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Can palliative radiotherapy influence prostate-specific antigen response in patients with castrate-resistant prostate cancer treated with systemic therapy(chemotherapy or abiraterone)?——a report of three cases

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Cancer Biology & Medicine 2015年第1期12卷 60-63页

作者： Mohan Hingorani Sanjay Dixit Pattu Pugazhenthi Simon Hawkyard Andrew Robertson richard khafagy Department of Clinical Oncology Castle Hill HospitalHull and East YorkshireNHS TrustCottinghamEast Riding of YorkshireHU16 5JQUK Department of Urology Scarborough District General Hospital

Palliative radiotherapy(pRT) is primarily employed for palliation of bone pain in patients with castrate-resistant prostate cancer(CRPC). However, evidence that p RT influences prostate-specific antigen response in patients with CRPC on systemic therapy is lacking. We describe three cases of CRPC progressing after treatment with docetaxel(n=2) and abiraterone(n=1), who responded unusually after p RT for bone pain with the development of a significant biochemical response and restoration of response to systemic therapy. The possibility of p RT influencing metastatic disease in CRPC has not been previously reported, and raises the possibility of radiation-induced modulation of anti-tumor immune response mechanisms that may play a role in the restoration of response to systemic treatment.

关键词：全身治疗特异性抗原前列腺癌报告处理患者抗性去势比特

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Sequential maximum androgen blockade(MAB) in minimally symptomatic prostate cancer progressing after initial MAB: two case reports

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Cancer Biology & Medicine 2014年第4期11卷 277-280页

作者： Mohan Hingorani Sanjay Dixit Fahim Bashir Mohammad Butt Simon Hawkyard richard khafagy Andrew Robertson Department of Clinical Oncology Castle Hill Hospital Department of Urology Scarborough General Hospital

The management of castrate-resistant prostate cancer progressing after maximum androgen blockade(MAB) has evolved in the last decade with the development of several novel therapeutic options. However, the initial therapeutic strategy in these patients usually involves withdrawal of anti-androgen that can be associated with biochemical response in approximately 20% of patients. Notably, we have observed evidence of sustained biochemical response in two patients following secondand third-line MAB using rechallenge schedule of previously administered anti-androgen after latent interval. The possibility of response following sequential MAB using the same anti-androgen agent has not yet been reported.

关键词：抗雄激素前列腺癌 MAB 案例症状治疗方案生化反应时间表

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维普期刊数据库

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