming is most pronounced. We describe a rare instance of an entirely Arctic river with limited but well documented historical and recent data regarding the type of breakup. Time-series ground imagery of spring breakup from 1966, 1975, 1978, 2009, 2010 and 2012, incombination with interviews of local inhabitants, documents a shift from predominantly mechanical to predominantly thermal breakup after spring 1978 and by spring 2009 within the context of a locally and regionally warming Arctic. The resultant shift from predominantly mechanical to predominantly thermal breakup is predicted to result in significant changes to water, sediment, nutrient and organic carbon fluxes, as well as riparian ecology and human activities.

关键词： Arctic Alaska Climate Change Meade River Thermal Breakup Mechanical Breakup Ice Snow

α-synuclein A30P突变减弱小鼠侧脑室下区的神经发生及嗅球的分化

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α-synuclein A30P突变减弱小鼠侧脑室下区的神经发生及嗅球的分化

中国畜牧兽医学会动物解剖学及组织胚胎学分会第五次会员代表大会暨第十六次学术研讨会

作者：张学明 Yongsoo kim Jenny Brown richard Wade-Martins Francis Szele 吉林大学畜牧兽医学院动物胚胎工程吉林省重点实验室 Department of Physiology Anatomy and GeneticsUniversity of Oxford

脑室下区(subventricular zone,SVZ)及海马齿状回颗粒下区(subgranular zone,SGZ)是哺乳动物脑内终生存在神经发生的两个主要区域。SVZ产生的多巴胺能神经元经吻侧迁移流(rostral migratory stream,RMS)迁移至嗅球(olfactory bulb,OB)并分化为颗粒细胞层(granular cell layer,GCl)、僧帽细胞层(mitral cell layer,MCl)、外从状层(external plexiform layer,EPl)、突触球层(glomerular layer,Gl)等内的中间神经元;SGZ产生的神经元则迁移至海马齿状回颗粒层成为颗粒细胞。这些细胞能整合入神经网络并发挥功能。已知a-synuclein(SNCA)编码突触核蛋白SNCA,能影响SVZ神经发生中的多巴胺能性神经传递及嗅球的分化。研究表明,SNCA在人类帕金森病等多巴胺能神经退行性疾病的发生发展中扮演着关键角色。现已在家族性帕金森病病例中发现了SNCA的3个点突变:A53T(丙氨酸53-苏氨酸)、A30P(丙氨酸30-脯氨酸)、E46K(谷氨酸46-赖氨酸)。但有关SNCA及其突变对成体SVZ神经发生及嗅球分化的确切作用尚不清楚。本研究采用了携带人SNCA顺式调控元件的细菌人工染色体转基因小鼠(遗传背景均为C57BL),设正常对照(C57BL)、SNCA敲除组(SNCA-/-)及SNCA敲除并表达人SNCAA30P突变(A30PSNCA-/-)3个组,用免疫荧光组织化学方法分析了3组间SVZ神经细胞增殖及嗅球细胞分化的差异。结果显示,①在SVZ内,磷酸化组蛋白3(PH3)阳性的增殖细胞在SNCA-/-鼠明显减少,在A30P SNCA-/-鼠显著减少;②Mash1+细胞在A30PSNCA-/-鼠SVZ内显著减少;③SNCA-/-及SNCAA30P突变致嗅球中心及突触球层(Gl)内的双皮质素Dcx+细胞显著减少;④SNCA-/-及SNCA A30P突变致嗅球Gl内的TH+、Calbindin(CalB)+、Calretinin(CalR)+细胞显著减少;⑤Tunel染色显示,SNCA-/-及A30P SNCA-/-组小鼠嗅球中的细胞凋亡数减少。上述结果提示,SNCA A30P突变减弱了成体SVZ内的神经发生,迟滞了SVZ增殖神经细胞向嗅球的迁移并迟缓了这些迁移细胞向嗅球中间神元的分化。

关键词：小鼠侧脑室下区 SNCAA30P 神经发生嗅球分化

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STYLE NOTEBOOK

明日风尚 2009年第7期 66-69页

作者： Kiki Feng Ron Lam kim Au

横跨半个世纪的时尚摄影> 01 ICP(International Center of Photography)由即日起至9月6日举办一场名为"Avedon Fashion 1944-2000"的展览,是专门针对richard Avedon的时尚摄影作品的展览。richard Avedon的摄影风格深受匈牙利摄影师Martin Munkacsi影响,更以独有的美式风格撼动了战后欧洲呆板的时装摄影格局。他让模特们走出摄影棚,走上街头海滩,跳跃舞动欢笑。他抓拍行动中的模特并为定格为其招牌的"Avedon Blur"。

关键词：摄影风格时尚摄影美式风格 STYLE NOTEBOOK 时尚品牌波普艺术意大利品牌波普文化

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爱在黎明破晓前&爱在日落黄昏时