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Science China Life Sciences 2024年

作者： Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shuzhen Huang richard H.Finnell Fanyi Zeng Shanghai Institute of Medical Genetics Shanghai Children's Hospital Shanghai Jiao Tong University School of Medicine Department of Histo-Embryology Genetics and Developmental Biology Shanghai Jiao Tong University School of Medicine NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction Engineering Center for Precision Environmental Health Baylor College of Medicine School of Pharmacy Macau University of Science and Technology

Autosomal recessive spinocerebellar ataxias（SCARs） are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation（c.1A>G, p.M1V） in the AFG3L2 start codon. The proband's genotype included heterozygous mutations of the compound AFG3L2(p.[M1V]; [R632X]（c.[1A>G];[1894.C>T]）), which were inherited from the father（c.1A>G, p.M1V） and mother（c.1894C>T, p.R632X）. Functional studies performed on hiPSCs（human induced pluripotent stem cells） generated from the patients and HEK293T cells showed that the mutations impair mitochondrial function and the unbalanced expression of AFG3L2 mRNA and protein levels. Furthermore, this novel mutation resulted in the degradation of the protein and the reduction of the stability of the AFG3L2 protein, and MCU（mitochondrial calcium uniporter） complex mediated Ca2+overload.

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文化、道德、行为等与会计行业相关的事项

新理财（公司理财） 2024年第1期 76-78页

作者： richard Crump 不详

当我们作出正确决策时,要从各个角度去考虑,并非所有事情都像合规处理一样有明确的界限。道德分析,金融道德学副教授、Tezos基金会首席财务官和瑞银集团首席运营官埃尔科·菲奥莱(Ecelco Fiole)认为,金融从业人员面临的一个问题是,他们... 详细信息

当我们作出正确决策时,要从各个角度去考虑,并非所有事情都像合规处理一样有明确的界限。道德分析,金融道德学副教授、Tezos基金会首席财务官和瑞银集团首席运营官埃尔科·菲奥莱(Ecelco Fiole)认为,金融从业人员面临的一个问题是,他们接受的道德决策培训非常有限,面对道德困境时,只能运用个人的道德观念来进行评判,不能客观、公平地分析与判断。

关键词：金融从业人员会计行业道德决策道德分析道德困境道德观念首席运营官正确决策

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感恩记录

疯狂英语（初中天地） 2024年第1期 21-24页

作者： richard Edwards 不详

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享... 详细信息

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享受生命的美好,发现感恩的力量。

关键词：感恩享受生命用心记录

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Fetal MRI Artifacts: Semi-Supervised Generative Adversarial Neural Network for Motion Artifacts Reducing in Fetal Magnetic Resonance Images

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Journal of Computer and Communications 2024年第6期12卷 210-225页

作者： Ítalo Messias Félix Santos Gilson Antonio Giraldi Heron Werner Junior Bruno richard Schulze National Laboratory for Scientific Computing Rio de Janeiro Brazil Biodesign Laboratory Dasa/PUC-Rio Rio de Janeiro Brazil

This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specifically utilizing Cycle GAN. Synthetic pairs of images, simulating artifacts in fetal MRI, are generated to train the model. Our primary contribution is the use of Cycle GAN for fetal MRI restoration, augmented by artificially corrupted data. We compare three approaches (supervised Cycle GAN, Pix2Pix, and Mobile Unet) for artifact removal. Experimental results demonstrate that the proposed supervised Cycle GAN effectively removes artifacts while preserving image details, as validated through Structural Similarity Index Measure (SSIM) and normalized Mean Absolute Error (MAE). The method proves comparable to alternatives but avoids the generation of spurious regions, which is crucial for medical accuracy.

关键词： Fetal MRI Artifacts Removal Deep Learning Image Processing Generative Adversarial Networks

Boehmeria nivea var. strigosa (Urticaceae), a new variety from Southwest China

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广西植物 2024年第9期44卷 1617-1624,I0001-I0006页

作者： ZHAO Ying richard I.MILNE LI Zhipeng Amos KIPKOECH WU Zengyuan Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Yunnan UniversityKunming 650091YunnanChina Institute of Molecular Plant Sciences/School of Biological Sciences University of EdinburghEH93JHEdinburghUK

Boehmeria nivea *** Zeng ***&***,a new variety of ***(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular *** new variety is mainly characterized by its green abaxial leaf blade,partly connate stipules,and densely patent strigose hairs on stems and *** phylogenetic analysis based on rbc L,nrDNA and rbc L+nrDNA datasets,revealed that all individuals of *** *** formed a monophyletic *** conservation status of *** *** is assessed as“Near Threatened”(NT)according to IUCN evaluation *** discovery of this new variety is not only crucial for the taxonomy of ramie,but also provides reference for the exploration and utilization of ramie.

关键词： Boehmeria nivea morphology molecular phylogeny new variety Southwest China Yunnan

Function and Application Progress of Probiotics in Food

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Agricultural Biotechnology 2024年第4期13卷 63-64,69页

作者： Junpeng ZHAO richard Avoi Azman Bin Atil@Azmi Jiao CHEN Ling YUN Tangshan Food and Drug Comprehensive Inspection and Testing Center Tangshan 063000China Hebei Agricultural Products Quality and Safety Testing Technology Innovation Center Tangshan 063000China Tangshan Institute of Industrial Technology for Functional Agricultural Products Tangshan 063000China Universiti Malaysia Sabah Faculty of Medicine and Health SciencesMalaysia Guizhou Forerunner College Guiyang 550000China Tangshan Center for Disease Prevention and Control Tangshan 063000China

Probiotics have a long history of use in human production and *** the gradual deepening of the research on the functions of probiotics,their various nutritional and health benefits for the human body have also become increasingly *** research shows that probiotics can regulate intestinal flora,and improve immunity and even the symptoms of some ***,in the food industry,the application of probiotics from traditional fermented foods to functional foods has become more and more *** this paper,the research progress of nutritional function and application of probiotics in food at home and abroad was reviewed,in order to provide some reference for the safe application of probiotics in food.

关键词： Probiotics Physiological function Food Development and application

Determination of 14 Organophosphorus Pesticide Residues in Mutton by Gel Permeation Chromatography-Gas Chromatography-Mass Spectrometry(GPC-GC-MS)

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Agricultural Biotechnology 2024年第3期13卷 28-30,33页

[Objectives]This study was conducted to purify mutton samples by gel permeation chromatography(GPC).[Methods]Fourteen organophosphorus pesticide residues in samples were qualitatively and quantitatively analyzed by gas chromatography-mass spectrometry(GC-MS)in selective ion scanning mode(SIM).[Results]The organophosphorus pesticide standard solutions showed good linearity in the mass concentration range of 0.1-10.0μg/ml with correlation coefficients(r)not lower than 0.999,and the detection limits(S=3 N)ranged from 0.01 to 0.05 mg/*** average recovery values were in the range of 80.2%-99.7%,with relative standard deviations(RSDs,n=3)in the range of 1.8%-6.3%,at the addition levels of 0.5,1.0 and 2.0 mg/kg.[Conclusions]The method is simple,sensitive and accurate,and can be used for the determination of organophosphorus pesticide residues in mutton.

关键词： Mutton Gas chromatography-mass spectrometry Gel permeation chromatography Organophosphorus Pesticide residue

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 97-104页

作者： Mihai A.Bentan Evan R.Reiter richard M.Costanzo Daniel H.Coelho Department of Otolaryngology-Head&Neck Surgery Virginia Commonwealth University School of MedicineRichmondVirginiaUSA

Objective:The aim of this study was to review findings from a large prospective national database of chemosensory disturbances associated with coronavirus disease 2019(COVID-19)*** Sources:The Virginia Commonwealth University Smell and Taste Center national database of COVID-19 chemosensory ***:A series of online surveys,first opened on April 10,2020,was made accessible nationwide to any adult with sudden chemosensory dysfunction since January *** received subsequent follow-up surveys 14 days,1 month,3 months,and 6 months after *** additional survey was sent to all participants on May 28,2022 to assess long-term *** pertaining to demographics,symptoms,comorbidities,treatments,and life impact was ***:Of 363 participants who reported complete smell recovery,51.2%recovered within 1 month,70%within 3 months,and 79%within 6 months,while 8.8%took over 1 year to completely *** all participants,7.5%had no smell *** predictors of recovery included age<40,male gender,and the presence of nasal *** predictors included difficulty breathing and prior head *** participants reported a decrease in quality of life and the presence of potential safety hazards associated with decreased smell ***:Most subjects with COVID-19-related chemosensory dysfunction recover,with the majority noting complete recovery within weeks of *** aged over 40 years and female gender were associated with lower rates of recovery.A considerable number of participants reported significant impact on quality of life and safety.

关键词： anosmia COVID-19 smell

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Evaluation of the Reproduction Parameters of “Lohmann Brown” Strain Chickens Fed with Cajanus cajan Leaf Meal in the Republic of Congo

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Open Journal of Animal Sciences 2024年第3期14卷 234-248页

作者： richard Missoko Mabeki Alexis Jonas Ognika Dora Chérita Ekou Nathalie Myreille Ockoyi Parisse Akouango Laboratory of Animal Production and Biodiversity National School of Agronomy and Forestry Marien Ngouabi University Brazzaville Republic of the Congo Department of Animal Production and Health Marien Ngouabi University Brazzaville Republic of the Congo

The objective of this study was to evaluate the reproductive parameters of “Lohmann Brown” strain chickens fed on Cajanus cajan leaves and to assess the viability of the chicks after hatching. 40 hens of the “Lohmann Brown” strain fed on Cajanus cajan leaf flour laid 219 eggs divided into four batches depending on the rate of incorporation of Cajanus cajan leaf flour in the rations (0%, 5%, 10% and 15%) were trained and introduced into the incubator. Results: the incubator indicates a hatching temperature of 38˚C to 37.2˚C and relative humidity of 60% to 70%. Hatching performance shows that: The 15% batch recorded the highest fertility rate 86.95% compared to 26.88% of the control batch. The CC 15% batch recorded the highest hatching rate 36.87. The lowest rate (17.18%) was recorded in the control batch (CC 0%). The highest embryonic mortality rate was recorded in the CC 15% batch. The lowest rate in the CC 10% batch. Concerning unfertilized eggs, the highest rate is 72.20% (CC 0%), and the lowest are (12.03%;57.42% and 66.66%) recorded in CC batches. 15%, CC 5% and CC 10% respectively. For the shell mortality rate, the highest is 18.58% recorded in the CC 15% batch. The lowest shell mortality rate is 2.07%, obtained in the control batch (CC 0%);the dust mortality rate was 0% for all chicks. The study seems to indicate that the incorporation of Cajanus cajan leaf meal up to 15% into the reproduction type ration in hens does not cause any harmful effects on the reproduction performance of laying hens.

关键词： Egg Incubation Hatching Fertility Mortality Viability

Clay Materials for Ceramics Application from N’Djamena in the Chad Republic: Mineralogical, Physicochemical and Microstructural Characterization

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Journal of Materials Science and Chemical Engineering 2024年第2期12卷 31-48页

作者： Ndjolba Madjihingam Djoda Pagore Jacques richard Mache Bebbata Warabi Bertin Pagna Kagonbe Patrick Mountapmbeme Kouotou Department of Civil Engineering National Advanced School of Engineering University of Maroua Maroua Cameroon Department of Mining Engineering School of Geology and Mining Engineering University of Ngaoundere Meiganga Cameroon Local Materials Authority Promotion (MIPROMALO) Yaoundé Cameroon Department of Environmental Sciences Advanced School of Agriculture Forestry Water and Environment University of Ebolowa Ebolowa Cameroon

Herein, we report some characteristics of the clayey materials (CMs) collected from Kaliwa (C1), Kabé (C2) and Malo (C3) district in N’Djamena (Chad). Three samples were characterized applying XRF, XRD, FTIR, SEM. In addition, TGA/DSC were performed to control decomposition/mass loss and show phase transitions respectively of CMs. Geochemical analysis by XRF reveals the following minerals composition: SiO2 (~57% - 66%), Al2O3 (~13% - 15%), Fe2O3 (~6% - 10%), TiO2 (~1% - 2%) were the predominant oxides with a reduced proportion in C1, and (~7%) of fluxing agents (K2O, CaO, Na2O). Negligible and trace of MgO (~1%) and P2O5 was noted. The mineralogical composition by XRD shows that, C1, C2 and C3 display close mineralogy with: Quartz (~50%), feldspar (~20%) as non-clay minerals, whereas clays minerals were mostly kaolinite (~15%), illite (~5%) and smectite (~10%). FTIR analysis exhibits almost seemingly similar absorption bands characteristic of hydroxyls elongation, OH valence vibration of Kaolinite and stretching vibration of some Metal-Oxygen bond. SEM micrographs of the samples exhibit microstructureformed by inter-aggregates particles with porous cavities. TGA/DSCconfirm the existence of quartz (570˚C to 870˚C), carbonates (600˚C - 760˚C), kaolinite (569˚C - 988˚C), illite (566˚C - 966˚C), MgO (410˚C - 720˚C) and smectite (650˚C - 900˚C). The overall characterization indicates that, these clayey soils exhibit good properties for ceramic application.

关键词： Clay Soils Characterization Mineralogy Physicochemical Properties Ceramic Application