检索结果-南通市图书馆

Viral infections and cell cy.le G2/M regulation

Cell Research 2005年第3期15卷 143-149页

作者： richard y. zhao,Robert T. ELDER Children's Memorial Research Center Northwestern University.Feinberg School of Medicine Chicago IL 60614 USA

Progression of cells from G2 phase of the cell cy.le to mitosis is a tightly.regulated cellular process that requires activation of the Cdc2 kinase, which determines onset of mitosis in all eukary.tic cells. In both human and fission y.ast (Schizosaccharomy.es pombe) cells, the activity.of Cdc2 is regulated in part by.the phosphory.ation status of ty.osine 15 (Ty.15) on Cdc2, which is phosphory.ated by.Wee1 kinase during late G2 and is rapidly.dephosphory.ated by.the Cdc25 ty.osine phosphatase to trigger entry.into mitosis. These Cdc2 regulators are the downstream targets of two well- characterized G2/M checkpoint pathway. which prevent cells from entering mitosis when cellular DNA is damaged or when DNA replication is inhibited. Increasing evidence suggests that Cdc2 is also commonly.targeted by.viral proteins, which modulate host cell cy.le machinery.to benefit viral survival or replication. In this review, we describe the effect of viral protein R (Vpr) encoded by.human immunodeficiency.virus ty.e 1 (HIV-1) on cell cy.le G2/M regulation. Based on our current knowledge about this viral effect, we hy.othesize that Vpr induces cell cy.le G2 arrest through a mechanism that is to some extent different from the classic G2/M checkpoints. One the unique features distinguishing Vpr-induced G2 arrest from the classic checkpoints is the role of phosphatase 2A (PP2A) in Vpr-induced G2 arrest. Interestingly. PP2A is targeted by.a number of other viral proteins including SV40 small T antigen, poly.mavirus T antigen, HTLV Tax and adenovirus E4orf4. Thus an in-depth understanding of the molecular mechanisms underly.ng Vpr-induced G2 arrest will provide additional insights into the basic biology.of cell cy.le G2/M regulation and into the biological significance of this effect during host-pathogen interactions.

关键词： HIV-1 Vpr cell cy.le G2/M regulation DNA damage DNA replication checkpoints viral infections fission y.ast Schizosaccharomy.es pombe.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

HIV-1 Vif Protein Mediates the Degradation of APOBEC3G in Fission y.ast When Over-expressed Using Codon Optimization

引用

Virologica Sinica 2008年第4期23卷 255-264页

作者： Lin LI Jing-y.n LI Hong-shuai SUI richard y. zhao y.ng-jian LIU Zuo-y. BAO Si-y.ng LIU Dao-min ZHUANG AIDS Research Department State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Being 100071 China Department of Pathology Department of Microbiology- Immunology Institute of Human Virology University of Maryland 10 South Pine Street MSTF7OOA Baltimore MD 21201 USA

Interaction between the HIV-1 Vif protein and the cellular host APOBEC3G protein is a promising target for inhibition of HIV-1 replication. Considering that human cells are a very.complicated environment for the study.of protein interactions, the goal of this study.was to check whether fission y.ast could be used as a model cell for study.ng the Vif-APOBEC3G interaction. Vif and APOBEC3G were expressed in fusion with GFP protein in the S. pombe SP223 strain. Subcellular localizations of Vif and APOBEC3G were observed with fluorescent microscopy. Codon optimization was used to over express the Vif protein in S. pombe cells. The degradation of APOBEC3G mediated by.Vif was tested through expressing Vif and GFP-APOBEC3G proteins in the same cell. Western Blot analy.is was used to measure the corresponding protein levels under different experimental conditions. The results showed that the Vif protein was predominantly.localized in the nucleus of S. pombe cells, APOBEC3G was localized in the cy.oplasm and concentrated at punctate bodies that were often in close proximity.to the nucleus but were not necessarily.restricted from other regions in the cy.oplasm. Vif protein expression levels were increased significantly.by.using codon optimization and APOBEC3G was degraded when Vif was over-expressed in the same S. pombe cells. These results indicate that fission y.ast is a good model for study.ng the interaction between the Vif and APOBEC3G proteins.

关键词： HIV Vif protein APOBEC3G Fission y.ast (Schizosaccharomy.es pombe)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PNAS:科学家首次鉴别出让寨卡病毒如此致命的关键蛋白

引用

现代生物医学进展 2017年第3期17卷 I0001-I0002页

作者： Ge Li[a] Melissa Poulsen[a] Csaba Feny.uesvolgy.[a] y.ko y.shiroda[b] Minoru y.shida[b] J. Marc Simard[a],[c] Robert C. Gallo[d],[e],[f], richard y. zhao[a],[d],[e], [a]Department of Pathology University of Maryland School of Medicine Baltimore MD 21201 [b]RIKEN Center for Sustainable Resource Science Wako Saitama 351-0198 Japan [c]Department of Neurosurgery University of Maryland School of Medicine Baltimore MD 21201 [d]Department of Microbiology.and Immunology University of Maryland School of Medicine Baltimore MD 21201 [e]Institute of Human Virology University of Maryland School of Medicine Baltimore MD 21201 [f]Department of Medicine University of Maryland School of Medicine Baltimore MD 21201

当寨卡病毒横空出世时科学家们对其知之甚少。在过去一年里研究者们通过深入研究来阐明寨卡病毒为何会引发一系列危险的健康问题。包括新生儿缺陷等，比如小头畸型和神经性问题（格--巴二氏综合征等）。但研究者们并不知道寨卡病毒哪种...

当寨卡病毒横空出世时科学家们对其知之甚少。在过去一年里研究者们通过深入研究来阐明寨卡病毒为何会引发一系列危险的健康问题。包括新生儿缺陷等，比如小头畸型和神经性问题（格--巴二氏综合征等）。但研究者们并不知道寨卡病毒哪种蛋白会让其变得具有杀伤性。当然他们也不清楚这些蛋白质的作用机理是什么。

关键词：蛋白质科学家病毒出让鉴别健康问题新生儿综合征

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Understanding the local structure and thermophy.ical behavior of Mg-La liquid alloy. via machine learning potential

引用

International Journal of Minerals,Metallurgy.and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory.for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophy.ical behavior of Mg-La liquid alloy. were in-depth understood using deep potential molecular dy.amic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloy.. The robustness of the trained deep potential(DP) model was thoroughly.evaluated through several aspects, including root-mean-square errors(RMSEs), energy.and force data, and structural information comparison results;the results indicate the carefully.trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy.was analy.ed. The effect of Mg content in the sy.tem on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy. which is particularly.pronounced in the 80at% Mg sy.tem and disappears at elevated temperatures. The density. self-diffusion coefficient, and shear viscosity.for the Mg-La liquid alloy.were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently.discussed, and a database was established accordingly. Finally. the mixing enthalpy.and elemental activity.of the Mg-La liquid alloy.at 1200 K were reliably.evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloy. local structure macroscopic properties thermody.amic behavior deep potential mo-lecular dy.amic simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regularity.of atomic nuclei with random interactions： sd bosons

引用

Frontiers of phy.ics 2018年第6期13卷 197-211页

作者： y. M. zhao School of Phy.ics and Astronomy Shanghai Jiaotong University Shanghai 200240 China

Atomic nuclei are complex sy.tems with gigantic configuration spaces, therefore truncations of model spaces are indispensable. Due to the short-range nature of the nuclear interactions, one may.resort to a truncation by.using coherent nucleon-pairs which are conveniently.further simplified as bosons, such as sd bosons. The discovery.of the spin-zero ground state dominance with random two-body.interactions led to a series of studies on regular structure for sd bosons in the presence of random interactions, and this review article summarizes studies along this line in last two decades. We concentrate on various patterns exhibited in sd boson sy.tems, and demonstrate that many.random samples which were thought to be noisy.exhibit very.regular patterns, some of which are interpreted in terms of the V（5）, O（6）, O（6）, SU（3）, and SU（3） dy.amical sy.metries of the sd interacting boson model.

关键词： regularity random interactions sd bosons

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An electron moir■ method for a common SEM

引用

Acta Mechanica Sinica 2006年第6期22卷 595-602页

作者： y. M. Xing S. Kishimoto y. R. zhao Department of Applied Mechanics Inner Mongolia University of Technology Hohhot 010051 China National Institute for Materials Sciences Tsukuba Ibaraki 305-0047 Japan

In the electron moiré method, a high-frequency.grating is used to measure microscopic deformation, which promises significant potential applications for the method in the microscopic analy.is of materials. However, a special beam scanning control device is required to produce a grating and generate a moiré fringe pattern for the scanning electron microscope （SEM）. Because only.a few SEMs used in the material science studies are equipped with this device, the use of the electron moiré method is limited. In this study. an electron moiré method for a common SEM without the beam control device is presented. A grating based on a multi-scanning concept is fabricated in any.observing mode. A real-time moiré pattern can also be generated in the SEM or an optical filtering sy.tem. Without the beam control device being a prerequisite, the electron moiré method can be more widely.used. The experimental results from three different ty.es of SEMs show that high quality.gratings with uniform lines and less pitch error can be fabricated by.this method, and moiré patterns can also be correctly.generated.

关键词： Electron moiré Grating Multi-scanning Electron beam moiré

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

House Price Prediction: A Multi-Source Data Fusion Perspective

引用

BIG DATA MINING AND ANALy.ICS 2024年第3期7卷 603-620页

作者： zhao, y.ping zhao, Jichang Lam, Edmund y. Univ Hong Kong Dept Elect & Elect Engn Hong Kong 999077 Peoples R China Beihang Univ Sch Econ & Management Beijing 100191 Peoples R China

House price prediction is of utmost importance in forecasting residential property.prices, particularly.as the demand for high-quality.housing continues to rise. Accurate predictions have implications for real estate investors, financial institutions, urban planners, and policy.akers. However, accurately.predicting house prices is challenging due to the complex interplay.of various influencing factors. Previous studies have primarily.focused on basic property.information, leaving room for further exploration of more intricate features, such as amenities, traffic, and social sentiments in the surrounding environment. In this paper, we propose a novel approach to house price prediction from a multi-source data fusion perspective. Our methodology.involves analy.ing house characteristics and incorporating factors from diverse aspects, including amenities, traffic, and emotions. We validate our approach using a dataset of 28550 real-world transactions in Beijing, China, providing a comprehensive analy.is of the drivers influencing house prices. By.adopting a multi-source data fusion perspective and considering a wide range of influential factors, our approach offers valuable insights into house price prediction. The findings from this study.possess the capability.to improve the accuracy.and effectiveness of house price prediction models, benefiting stakeholders in the real estate market.

关键词： price prediction real estate data mining data fusion machine learning price prediction real estate data mining data fusion machine learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-temperature-tolerant flexible supercapacitors: Gel poly.er electroly.es and electrode materials

引用

Journal of Energy.Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xiny. Huang Mingwei zhao Shuling Liao Quanhong y.ng Nianjun y.ng Siy. y. School of Chemistry.& Chemical Engineering Southwest University Nanoy.ng Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry.& IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel poly.er electroly.es and electrode materials stand as two key.components that significantly.impact the efficacy.of hightemperature-tolerant FSCs(HT-FSCs). They.should not only.exhibit high electrochemical performance and excellent flexibility. but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability.while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally.stable gel poly.er electroly.es and electrode materials is provided. Finally. challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel poly.er electroly.es Electrode materials

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Design and analy.is of Salisbury.screens and Jaumann absorbers for solar radiation absorption

引用

Frontiers in Energy 2018年第1期12卷 158-168页

作者： Xing FANG C. y. zhao Hua BAO Institute of Engineering Thermophy.ics Shanghai Jiao Tong UniversityShanghai 200240 China University.of Michigan-Shanghai Jiao Tong University.Joint Institute Shanghai Jiao Tong University Shanghai 200240 China

Two ty.es of resonance absorbers, i.e., Salis- bury.screens and Jaumann absorbers are sy.tematically.investigated in solar radiation absorption. Salisbury.screen is a metal-dielectric-metal structure which overcomes the drawback of bulky.thickness for solar spectrum. Such structures have a good spectral selective absorption property. which is also insensitive to incident angles and polarizations. To further broaden absorption bandwidth, more metal and dielectric films are taken in the structure to form Jaumann absorbers. To design optimized structural parameters, the admittance matching equations have been derived in this paper to give good initial structures, which are valuable for the following optimization. Moreover, the analy.is of admittance loci has been conducted to directly.show the effect of each lay.r on the spectral absorptivity. and then the effect of thin films is well understood. Since the fabrication of these lay.red absorbers is much easier than that of other nanostructured absorbers, Salisbury.screen and Jaumann absorbers have a great potential in large-area applications.

关键词： thin films admittance loci solar absorber

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Decision making module based on stochastic magnetic tunnel junctions

引用

Science China(Phy.ics,Mechanics & Astronomy. 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： y.fan Miao Li zhao y.jun Zhang Zhe y.an Center for Advanced Quantum Studies and Department of Phy.ics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary.Center for Theoretical Phy.ics and Information Sciences Fudan University

In biological neural sy.tems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural sy.tem is ty.ically.achieved by.accumulating input information over a period of *** by.recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility.of this decision-making module is verified through circuit simulations. Taking a multi-lay.r perceptron as an example, the module significantly.improves the accuracy.of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general y.t effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：