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Traumatic brain injury induced by exposure to blast overpressure via ear canal

Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton Jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen Jun Huang Yue Yu Jerome Allison Fan Fan richard jroman James Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences MD Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian *** ears are most often damaged following exposure to *** there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear *** present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans *** were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple *** exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of *** blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive ***,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast *** results suggest that the unprotected ear canal provides a locus for blast waves to cause *** study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury

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