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Fundamental movement skills training to promote physical activity in children with and without disability： A pilot study

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Journal of sport and Health science 2015年第3期4卷 235-243页

作者： Catherine M. Capio Cindy H.R sit Kathlynne F. Eguia Bruce Abernethy richard s.W. Masters Institute of Human Performance The University of Hong Kong Hong Kong China Department of sports science and Physical Education The Chinese University of Hong Kong Hong Kong China Alternative Learning Resource school Quezon City 1113 Philippines Faculty of Health sciences University of Queensland Brisbane Queensland 4072 Australia sports and Leisure studies Department The University of Waikato Hamilton 3240 New Zealand

Background： A positive association between fundamental movement skills （FMs） and physical activity （PA） has been shown in previous research of children with and without disability. This pilot study explored a causal mechanism for such relationship, and hypothesized that when FMs proficiency is improved, enhanced PA uptake will be found in children with and without disability. It was further hypothesized that improving FMs proficiency will have a greater impact on children with disability than those without disability. Methods： Participants include typically developing （TD） children without disability and children with cerebral palsy （CP）, who were allocated to FMs training groups （CP-FMs n = 12, TD-FMs n = 13） and control groups （CP-C n = 12, TD-C n = 13）. Training groups practiced five FMs （run, jump, kick, throw, catch） in weekly 45-min sessions for 4 weeks. Control groups had their regular physiotherapy （CP） or physical education （TD） sessions. FMs were evaluated using process- and product-oriented measures, and PA was measured using accelerometers, before and after training. Results： It was verified that training groups gained improvements in FMs while control groups did not. No significant changes in weekday PA were found. Increased weekend moderate to vigorous physical activity （MVPA） was found in the CP-FMs group, while decreased weekend sedentary time was found in the CP-FMs and TD-FMs groups. The percentages of participants who exceeded the minimum detectable change （MDC9o） in MVPA and sedentary time were larger in children with CP than in children without disability. Conclusion： The findings suggest that improved FMs proficiency could potentially contribute to heightened PA and decreased sedentary time during weekends for children. such effect of improved FMs proficiency on PA appears to be greater in those with physical disability than in those without disability. It is recommended that the findings of this pilot study should be further examined in future

关键词： Cerebral palsy Fundamental movement skills Motor learning Physical activity sedentary behavior

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怎样选择天体摄影相机

中国国家天文 2016年第4期10卷 110-115页

作者： richard s Wright 傅承启

问题不在于哪一种相机最好，而在于哪一种最适合于你的拍摄目标。

关键词：天体摄影相机业余摄影光学系统摄影技术天文台年代

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武器后坐力对不同材料和结构的作用效果

探测与控制学报 1987年第4期 37-49页

作者： richard s.simak ,王国太

1.引论设计弹药时必须对多种因素加以考虑,其中之一是各种载荷对构件性态的影响。在一些情况下需要构件能承受大应力或后坐力,在另一些情况下则要求构件在最小后坐力作用下有合理的“存活”周期,不失效。无论属于哪一种情况,都必须把判... 详细信息

1.引论设计弹药时必须对多种因素加以考虑,其中之一是各种载荷对构件性态的影响。在一些情况下需要构件能承受大应力或后坐力,在另一些情况下则要求构件在最小后坐力作用下有合理的“存活”周期,不失效。无论属于哪一种情况,都必须把判断构件的结构完善性作为开展该项设计工作的一个组成部分。

关键词：弹性预计值力学性能方程常数数学后坐力代入几何形状标准误差中误差粘性参数金属流动半正弦波

Using clinical cases to guide healthcare

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World Journal of Clinical Cases 2024年第9期12卷 1555-1559页

作者： Michael Colwill samantha Baillie richard Pollok Andrew Poullis Department of Gastroenterology St George's University Hospital NHS Foundation TrustLondon SW170QTUnited Kingdom

Evidence-based practice(EBP)has been the gold standard in healthcare for nearly three centuries and aims to assist physicians in providing the safest and most effective healthcare for their *** well-established hierarchy of evidence lists systematic reviews and meta-analyses at the top however these methodologies are not always appropriate or possible and in these instances case-control studies,case series and case reports are utilised to support ***-control studies allow simultaneous study of multiple risk factors and can be performed rapidly and relatively cheaply.A recent example was during the Coronavirus pandemic where case-control studies were used to assess the efficacy of personal protective equipment for healthcare *** series and case reports also play a role in EBP and are particularly useful to study rare diseases such as inflammatory bowel disease in transgender and gender non-conforming *** are also vital in generating and disseminating early signals and encouraging further *** these methodologies have weaknesses,particularly with regards to bias and loss of patient confidentiality for rare pathologies,they have an important part to play in EBP and when appropriately utilised can significantly impact upon clinical practice.

关键词： Evidence based medicine Hierarchy of evidence Case reports Case series

DELF A1 : 150 activités / richard Lescure, Emmanuelle Gadet.

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ATP binding cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia

2005年

作者： richard Lescure Emmanuelle Gadet.

来源：畅想之星图书光盘版（南... 评论

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Health 2013年第5期5卷 41-50页

作者： stuart s. Winter Jerec Ricci Li Luo Debbie M. Lovato Hadya M. Khawaja Tasha serna-Gallegos Natalie DeBassige richard s. Larson Department of Pathology Biostatistics Core the UNM Clinical and Translation Science Center Albuquerque USA Department of Pathology Pathology the UNM Clinical and Translation Science Center Albuquerque USA Departments of Pediatrics Division of Pediatric Hematology/Oncology Albuquerque USA The Department of Family and Community Medicine The University of New Mexico Health Sciences Center Albuquerque USA

Purpose: In acute lymphoblastic leukemia (ALL), multidrug resistance is often mediated by AT- Pase Binding Cassette (ABC) proteins, which principally involve ABCC1 (multidrug resistance protein 1, MRP1) and ABCB1 (multidrug resistance 1, MDR1). However, direct comparisons between the differential effects of ABCC1 and ABCB1 have been difficult, since identical cell lines with differential expression of these transporters have not been developed. Experimental Design: In this study, we developed and compared the biological profiles of Jurkat cell lines that selectively over-expressed ABCC1 and ABCB1. Vincristine (VCR) plays an important role in the treatment of T-lineage ALL (T-ALL), and is often the first drug given to newly-diagnosed patients. Because of its importance in treatment, we provide descalating, sub-lethal doses of VCR to Jurkat cells, and extended our observations to expression profiling of newly diagnosed patients with T-ALL. Results: We found that VCR-resistant cells over-expressed ABCC1 nearly 30-fold. The calcein AM assay confirmed that VCR-resistant cells actively extruded VCR, and that ABCC1-mediated drug resistance conferred a different spectrum of multidrug resistance than other T-ALL induction agents. siRNA experiments that blocked ABCC1 export confirmed that VCR resistance could be reversed in vitro. Analyses of T-lymphoblasts obtained from 100 newly diagnosed T-ALL patients treated on Children’s Oncology Group Phase III studies 9404 and AALL0434 that induction failure could be could be partially explained by the over-expression of ABCC1 and ABCB1. Conclusions: Taken together, these results suggest that over-expression of ABC transporters plays a contributing role in mediating treatment failure in T-ALL, and underscore the need to employ alternate treatment approaches in patients for whom induction failed or for those with relapsed disease.

关键词： ATP Binding Cassette Proteins C1 and B1 Multi-Drug Resistance T-Lineage Acute Lymphoblastic Leukemia

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沃森家族

Wildfire severity alters soil microbial exoenzyme production and fungal abundances in the southern Appalachian Mountains

作者： (美)理查德·s. 泰德洛(richard s. Tedlow)

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Pedosphere 2024年第5期34卷 865-878页

作者： Megan L.sCHILL richard BAIRD shawn P.BROWN Allison M.VEACH Department of Integrative Biology University of Texas at San Antonio Biochemistry Molecular Biology Entomology and Plant Pathology Department Mississippi State University Department of Biological sciences The University of Memphis

Climate change has increased drought frequency and duration that are exacerbated by increased temperatures globally. This effect has, and will continue,to increase fire occurrence across many regions of North America. In the southern Appalachian Mountains, wildfires with high burn severity occurred in 2016due to increased drought and human activity. To investigate the effects of burn severity on soil physicochemical properties, microbial extracellular enzyme production, and microbial abundances in a temperate region, surface soils (0–15 cm) were collected from two sites (the Great smoky Mountains National Park in Tennessee and the Nantahala National Forest in North Carolina, UsA) spanning lightly, moderately, and severely burned areas, accompanied by adjacent unburned locations that act as controls. The soil samples were collected at three time points between 2017 and 2019 (i.e., 0.5, 1, and 2.5 years post-fire)among burn severity plots. Total hydrolytic enzyme production varied over time, with severe burn plots having significantly lower enzyme production at 2.5years post-fire. Individual enzymes varied among burn severities and across time post-fire. Light burn plots showed greater carbon-specific (β-glucosidase and β-xylosidase) and phosphorus-specific (acid phosphatase) enzyme activities at 0.5 years post-fire, but this effect was transient. At 2.5 years post-fire, theβ-xylosidase and acid phosphatase activities were lower in severe or moderate burn plots relative to the controls. In contrast, the activity of nitrogen-specific enzyme leucyl aminopeptidase was the lowest in severe burn plots at 0.5 years post-fire, but was the lowest in light burn plots at 2.5 years post-fire. The fungi:bacteria ratio declined with burn severity, indicating that fungi are sensitive or less resilient to high burn severity during recovery. These results suggest that wildfires alter trajectories for soil microbial structure and function within a 2.5-year timeframe, which potentially

关键词： 16s rRNA burn severity extracellular enzyme fungi:bacteria ratio internal transcribed spacer microbial structure

空间站时代信息管理和存取的人工智能方法——快速样机法

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国外导弹与航天运载器 1992年第6期 17-34页

作者： richard s.Carnahan 于碧媛

这项工作过去和现在都着力于将速快试制样机和人工智能方法应用于解决与空间站时代信息管理系统有关的一些问题。我们工作的中心放在与(1)智能人机接口应用于科学数据用户支持和(2)智能信息管理系统(IIMs)能有效地处理有关所处理数据类... 详细信息

这项工作过去和现在都着力于将速快试制样机和人工智能方法应用于解决与空间站时代信息管理系统有关的一些问题。我们工作的中心放在与(1)智能人机接口应用于科学数据用户支持和(2)智能信息管理系统(IIMs)能有效地处理有关所处理数据类型的元数据修改要求有关的一些问题上。先进的IIMs有着几乎完全由满足可能用户的需要而产生的一切实用能力。预计由空间站时代工程项目(例如EOs)所产生的科学数据的数量和复杂性可能比目前所处理和分析的数据大得多。应该将科学数据的信息以清楚而简明的方式向可能的用户显示,引入的支持性能对各种专门知识水平的用户都有用,而且它能使这些用户进行效能成本合算的数据存取。另外,由于时常出现数据修改和增加,为了使IIMs元数据修改处理更有效,应提出一些机制。为此,我们的工作对IIMs设计的以下几个方面进行了检验:(1)IIMs数据和元数据模型,包括IIMs所包含的元数据的自动修改,(2)IIMs用户-系统接口的考虑,包括与远程存取、用户概要和联机指导能力有关的一些重大问题,以及(3)IIMs查询和浏览设备的开发,包括处理空间信息的能力,已经开发了工作样机,并正在不断进行完善。将来的工作想弄清我们目前工作中出现的一些问题,特别是有关IIMs信息库基本结构,及其与用户-支持的关系,以及分布式多机种数据库存取的一些问题。

关键词：人工智能信息管理存取

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