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Efficacy of Detoxsan~? powder on diarrhea caused by gastrointestinal neuroendocrine tumors

World Journal of Gastroenterology 2019年第17期25卷 2133-2143页

作者： Thomas Langbein Wilfried Dathe Anika Deuerling richard p baum Theranostics Center for Molecular Radiotherapy and Molecular Imaging Zentralklinik Bad Berka Scientific Managment Heck Bio-Pharma GmbH

BACKGROUND patients with neuroendocrine tumors(NETs) of the gastrointestinal tract suffer frequently from chronic diarrhea. A well characterized medical advice containing zeolite(Detoxsan~? powder) was applied to patients suffered from therapyrefractory diarrhea either by its frequency or by watery stool, despite receiving standard pharmacotherapy according to the guidelines for carcinoid syndrome and comorbidities. Detoxsan~? powder acts as an adsorbent and might reduce significantly symptoms of diarrhea in patients suffering from *** To overcome the therapy-refractory diarrhea of patients with NETs by the zeolite containing medical advice Detoxsan~? *** A total of 20 patients(12 female and 8 male) suffering from diarrhea either by its frequency or from watery stool caused by NETs were included. In each patient,the diagnosis had been confirmed by histology and somatostatin receptors expression proven by positron emission tomography/computed tomography using Ga-68-labeled somatostatin analogs. All patients received standard-of-care pharmacotherapy and were additionally given Detoxsan~? powder as an extemporaneous drug containing 90% natural Cuban zeolite and 10% magnesium aspartate. Recommended daily dosage ranges between 3 g once to three times per day. Each day dose and bowel movements were documented by the patients themselves in a pre-defined table. Additionally to the bowel movements quantitative determinations of serotonin, urea, creatinine and single ions were performed within the serum of the patients by commercially available equipment used as a matter of routine in the *** All patients enrolled in this pilot study did not only suffer from NETs, but also from comorbidities and treatment-resistant diarrhea. There was insufficient control of diarrhea, most probably due to the secretion of hormones like serotonin produced by the slowly growing and highly differentiated NETs. All patients only took Detoxsan~? powder as an antidiarrhea

关键词： Neuroendocrine tumor Diarrhea Carcinoid syndrome Treatment Clinoptilolite Mordenite Zeolite

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非小细胞肺癌^(18)F-FDG pET显像与DNA倍体分析的相关研究

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中华核医学杂志 2002年第2期22卷 116-117页

作者：吴锦昌 richard p.baum 苏州大学附属第二医院核医学科苏州大学核医学研究所215004 Center for pET Zentralklinik Bad Berka

目的　评价非小细胞肺癌 (NSCLC)的葡萄糖代谢与肿瘤细胞DNA倍体之间的相关性。方法　 49例组织病理学检查证实为NSCLC患者手术前行全身18F 脱氧葡萄糖 (FDG)pET显像 ,计算肿瘤原发灶内葡萄糖标准摄取值 (SUV)和肿瘤代谢直径 (MTD) ;术... 详细信息

目的　评价非小细胞肺癌 (NSCLC)的葡萄糖代谢与肿瘤细胞DNA倍体之间的相关性。方法　 49例组织病理学检查证实为NSCLC患者手术前行全身18F 脱氧葡萄糖 (FDG)pET显像 ,计算肿瘤原发灶内葡萄糖标准摄取值 (SUV)和肿瘤代谢直径 (MTD) ;术中取新鲜肿瘤标本 ,用DNA图像分析技术检测Schiff染色肿瘤细胞DNA含量、二倍体偏离指数 (2cDI)和肿瘤细胞DNA恶性度分级(DNA MG)。分析SUV值分别与MTD、2cDI和DNA MG之间的相关关系。结果　 49例患者的原发肿瘤病变及其转移性淋巴结 ,其pET显像均获清晰的阳性结果 ,其SUV和MTD测定结果可靠 ;DNA直方图示 46例 (93.88% )为非整倍体 ,仅 3例 (6 .12 % )呈 4倍体表现。线性相关分析表明 ,SUV与MTD、2cDI和DNA MG之间存在一定的相关性 ,其r分别为 0 .6 32 (p p p pET显像测得的SUV值与 2cDI或DNA MG存在一定的相关关系。

关键词：非小细胞肺癌 ^18F-FDG pET显像鉴别诊断 NSCLC 预后脱氧葡萄糖 DNA倍体

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Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor

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World Journal of Gastroenterology 2009年第46期15卷 5867-5870页

作者： Daniel Kaemmerer Vikas prasad Wolfgang Daffner Dieter Hrsch Günter Klppel Merten Hommann richard p baum Department of General and Visceral Surgery Zentralklinik Bad Berka Department of Nuclear Medicine Center for PETZentralklinik Bad Berka Department of Internal Medicine Gastroen-terologyEndocrinology and OncologyZentralklinik Bad Berka Department of pathology University of Kiel

pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the *** diagnosis many of them are already advanced and diff icult to *** report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman,who received neoadjuvant peptide receptor radionuclide therapy(pRRT)as firstline *** resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical ***-up for eighteen months revealed a complete *** is the first report on neoadjuvant pRRT in a neuroendocrine neoplasm with subsequent successful complete resection.

关键词： Endocrine pancreatic carcinoma peptidereceptor radionuclide therapy Neodjuvant treatment pancreatic surgery Molecular imaging Receptor pan-creatic endocrine tumor Computed tomography

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^(99)Tc^m标记抗粘蛋白McAb乳腺癌放射免疫显像的临床研究

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中华核医学杂志 2000年第2期20卷 75-77页

作者：吴浩荣吴锦昌 richardp.baum 苏州医学院附属第二医院外科 215004 苏州医学院附属第二医院核医学科 215004 Department of Molecular Nuclear Medicine

目的　评价99Tcm 标记抗乳腺癌粘蛋白单克隆抗体 (McAb)放射免疫显像 (RII)诊断乳腺癌的临床价值。方法　选择 17例乳腺肿瘤患者进行RII。结果　 9例原发性乳腺癌中 8例RII阳性 ,灵敏度 88 89% ;5例原发性乳腺癌伴腋淋巴结转移及 1例右... 详细信息

目的　评价99Tcm 标记抗乳腺癌粘蛋白单克隆抗体 (McAb)放射免疫显像 (RII)诊断乳腺癌的临床价值。方法　选择 17例乳腺肿瘤患者进行RII。结果　 9例原发性乳腺癌中 8例RII阳性 ,灵敏度 88 89% ;5例原发性乳腺癌伴腋淋巴结转移及 1例右乳腺浸润性导管癌根治术 5a后出现右腋淋巴结转移 ,RII发现其中 5例出现淋巴结转移 ;而 6例乳腺良性病变和 1例右乳腺单纯癌根治术7a后随访 ,RII阴性。结论　99Tcm 标记抗粘蛋白McAbRII可作为乳腺癌特异性诊断的重要辅助手段 ,并对淋巴结转移、术后复发等具有一定的诊断价值。

关键词： McAb 乳腺癌锝99m 放射免疫显像单克隆抗体

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Is <sup>18</sup>F-FDG-pET/CT a Valid Non-Invasive predictor for Regression Grade after Neoadjuvant Treatment in patients with NSCLC Stage III?

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Journal of Cancer Therapy 2014年第6期5卷 531-541页

作者： Natalie Desiree Klass richard p. baum Michael Schmuecking Norbert presselt Klaus-Michael Mueller Thomas G. Wendt Reiner Bonnet Department of Nuclear Medicine Zentralklinik Bad Berka Bad Berka Germany Department of pneumology Zentralklinik Bad Berka Bad Berka Germany Department of Radiation Oncology University of Jena Jena Germany Department of Radiation-Oncology Inselspital Bern University Hospital and University of Bern Bern Switzerland Department of Thoracic Surgery Zentralklinik Bad Berka Bad Berka Germany Institute of pathology University of Münster Münster Germany

Introduction: CT alone cannot provide sufficient information referring to response after neoadjuvant therapy in a timely manner. To evaluate the role of 18F-FDG-pET after neoadjuvant chemoradiation as a valid, non-invasive predictor for early therapy response and its effect on survival as compared to histopathologic tumor response, data of 32 of 210 randomized patients with NSCLC stage IIIA/IIIB, who were treated in a?prospective randomized controlled multicenter trial (LUCAS- MD), were re-evaluated. Material and Methods: For 32 patients with NSCLC stage IIIA (44%) IIIB (56%) neoadjuvant treatment consisted of two to three cycles of chemotherapy (225 mg/m2 paclitaxel and carboplatin AUC 6 d1q22) and concomitant chemoradiation (50 mg/m2 paclitaxel and carboplatin AUC 2 d1, d8, d15;1.5 Gy b.i.d. up to 45 Gy). Documentation of involved lymph node stations as detected by 18F-FDG-pET/CT and lymph node sampling during surgery according to the IASLC lymph node mapping (2009). Evaluation of histological regression grade (RG) according to Junker et al. (2001) and correlation with?18F-FDG-pET/CT for primary tumor and each lymph node station. Calculation of disease free survival using Kaplan-Meier estimates and log rank tests. Results: Actuarial tumor specific survival for the 32 patients with concomitant chemoradiation plus?chemotherapy: complete vs. incomplete metabolic remission prior to surgery after 60 months:?40% vs. 24% (p?= 0.018). RG III/IIb (no/less than 10% of vital tumor cells) vs. RG IIa/I (more than 10% vital tumor cells) after 60 months: 46% vs. 15% (p?= 0.006). 18/32 (56%) patients had RG III/IIb, 8/32 (25%) patients had regression grade III. 1/8 pts. with RG III were in the 18F-FDG- pET/CT false positive, 10 pts. with RG IIb (i.e. all pts. with RG IIb) were in the 18F-FDG-pET/CT false negative. One patient with RG IIa was in the 18F-FDG-pET/CT false negative. Hence, the cut-off level in detecting vital tumor cells by 18F-FDG-pET/CT after neoadjuvant chemoradia

关键词： NSCLC 1818F-FDG-pET Neoadjuvant Treatment Non-Invasive predictor

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Molecular phylogeny of Solms-laubachia(Brassicaceae) s.l.,based on multiple nuclear and plastid DNA sequences,and its biogeographic implications

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Journal of Systematics and Evolution 2009年第5期47卷 402-415页

作者： David A.baum Ihsan A.AL-SHEHBAZ richard REE Department of Botany University of Wisconsin Missouri Botanical Garden PO Box 299St LouisMO 63166-0299USA 3. Department of BotanyThe Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA

The Hengduan Mountains region of south-west China is a noted biodiversity hotspot,but the geographic origins and historical assembly of its rich endemic flora,including the sky-island species of Solms-laubachia Muschl.(Brassicaceae),have been little *** molecular studies on the phylogeny of Solms-laubachia showed it to be paraphyletic,leading to considerable expansion not only of its taxonomic limits,but also its geographic range,with the inclusion of taxa from outside the Hengduan ***,these studies provided little resolution of interspecific relationships,preventing inferences about historical biogeography within the *** the present study,new sequence data from two nuclear genes(LEAFY and G3pdh) and two chloroplast intergenic spacers(petN-psbM and psbM-trnD) were combined with existing markers to increase phylogenetic *** villosum(Maxim.) Al-Shehbaz was found to be nested within Solms-laubachia *** general,phylogenetic relationships appear to be a good predictor of geography,with the Hengduan Mountain endemics embedded in a paraphyletic grade of species from the western Himalayas and central Asia,but they also imply morphological *** was detected between the nuclear and chloroplast gene trees,perhaps resulting from incomplete lineage sorting of ancestral *** crown age of Solms-laubachia *** estimated to be approximately 1.42-3.68 mya,using Bayesian relaxed molecular clock *** biogeographic analysis using a parametric dispersal-extinction-cladogenesis model inferred central Asia and the western Himalayas as most probable ancestral range of Solms-laubachia s.l.,and estimated higher rates of eastward expansion than westward during the diversification of descendant *** summary,our results suggest that Solms-laubachia *** during the pliocene in central Asia,and subsequently migrated eastward into the Hengduan Mountains,colonizing sky-island,alpine scr

关键词： biogeography Brassicaceae Hengduan Mountains phylogeny Solms-laubachia s.l.

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Effect of Afforestation on Soil properties and Mycorrhizal Formation

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pedosphere 2005年第6期15卷 754-760页

作者： p. KAHLE C. baum B. BOELCKE Institute of Land Use University of Rostock Justus-von-Liebig-Weg 6 D 18051 Rostock (Germany) Research Centre for Agriculture and Fishery Institute of Agronomy and Crop Science Dorfplatz 1 D 18276 Gülzow (Germany)

A study was conducted on Cambisols in Northern Germany to analyze the effect of fast growing trees （Salix and populus spp.） used in agroforestry on soil chemical and physical properties and also on endo- and ectomycorrhizal colonization of the fine roots. Representative plots of three trials, Giilzow （GUL）, Vipperow （VIp） and Rostock （ROS）, were used to measure the topsoil inventories at the very beginning and after six （GUL）, seven （VIp） and ten （ROS） years of afforestation with fast growing trees. The effect on soil organic carbon, plant available nutrients, reaction, bulk density, porosity and water conditions was analyzed, Arable soils without tree coppice were used as controls. Additionally, the endoand ectomycorrhizal colonization of two Salix and two populus clones were investigated at one site （GUL） in 2002. The amounts of organic carbon in the topsoil increased significantly （p 〈 0.01） presumably induced by leaf and root litter and also by the lack of tillage. The soil bulk density significantly decreased and the porosity of the soil increased significantly （both p 〈 0.01）. The proportion of medium pores in the soil also rose significantly （p 〈 0.05 and 0.01）. Generally, afforestation of arable soils improved soil water retention. Ectomycorrhizas dominated the mycorrhizal formation of the Salix and populus clones, with the accumulation of organic matter in the topsoil suspected of supporting the ectomycorrhizal formation. Thus, agroforestry with Salix and populus spp. conspicuously affected chemical and additionally physical properties of the top layer of Cambisols within a period of six years.

关键词： agroforestry fast growing tree mycorrhiza soil organic matter soil water retention

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A Method of Characterizing Radio Signal Space for Wireless Device Localization

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Tsinghua Science and Technology 2015年第4期20卷 385-408页

作者： John-Austen Francisco richard p.Martin Department of Computer Science Rutgers University

In this work we present a novel approach for describing radio signal spaces for localization algorithms. We first introduce a new metric, the Discretely Distributed Log-H61der Metric （DDLHM）. The DDLHM is designed to characterize the type and degree of signal distortion relative to Iognormal signal-to-distance path models. We first show how the DDLHM can describe and discriminate distortions in an exhaustive set of synthetic signal spaces. We then determine a reduced set of maximally diagnostic distortion parameters. Using only 4% of the maximal set of DDLHMs, we found the reduced set matches with an acceptable degree of error 95% of the time. Using the synthetic reduced set, we characterized a variety of wireless localization algorithms＇ behaviors to attenuation, bias, and multipath. We found algorithms made much different tradeoffs between best case and average case error. We then use the DDLHM to identify distortion types in three different physical environments using measured 802.11 signal strengths, and predict the positioning performance of several localization algorithms. Our approach predicts average localization error to within 2 meters of the observed average error.

关键词： radio propgation 802.11 WiFi

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Meteor Shower

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当代外语研究 2001年第10期 4-9页

作者： richard baum 管抒野

Meteors are particles of space dust that enter the earth’s atmosphere and burnup, creating a streak of light in the night sky. Over 120 recognized meteor showersoccur during the year. Humans have recorded observations of meteor showers for atleast 3000 years. Within the last 50 years astronomers have begun to study meteorshowers with photography, video, radio, and radar equipment. Observations

关键词：地球轨道天文学家观测者粒子流流星雨 Meteor Shower 宇宙尘埃

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TLR signaling that induces weak inflammatory response and SHIp1 enhances osteogenic functions

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Bone Research 2014年第4期2卷 218-230页

作者： Manoj Muthukuru richard p Darveau West Virginia University Department of PeriodonticsSchool of DentistryMorgantownWVUSA University of Washington Department of PeriodonticsSchool of DentistrySeattleWAUSA

Toll-like receptor （TLR）-mediated inflammatory response could negatively affect bone metabolism. In this study, we determined how osteogenesis is regulated during inflammatory responses that are downstream of TLR signaling. Human primary osteoblasts were cultured in collagen gels. pam3CSK4 （p3C） and Escherichia coli lipopolysaccharide （EcLpS） were used as TLR2 and TLR4 ligand respectively. porphyromonas gingivalis LpS having TLR2 activity with either TLR4 agonism （pg1690） or TLR4 antagonism （pg1449） and mutant E. coli LpS （LpxE/LpxF/WSK） were used. IL-lp, SH2-containing inositol phosphatase-1 （SHIp1） that has regulatory roles in osteogenesis, alkaline phosphatase and mineralization were analyzed. 3α-Aminocholestane （3AC） was used to inhibit SHIp1. Our results suggest that osteoblasts stimulated by p3C, poorly induced IL-1β but strongly upregulated SHIp1 and enhanced osteogenic mediators. On the contrary, EcLpS significantly induced IL-1β and osteogenic mediators were not induced. While pg1690 downmodulated osteogenic mediators, pg1449 enhanced osteogenic responses, suggesting that TLR4 signaling annuls osteogenesis even with TLR2 activity. Interestingly, mutant E. coli LpS that induces weak inflammation upregulated osteogenesis, but SHIp1 was not induced. Moreover, inhibiting SHIp1 significantly upregulated TLR2-mediated inflammatory response and downmodulated osteogenesis. In conclusion, these results suggest that induction of weak inflammatory response through TLR2 （with SHIp1 activity） and mutant TLR4 ligands could enhance osteogenesis.

关键词： TLR signaling that induces weak inflammatory response and SHIp1 enhances osteogenic functions SHIp Figure

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