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Mental health and quality of life burden in Buruli ulcer disease patients in Ghana

Infectious Diseases of Poverty 2021年第4期10卷 93-94页

作者： Yaw Ampem Amoako Nancy Ackam John-Paul Omuojine Michael Ntiamoah Oppong Abena Gyawu Owusu-Ansah Harriet Boateng Mohammed Kabiru Abass George Amofa Elizabeth Ofori Portia Boakye Okyere Michael Frimpong Freddie Bailey David Hurst Molyneux richard odame phillips Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and TechnologyKumasiGhana 不详

Background Buruli ulcer disease(BUD)is a necrotic skin neglected tropical disease(NTD)that has both a mental and physical health impact on affected *** there is increasing evidence suggesting a strong association between neglected tropical diseases(NTDs)and mental illness,there is a relative lack of information on BUD’s impact on the mental health and quality of life(QoL)of affected individuals in *** study is to assess the impact of BUD on mental health and quality of life of patients with active and past BUD infection,and their *** We conducted a case control study in 3 BUD endemic districts in Ghana between August and November ***-to-face structured questionnaire-based interviews were conducted on BUD patients with active and past infection,as well as caregivers of BUD patients using WHO Quality of Life scale,WHO Disability Assessment Schedule,Self-Reporting Questionnaire,Buruli Ulcer Functional Limitation Score and Hospital Anxiety and Depression Scale data *** statistics were used to summarize the characteristics of the study *** groups were compared using student t test and chi-square(χ2)or Fisher’s exact *** quality of life scores are reported with their respective 95%confidence *** was analysed using STATA statistical *** Our results show that BUD patients with active and past infection,along with their caregivers,face significant levels of distress and mental health sequelae compared to ***(P=0.003)was more common in participants with active(27%)and past BU infection(17%),compared to controls(0%).Anxiety was found in 42%(11/26)and 20%(6/29)of participants with active and past BUD infection compared to 14%(5/36)of *** of life was also significantly diminished in active BUD infection,compared to *** the physical health domain,mean QoL scores were 54±11.1 and 56±11.0(95%CI:49.5‒58.5 and 52.2‒59.7)respectively for p

关键词： Mental health Depression Anxiety Quality of life Buruli ulcer disease Neglected tropical disease

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Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology:What can we learn from this phenomenon for application to inflammatory syndromes?

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Cellular & Molecular Immunology 2021年第8期18卷 2062-2064页

作者： Ernest Adankwah Julia Seyfarth richard phillips Marc Jacobsen Department of General Pediatrics Medical FacultyUniversity Hospital DüsseldorfHeinrich-Heine-UniversityDüsseldorfGermany Department of Medical Diagnostics College of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Department of Medicine School of Medicine and DentistryCollege of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Kumasi Centre for Collaborative Research in Tropical Medicine(KCCR) KumasiGhana

Our previous study published in Cellular&Molecular Immunology(Harling et al.1)described aberrant immunological features in the pathogenesis of ***,we provided evidence supporting an impact chain regarding aberrant high interleukin(IL)-6 and IL-10 cytokine expression and respective receptor signaling affecting T-cell functions in acute *** STAT3 phosphorylation,high expression of its key regulator suppressor of cytokine signaling(SOCS)3 and spontaneous IL-6/IL-10 secretion characterized CD4^(+)T cells from tuberculosis patients.

关键词： tuberculosis cytokine STAT3

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Accuracy of ultrasound to identify chronic liver disease

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World Journal of Gastroenterology 2010年第28期16卷 3510-3520页

作者： richard Allan Kerry Thoirs Maureen phillips Division of Medical Imaging Flinders Medical CentreFlinders DriveBedford Pk5042South Australia Australia School of Health Sciences University of South AustraliaCity East CampusNorth TerraceAdelaide5000South AustraliaAustralia International Centre of Allied Health Evidence University of South AustraliaCity East CampusNorth TerraceAdelaide5000South AustraliaAustralia

AIM:To identify and assess studies reporting the diagnostic performance of ultrasound imaging for identifying chronic liver disease(CLD)in a high risk population. METHODS:A search was performed to identify studies investigating the diagnostic accuracy of ultrasound imaging for *** authors independently used the quality assessment of diagnostic accuracy studies(QUADAS)checklist to assess the methodological quality of the selected ***-observer reliability of the QUADAS tool was assessed by measuring the degree of agreement(percent agreement,κstatistic)between the reviewers for each assessment prior to a *** characteristics of each study population, sensitivity and specificity results for the index tests, and results of any testing for observer agreement were extracted from the *** Operator Characteristic plots were generated using Microsoft Excel 2003 software and used to graphically display the diagnostic performance data and to explore the relationships between the reported ultrasound techniques and study characteristics,and methodology quality. RESULTS:Twenty-one studies published between 1991 and 2009 were retained for data extraction,analysis and assessment for methodological *** of methodology quality was performed on the 21 selected studies by two independent reviewers(RA&KT) using the QUADAS assessment *** all studies the mean number of responses within the QUADAS assessment tool was 10(range 7-13)for"Yes",1(range 0-3)for"No"and 3(range 0-6)for"unclear".Interrater agreement for assessment of methodology quality was significantly greater than chance when assessing for representative spectrum,clear selection criteria, appropriate delay between reference and index tests, adequate descriptions of the index and reference tests, reference and index test blinding,and if relevant clinical information was *** studies reported moderate to high observer agreement for ultrasound ***

关键词： Chronic liver disease Liver surface Systematic review Ultrasonography

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美国造纸工业发展趋势——可供中国借鉴的经验教训

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中华纸业 2004年第10期25卷 52-57页

作者： richard B.phillips 美国国际纸业公司

论述了美国造纸工业,尤其是美国国际纸业公司近三十年来发展的经验教训,尊重环境, 尊重供求规律,尊重在职职工。从一个侧面反映了世界发达国家造纸工业发展的规律。

关键词：中国造纸工业经验教训美国供求规律国际纸业公司发展尊重侧面借鉴

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Individual consistency and sex differences in migration strategies of Scopoli＇s shearwaters Calonectris diomedea despite year differences

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Current Zoology 2014年第5期60卷 631-641页

作者： Martina S. MULLER Bruno MASSA richard A. phillips Giacomo DELL Graduate School of Environmental Studies Nagoya University Japan University of Palermo Department of Agriculture and Forest Sciences Italy British Antarctic Survey Natural Environment Research Council Cambridge CB3 0ET UK Ornis italica Rome Italy

Recently-developed capabilities for tracking the movements of individual birds over the course of a year or longer has provided increasing evidence for consistent individual differences in migration schedules and destinations. This raises questions about the relative importance of individual consistency versus flexibility in the evolution of migration strategies, and has implications for the ability of populations to respond to climatic change. Using geolocators, we tracked the migrations of Scopoli＇s shearwaters Calonectris diomedea breeding in Linosa （Italy） across three years, and analysed timing and spatial aspects of their movements. Birds showed remarkable variation in their main wintering destination along the western coast of Africa. We found significant individual consistency in the total distance traveled, time spent in transit, and time that individuals spent in the win- tering areas. We found extensive sex differences in scheduling, duration, distances and destinations of migratory journeys. We also found sex differences in the degree of individual consistency in aspects of migration behaviour. Despite strong evidence for individual consistency, which indicates that migration journeys from the same bird tended to be more similar than those of dif- ferent birds, there remained substantial intra-individual variation between years. Indeed, we also found clear annual differences in departure dates, return dates, wintering period, the total distance traveled and re^rn routes from wintering grounds back to the colony. These findings show that this population flexibly shifts migration schedules as well as routes between years in response to direct or indirect effects of heterogeneity in the environment, while maintaining consistent individual migration strategies [Current Zoology 60 （5）： 631-641, 2014].

关键词： Avian migration GLS loggers Repeatability Individual strategies

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U. S. Paper Industry Trends Lessons Learned for China to Consider

U. S. Paper Industry Trends Lessons Learned for China to Con...

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2004中国造纸学会学术报告会

作者： richard B．phillips Senior Vice President-Technology International Paper 6285 Tri-Ridge Boulevard Loveland Ohio 45140-7910

＜正＞[SLIDE 1] The current rapid expansion of the pulp and paper industry in China shows many similarities to the growth of the industry in the United States 1960’s and 1970’s. In my 33 years with International Paper, I have had the opportunity to witness many changes in this highly competitive global industry. From the perspective of 2004,1

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Classic Feynman : all the adventures of a curious character 1st ed.

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2006年

作者： Feynman richard phillips.

来源：畅想之星图书光盘版（南... 评论

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打浆对绿液预处理阔叶木酶水解的促进作用

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南京林业大学学报（自然科学版） 2013年第6期37卷 116-120页

作者：金永灿 Houmin Chang Hasan Jameel richard phillips 南京林业大学江苏省制浆造纸科学与工程重点实验室江苏南京210037 美国北卡罗菜那州立大学森林生物材料系罗利NC27965

以总碱用量为12%(Na2O计)的绿液预处理的混合阔叶木浆为原料,探讨了PFI打浆处理对改善浆料酶水解效率的作用。结果表明:酶水解糖的得率随着PFI磨浆转数的增加而提高,其中葡聚糖得率的增加较木聚糖显著,在较低的酶用量下提高PFI磨浆转数... 详细信息

以总碱用量为12%(Na2O计)的绿液预处理的混合阔叶木浆为原料,探讨了PFI打浆处理对改善浆料酶水解效率的作用。结果表明:酶水解糖的得率随着PFI磨浆转数的增加而提高,其中葡聚糖得率的增加较木聚糖显著,在较低的酶用量下提高PFI磨浆转数有利于提高浆料的酶水解糖化得率;经打浆处理的绿液预处理浆可以在较短的时间内大幅度提高酶水解糖总糖得率,随着酶水解时间的延长,得率的增值逐渐减小;与清水介质比较,浆料在1%NaOH中磨浆对提高酶水解糖得率具有更好的促进作用。

关键词：混合阔叶木打浆绿液预处理酶水解糖

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Complications, imaging results, and midterm clinical outcomes of pipeline embolisation device in the treatment of cerebral aneurysms

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World Journal of Neuroscience 2014年第1期4卷 58-67页

作者： Hamed Asadi Timothy phillips richard Dowling Bernard Yan Peter Mitchell Melbourne Brain Centre Department of Medicine Royal Melbourne Hospital University of Melbourne Parkville Australia Neurological Intervention & Imaging Service of Western Australia Perth Australia

Background: The introduction of pipeline embolisation device (PED) has improved the feasibility of endovascular treatment of intracranial aneurysms. The device allows for endoluminal reconstruction across the aneurysm neck but is permeable enough that flow is preserved across the pressure gradients into sidebranch arteries. In spite of higher rates of aneurysm occlusion, there is lack of data concerning medium to long-term clinical and imaging results. Methods: This study was a prospective single center analysis of complications, imaging results, and medium term clinical outcomes after PED treatment of intracranial aneurysms. We included cases over a 17-month period in a tertiary interventional neuroradiology center. We collected data on demographics, vascular risk factors, clinical presentation, angiographic results post treatment, angiographic follow-up and clinical follow-up. Results: Thirty-three patients were included, 25 females and 8 males, with mean age of 55 years;3 presented with acute subarachnoid hemorrhage and 30 for elective treatment. Thirty-seven aneurysms were treated: 35 Internal Carotid Artery (ICA), 1 basilar trunk fusiform, and 1 vertebral artery intradural dissecting aneurysms. No deaths have occurred. Five patients suffered transient neurological complications (15%). Overall aneurysm occlusion was demonstrated in 85% of patients at the end of one year. Discussion:?Overall, the technique of flow diversion and endoluminal reconstruction differs greatly from the established endosaccular packing techniques of standard coiling, balloon remodeling, or stent assisted coiling. Our midterm follow-up confirms that, the rates of clinically significant complications compare favorably with published data on stent assisted coiling, potentially making these devices a truly revolutionizing technique.

关键词： Cerebral Aneurysm Flow Diverting Stents Pipline Embolisation Device Endovascular Treatment

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绿液预处理对麦草化学成分及酶水解糖化的影响

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林产化学与工业 2011年第5期31卷 48-54页

作者：黄婷陆青山金永灿谷峰张厚民 JAMEEL Hasan phillips richard 李忠正南京林业大学江苏省制浆造纸科学与工程重点实验室江苏南京210037 南京林业大学林木遗传与生物技术省部共建教育部重点实验室江苏南京210037 美国北卡罗莱那州立大学林业生物材料系罗利nc27965

主要探讨在不同温度、用碱量和硫化度条件下绿液预处理对麦草化学成分及酶水解效率的影响。随着预处理用碱量和硫化度的提高木质素的脱除率增加,但同时也加剧了碳水化合物的降解,导致麦草浆得率下降。绿液预处理废液的pH值小于9.5,弱碱... 详细信息

主要探讨在不同温度、用碱量和硫化度条件下绿液预处理对麦草化学成分及酶水解效率的影响。随着预处理用碱量和硫化度的提高木质素的脱除率增加,但同时也加剧了碳水化合物的降解,导致麦草浆得率下降。绿液预处理废液的pH值小于9.5,弱碱介质可以减少碳水化合物的降解,同时避免禾草原料含量较高的硅溶解在黑液中,有利于废液的碱回收利用。预处理后浆料经过由纤维素酶、木聚糖酶和β-葡萄糖苷酶组合而成的混合酶液水解,纤维素酶用量从5 FPU/g增加到10 FPU/g时,总糖得率及转化率显著增加。在酶用量为10 FPU/g条件下经过48 h的酶水解后,温度130℃、用碱量8%、硫化度40%条件下的预处理浆料总糖得率达到最大值43%,总糖转化率为73.1%。

关键词：麦草绿液化学成分木质素脱除率酶水解糖

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