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Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms

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World Journal of Gastroenterology 2016年第48期22卷 10601-10608页

作者： Eli D Ehrenpreis Grigory Roginsky richard m.gore University of Chicago Center for the Study of Complex Diseases Gastroenterology North Shore University Health System Highland Park Hospital Department of Radiology North Shore University HealthS ystem

AIm To clarify the association of malignancy with mesenteric panniculitis-like changes on computed tomography(CT).mETHODS All abdominal CT scans performed at North Shore University HealthS ystem showing mesenteric panniculitis from January 2005 to August 2010 were identified in the Radnet(Rad Net Corporation, Los Angeles, CA) database. Patients with a new or known diagnosis of a malignancy were included for this analysis. Longitudinal clinical histories were obtained from electronic medical *** In total, 147794 abdominal CT scans were performed during the study period. Three hundred and fiftynine patients had mesenteric panniculitis(mP)-like abnormalities on their abdominal CT. Of these patients, 81 patients(22.6%) had a known history of cancer at the time of their CT scan. Nineteen(5.3%) had a new diagnosis of cancer in concurrence with their CT, but the majority of these(14/19, 74%) were undergoing CT as part of a malignancy evaluation. Lymphomas were the most common cancers associated with mPlike findings on CT(36 cases, 36%), with follicular lymphoma being the most frequent subtype(17/36). A variety of solid tumors, most commonly prostate(7) and renal cell cancers(6) also were seen. CT follow up was obtained in 56 patients. Findings in the mesentery were unchanged in 45(80%), worsened in 6(11%), and improved in 5 patients(9%). Positron emission tomography(PET) scans performed in 44 patients only showed a positive uptake in the mesenteric mass in 2 patients(5%). CONCLUSION A new diagnosis of cancer is uncommon in patients with CT findings suggestive of mP. mP-like mesenteric abnormalities on CT generally remain stable in patients with associated malignancies. PET scanning is not recommended in the evaluation of patients with mesenteric panniculitis-like findings on CT.

关键词： Panniculitis Peritoneal X ray Neoplasms Computed tomography Small intestine misty mesentery Lymphoma Tomography Positron emission tomography

Biomarker and animal models for assessment of retinoid efficacy in cancer chemoprevention

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Acta Pharmacologica Sinica 2007年第9期28卷 1383-1391页

作者： richard m NILES Department of Biochemistry and microbiology Joan C Edwards School of MedicineMarshall UniversityHuntingtonWV 25701USA

Vitamin A is essential for normal growth and *** andlaboratory studies suggest that decreased vitamin A levels and defective metabo-lism/action may contribute to the genesis of certain *** on thisinformation,natural and synthetic derivatives of vitamin A (retinoids) have beenused for chemoprevention of *** have had some success in thechemoprevention of leukoplakia and in the decreased incidence of second prima-ries in head and neck *** is little information on biomarkers that can beused to assess the efficacy of the chemopreventive activity of *** of retinoids to induce RARb has been consistently shown to correlate withthe response of cells and tissues to retinoic acid,but few other biomarkers havebeen certified as indicators of retinoid *** light of the failure of the ATBCand CARET clinical intervention trials for chemoprevention of lung cancer,greateruse of animal models for chemoprevention studies is *** potentialcombination of phytochemicals that inhibit DNA methyltransferase activity withretinoids holds promise for more effective chemoprevention of retinoid-unrespon-sive premalignant lesions.

关键词： vitamin A retinoic acid chemoprevention biomarkers animal models transgenic animals

Hereditary pancreatitis

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World Journal of Gastroenterology 2003年第1期9卷 1-4页

作者： richard m Charnley Consultant Surgeon Freeman HospitalNewcastle upon TyneNE7 7DNUK

Hereditary pancreatitis is an autosomal dominant condition,which results in recurrent attacks of acute pancreatitis,progressing to chronic pancreatitis often at a young *** majority of patients with hereditary pancreatitis expressone of two mutations (R122H or N29I) in the cationictrypsinogen gene (PRSS1 gene). It has been hypothesisedthat one of these mutations, the R122H mutation causespancreatitis by altering a trypsin recognition site sopreventing deactivation of trypsin within the pancreas andprolonging its action, resulting in autodigestion. Families withthese two mutations have been identified in many countriesand there are also other rarer mutations, which have alsobeen linked to hereditary *** with hereditary pancreatitis present in the sameway as those with sporadic pancreatitis but at an earlierage. It is common for patients to remain undiagnosed formany years, particularly ifthey present with non-specificsymptoms. Hereditary pancreatitis should always beconsidered in patients who present with recurrent pancreatitiswith a family history of pancreatic disease. If patients withthe 2 common mutations are compared, those with theR122H mutation are more likely to present at a younger ageand are more likely to require surgical intervention than thosewith N29I. Hereditary pancreatitis carries a 40 % lifetimerisk of pancreatic cancer with those patients aged between50 to 70 being most at risk in whom screening tests maybecome important.

关键词： Trypsin Genetic Counseling Genetic Screening Humans Pancreatitis Point mutation Risk Factors Trypsinogen

Orientation of larval and juvenile horseshoe crabs Limulus polyphemus to visual cues: Effects of chemical odors

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Current Zoology 2010年第5期56卷 618-633页

作者： Julie m.mEDINA richard A.TANKERSLEY Department of Biological Sciences Florida Institute of Technology

Adult horseshoe crabs Limulus polyphemus have long served as models for the study of vision in marine arthropods. Yet, little is known about the ability of early life history stages to detect and respond to visual cues. We examined the visually directed movements of larvae and first stage juveniles to horizons containing dark visual targets of different sizes. The study tested the hypotheses that （1） larval and juvenile crabs can detect and respond to visual targets and （2） the direction of orientation varies with the presence of chemical cues associated with settlement habitats. Orientation of larval and juvenile crabs to rectangles subtending angles from 30--330~ was tested in a circular arena containing water that either lacked estuarine chemical cues （offshore water） or contained odors from aquatic vegetation or known predators. In the absence of chemical odors, larvae oriented toward and juveniles moved away from dark horizons subtending angles 〉 60~. When placed in water containing chemical odors from potential nursery habitats, including the seagrasses Halodule wrightii and Syringodium filiforme, crabs reversed their direction of orientation relative to their responses in offshore water. Odors from two known predators, the mummichug Fundulus grandis and blue crab Callinectes sapidus, had no affect on the orientation of larvae. Yet, juveniles responded to both odors by moving toward the visual target. Results support the hypothesis that the visual orientation of larval and juvenile horseshoe crabs changes upon exposure to habitat and predator cues and that the direction of the response undergoes an ontogenetic shift following metamorphosis

关键词： Orientation Visual cues Chemical odors

Understanding Science Through the Computational Lens

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Journal of Computer Science & Technology 2011年第4期26卷 569-577页

作者： richard m.Karp Department of Electrical Engineering and Computer Sciences University of California

This article explores the changing nature of the interaction between computer science and the natural and social sciences. After briefly tracing the history of scientific computation, the article presents the concept of computational lens, a metaphor for a new relationship that is emerging between the world of computation and the world of the sciences. Our main thesis is that, in many scientific fields, the processes being studied can be viewed as computational in nature, in the sense that the processes perform dynamic transformations on information represented as digital data. Viewing natural or engineered systems through the lens of their computational requirements or capabilities provides new insights and ways of thinking. A number of examples are discussed in support of this thesis. The examples are from various fields, including quantum computing, statistical physics, the World Wide Web and the Internet, mathematics, and computational molecular biology.

关键词： computational process computer science and other sciences computational lens

metamorphic consequences of secular changes in oceanic crust composition and implications for uniformitarianism in the geological record

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Geoscience Frontiers 2018年第4期9卷 1009-1019页

作者： richard m.Palin Brendan Dyck Department of Geology and Geological Engineering Colorado School of Mines Department of Earth Sciences Simon Fraser University

Cooling of the Earth＇s mantle since the meso-Archean is predicted by thermal and petrological models to have induced a secular change in the composition of primary mantle-derived magmas-and thus bulk oceanic crust; in particular, suggesting a decrease in maficity over time. This hypothesis underpins several recent studies that have addressed key geological questions concerning evolving plate tectonic styles, the rates and timing of continental crust formation, comparative planetology, and the emergence of complex life on Earth. major, minor, and trace element geochemical analyses of（meta）mafic rocks preserved in the geological record allows exploration of this theory, although no consensus currently exists about the magnitude of this change and what compositions-if anything-constitute representative examples of Paleo-, meso-, or Neo-Archean primitive oceanic crust. In this work, we review the current state of understanding of this issue, and use phase equilibria to examine the different mineral assemblages and rock types that would form during metamorphism of basalt of varying maficity in subduction zone environments. The presence（or absence） of such metamorphic products in the geological record is often used as evidence for（or against） the operation of modern-day subductiondriven plate tectonics on Earth at particular time periods; however, the control that secular changes in composition have on the stability of mineral assemblages diagnostic of subduction-zone metamorphism weakens such uniformitarianistic approaches. Geodynamic interpretations of the Archean metamorphic rock record must therefore employ a different set of petrological criteria for determining tectonothermal histories than those applied to Proterozoic or Phanerozoic equivalents.

关键词： Archean mantle cooling Oceanic crust Basalt metamorphism Uniformitarianism

What we have learned from randomized trials of prostate cancer screening

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Asian Journal of Andrology 2011年第3期13卷 369-373,510页

作者： richard m Hoffman Anthony Y Smith medicine Service New Mexico VA Health Care System Albuquerque NM 87108 USA Department of medicine University of New Mexico School of Medicine Albuquerque NM 87108 USA Department of Surgery University of New Mexico School of Medicine Albuquerque NM 87108 USA

The introduction of prostate-specific antigen （PSA） for prostate cancer screening in the late 1980s led to an epidemic of prostate cancer, particularly in developed countries. However, the first valid reports from randomized controlled trials on the efficacy of screening were not published until 2009. men in the screening group in the European Randomized Study of Screening for Prostate Cancer were 20% less likely than those in the control group to die from prostate cancer. The absolute difference was only 0.7/1000, implying that over 1400 men needed to be screened to prevent one prostate cancer death. Screening was also associated with a 70% increased risk for being diagnosed with prostate cancer. The American Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial found no survival benefit for screening. Results were not conclusive because a substantial proportion of study subjects had previously undergone PSA testing, over half of the control group had PSA testing, follow-up was relatively short, and fewer than 100 subjects died from prostate cancer. Balancing the potential survival benefit from screening is the risk of overdiagnosis--finding cancers that would not otherwise cause clinical problems^and the risk of treatment complications, including urinary, sexual and bowel dysfunction. Prostate cancer screening efforts would benefit from improved biomarkers, which more readily identify clinically important cancers. Cancer control efforts might also need to include chemoprevention, though currently available agents are controversial. In the meantime, oatients need to be supoorted in achievine informed decisions on whether to be screened for orostate cancer.

关键词： cancer screening prostate-specific antigen prostatic neoplasms randomized controlled trials as topic

Seismic performance of steel mRF building with nonlinear viscous dampers

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 254-271页

作者： Baiping DONG James m. RICLES richard SAUSE ATLSS Engineering Research Center Department of Civil and Environmental Engineering Lehigh University Bethlehem PA 18015 USA

This paper presents an experimental study of the seismic response of a 0.6-scale three-story seismicresistant building structure consisting of a moment resisting frame （mRF） with reduced beam sections （RBS）, and a frame with nonlinear viscous dampers and associated bracing （called the DBF）. The emphasis is on assessing the seismic performance for the design basis earthquake （DBE） and maximum considered earthquake （mCE）. Three mRF designs were studied, with the mRF designed for 100%, 75%, and 60%, respectively, of the required base shear design strength determined according to ASCE 7-10. The DBF with nonlinear viscous dampers was designed to control the lateral drift demands. Earthquake simulations using ensembles of DBE and mCE ground motions were conducted using the real-time hybrid simulation method. The results show the drift demand and damage that occurs in the mRF under seismic loading. Overall, the results show that a high level of seismic performance can be achieved under DBE and mCE ground motions, even for a building structure designed for as little as 60% of the base shear design strength required by ASCE 7-10 for a structure without dampers.

关键词： seismic response steel mRF nonlinear viscous damper design basis earthquake real-time hybrid simulation

The dilemma of the Jiaodong gold deposits: Are they unique?

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Geoscience Frontiers 2014年第2期5卷 139-153页

作者： richard J.Goldfarb m.Santosh U.S.Geological Survey Box 25046 MS 973 Denver Federal Center State Key Laboratory of Geological Processes and mineral Resources School of Earth Sciences and Resources China University of Geosciences Centre for Exploration Targeting School of Earth and Geographical Sciences University of Western Australia Crawley

The ca. 126e120 ma Au deposits of the Jiaodong Peninsula, eastern China, define the country＇s largest gold province with an overall endowment estimated as＆gt;3000 t Au. The vein and disseminated ores are hosted by NE-to NNE-trending brittle normal faults that parallel the margins of ca. 165e150 ma, deeply emplaced, lower crustal melt granites. The deposits are sited along the faults for many tens of kilometers and the larger orebodies are associated with dilatational jogs. Country rocks to the granites are Pre-cambrian high-grade metamorphic rocks located on both sides of a Triassic suture between the North and South China blocks. During early mesozoic convergent deformation, the ore-hosting structures developed as ductile thrust faults that were subsequently reactivated during Early Cretaceous ＂Yan-shanian＂intracontinental extensional deformation and associated gold formation. 〈br〉 Classification of the gold deposits remains problematic. many features resemble those typical of orogenic Au including the linear structural distribution of the deposits, mineralization style, ore and alteration assemblages, and ore fluid chemistry. However, Phanerozoic orogenic Au deposits are formed by prograde metamorphism of accreted oceanic rocks in Cordilleran-style orogens. The Jiaodong de-posits, in contrast, formed within two Precambrian blocks approximately 2 billion years after devolati-lization of the country rocks, and thus require a model that involves alternative fluid and metal sources for the ores. A widespread suite of ca. 130e123 ma granodiorites overlaps temporally with the ores, but shows a poor spatial association with the deposits. Furthermore, the deposit distribution and mineral-ization style is atypical of ores formed from nearby magmas. The ore concentration requires fluid focusing during some type of sub-crustal thermal event, which could be broadly related to a combination of coeval lithospheric thinning, asthenospheric upwelling, paleo-Pacific plate subducti

关键词： Gold Jiaodong North China block Tectonics mineral deposit mode