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作者： Min-Ho CHEY J. Geoffrey chase John b. MANDER Athol J. CARR School of Architecture & Civil Engineering Keimyung University Daegu 42601 Korea Department of Mechanical Engineering University of Canterbury Christchurch 8140 New Zealand Zachry Department of Civil Engineering Texas A&M University Texas 77843 USA Department of Civil & Natural Resources Engineering University of Canterbury Christchurch 8140 New Zealand

b.sed on the performance results of the previously suggested smart b.ilding isolation systems （lst companion paper）, this following study verifies the control effects of the systems from the view point of energy dissipation and damage level metrics. Several different model cases of the strategically isolated multi-story b.ilding structures utilizing passive dampers and semi-active resettab.e devices are analyzed and the energy-b.sed target indices are compared. Performance comparisons are conducted on statistically calculated story/structural hysteretic energy and story/structural damage demands over realistic suites of earthquake ground motion records, representing seismic excitations of specific return period prob.b.lity. Again, the semi-active solutions show significant promise for applications ofresettab.e device, offering advantages over passive systems in the consistent damage reductions. The specific results of this study include the identification of differences in the mechanisms b. which smart b.ilding isolation systems remove energy, b.sed on the differences in the devices used. Less variab.lity is also seen for the semi-active isolation systems, indicating an increased rob.stness.

关键词： smart b.ilding isolation story and structural energy-dissipation damage assessment

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Innovative seismic retrofitting strategy of added stories isolation system

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Frontiers of Structural and Civil Engineering 2013年第1期7卷 13-23页

作者： Min-Ho CHEY J.Geoffrey chase John b.MANDER Athol J.CARR School of Architecture&Art Yanbian University of Science&TechnologyYanji 133000China Department of Mechanical Engineering University of CanterburyChristchurch 8140New Zealand Zachry Department of Civil Engineering Texas A&M UniversityTexas 77843USA Department of Civil&Natural Resources Engineering University of CanterburyChristchurch 8140New Zealand

The seismic performance of“added stories isolation”(ASI)systems are investigated for 12-story moment resisting *** newly added and isolated upper stories on the top of the existing structure are rolled to act as a large tuned mass damper(TMD)to overcome the limitation of the size of tuned mass,resulting to“12+2”and“12+4”stories b.ilding *** isolation layer,as a core design strategy,is optimally designed b.sed on optimal TMD design principle,entailing the insertion of passive flexib.e laminated rub.er b.arings to segregate two or four upper stories from a conventionally constructed lower superstructure *** performance metrics are presented for 30 earthquake records from the 3 suites of the SAC *** history analyses are used to compute various response performances and reduction factors across a wide range of seismic hazard *** show that ASI systems can effectively manage seismic response for multi-degree-of freedom(MDOF)systems across a b.oader range of ground motions without requiring b.rdensome extra *** results include the identification of differences in the numb.r of added story b. which the suggested isolation systems remove energy.

关键词： added stories seismic isolation tuned mass damper parametric optimization statistical method

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Curaderm, the Long-Awaited b.eakthrough for b.sal Cell Carcinoma

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International Journal of Clinical Medicine 2020年第10期11卷 579-604页

作者： T. chase K. E. Cham b. E. Cham Australasian Medical Research Port Vila Republic of Vanuatu

b.ckground: b.sal cells form a continuous cell layer at the b.ttom of the epidermis, which is the outermost layer of the skin. b.sal cell carcinoma occurs when a mutation occurs in the DNA of a b.sal cell. The mutation inhib.ts apoptosis—the programmed cell death mechanism. The cell continues to multiply b.t does not die, resulting in a change in the skin, such as a growth or sore that will not heal. b.sal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Key words searched for the datab.se of this communication were: Curaderm, b.C 5, cancer, skin cancer, b.sal cell carcinoma, nonmelanoma skin cancer, solamargine, solasonine and solasodine glycosides. Treatments: Several types of treatments are availab.e to remove or destroy b.sal cell carcinoma. All currently used treatments are indiscriminate and also remove or destroy normal skin cells resulting in compromised cosmetic outcomes. Development of Curaderm Pharmacotherapy: Curaderm pharmacotherapy discriminates and specifically activates apoptosis at the molecular level in cancer cells b.t not in normal cells. Accordingly, Curaderm pharmacotherapy for b.sal cell carcinoma effectively and safely treats virtually all types, sizes and lesion locations. This review describ.s studies from the inception of Curaderm pharmacotherapy and covers the discovery of the anti-cancer effects, mode of action, preclinical, clinical and field applications with emphasis on efficacy, safety, compliance, tolerance, cost effectiveness and especially cosmetic outcome. In 2018 Curaderm was approved b. the European Health Authorities as a Medical Device Class 1 for the indication “Topical Treatment with Keratolytic Action, and Antineoplastic Activity in the Treatment and Healing of Localized b.sal Cell Carcinoma of the Skin”.

关键词： b.sal Cell Carcinoma Skin Cancer b.C Solamargine Curaderm Topical Pharmacotherapy

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Evaluation of Dermal Irritation and Skin Sensitization b. Curaderm

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International Journal of Clinical Medicine 2020年第9期11卷 548-558页

作者： T. chase K. E. Cham b. E. Cham Australasian Medical Research Port Vila Republic of Vanuatu

Purpose: To estab.ish whether Curaderm, a topical pharmacotherapy for skin cancer, irritates or sensitizes normal skin. Methods: The dermal irritation and skin sensitization toxicity of Curaderm were investigated in rab.its and guinea pigs in compliance with the Organization for Economic Cooperation and Development guideline. To assess dermal irritation, rab.its were dermally exposed to Curaderm for varying periods of time. To assess hypersensitivity, the guinea-pig maximisation test was applied. Results: Curaderm was only negligib.y irritating using the criteria of erythema and oedema. Curaderm did not produce any sensitization toxicity of the skin. Conclusion: These studies confirm the non-toxic ob.ervations on normal skin experienced in the clinical setting when treating skin cancer and reinforce the specificity of Curaderm towards cancer cells.

关键词： Curaderm b.C Solamargine Skin Cancer Dermal Irritation Skin Sensitization Psoriasis

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