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t.e JAK2&lt.sup&gt.V617F&lt./sup&gt.Mut.t.on Seen in Myeloproliferat.ve Neoplasms (MPNs) Occurs in Pat.ent. wit. Inflammat.ry Bowel Disease: Implicat.ons of a Pilot.St.dy

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Int.rnat.onal Journal of Clinical Medicine 2013年第12期4卷 10-15页

作者： Emil Kuriakose Elena Lascu Y. Lynn Wang St.fani Gjoni Nicholas C. P. Cross Rut. Baumann Kerilee t.m Ellen Scherl Randy S. Longman richard t. silver Depart.ent.of Pat.ology University of Chicago Chicago USA Division of Hemat.logy and Medical Oncology Weill Cornell Medical College New York USA Jill Robert. Cent.r for Inflammat.ry Bowel Disease Division of Gastroenterology Weill Cornell Medical College New York USA Wessex Regional Genet.cs Laborat.ry Salisbury District Hospital University of Southampton Salisbury UK

Pat.ent. wit. IBD frequent.y have hemat.logic abnormalit.es suggest.ve of JAK2 mut.t.d MPNs, but.are t.adit.onally classified as react.ve processes. Haplot.pe 46/1 is a well-charact.rized genet.c predisposit.on, common t. bot. inflammat.ry bowel disease (IBD) and myeloproliferat.ve neoplasms (MPN). In view of t.is shared genet.c predisposit.on, we measured t.e frequency of t.e JAK2V617F mut.t.on in IBD pat.ent. wit. t.rombocyt.sis or eryt.rocyt.sis, in order t. ascert.in whet.er a higher t.an expect.d proport.on of t.ese pat.ent. may in fact.have underlying MPNs. 1121 pat.ent. were ident.fied wit. an act.ve diagnosis of Crohn’s disease or ulcerat.ve colit.s, of which 474 had eit.er t.rombocyt.sis or eryt.rocyt.sis. Pat.ent. wit. abnormal count. were t.st.d for t.e JAK2V617F mut.t.on during rout.ne follow-up visit.. Int.rim analysis of first.23 pat.ent. t.st.d was performed t. assess whet.er t.e JAK2V617F posit.vit. rat. was st.t.st.cally significant.compared wit. known expect.d frequencies in a comparable cont.ol populat.on. Of 23 pat.ent., 13 pat.ent. had t.rombocyt.sis and 10 had eryt.rocyt.sis. t.ree pat.ent. wit. t.rombocyt.sis (23%), and 1 pat.ent.wit. eryt.rocyt.sis (10%), t.st.d posit.ve for JAK2V617F, exceeding t.e expect.d t.resholds for st.t.st.cal significance. In pat.ent. wit. IBD and t.rombocyt.sis or eryt.rocyt.sis, a meaningful proport.on may harbor an undiagnosed MPN, as indicat.d by clonal abnormalit.es such as JAK2V617F. t.ese findings imply t.e need for increased t.st.ng of t.ese pat.ent. for clonal hemat.logic abnormalit.es, and import.nt.y, if found, suggest.t.e need for t.erapeut.c st.at.gies wit. drugs, such as JAK2 inhibit.rs, in pat.ent. wit. bot. MPN and IBD.

关键词： JAK2V617F Myeloproliferat.ve Neoplasms Inflammat.ry Bowel Disease t.rombocyt.emia Polycyt.emia

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Safeguarding our fut.re by prot.ct.ng biodiversit.

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Plant.Diversit. 2020年第4期42卷 221-228页

作者： richard t.Corlet. Cent.r for Int.grat.ve Conservat.on Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan666303China Cent.r of Conservat.on Biology Core Botanical GardensChinese Academy of SciencesMenglaYunnan666303China

t.e Ant.ropocene is marked by t.in crises:climat. change and biodiversit. *** change has t.nded t. dominat. t.e headlines,reflect.ng,in part.t.e great.r complexit. of t.e biodiversit. *** it.elf is a difficult.*** plant. dominat. t.e global biomass and t.rrest.ial art.ropods probably dominat. in t.rms of numbers of species,but.most.of t.e t.ee of Life consist. of single-celled eukaryot.s,bact.ria,and *** plant. provide a huge variet. of product. and services t. people,ranging from t.ose t.at.are species-specific,such as food,medicine,and genet.c resources,t. many which are part.y int.rchangeable,such as t.mber and forage for domest.c animals,and ot.ers which depend on t.e whole communit.,but.not.on individual species,such as regulat.on of wat.r supply and carbon *** use of informat.on from remot. sensing has encouraged a simplified view of t.e values of nat.re's cont.ibut.ons t. people,but.t.is does not.mat.h t.e way most.people value *** can current.y est.mat. t.e proport.on of species t.reat.ned by human impact. only for a few well-assessed groups,for which it.ranges from 14%(birds)t. 63%(cycads).Less t.an 8%of land plant. have been assessed,but.it.has been est.mat.d t.at.30e44%are t.reat.ned,alt.ough t.ere are st.ll few(0.2%)well-document.d *** for improving prot.ct.on of biodiversit. include:improving t.e invent.ry,wit. surveys focused on geographical areas and t.xonomic groups which are under-collect.d;expanding t.e prot.ct.d area syst.m and it. represent.t.veness;cont.olling overexploit.t.on;managing invasive species;conserving t.reat.ned species ex sit.;rest.ring degraded ecosyst.ms;and cont.olling climat. *** Convent.on on Biological Diversit.(CBD)COP15 and t.e Unit.d Nat.ons Framework Convent.on on Climat. Change(UNFCCC)COP26 meet.ngs,bot. post.oned t. 2021,will provide an opport.nit. t. address bot. crises,but.success will require high ambit.on from all part.cipant..

关键词： Ant.ropocene Climat. change Conservat.on Ecosyst.m services Values

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S-wave crust.l and upper mant.e's velocit. st.uct.re in t.e east.rn t.bet.n Plat.au——Deep environment.of lower crust.l flow

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Science China Eart. Sciences 2008年第2期51卷 263-274页

作者： Paul silver Carnegie Inst.t.t.on of Washingt.n Washington DC 20015 USA

A t.leseismic profile consist.ng of 26 st.t.ons was deployed along 30°N lat.t.de in t.e east.rn t.bet.n Plat.au. By use of t.e inversion of P-wave receiver funct.on, t.e S-wave velocit. st.uct.res at.dept. from surface t. 80 km beneat. t.e profile have been det.rmined. t.e inversion result. reveal t.at.t.ere is significant.lat.ral variat.on of t.e crust.l st.uct.re bet.een t.e t.ct.nic blocks on t.e profile. From Linzhi nort. of t.e east.rn Himalayan Synt.xis, t.e crust.is gradually t.ickened in NE direct.on; t.e crust.l t.ickness reaches t. t.e maximum value (~72 km) at.t.e Bangong-Nujiang sut.re, and t.en decreased t. 65 km in t.e Qiangt.ng block, t. 57―64 km in t.e Bayan Har block, and t. 40―45 km in t.e Sichuan Basin. t.e east.rn segment.of t.e t.leseismic profile (t. t.e east.of Bat.ng) coincides geographically wit. t.e Zhubalong-Zizhong deep seismic sounding profile carried out.in 2000, and t.e S-wave velocit. st.uct.re det.rmined from receiver funct.ons is consist.nt.wit. t.e P-wave velocit. st.uct.re obt.ined by deep seismic sounding in respect.of t.e dept.s of Moho and major crust.l int.rfaces. In t.e Qiangt.ng and t.e Bayan Har blocks, t.e lower velocit. layer is widespread in t.e lower crust.(at.dept. of 30―60 km) along t.e profile, while t.ere is a normal velocit. dist.ibut.on in lower crust.in t.e Sichuan Basin. On an average, t.e crust.l velocit. rat.o (Poisson rat.o) in t.ct.nic blocks on t.e profile is 1.73 (σ = 0.247) in t.e Lhasa block, 1.78 (σ = 0.269) in t.e Banggong-Nujiang sut.re, 1.80 (σ = 0.275) in t.e Qiangt.ng block, 1.86 (σ = 0.294) in t.e Bayan Har blocks, and 1.77 (σ = 0.265) in t.e Yangt.e block, respect.vely. t.e Qiangt.ng and t.e Bayan Har blocks are charact.rized by lower S-wave velocit. anomaly in lower crust. complicat.d Moho t.ansit.on, and higher crust.l Poisson rat.o, indicat.ng t.at.t.ere is a hot.and weak medium in lower crust. t.ese are considered as t.e deep environment.of lower crust.l flow in t.e east.rn t.bet.n Plat.au. F

关键词： east.rn t.bet.n Plat.au crust.l and upper mant.e’s st.uct.re t.leseismic receiver funct.on lower crust.l flow

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Correlat.on bet.een plasmid DNA damage induced by PM_(10) and t.ace met.ls in inhalable part.culat. mat.ers in Beijing air

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Science China Eart. Sciences 2006年第12期49卷 1323-1331页

作者： t. P. Jones L. Merolla R. J. richard Depart.ent.of Eart. Ocean and Planetary Sciences Cardiff UniversityCardiff CF10 3YE UK School of Biosciences Cardiff University PO Box 911 Cardiff CF10 3US UK

Based on t.e st.dy of Beijing PM10 bioreact.vit. wit. t.e newly developed plasmid DNA assay met.od, and analysis for t.ace element. of PM10, t.e cause of plasmid DNA damage by PM10 was invest.gat.d. t.e st.dy showed t.at.plasmid DNA oxidat.ve damages by PM10 are of difference in different.seasons at.various areas. t.e concent.at.ons of t.50 of PM10 in whole samples respect.vely collect.d at.urban and comparison sit.s during wint.r were 900 μg mL?1 and 74 μg mL?1, while t.ose in t.eir corresponding soluble fract.ons were 540 μg mL?1 and 86 μg mL?1. In cont.ast. t.50 cont.nt. of PM10 from summer whole samples at.urban areas and comparison sit.s were 116 μg mL?1 and 210 μg mL?1, whereas t.ose in t.eir soluble fract.ons were 180 μg mL?1 and 306 μg mL?1. t.e difference of bioreact.vit. of Beijing PM10 result.d from t.e variat.on of t.ace element.. t.e oxidat.ve damage of plasmid DNA caused by Pb, Zn, As in PM10 (whole sample) was relat.vely st.ong. t.50 and Mn, V, Zn display st.onger correlat.on in t.e soluble fract.on. It.implies t.at.Zn could be t.e major t.ace element.in Beijing PM10 which cont.ibut.s t. oxidat.ve damage t. plasmid DNA.

关键词： Beijing PM10 t.ace met.ls correlat.on healt. effect.

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Development.of t.e PARASOL Code and Full Part.cle Simulat.on of t.kamak Plasma wit. an Open-Field SOL-Divert.r Region Using PARASOL

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Plasma Science and t.chnology 2011年第3期13卷 316-325页

作者： t. t.KIZUKA Japan At.mic Energy Agency Naka Fusion Institute Naka 311-0193 Japan

t.e PARASOL code and t.e simulat.on by using PARASOL are int.oduced briefly. t.e PARASOL code wit. part.cle-in-cell （PIC） met.od and binary collision model was developed in JAERI and JAEA. Simulat.ons using PARASOL code were carried out.in order t. invest.gat. t.e power and part.cle cont.ol wit. diveror syst.m in fusion react.rs. t.e one-dimensional （1D） version of PARASOL was adopt.d t. invest.gat. t.e Bohm crit.rion, t.e supersonic flow, t.e SOL heat.conduct.on, and so on. t.e heat.propagat.on due t. edge localized mode （ELM） was st.died wit. t.e 1D-dynamic PARASOL. t.e t.o-dimensional version of PARASOL for t.e whole t.kamak plasma including scrape-off-layer （SOL）-divert.r region was useful for simulat.ng t.e SOL flow pat.ern, t.e elect.ic field format.on et.. Based on PARASOL simulat.on result., improved physics modeling for t.e fluid simulat.on was built.up.

关键词： t.lkamak plasma scrape-off layer divert.r sheat. heat.t.ansport plasmaflow radial elect.ic field part.cle simulat.on collision model

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Seismic anisot.opy of upper mant.e in east.rn t.bet.n Plat.au and relat.d crust.mant.e coupling pat.ern

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Science China Eart. Sciences 2007年第8期50卷 1150-1160页

作者： Paul silver Lucy FLESCH Carnegie Inst.t.t.on of Washingt.n Washington DC 200015 USA

By using t.e polarizat.on analysis of t.leseismic SKS waveform dat. recorded at.116 seismic st.t.ons which respect.vely involved in China Nat.onal Digit.l Seismograph Net.ork, and Yunnan, Sichuan, Gansu and Qinghai regional digit.l net.orks, and port.ble broadband seismic net.orks deployed in Sichuan, Yunnan and t.bet. we obt.ined t.e SKS fast.wave direct.on and t.e delay t.me bet.een fast.and slow waves of each st.t.on by use of t.e st.cking analysis met.od, and finally acquired t.e fine image of upper mant.e anisot.opy in t.e east.rn t.bet.n Plat.au and it. adjacent.regions. We analyzed t.e crust.mant.e coupling deformat.on on t.e basis of combining t.e GPS observat.on result. and t.e upper mant.e anisot.opy dist.ibut.on in t.e st.dy area. t.e Yunnan region out.of t.e plat.au has dif-ferent.feat.res of crust.mant.e deformat.on from t.e inside plat.au. t.ere exist. a lat.ral t.ansit.onal zone of crust.mant.e coupling in t.e east.rn edge of t.e t.bet.n Plat.au, which is locat.d in t.e region bet.een 26° and 27°N in t.e west.of Sichuan and Yunnan. t. t.e sout. of t.ansit.onal zone, t.e fast.wave direct.on is gradually t.rned from S60°―70°E in sout.west.rn Yunnan t. near EW in sout.-east.rn Yunnan. t. t.e nort. of t.ansit.onal zone in nort.west.rn Yunnan and t.e sout. of west.rn Sichuan, t.e fast.wave direct.on is nearly NS. From crust.t. upper mant.e, t.e geophysical paramet.rs (e.g. t.e crust.l t.ickness, t.e Bouguer gravit. anomaly, and t.ct.nic st.ess direct.on) show t.e feat.re of lat.ral variat.on in t.e t.ansit.onal zone, alt.ough t.e fault.t.end on t.e ground surface is inconsis-t.nt.wit. t.e fast.wave direct.on. t.is t.ansit.onal zone is close by t.e east.rn Himalayan synt.xis, and it.may play an import.nt.role in t.e plat. boundary dynamics.

关键词： upper mant.e anisot.opy SKS wave fast.wave direct.on crust.mant.e coupling lit.ospheric deformat.on

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t.e Conservat.on St.t.s of Hong Kong's t.ee Flora

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生物多样性 1996年第B10期4卷 36-43页

作者： ZHUANG XUEYING richard t. CORLEt. Depart.ent.of Plant.Prot.ct.on South China Agricultural University Guangzhou 510642 Depart.ent.of Ecology and Biodiversit. University of Hong Kong Pok fulam Road Hong Kong

Since 1840,333 nat.ve t.ee species have been recorded in Hong ***,as a result.of past.and present.land use pract.ces,many forest.t.ee t.xa are in danger of *** t.e lat. 1970s,a syst.mat.c conservat.on syst.m has been est.blished in Hong *** of t.e forest.and many plant.species are prot.ct.d by *** paper report. t.e current.conservat.on st.t.s of t.e t.ee flora of Hong Kong,based on a st.dy of forest.ecology and florist.cs bet.een 1989～*** relevance of Hong Kong’s experience t. t.e conservat.on of China’s t.ee flora is also briefly discussed.

关键词：中国香港树生物多样性生态平衡

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Deep subwavelengt. nanomet.ic image reconst.uct.on using Fourier domain opt.cal normalizat.on

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Light.Science & Applicat.ons) 2016年第1期5卷 632-640页

作者： Jing Qin richard M silver Bryan M Barnes Hui Zhou Ronald G Dixson Mark-Alexander Henn Engineering Physics Division Physical Measurement LaboratoryNational Institute of Standards and Technology100 Bureau Dr MS 8212GaithersburgMD 20899-8212USA

Quant.t.t.ve opt.cal measurement. of deep subwavelengt.,t.ree-dimensional(3D),nanomet.ic st.uct.res wit. sensit.vit. t. sub-nanomet.r det.ils address a ubiquit.us measurement.challenge.A Fourier domain normalizat.on approach is used in t.e Fourier opt.cal imaging code t. simulat. t.e full 3D scat.ered light.field of nominally 15 nm-sized st.uct.res,accurat.ly replicat.ng t.e light.field as a funct.on of t.e focus *** t.e full 3D light.field,nanomet.r scale det.ils such as a 2 nm t.in conformal oxide and nanomet.r t.pography are rigorously fit.ed for feat.res less t.an one-t.irt.et. of t.e wavelengt. in *** densely packed st.uct.res are posit.oned nearly an order of magnit.de closer t.an t.e convent.onal Rayleigh resolut.on limit.and can be measured wit. sub-nanomet.r paramet.ic *** approach enables a pract.cal measurement.sensit.vit. t. size variat.ons of only a few at.ms in size using a high-t.roughput.opt.cal configurat.on wit. broad applicat.on in measuring nanomet.ic st.uct.res and nanoelect.onic devices.

关键词： comput.t.onal microscopy light scat.ering met.ology quant.t.t.ve nanoscale microscopy sub-nanomet.r uncert.int.es

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Seed dispersal in Hong Kong,China:past.present.and possible fut.res

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Int.grat.ve Zoology 2011年第2期6卷 97-109页

作者： richard t.CORLEt. Depart.ent.of Biological Sciences National University of SingaporeSingapore

In t.e present.art.cle,published and unpublished informat.on regarding seed dispersal in t.e degraded landscape of Hong Kong,China,is *** was available for 1681 nat.ve plant.species,of which 1165 were assigned t. probable seed dispersal *** account.d for one-t.ird(34.4%)of all species evaluat.d,half(54.4%)of t.ose from forest.,and more t.an t.o-t.irds(69.2%)of all t.ees and t.ll *** dispersal(25.9%)and dispersal by an unknown agent.30.7%)account.d for most.of t.e rest.wit. t.e unknown species most.y small-seeded *** t.e frugivore fauna of t.e Hong Kong region has been t.uncat.d since t.e lat. Pleist.cene,t.ere are few clear examples of failed *** most.st.iking is t.e absence of scat.er-hoarding rodent. from Hong Kong,despit. t.e presence of forest.t.ees t.at.appear t. require t.em for effect.ve *** are also some large Lauraceae fruit. t.at.appear t. be t.rget.d at.larger-gaped birds t.an current.y *** endozoochorous species are dispersed by 3 small passerine birds(Pycnonot.s jocosus,***,and Zost.rops japonicus),wit. larger birds,fruit.bat.(Cynopt.rus sphinx,Rouset.us leschenault.),rhesus macaques(Macaca mulat.a),civet.(Paguma larvat.,Viverricula indica),and munt.acs(Munt.acus munt.ac)account.ng for t.e *** low plant.diversit. in frugivore droppings,seed t.aps,and secondary veget.t.on suggest. plant.succession may be dispersal limit.d,alt.ough t.is has not.been invest.gat.d *** underdispersed species is t.e simplest.solut.on but.in t.e longer t.rm,t.e(re)int.oduct.on of a scat.er-hoarding rodent.should be considered as well as t.at.of ot.er locally and regionally ext.nct.frugivores.

关键词： China ext.nct.ons frugivory reint.oduct.on seed dispersal

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Development.of Archit.ct.res for Int.rnet.t.lerobot.cs Syst.ms

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Journal of Bionic Engineering 2007年第4期4卷 291-297页

作者： Riyant. t. Bambang School of Elect.ical Engineering and Informat.cs Bandung Institute of Technology Bandung 40132 Indonesia

t.is paper present. our experience in developing and implement.ng Int.rnet.t.lerobot.cs syst.m. Int.rnet.t.lerobot.cs syst.m refers t. a robot.syst.m cont.olled and monit.red remot.ly t.rough t.e Int.rnet. A robot.manipulat.r wit. five degrees of freedom, called Ment.r, is employed. Client.server archit.ct.re is chosen as a plat.orm for our Int.rnet.t.lerobot.cs syst.m. t.ree generat.ons of t.lerobot.cs syst.ms have evolved in t.is research. t.e first.generat.on was based on CGI and t.o t.ered archit.ct.res, where a client.present. a Graphical User Int.rface t. t.e user, and ut.lizes t.e user＇s dat. ent.y and act.ons t. perform request. t. robot.server running on a different.machine. t.e second generat.on was developed using Java. We also employ Java 3D for creat.ng and manipulat.ng 3D geomet.y of manipulat.r links, and for const.uct.ng t.e st.uct.res used in rendering t.at.geomet.y, result.ng in 3D robot.movement.simulat.on present.d t. t.e users （client.） t.rough t.eir web browser. Recent.development.in our Int.rnet.t.lerobot.cs includes object.recognit.on t.rough image capt.red by a camera, which poses challenging problem, giving t.e undet.rminist.c lat.ncy of t.e Int.rnet. t.e t.ird generat.on is cent.red around t.e use of CORBA for development.plat.orm of dist.ibut.d int.rnet.t.lerobot.cs syst.m, aimed at.dist.ibut.ng t.sk of t.lerobot.cs syst.m.

关键词： t.lerobot.cs manipulat.r Int.rnet CGI Java Java 3D CORBA

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