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International Journal of Disaster Risk Science 2019年第4期10卷 462-477页

作者： Henry Ngenyam Bang Lee Stuart Miles richard Duncan gordon Disaster Management Centre Bournemouth UniversityDorsetTalbot CampusFern BarrowPoole BH125BBUK

Many African countries are prone to numerous hazardous events,exacerbated by the vulnerability of their rapidly increasing population and leading to frequent disasters that often have dire fiscal and development ***,there is declining sensitivity to these risks,contrary to the conventional wisdom of disaster management(DM)*** primary aim of this research is to understand the constraints and/or challenges limiting the ability of contemporary African DM systems/institutional frameworks from implementing adequate disaster risk reduction(DRR)*** a qualitative,case study based research strategy,this research investigates resistance to the effective implementation of DM/DRR within Cameroon’s contemporary DM system by using the Sendai Framework for Disaster Risk Reduction 2015–2030 guiding principles for DRR as *** findings reveal the existence of resistance factors that particularly complicate the communication,decision making,and coordination of DRR activities,the provision of resources,aspects of international assistance,as well as DRR planning and *** authors argue that such resistance factors contribute to making Cameroon’s DM system more reactive and further undermine risk *** article concludes by offering key recommendations that have the potential to alleviate the identified resistance factors as well as strengthen Cameroon’s DM,particularly in relation to capacity building,training,research development,and organizational resilience.

关键词： Cameroon Communication resistance Disaster management Disaster management system Disaster risk reduction West Africa

The Irony of Flood Risks in African Dryland Environments: Human Security in North Cameroon

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World Journal of Engineering and Technology 2017年第3期5卷 109-121页

作者： Henry Bang Lee Miles richard gordon Disaster Management Centre Faculty of Management Bournemouth University Bournemouth United Kingdom

North Cameroon, though located in an arid environment, ironically also suffers from the serious threat of flooding in the region. This article examines contemporary challenges resulting from frequent flooding in North Cameroon. Using Cutter’s “Hazard of Place Model” of vulnerability as the conceptual basis, the article triangulates data from a variety of sources to analyze environmental risks, social and biophysical vulnerability and flood impact, including flood risk management in North Cameroon. The findings reveal that North Cameroon is vulnerable to frequent flooding due to a combination of environmental, socio-economic, and geographic factors further compounded by low organizational resilience to flooding with dire consequences for livelihoods. We argue that, if not handled appropriately, the impact of flooding in North Cameroon risks trapping the population in a permanent and vicious cycle of destitution and poverty. The government urgently needs to review its disaster management policies to be more proactive and strategic in flood management in order to enhance human security and prevent permanent damage to the livelihoods and the micro-economy of the region. Lessons learned from this research, when applied, can help to reduce the vulnerabilities of the poverty-stricken population and enhance resilience to flood risks.

关键词： Frequent Flooding North Cameroon Vulnerability Flood Management

Hurricane Occurrence and Seasonal Activity: An Analysis of the 2017 Atlantic Hurricane Season

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American Journal of Climate Change 2019年第4期8卷 454-481页

作者： Henry Ngenyam Bang Lee Stuart Miles richard Duncan gordon Disaster Management Centre Bournemouth University Dorset Talbot Campus Fern Barrow Poole UK

This article provides a reckoning of the 2017 Atlantic Hurricane Season’s place in history to ascertain how unique it was from other hurricane seasons. A research strategy involving qualitative, descriptive and analytical research approaches, including content analysis, sequential description of events and comparative analysis, were used to assess how and why the 2017 AHS season is distinct from others. Findings reveal that the 2017 AHS was extraordinary by all meteorological standards—in many ways, being hyperactive, and producing a frenetic stretch of huge, long-lived and dramatic, tropical storms including 10 hurricanes. The season was, arguably, the most expensive in history and will be remembered for the unprecedented devastation caused by the season’s major hurricanes (Harvey, Irma and Maria). While the extremely active season can be attributed to anomalously high, climate change induced, hurricane friendly environmental conditions in the Atlantic basin, early forecasts did not also predict the hyperactivity of the season. This article, therefore, advances for a more strategic anticipatory and proactive approach in dealing with these severe storms, underpinned by effective mitigation of their effects. Furthermore, the article adds value to the literature examining extreme natural forces, particularly in understanding variations in the ferocity of the meteorological events associated with hurricane seasons.

关键词： Hurricanes Disaster Hurricane Season Tropical Cyclones Seasonal Activity

Flexible ultra-thin super-resolution endoscopy

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 171-172页

作者： George S.D.gordon Department of Electrical and Electronic Engineering University of NottinghamNottingham NG7 2RDUK

In recent years, multimode fiber(MMF) has become an important tool for high-resolution endoscopic imaging in narrow channels(e.g., in the brain via needles or inside blood vessels) due to its high mode density and fine diameter, typically <0.125 mm [1-6]. However, a major obstacle to widespread deployment in applications is that realistic perturbations, including bending, twisting and changes in temperature, cause unacceptable image degradation.

关键词： fiber resolution typically

Apoer2/Lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： gordon C.Werthmann Joachim Herz Department of Molecular Genetics and Center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas Southwestern Medical Center at Dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

Mixed plastics waste valorization to high-added value products via thermally induced phase separation and spin-casting

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Green Energy & Environment 2024年第10期9卷 1627-1640页

作者： Junaid Saleem Moghal Zubair Khalid Baig Usman Bin Shahid Rafael Luque gordon McKay Division of Sustainable Development College of Science and EngineeringHamad Bin Khalifa University Center for Advanced Materials Qatar University Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Universidad ECOTEC

Plastic waste is an underutilized resource that has the potential to be transformed into value-added ***,its chemical diversity leads to cost-intensive sorting techniques,limiting recycling and upcycling ***,we report an open-loop recycling method to produce graded feedstock from mixed polyolefins waste,which makes up 60%of total plastic *** method uses heat flow scanning to quantify the composition of plastic waste and resolves its compatibility through controlled *** resulting feedstock is then used to synthesize blended pellets,porous sorbents,and superhydrophobic coatings via thermally induced phase separation and *** hybrid approach broadens the opportunities for reusing plastic waste,which is a step towards creating a more circular economy and better waste management practices.

关键词： Plastic waste Valorization Superhydrophobic coatings Blended pellets Porous materials Sorbents

Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis Paulo Bartolo Andrew Weightman Glen Cooper gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

Fixed-effect and random-effects models in meta-analysis

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Chinese Medical Journal 2024年第1期137卷 1-4页

作者： Chunjuan Zhai gordon Guyatt Department of Cardiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8S 4L8OntarioCanada

A systematic review synthesizes evidence addressing a structured clinical question using systematic and explicit methods to search,identify,screen,critically appraise,and extract and analyze data from relevant studies.[1]A meta-analysis,on the other hand,is a statistical method that combines the quantitative results of available primary studies addressing the same question to generate a pooled summary estimate and confidence interval(CI).[2]Meta-analyses can increase statistical power,enhance precision,and answer questions that single trials are underpowered to *** there are systematic reviews where meta-analyses are not appropriate,when they are well-conducted and reported,systematic reviews combined with meta-analyses provide valuable information for clinicians,researchers,and policymakers.

关键词： Fixed analysis effect

Highly stretchable double-network gel electrolytes integrated with textile electrodes for wearable thermo-electrochemical cells

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SusMat 2024年第4期4卷 77-89页

作者： Yuetong Zhou Ding Zhang Shuai Zhang Yuqing Liu Rujun Ma gordon Wallace Jun Chen School of Materials Science and Engineering National Institute for Advanced MaterialsNankai UniversityTianjinChina Intelligent Polymer Research Institute ARC Centre of Excellence for Electromaterials ScienceAustralian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South WalesAustralia State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of ChinaChengduChina

Thermo-electrochemical cells(TECs)provide a new potential for self-powered devices by converting heat energy into ***,challenges still remain in the fabrication of flexible and tough gel electrolytes and their compat-ibility with redox actives;otherwise,contact problems exist between electrolytes and electrodes during stretching or ***,a novel robust and neutral hydrogel with outstanding stretchability was developed via double-network of crosslinked carboxymethyl chitosan and polyacrylamide,which accommodated both n-type(Fe^(2+)/Fe^(3+))and p-type([Fe(CN)_(6)]^(3-)/[Fe(CN)_(6)]^(4-))redox couples and maintained stretchability(>300%)and recoverability(95%compression).Moreover,poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)textile elec-trodes with porous structure are integrated into gel electrolytes that avoid contact issues and effectively boost the P_(max) of n-and p-type thermocell by 76%and 26%,*** optimized thermocell exhibits a quick current density response and is continually fully operational under deformations,which satisfies the working conditions of wearable *** thermocells(four pairs)are effectively connected in alternating single n-and p-type cells in series and out-putted nearly 74.3 mV atΔT=10℃.The wearable device is manufactured into a soft-pack thermocells to successfully harvest human body heat and illuminate an LED,demonstrating the potential of the actual application of the thermocell devices.

关键词： human body heat porous textile electrodes stretchable double-network hydrogel electrolytes thermo-electrochemical cells wearable devices

Targeting proprotein convertase subtilisin/kexin type 9(PCSK9):from bench to bedside

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Signal Transduction and Targeted Therapy 2024年第2期9卷 509-557页

作者： Xuhui Bao Yongjun Liang Hanman Chang Tianji Cai Baijie Feng Konstantin gordon Yuekun Zhu Hailian Shi Yundong He Liyi Xie Institute of Therapeutic Cancer Vaccines Fudan University Pudong Medical CenterShanghaiChina Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina Department of Oncology Fudan University Pudong Medical CenterShanghaiChina Center for Clinical Research Fudan University Pudong Medical CenterShanghaiChina Clinical Research Center for Cell-based Immunotherapy Fudan UniversityShanghaiChina Department of Pathology Duke University Medical CenterDurhamNCUSA Center for Medical Research and Innovation Fudan University Pudong Medical CenterShanghaiChina Institute for Food Safety and Health Illinois Institute of TechnologyChicagoILUSA Department of Sociology University of MacaoTaipaMacaoChina Medical Institute Peoples’Friendship University of RussiaMoscowRussia A.Tsyb Medical Radiological Research Center ObninskRussia Department of Colorectal Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Shanghai Key Laboratory of Compound Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineZhangjiang Hi-tech ParkShanghaiChina Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina

Proprotein convertase subtilisin/kexin type 9(PCSK9)has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases(CVD).This comprehensive review delineates the intricate roles and wide-ranging implications of PCSK9,extending beyond CVD to emphasize its significance in diverse physiological and pathological states,including liver diseases,infectious diseases,autoimmune disorders,and notably,*** exploration offers insights into the interaction between PCSK9 and low-density lipoprotein receptors(LDLRs),elucidating its substantial impact on cholesterol homeostasis and cardiovascular *** also details the evolution of PCSK9-targeted therapies,translating foundational bench discoveries into bedside applications for optimized patient *** advent and clinical approval of innovative PCSK9 inhibitory therapies(PCSK9-iTs),including three monoclonal antibodies(Evolocumab,Alirocumab,and Tafolecimab)and one small interfering RNA(siRNA,Inclisiran),have marked a significant breakthrough in cardiovascular *** therapies have demonstrated unparalleled efficacy in mitigating hypercholesterolemia,reducing cardiovascular risks,and have showcased profound value in clinical applications,offering novel therapeutic avenues and a promising future in personalized medicine for cardiovascular ***,emerging research,inclusive of our findings,unveils PCSK9’s potential role as a pivotal indicator for cancer prognosis and its prospective application as a transformative target for cancer *** review also highlights PCSK9’s aberrant expression in various cancer forms,its association with cancer prognosis,and its crucial roles in carcinogenesis and cancer *** conclusion,this synthesized review integrates existing knowledge and novel insights on PCSK9,providing a holistic perspective on its transformative impact in reshaping therapeutic paradigms acr

关键词： PCSK9 metabolism convert