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Geomechanical properties will constrain CO_(2)injection into the lower Ordovician Rose Run sandstone deep saline reservoir,Appalachian Basin,Kentucky,USA

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 947-960页

作者： john richard Bowersox Stephen F.Greb Junfeng Zhu David C.Harris Kentucky Geological Survey University of KentuckyLexingtonKY40506-0107USA

The Kentucky Geological Survey(KGS)1 Hanson Aggregates stratigraphic research well,Carter County,Kentucky,USA,was drilled to a total depth of 1474 m as a field-scale test of potential CO2 storage reservoir properties in the Central Appalachian *** properties of the Rose Run sandstone(upper Ordovician Knox group)were tested for its suitability as a storage reservoir.A 9.8-m thick section of the Rose Run was penetrated at 1000 m drilled depth and a whole-diameter core and rotary sidewall cores were *** porosity and permeability measured in core plugs were 9.1%and 44.6 mD,*** vertical stress gradient calculated in the wellbore was 26 MPa/*** fractures in dolomites underlying and overlying the Rose Run follow the contemporary N53E Appalachian Basin stress *** Rose Run elastic geomechanical properties were calibrated to values measured in core plugs to evaluate its fracturing risk as a CO2 storage *** Young’s modulus and Poisson’s ratio values of the Rose Run were 45 GPa and 0.23,respectively,whereas Young’s modulus and Poisson’s ratio values were 77.1 GPa and 0.28,respectively,in the overlying Beekmantown dolomite,suggesting the Rose Run may fracture if overpressured during CO2 injection but be confined by the *** compressive strength measured in core plugs found the Rose Run and Beekmantown fractured at mean axial stresses of 156.5 MPa and 282.2 MPa,respectively,confirming the Beekmantown as suitable for confining CO2 injected into the Rose Run.A step-rate test was conducted in a mechanically-isolated 18.6-m interval bracketing the Rose *** Rose Run reservoir pressure was 9.3 MPa,and fracture gradient under injection was 13.6 MPa/km,suggesting step-rate testing before CO2 injection,and subsequent pressure monitoring to ensure *** the region around the KGS 1 Hanson Aggregates well is underpressured and adjacent to faulted Precambrian basement,further research is neede

关键词： Appalachian Basin Rose Run sandstone Geomechanics Carbon sequestration Step-rate testing

HOX transcription factors and the prostate tumor microenvironment

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Journal of Cancer Metastasis and Treatment 2017年第1期3卷 278-287页

作者： richard morgan Hardev S.Pandha Institute of Cancer Therapeutics Faculty of Life SciencesUniversity of BradfordBradford BD71DPUK Faculty of Health and Medical Sciences University of SurreyGuildfordSurrey GU27XHUK.

It is now well established that the tumor microenvironment plays an essential role in the survival,growth,invasion,and spread of cancer through the regulation of angiogenesis and localized immune *** review examines the role of the HOX genes,which encode a family of homeodomain-containing transcription factors,in the interaction between prostate tumors and their *** studies have established that HOX genes have an important function in prostate cancer cell survival in vitro and in vivo,but there is also evidence that HOX proteins regulate the expression of genes in the cancer cell that influence the tumor microenvironment,and that cells in the microenvironment likewise express HOX genes that confer a tumor-supportive *** we provide an overview of these studies that,taken together,indicate that the HOX genes help mediate cross talk between prostate tumors and their microenvironment.

关键词： Prostate cancer tumor microenvironment HOX PBX metastasis angiogenesis

Beyond Carbon:Scientists Worry About Nitrogen’s Effects

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当代外语研究 2008年第10期 27-30页

作者： richard morgan 丁立福淮南师范学院

二氧化碳因温室效应而臭名昭著,几乎成了全人类的"公敌";如今再提"氮的不良作用有甚于碳",似乎有故作玄虚、哗众取宠之嫌。然而人类为了提高农作物产量正在不断地施加氮肥,其中只有小部分被吸收利用,而大部分则和含氮污水一同流入湖泊... 详细信息

二氧化碳因温室效应而臭名昭著,几乎成了全人类的"公敌";如今再提"氮的不良作用有甚于碳",似乎有故作玄虚、哗众取宠之嫌。然而人类为了提高农作物产量正在不断地施加氮肥,其中只有小部分被吸收利用,而大部分则和含氮污水一同流入湖泊、水库、河口、海湾等缓流水体。那些地方的浮游生物尤其是藻类便大量繁殖,相反水底生植物则因光合作用受到阻碍而死去,其腐败后所释放出的氮、磷等营养物质再供藻类利用。这样年深月久,难免不步入恶性循环圈:藻类越是大量繁殖,水质越是恶化;水质越是恶化,藻类越是大量繁殖,结果堪忧———科学家们将其称为富营养化(eutrophication),实在是某种程度的"自我解嘲"!

关键词：大量繁殖富营养化藻类二氧化碳农作物产量地球物理研究温室效应缓流水体光合作用浮游生物

Vegetation and Environment History for the Past 14 000 yr BP from Dingnan, Jiangxi Province, South China

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Journal of Integrative Plant Biology 2006年第9期48卷 1018-1027页

作者： john richard Dodson Shirene Hickson Rachel Khoo Xiao-Qiang Li Jemina Toia Wei-Jian Zhou Institute for the Environment Brunel University Uxbridge UB8 3PH England School of Earth and Geographical Sciences University of Western Australia Perth WA 6009 Australia State Key Laboratory of Loess and Quaternary Institute for Earth Environment the Chinese Academy of Sciences Xi＇an 710075 China

A Late Pleistocene-Holocene pollen, phosphorus, and charcoal record was reconstructed from a peatland in southern Jiangxi Province in southern China. The area today has a mountainous and rolling landscape with villages, small towns, and agriculture dominated by rice paddies, vegetable, and fruit gardens, as well as areas of secondary forest and pine re-afforestation. The record opens before 14 300 yr BP, with Alnus woodland dominating the wetland areas and with an open Quercus woodland on the surrounding slopes. The forest area becomes more complex from approximately 12 800 yr BP and further from 9 000 yr BP. At approximately 6 000 yr BP, there is evidence of clearing and, by 4 500-4 000 yr BP, a complete collapse in the wetland Alnus and terrestrial forest as the low-lying areas are converted to rice production. For much of the record, the occurrence of fire around the site was low, although there is evidence of regional fires. Fire was used as a tool in clearing and then used in the annual cycles of stubble burning after rice harvest. Nutrient levels, as reflected by total phosphorus in the sediment, seem to be closely related to forest changes and high values in the surface layers probably result from land-management techniques associated with agriculture. Therefore, human impact greatly altered forest cover, fire frequency, and nutrient dynamics; this has been evident for approximately 6 000 yr BP and then intensities towards the present day.

关键词： development of rice agriculture nutrient and fire history South China vegetation history

Epidemiological, Diagnostic, Therapeutic and Progressive Aspects of Arterial Hypertension in Children at the University Hospital Center of Bouaké (Côte d’Ivoire)

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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

Open Journal of Pediatrics（儿科学期刊） 2024年第2期 379页

作者： richard Azagoh-Kouadio Yao Kossonou Roland Yeboua Kouassi Christian Yao john Patrick Yenan Iburaima Alamun Akanji Kouadio Vincent Assé

来源：博看期刊评论

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博看期刊

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Family Medicine and Community Health 2024年第S3期12卷 12-22页

作者： William B Ventres Leslie A Stone Rupal Shah Tamala Carter Geoffrey M Gusoff Winston Liaw Bich-May Nguyen Joanna V Rachelson Mary Alice Scott Teresa L Schiff-Elfalan Seiji Yamada Robert C Like Kathleen Zoppi A Peter Catinella richard M Frankel Shailendra Prasad Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn Center for Community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National Clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New Mexico Family Medicine Residency Program Las CrucesNew MexicoUSA New Mexico Primary Care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family Medicine and Community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family Medicine and Community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine and Community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘Context—grounding family medicine in time,place and being’,‘Recentring community’,‘Community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’May readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

Is irritable bowel syndrome an infectious disease?

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World Journal of Gastroenterology 2016年第4期22卷 1331-1334页

作者： john richard Thompson Department of Pharmacy Practice Lipscomb University College of PharmacyOne University Park DriveNashvilleTN 37204United States

Irritable bowel syndrome(IBS) is the most common of all gastroenterological diseases. While many mechanisms have been postulated to explain its etiology, no single mechanism entirely explains the heterogeneity of symptoms seen with the various phenotypes of the disease. Recent data from both basic and clinical sciences suggest that underlying infectious disease may provide a unifying hypothesis that better explains the overall symptomatology. The presence of small intestinal bowel overgrowth(SIBO) has been documented in patients with IBS and reductions in SIBO as determined by breath testing correlate with IBS symptom improvement in clinical trials. The incidence of new onset IBS symptoms following acute infectious gastroenteritis also suggests an infectious cause. Alterations in microbiota-host interactions may compromise epithelial barrier integrity, immune function, and the development and function of both central and enteric nervous systems explaining alterations in the brain-gut axis. Clinical evidence from treatment trials with both probiotics and antibiotics also support this etiology. Probiotics appear to restore the imbalance in the microflora and improve IBS-specific quality of life. Antibiotic trials with both neomycin and rifaximin show improvement in global IBS symptoms that correlates with breath test normalization in diarrhea-predominant patients. The treatment response to two weeks of rifaximin is sustained for up to ten weeks and comparable results are seen in symptom reduction with retreatment in patients who develop recurrent symptoms.

关键词： irritable bowel syndrome pathopohysiology etiology Probiotics antibiotics infectious disease

Optical read-out and modulation of peripheral nerve activity

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Neural Regeneration Research 2018年第1期13卷 58-61页

作者： Arjun K.Fontaine Hans E.Anderson john H.Caldwell richard F.Weir Department of Bioengineering University of Colorado – Anschutz Medical Campus Department of Cell and Developmental Biology University of Colorado – Anschutz Medical Campus

Numerous clinical and research applications necessitate the ability to interface with peripheral nerve fibers to read and control relevant neural pathways. Visceral organ modulation and rehabilitative prosthesis are two areas which could benefit greatly from improved neural interfacing approaches. Therapeutic neural interfacing, or ‘bioelectronic medicine’, has potential to affect a broad range of disorders given that all the major organs of the viscera are neurally innervated. However, a better understanding of the neural pathways that underlie function and a means to precisely interface with these fibers are required. Existing peripheral nerve interfaces, consisting primarily of electrode-based designs, are unsuited for highly specific （individual axon） communication and/or are invasive to the tissue. Our laboratory has explored an optogenetic approach by which optically sensitive reporters and actuators are targeted to specific cell （axon） types. The nature of such an approach is laid out in this short perspective, along with associated technologies and challenges.

关键词： peripheral nerve interface optogenetics bioelectronic medicine prosthesis control adeno-associated virus GCaMP

Climate change effects on rangelands and rangeland management:affirming the need for monitoring

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Ecosystem Health and Sustainability 2017年第3期3卷 1-14页

作者： Daniel W.McCollum john A.Tanaka Jack A.morgan john E.Mitchell William E.Fox Kristie A.Maczko Lori Hidinger Clifford S.Duke Urs P.Kreuter Rocky Mountain Research Station USDAForest Service240 W.Prospect RoadFort CollinsColorado 80526 USA James C.Hageman Sustainable Agriculture Research and Extension Center University of WyomingDept 33541000 E.University AvenueLaramieWyoming 82071 USA USDA ARS Rangelands Resources Research Unit8408 Hildreth RoadCheyenneWyoming 82009 USA Texas A&M AgriLife Research Ecosystem Science&Management720 E.Blackland RoadTempleTexas 76502 USA Consortium for Science Policyand OutcomesArizona State UniversityPO Box 875603TempeArizona 85287 USA Ecological Society of America 1990 M StreetNWSuite 700WashingtonD.C.20036 USA Ecosystem Science and Management Texas A&M University2138 TAMUCollege StationTexas 77843 USA

Uncertainty as to the extent and magnitude of changes in conditions that might occur due to climate change poses a problem for land and resource managers as they seek to adapt to changes and mitigate effects of climate *** illustrate using scenarios of projected future conditions on rangelands in the Northern Great Plains and Desert Southwest of the United *** two regions are different in the ways climate change is projected to affect the *** of a longer and warmer growing season in the Northern Great Plains could lead to increased forage production and land *** uncertain effects on summer monsoons that primarily control rangeland productivity in the Desert Southwest,combined with the possibility of more intense and/or frequent drought events,could present land managers with challenges stemming from decreased forage production and land *** projections,though uncertain,provide land managers with basic insight into future conditions they might *** need more.A focus on vulnerability and resilience,with explicit recognition of interactions between ecological and socio-economic factors,coupled with systematic monitoring and assessment of observable conditions on the land to supplement information based on climate projections,will more effectively provide critical and specific information managers need to adaptively manage rangelands under uncertain climate futures.

关键词： adaptive management climate change indicators monitoring rangelands resilience uncertainty vulnerability