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On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus

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Science China(Life Sciences) 2013年第9期56卷 767-779页

作者： TSIEN Joe Z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip Lei frey Sabine frey Julietta ZHU DaJiang LIU TianMing ZHAO Fang KUANG Hui Brain and Behavior Discovery Institute Medical College of Georgia Georgia Regents University Department of Mathematics and Institute of Neuroscience Georgia State University Department of Cell and Developmental Biology University College London Shanghai Institute of Brain Functional Genomics East China Normal University Department of Computer Science & Bioimaging Research Center The University of Georgia Brain Decoding Center Banna Biomedical Research Institute Xi-Shuang-Ban-Na Prefecture

The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research.

关键词： BRAIN project Brain Decoding Project brain activity map learning and memory episodic memory semantic knowledge imagination concepts fear conditioning earthquake experiences neural code

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Learning from the crowd:Road infrastructure monitoring system

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第5期4卷 451-463页

作者： Johannes Masino Jakob Thumm Michael frey Frank Gauterin Institute of Vehicle System Technology Karlsruhe Institute of Technology(KIT)Karlsruhe 76131Germany

The condition of the road infrastructure has severe impacts on the road safety, driving comfort, and on the rolling resistance. Therefore, the road infrastructure must be moni- tored comprehensively and in regular intervals to identify damaged road segments and road hazards. Methods have been developed to comprehensively and automatically digitize the road infrastructure and estimate the road quality, which are based on vehicle sensors and a supervised machine learning classification. Since different types of vehicles have various suspension systems with different response functions, one classifier cannot be taken over to other vehicles. Usually, a high amount of time is needed to acquire training data for each individual vehicle and classifier. To address this problem, the methods to collect training data automatically for new vehicles based on the comparison of trajectories of untrained and trained vehicles have been developed. The results show that the method based on a k-dimensional tree and Euclidean distance performs best and is robust in transferring the information of the road surface from one vehicle to another. Furthermore, this method offers the possibility to merge the output and road infrastructure information from multiple vehicles to enable a more robust and precise prediction of the ground truth.

关键词： Road infrastructure condition Monitoring Tree graphs Euclidean distance Machine learning Classification

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An Update on Abscisic Acid Signaling in Plants and More

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Molecular Plant 2008年第2期1卷 198-217页

作者： Aleksandra Wasilewsk.a Florina Vlad Caroline Sirichandra Yulia Redko Fabien Jammes Christiane Valon Nicolas Frei dit frey Jeffrey Leung Institut des Sciences du Vegetal Centre National de la Recherche Scientifique UPR 23551 Avenue de la Terrasse Bat. 23 91190 Gif-sur-Yvette France CNRS UPR9073 Institut de Biologie Physico-Chimique 13 rue Pierre et Marie Curie 75005 Paris France Laboratoire Signalisation et Regulation Coordonnee du Metabolisme Carbone et Azote Institut de Biotechnologie des Plantes (UMR8618) Universite Paris-Sud F-91405 Orsay Cedex France

The mode of abscisic acid （ABA） action, and its relations to drought adaptive responses in particular, has been a captivating area of plant hormone research for much over a decade. The hormone triggers stomatal closure to limit water loss through transpiration, as well as mobilizes a battery of genes that presumably serve to protect the cells from the ensuing oxidative damage in prolonged stress. The signaling network orchestrating these various responses is, however, highly complex. This review summarizes several significant advances made within the last few years. The biosynthetic pathway of the hormone is now almost completely elucidated, with the latest identification of the ABA4 gene encoding a neoxanthin synthase, which seems essential for de novo ABA biosynthesis during water stress. This leads to the interesting question on how ABA is then delivered to perception sites. In this respect, regulated transport has attracted renewed focus by the unexpected finding of a shoot-to-root translocation of ABA during drought response, and at the cellular level, by the identification of a B-galactosidase that releases biologically active ABA from inactive ABA-glucose ester. Surprising candidate ABA receptors were also identified in the form of the Flowering Time Control Protein A （FCA） and the Chloroplastic Magnesium Protoporphyrin-IX Chelatase H subunit （CHLH） in chloroplast-nucleus communication, both of which have been shown to bind ABA in vitro. On the other hand, the protein（s） corresponding to the physiologically detectable cell-surface ABA receptor（s） is （are） still not known with certainty. Genetic and physiological studies based on the guard cell have reinforced the central importance of reversible phosphorylation in modulating rapid ABA responses. Sucrose Non-Fermenting Related Kinases （SnRK）, Calcium-Dependent Protein Kinases （CDPK）, Protein Phosphatases （PP） of the 2C and 2A classes figure as prominent regulators in this single-cell model. Identifying their d

关键词： Abscisic Acid Signaling Plants and More

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Taking FAIR on the ChIN:The Chemistry Implementation Network

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Data Intelligence 2020年第1期2卷 131-138,310页

作者： Simon J.Coles Jeremy G.frey Egon L.Willighagen Stuart J.Chalk School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK Department of Bioinformatics Maastricht UniversityMaastrichtLimburg 6200 MDThe Netherlands Department of Chemistry University of North FloridaJacksonvilleFL 32224-7699USA

The Chemistry Implementation Network(ChIN)is focused on supporting the FAIR Data needs of the research community regarding chemical related *** Implementation Network is a consortium drawn from a community,in this case the chemistry discipline,committed to defining and constructing standards,materials and software in the spirit of the FAIR data principles and under the structure of the GO FAIR ***,as a core science the ChIN has to reach beyond the chemistry community and support the use of chemical information in other *** will be facilitated through connections in the GO FAIR ecosystem of Implementation *** of the FAIR chemical concepts that need to be supported include molecular and materials structures,chemical reactions,nomenclature and other chemical terminology and *** ChIN aims to drive forward the application of the FAIR Data Principles relating to the full range of chemistry concepts that are key to the transparent and efficient communication of chemical *** the goal of FAIR chemistry data will require a culture change across the *** this is best addressed once a critical mass of tools and approaches has been developed.

关键词： Chemistry Chemical information Chemistry data Chemical data standards Infrastructure Nomenclature Molecular structure Materials structure Chemical reactions Education Community engagement Endorsement and governance

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frey procedure for the treatment of chronic pancreatitis associated with common bile duct stricture

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 637-644页

作者： Lionel Rebibo Thierry Yzet Cyril Cosse richard Delcenserie Eric Bartoli Jean-Marc Regimbeau Department of Digestive Surgery Amiens University Medical Center the Jules Verne University of Picardie Department of Radiology Amiens University Medical Center and the Jules Verne University of Picardie Department of Digestive SurgeryAmiens University Medical Center and the Jules Verne University of Picardie Department of Gastroenterology Amiens University Medical Center and the Jules Verne University of Picardie

BACKGROUND:The frey procedure(FP)is the treatment of choice for symptomatic chronic pancreatitis(CP).In cases of biliary stricture,biliary derivation can be performed by choledochoduodenostomy,Roux-en-Y choledochojejunostomy or,more recently,reinsertion of the common bile duct(CBD)into the resection *** objective of the present study was to evaluate the outcomes associated with each of these three types of biliary ***:We retrospectively analyzed demographic,CPrelated,surgical and follow-up data for patients having undergone FP for CP with biliary derivation between 2004and 2012 in our university medical *** primary efficacy endpoint was the rate of CBD stricture *** secondary endpoints were surgical parameters,postoperative complications,postoperative follow-up and the presence of risk factors for secondary CBD ***:Eighty patients underwent surgery for CP during the study *** these,15 patients received biliary derivation with the *** of the FPs(53.3%)were combined with choledochoduodenostomy,4(26.7%)with choledochojejunostomy and 3(20.0%)with reinsertion of the CBD into the resection *** mean operating time was *** complications(73.3%)were recorded,including one major complication(6.7%)that necessitated radiologicallyguided drainage of an abdominal *** mean(range)length of stay was 17 days(8-28)and the median(range)follow-up time was 35.2 months(7.2-95.4).Two patients presented stricture after CBD reinsertion into the resection cavity;one was treated with radiologically-guided dilatation and the other underwent revisional Roux-en-Y *** patients presented alkaline reflux gastritis(37.5%),one(12.5%)cholangitis and one CBD stricture after FP with *** risk factors for secondary CBD stricture were ***:As part of a biliary derivation,the FP gave good *** did not observe any complications specifically relat

关键词： common bile duct stricture chronic pancreatitis frey procedure pancreatectomy

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Confirming the 115.5-day periodicity in the X-ray light curve of ULX NGC 5408 X-1

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Research in Astronomy and Astrophysics 2012年第12期12卷 1597-1602页

作者： Xu Han Tao An Jun-Yi Wang Ji-Ming Lin Ming-Jie Xie Hai-Guang Xu Xiao-Yu Hong Sandor frey Key Laboratory of Cognitive Radio & Information Processing Ministry of Education Guilin University of Electronic Technology Guilin 541004 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China School of Mathematics and Computational Science Xiangtan University Xiangtan 411105China Key Laboratory of Radio Astronomy Chinese Academy of Sciences Nanjing 210008 China Department of Physics Shanghai Jiao Tong University Shanghai 200240 China FOMI Satellite Geodetic Observatory EO. Box 585 H-1592 Budapest Hungary

The Swift/XRT light curve of the ultraluminous X-ray source NGC 5408 X-1 was re-analyzed with two new numerical approaches, the Weighted Wavelet Ztransform and CLEANest, and the results are different from previous studies. Both techniques detected a prominent periodicity with a time scale of 115.5 ± 1.5 days, in excellent agreement with the detection of the same periodicity first reported by Strohmayer . Monte Carlo simulations were employed to test the statisitical confidence of the 115.5-day periodicity, yielding a statistical significance of 〉 99.98% （or 〉 3.8σ）. The robust detection of the 115.5-day quasi-periodic oscillations, if they are due to the orbital motion of the binary, would infer a mass of a few thousand M⊙ for the central black hole, implying there is an intermediate-mass black hole in NGC 5408 X-1.

关键词： methods: statistical - galaxies: individual (NGC 5408) - stars: oscil- lations

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4Z1c实时容积成像探头

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中华医学超声杂志（电子版） 2010年第3期7卷 78-80页

作者： Gregg frey richard Chiao 西门子医疗(美国)超声事业部

成像技术的突破性往往要求彻底改变传统的方法.容积成像的优化和超声心动图的检查需提供高质量的心脏全容积扫描、高帧频图像和卓越的图像质量.西门子专门设计的4Z1c实时容积成像探头可用单一探头就能实现成人超声心动图成像,它融合了... 详细信息

成像技术的突破性往往要求彻底改变传统的方法.容积成像的优化和超声心动图的检查需提供高质量的心脏全容积扫描、高帧频图像和卓越的图像质量.西门子专门设计的4Z1c实时容积成像探头可用单一探头就能实现成人超声心动图成像,它融合了材料学、电子学和人机工程学设计等领域的最新进展,能够以很高的容积率对整个心脏进行前作未有的成像检查,而无需采用门控采集和成像拼接技术.

关键词：容积成像探头超声心动图图像质量人机工程学成像技术容积扫描集成电路

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Towards a Model-Driven IEC 61131-Based Development Process in Industrial Automation

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Journal of Software Engineering and Applications 2011年第4期4卷 217-226页

作者： Kleanthis Thramboulidis Georg frey 不详

The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise compliance with it. On the other side, Model Driven Development (MDD) has been proved as a quite successful paradigm in general-purpose computing. This was the motivation for exploiting the benefits of MDD in the industrial automation domain. With the emerging IEC 61131 specification that defines an object-oriented (OO) extension to the function block model, there will be a push to the industry to better exploit the benefits of MDD in automation systems development. This work discusses possible alternatives to integrate the current but also the emerging specification of IEC 61131 in the model driven development process of automation systems. IEC 61499, UML and SysML are considered as possible alternatives to allow the developer to work in higher layers of abstraction than the one supported by IEC 61131 and to more effectively move from requirement specifications into the implementation model of the system.

关键词： Industrial Automation Systems Model Driven Development IEC 61131 System Modeling UML SysML IEC 61499 Development Process

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Impact of dental clearance on total joint arthroplasty: A systematic review

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World Journal of Orthopedics 2019年第12期10卷 416-423页

作者： Christopher frey Sergio M Navarro Terri Blackwell Carla Lidner H Del Schutte Jr Department of Orthopedic Surgery Stanford MedicineRedwood CityCA 94063United States Department of Surgery Baylor College of MedicineHoustonTX 77030United States Said School of Business University of Oxford Oxford OX11HPUnited Kingdom Comprehensive Joint Program Charleston Institute for Advanced OrthopedicsCharlestonSC 29464United States Dentistry Orange County Dental SocietyOrangeCA 92868United States

Many orthopedic surgeons require that their patients obtain dental clearance before elective total joint arthroplasty(TJA).However,there is no consensus substantiating the *** this end,a systematic review on the prevalence of dental pathology in TJA patients,risk factors for failing dental screening,and impact of dental evaluations was *** was sourced from PubMed and Scopus *** papers were sourced from the initial search,one study was extracted from the references of the original six manuscripts,and one new publication was retrieved from a second search conducted after the *** prevalence of dental pathology ranged from 8.8%to 29.4%across *** of four papers reported lower than average or improvements in postoperative infection with pre-operative dental evaluations while two found no such *** is insufficient evidence to support universal dental clearance before TJA.

关键词： Total knee arthroplasty Total hip arthroplasty Total joint arthroplasty Periprosthetic joint infection Dental screening

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中医药在德国的市场现状

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临床药物治疗杂志 2009年第2期7卷 13-17页

作者：理查德·傅莱（richard frey）德国市场经济信息公司德国40237

改革开放30年来,东西方文化与科学技术的交流有了很大的发展,中国的国粹--中医药也加快了走出国门的步伐.包括德国在内的欧洲国家,对中医传统植物药疗效的认可有了很大的提高.中医中药已经为世界人民的健康,做出了巨大的贡献.

关键词：中医药市场现状德国东西方文化传统植物药改革开放科学技术欧洲国家

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