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多巴胺舒张猪冠状动脉及激活冠状动脉平滑肌细胞钾通道

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中国药理学与毒理学杂志 2000年第6期14卷 421-424页

作者：韩桂春 Patricia jp McM ILLIN richard E WHITE 大连医科大学生理学教研室辽宁大连116027 Department of Physiology and Biophysics

采用血管环实验和膜片钳细胞贴附式技术分别在器官和细胞分子水平观察多巴胺舒张猪冠状动脉作用及对平滑肌细胞大电导型钙激活钾通道(BKCa)的影响 .结果表明多巴胺引起前列腺素 F2α(PGF2α)预收缩动脉环浓度依赖性舒张反应 ,而不引起高... 详细信息

采用血管环实验和膜片钳细胞贴附式技术分别在器官和细胞分子水平观察多巴胺舒张猪冠状动脉作用及对平滑肌细胞大电导型钙激活钾通道(BKCa)的影响 .结果表明多巴胺引起前列腺素 F2α(PGF2α)预收缩动脉环浓度依赖性舒张反应 ,而不引起高 K+预收缩动脉环舒张反应 .表明多巴胺引起的冠状动脉血管舒张反应依赖于 K+生理浓度梯度的存在 ,结果提示钾通道参与了多巴胺的血管舒张反应 .向细胞浴液内灌流多巴胺增强冠状动脉血管平滑肌细胞膜 BKCa通道活性 .用 DA1受体阻断剂 SCH2 3390预处理细胞 ,完全阻断多巴胺的这一作用 ,而用 β受体阻断剂普萘洛尔无影响 .提示多巴胺通过 DA1受体激活 BKCa通道引起

关键词：多巴胺冠状动脉平滑肌细胞钾通道多胺受体

Identification of patients with pancreatic adenocarcinoma due to inheritable mutation:Challenges of daily clinical practice

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World Journal of Gastrointestinal Oncology 2019年第2期11卷 102-116页

作者： Alexander jp Fulton Angela Lamarca Christina Nuttall Lynne McCallum Rille Pihlak Derek O'Reilly Fiona Lalloo Mairéad G McNamara richard A Hubner Tara Clancy Juan W Valle Department of Medical Oncology The Christie NHS Foundation Trust Hepato-pancreato-biliary Surgical Department Manchester Royal InfirmaryCentral Manchester University Hospitals NHS Foundation Trust Manchester Centre for Genomic Medicine Central Manchester University Hospitals NHS Foundation Trust Saint Mary's Hospital

BACKGROUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma(PDAC) could impact on patient/*** To assess the referral pathways for genetic consultations in *** Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer(EUROPAC)*** Four-hundred patients were eligible. Of 113 patients(28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole *** referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

关键词： Genetic counselling Pancreatic adenocarcinoma Genetic consultation BRCA Germline

环境因子对双孢蘑菇损伤敏感性的影响（英文）

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菌物学报 2016年第11期35卷 1375-1386页

作者：高巍 BAARS Johan jp DOLSTRA Oene VISSER richard GF 张金霞 SONNENBERG Anton SM Plant Breeding Wageningen University and Research Center 中国农业科学院农业资源与农业区划研究所北京100081

在机械损伤过程中,白色双孢蘑菇极易被损伤并迅速褐变,使得机械采收的鲜菇质量低下,并且影响机械采收技术的应用和发展。机械采收双孢蘑菇的褐变程度(损伤敏感性)受栽培环境条件的影响。本文应用因子设计分析的方式研究多个因子对双孢... 详细信息

在机械损伤过程中,白色双孢蘑菇极易被损伤并迅速褐变,使得机械采收的鲜菇质量低下,并且影响机械采收技术的应用和发展。机械采收双孢蘑菇的褐变程度(损伤敏感性)受栽培环境条件的影响。本文应用因子设计分析的方式研究多个因子对双孢蘑菇机械损伤敏感性的影响。以4个菌株为材料测试3个环境因子对双孢蘑菇损伤敏感性的影响,即覆土的厚度(分为2.5cm和5cm两个水平),覆土的湿度(分为干覆土和正常覆土两个水平),以及菇房内的相对湿度(分为80%和87%两个水平)。目的是找出能够在不敏感菌株和敏感菌株间产生最大敏感性差异的环境条件,由此得到的环境条件将应用到后续的群体分离分析中以得到最大的敏感性变异率。根据方差分析结果得出基因型(菌株)和覆土厚度是影响损伤敏感性的显著性因子,因子间相互作用显著。能够在不敏感菌株和敏感菌株间产生最大的损伤敏感性差异的环境条件为正常湿度的5cm厚覆土材料和87%的菇房内相对湿度。

关键词：双孢蘑菇损伤敏感性环境因子空气相对湿度覆土含水量覆土厚度

Digital imaging approaches for phenotyping whole plant nitrogen and phosphorus response in Brachypodium distachyon

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Journal of Integrative Plant Biology 2014年第8期56卷 781-796页

作者： richard Poiré Vincent Chochois Xavier R.R.Sirault John P.Vogel Michelle Watt Robert T.Furbank CSIRO Plant Industry High Resolution Plant Phenomics Centre CSIRO Plant Industry USDA-ARS Western Regional Research Center

This work evaluates the phenotypic response of the model grass （Brachypodium distacbyon （L.） P. Beauv.） to nitrogen and phosphorus nutrition using a combination of imaging techniques and destructive harvest of shoots and roots. Reference line Bd21-3 was grown in pots using 11 phosphorus and 11 nitrogen concentrations to establish a dose-response curve. Shoot biovolume and biomass, root length and biomass, and tissue phosphorus and nitrogen concentrations increased with nutrient concentration. Shoot biovolume, estimated by imaging, was highly correlated with dry weight （R2 〉 0.92） and both biovolume and growth rate responded strongly to nutrient availability. Higher nutrient supply increased nodal root length more than other root types. Photochemical efficiency was strongly reduced by low phosphorus concentrations as early as 1 week after germination, suggesting that this measurement may be suitable for high throughput screening of phosphorus response. In contrast, nitrogen concentration had little effect on photochemical efficiency. Changes in biovolume over time were used to compare growth rates of four accessions in response tonitrogen and phosphorus supply. We demonstrate that a time series image-based approach coupled with mathematical modeling provides higher resolution of genotypic response to nutrient supply than traditional destructive techniques and shows promise for high throughput screening and determina- tion of genomic regions associated with superior nutrient use efficiency.

关键词： Nutrients uptake phenomics photosynthesis root shootCitation: Poire R, Chochois V, Sirault XRR, Vogel jp, Watt M, Furbank RT(2o14) Digital imaging approaches for phenotyping whole plantnitrogen and phosphorus response in Brachypodium distachyon.

Bimeron clusters in chiral antiferromagnets

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npj Computational Materials 2020年第1期6卷 270-278页

作者： Xiaoguang Li Laichuan Shen Yuhao Bai Junlin Wang Xichao Zhang Jing Xia Motohiko Ezawa Oleg A.Tretiakov Xiaohong Xu Michal Mruczkiewicz Maciej Krawczyk Yongbing Xu richard F.L.Evans Roy W.C.hantrell Yan Zhou School of Science and Engineering The Chinese University of Hong Kong518172 ShenzhenChina Hefei National Laboratory for Physical Sciences at the Microscale Department of PhysicsUniversity of Science and Technology of China230026 HefeiChina Research Institute of Materials Science of Shanxi Normal University&Collaborative Innovation Center for Shanxi Advanced Permanent Magnetic Materials and Technology 041004 LinfenChina School of Physics and Electronic Information Shanxi Normal University041004 LinfenChina Department of Physics University of YorkYork YO105DDUK York-Nanjing International Center of Spintronics(YNICS) Nanjing University210093 NanjingChina Department of Applied Physics The University of Tokyo7-3-1 HongoTokyo 113-8656Japan School of Physics The University of New South WalesSydney 2052Australia National University of Science and Technology‘MISiS’ Moscow 119049Russia School of Chemistry and Materials Science of Shanxi Normal University&Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education 041004 LinfenChina Institute of Electrical Engineering Slovak Academy of SciencesDúbravskácesta 984104 BratislavaSlovakia Centre for Advanced Materials Application CEMEA Slovak Academy of SciencesDúbravskácesta 5807/984511 BratislavaSlovakia Faculty of Physics Adam Mickiewicz University in PoznanUniwersytetu Poznanskiego 261-614 PoznanPoland

A magnetic bimeron is an in-plane topological counterpart of a magnetic *** the topological equivalence,their statics and dynamics could be distinct,making them attractive from the perspectives of both physics and spintronic *** this work,we demonstrate the stabilization of bimeron solitons and clusters in the antiferromagnetic(AFM)thin film with interfacial Dzyaloshinskii–Moriya interaction(DMI).Bimerons demonstrate high current-driven mobility as generic AFM solitons,while featuring anisotropic and relativistic dynamics excited by currents with in-plane and out-ofplane polarizations,***,these spin textures can absorb other bimeron solitons or clusters along the translational direction to acquire a wide range of Néel topological *** clustering involves the rearrangement of topological structures,and gives rise to remarkable changes in static and dynamical *** merits of AFM bimeron clusters reveal a potential path to unify multibit data creation,transmission,storage,and even topology-based computation within the same material system,and may stimulate spintronic devices enabling innovative paradigms of data manipulations.

关键词： properties topological clusters

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jp摩根:对中国CDMA手机用户的调查

商务周刊 2003年第12期 44-47页

作者： Edison Lee richard Wu 邓瑾

为什么要做该项调查,怎么做的? 对投资者来说,CDMA就像是个黑洞。中国联通的CDMA业务对中国联通自己和中国移动来说都增加了非常大的不确定性。CDMA 1X服务在韩国和日本部获得了成功,但中国联通CDMA的早期财务表现却让人失望。尽管这项... 详细信息

为什么要做该项调查,怎么做的? 对投资者来说,CDMA就像是个黑洞。中国联通的CDMA业务对中国联通自己和中国移动来说都增加了非常大的不确定性。CDMA 1X服务在韩国和日本部获得了成功,但中国联通CDMA的早期财务表现却让人失望。尽管这项技术前景很好,但在中国还有待证明。是CDMA有问题,还是联通的战略有问题?

关键词： CDMA 受访者中国联通网络质量 jp摩根手机用户顾客满意度用户群网络覆盖蜂窝网络

An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro